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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SYNRG-CCR7 (FusionGDB2 ID:88499)

Fusion Gene Summary for SYNRG-CCR7

check button Fusion gene summary
Fusion gene informationFusion gene name: SYNRG-CCR7
Fusion gene ID: 88499
HgeneTgene
Gene symbol

SYNRG

CCR7

Gene ID

11276

1236

Gene namesynergin gammaC-C motif chemokine receptor 7
SynonymsAP1GBP1|SYNGBLR2|CC-CKR-7|CCR-7|CD197|CDw197|CMKBR7|EBI1
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionsynergin gammaAP1 gamma subunit binding protein 1AP1 subunit gamma-binding protein 1adaptor-related protein complex 1 gamma subunit-binding protein 1gamma-synerginC-C chemokine receptor type 7Bukitt's lymphoma receptor 2CC chemokine receptor 7EBV-induced G protein-coupled receptor 1Epstein-Barr virus induced gene 1Epstein-Barr virus-induced G-protein coupled receptor 1MIP-3 beta receptorchemokine (C-C motif)
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339208, ENST00000345615, 
ENST00000346661, ENST00000394378, 
ENST00000502449, ENST00000585472, 
ENST00000591288, ENST00000588194, 
ENST00000579344, ENST00000246657, 
Fusion gene scores* DoF score21 X 26 X 10=54607 X 2 X 7=98
# samples 219
** MAII scorelog2(21/5460*10)=-4.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/98*10)=-0.122856747785533
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYNRG [Title/Abstract] AND CCR7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSYNRG(35921297)-CCR7(38715194), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCR7

GO:0002408

myeloid dendritic cell chemotaxis

11602640

TgeneCCR7

GO:0071345

cellular response to cytokine stimulus

11602640

TgeneCCR7

GO:0090023

positive regulation of neutrophil chemotaxis

21051556


check buttonFusion gene breakpoints across SYNRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCR7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0BZ-01ASYNRGchr17

35921297

-CCR7chr17

38715194

-


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Fusion Gene ORF analysis for SYNRG-CCR7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339208ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5CDS-5UTRENST00000345615ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5CDS-5UTRENST00000346661ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5CDS-5UTRENST00000394378ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5CDS-5UTRENST00000502449ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5CDS-5UTRENST00000585472ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5CDS-5UTRENST00000591288ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
5UTR-3CDSENST00000588194ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
5UTR-5UTRENST00000588194ENST00000579344SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000339208ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000345615ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000346661ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000394378ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000502449ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000585472ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-
In-frameENST00000591288ENST00000246657SYNRGchr17

35921297

-CCR7chr17

38715194

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339208SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-39041804932930945
ENST00000346661SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-38461746352872945
ENST00000345615SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-3585148582611867
ENST00000502449SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-35601460312586851
ENST00000591288SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-33061206262332768
ENST00000394378SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-35551455262581851
ENST00000585472SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-35521452262578850

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339208ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.000871940.99912804
ENST00000346661ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0009497830.9990502
ENST00000345615ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0020885210.9979115
ENST00000502449ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0021116820.99788827
ENST00000591288ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0026100510.99739
ENST00000394378ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0020987560.9979012
ENST00000585472ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0020819850.99791807

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Fusion Genomic Features for SYNRG-CCR7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SYNRG-CCR7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35921297/chr17:38715194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322115_1555541315.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220115_1554761225.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321115_1555541303.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221115_1554751236.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120115_1553931109.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322295_3885541315.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220295_3884761225.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321295_3885541303.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221295_3884751236.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120295_3883931109.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322457_4615541315.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220457_4614761225.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321457_4615541303.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221457_4614751236.0MotifNote=DFXDF motif 1
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703117_1303379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703153_1703379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703192_2193379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703248_2633379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570325_593379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703290_3133379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703332_3783379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570387_953379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703131_1523379.0TransmembraneHelical%3B Name%3D3
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703171_1913379.0TransmembraneHelical%3B Name%3D4
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703220_2473379.0TransmembraneHelical%3B Name%3D5
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703264_2893379.0TransmembraneHelical%3B Name%3D6
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703314_3313379.0TransmembraneHelical%3B Name%3D7
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570360_863379.0TransmembraneHelical%3B Name%3D1
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570396_1163379.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322690_6945541315.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322775_7795541315.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220690_6944761225.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220775_7794761225.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321690_6945541303.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321775_7795541303.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221690_6944751236.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221775_7794751236.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120457_4613931109.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120690_6943931109.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120775_7793931109.0MotifNote=DFXDF motif 3


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Fusion Gene Sequence for SYNRG-CCR7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88499_88499_1_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000339208_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3904nt_BP=1804nt
AGTCACGTGGGCGCGAGGCCCCGCCCCATCGCCCGGTCCGCGGCGAGGTGGGGCCTGGTGTTTGACCCGGAAGTGGCTGTGTTCAGCTGA
CAGCTGCTGATAAGGTGGCGGCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGG
GCCGCGGGAGCTGGCGCGGGGTCCGCCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAGGTGGGATAAGACCCCCTCAAGCAGGCCTGATG
CCGATGCAGCAACAAGGATTTCCTATGGTCTCTGTCATGCAGCCTAATATGCAAGGCATTATGGGAATGAATTACAGCTCTCAGATGTCC
CAAGGACCTATTGCTATGCAGGCAGGAATACCAATGGGACCAATGCCAGCAGCGGGAATGCCTTACCTAGGACAAGCACCCTTCCTGGGC
ATGCGTCCTCCAGGCCCACAGTACACTCCAGACATGCAGAAGCAGTTTGCCGAAGAGCAGCAGAAACGATTTGAACAGCAGCAAAAACTC
TTAGAAGAAGAAAGAAAAAGACGCCAGTTTGAAGAGCAGAAGCAAAAGCTCAGACTTTTGAGCAGTGTGAAACCCAAGACAGGAGAGAAG
AGTAGAGATGATGCTTTGGAAGCCATAAAAGGAAATTTAGATGGGTTTTCCAGAGATGCAAAAATGCACCCTACTCCAGCATCGCACCCC
AAGAAACCAGGCCCTTCCTTGGAGGAGAAGTTCCTAGTATCTTGTGATATAAGTACATCTGGGCAGGAACAAATTAAATTAAATACTTCT
GAAGTTGGCCACAAAGCCCTAGGCCCAGGTTCCAGTAAGAAGTATCCCAGTTTAATGGCCAGTAACGGGGTTGCTGTAGATGGATGTGTA
AGTGGTACCACCACTGCAGAGGCAGAAAATACTTCAGATCAAAACCTGTCAATTGAAGAGAGTGGTGTGGGAGTATTTCCCTCACAGGAT
CCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTCCAGATGCCTATAAGAAAATCTTAGAAACCACAATGACTCCA
ACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGCTTCCCAGGGAAACTCTTGGACAGATATGGGCCTTAGCTAAT
CGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAGCCATGATAGCGGTAACACAGAGGGGCGTTCCTGCAATGAGT
CCTGATGCTTTAAACCAGTTCCCAGCAGCTCCTATTCCAACTTTAAGTGGCTTTTCTATGACTCTGCCTACACCGGTGAGTCAGCCAACT
GTGATACCTTCAGGTCCTGCGGGCTCCATGCCCCTCAGCCTTGGACAGCCAGTCATGGGCATTAACCTTGTTGGACCAGTGGGTGGAGCT
GCAGCCCAGGCTTCTAGTGGTTTCATACCAACCTACCCTGCAAATCAGGTAGTAAAGCCAGAAGAAGATGACTTCCAGGATTTTCAAGAT
GCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGTTGCCTGCTTCTTCAAAAACAAGTAACTCCCAGCATGGAAAC
AGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTTCAATGGACAAATATGCTGTGTTTAAAGGAATTGCAGCTGAC
AAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATAGTGCTTTCAGAGAACTTGAACAGACAGCAGAGAATAAACCT
TTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGAGGTCACGGACGATTAC
ATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAAAGCCTGGTTCCTCCCT
ATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAAGAGGCTCAAGACCATG
ACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAGCGCGGCCAAGTCCTGG
GTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACTTCTTTGCATCAGCATT
GACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCTGTCCTGTGTGGGCATC
TGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGCGATGCGATGCTCTCTC
ATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCTGGCCATGAGCTTCTGT
TACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGCTGTGGTCGTGGTCTTC
ATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCACCTGTGAGCTCAGTAAG
CAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGCCTTCATCGGCGTCAAG
TTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTCCTGTCGGCACATCCGG
CGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTCTTCTGCCTGGACTAGAGGGACCTCTCCCAGGG
TCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAGCTGCTCAGGGAAAAGCAGCTCTCCCCTCAGAG
TGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGCCAAAAAAAGACAGGGCTGATAAGCTAACACCA
GACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAAAGTCCAGAAACTGTTCCCACCTGCTGGAGTGA
AGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAATGAACCTTCTGGCCTCCCACAGACTCAAATGCT
CAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGACTTCTTGGCTTGGTGAGGAAAAGCGGACATCAG
CTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAGCCAGCGGGAATGGCAGCTGCCACGCCGCCCTA
AAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGAGTGTGGTGTTTCCTGCAGGCCAGGCCAGCTGC
CTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCTCTTGGCTCCACTGGGATGGGAGGAGAGGACAA
GGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTCTTTGTTCTTTGTCACAGGGACTGAAAACCTCT
CCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAAGTTTTCCCTTGAGGAAACAACAGCTTTAAAAG

>88499_88499_1_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000339208_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=945AA_BP=568
MLIRWRRRRQRQVGSKMALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQ
GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKS
RDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVS
GTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANR
TTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAA
AQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADK
SSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPI
MYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISID
RYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCY
LVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKF

--------------------------------------------------------------
>88499_88499_2_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000345615_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3585nt_BP=1485nt
GCTGACAGCTGCTGATAAGGTGGCGGCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCG
GCGGGGCCGCGGGAGCTGGCGCGGGGTCCGCCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAGGTGGGATAAGACCCCCTCAAGCAGGCC
TGATGCCGATGCAGCAACAAGGATTTCCTATGGTCTCTGTCATGCAGCCTAATATGCAAGGCATTATGGGAATGAATTACAGCTCTCAGA
TGTCCCAAGGACCTATTGCTATGCAGGCAGGAATACCAATGGGACCAATGCCAGCAGCGGGAATGCCTTACCTAGGACAAGCACCCTTCC
TGGGCATGCGTCCTCCAGGCCCACAGTACACTCCAGACATGCAGAAGCAGTTTGCCGAAGAGCAGCAGAAACGATTTGAACAGCAGCAAA
AACTCTTAGAAGAAGAAAGAAAAAGACGCCAGTTTGAAGAGCAGAAGCAAAAGCTCAGACTTTTGAGCAGTGTGAAACCCAAGACAGGAG
AGAAGAGTAGAGATGATGCTTTGGAAGCCATAAAAGGAAATTTAGATGGGTTTTCCAGAGATGCAAAAATGCACCCTACTCCAGCATCGC
ACCCCAAGAAACCAGGTGTGGGAGTATTTCCCTCACAGGATCCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTC
CAGATGCCTATAAGAAAATCTTAGAAACCACAATGACTCCAACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGC
TTCCCAGGGAAACTCTTGGACAGATATGGGCCTTAGCTAATCGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAG
CCATGATAGCGGTAACACAGAGGGGCGTTCCTGCAATGAGTCCTGATGCTTTAAACCAGTTCCCAGCAGCTCCTATTCCAACTTTAAGTG
GCTTTTCTATGACTCTGCCTACACCGGTGAGTCAGCCAACTGTGATACCTTCAGGTCCTGCGGGCTCCATGCCCCTCAGCCTTGGACAGC
CAGTCATGGGCATTAACCTTGTTGGACCAGTGGGTGGAGCTGCAGCCCAGGCTTCTAGTGGTTTCATACCAACCTACCCTGCAAATCAGG
TAGTAAAGCCAGAAGAAGATGACTTCCAGGATTTTCAAGATGCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGT
TGCCTGCTTCTTCAAAAACAAGTAACTCCCAGCATGGAAACAGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTT
CAATGGACAAATATGCTGTGTTTAAAGGAATTGCAGCTGACAAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATA
GTGCTTTCAGAGAACTTGAACAGACAGCAGAGAATAAACCTTTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTT
TCCAGGTATGCCTGTGTCAAGATGAGGTCACGGACGATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCT
CCAAGAAGGACGTGCGGAACTTTAAAGCCTGGTTCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGG
TCGTGTTGACCTATATCTATTTCAAGAGGCTCAAGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCC
TGACCCTTCCCTTCTGGGCCTACAGCGCGGCCAAGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGA
GCTTCTTCAGTGGCATGCTCCTACTTCTTTGCATCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTG
CCCGCGTCCTTCTCATCAGCAAGCTGTCCTGTGTGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACC
TCCAGAGGAGCAGCAGTGAGCAAGCGATGCGATGCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGG
TGATCGGCTTTCTGGTCCCCCTGCTGGCCATGAGCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCA
ACAAGGCCATCAAGGTGATCATCGCTGTGGTCGTGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGG
CCAACTTCAACATCACCAGTAGCACCTGTGAGCTCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCT
GCTGCGTCAACCCTTTCTTGTACGCCTTCATCGGCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCC
AGGAGCAGCTCCGGCAGTGGTCTTCCTGTCGGCACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCAT
AGGCGACTCTTCTGCCTGGACTAGAGGGACCTCTCCCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCC
CGCCAAAAGCTGCTCAGGGAAAAGCAGCTCTCCCCTCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTC
AACCAATGCCAAAAAAAGACAGGGCTGATAAGCTAACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACT
GAAAGTGAAAGTCCAGAAACTGTTCCCACCTGCTGGAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGT
CCTCTGAATGAACCTTCTGGCCTCCCACAGACTCAAATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAG
TGGGGAGACTTCTTGGCTTGGTGAGGAAAAGCGGACATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTG
TCCTCCAAGCCAGCGGGAATGGCAGCTGCCACGCCGCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAA
CAGGGGAGAGTGTGGTGTTTCCTGCAGGCCAGGCCAGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATG
CACTCAGCTCTTGGCTCCACTGGGATGGGAGGAGAGGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACG
AGCTTGTTCTTTGTTCTTTGTCACAGGGACTGAAAACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACAC

>88499_88499_2_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000345615_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=867AA_BP=490
MLIRWRRRRQRQVGSKMALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQ
GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKS
RDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPR
ETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVM
GINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMD
KYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKK
DVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFF
SGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIG
FLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCV

--------------------------------------------------------------
>88499_88499_3_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000346661_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3846nt_BP=1746nt
TGTTTGACCCGGAAGTGGCTGTGTTCAGCTGACAGCTGCTGATAAGGTGGCGGCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGC
TGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCGCCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAG
GTGGGATAAGACCCCCTCAAGCAGGCCTGATGCCGATGCAGCAACAAGGATTTCCTATGGTCTCTGTCATGCAGCCTAATATGCAAGGCA
TTATGGGAATGAATTACAGCTCTCAGATGTCCCAAGGACCTATTGCTATGCAGGCAGGAATACCAATGGGACCAATGCCAGCAGCGGGAA
TGCCTTACCTAGGACAAGCACCCTTCCTGGGCATGCGTCCTCCAGGCCCACAGTACACTCCAGACATGCAGAAGCAGTTTGCCGAAGAGC
AGCAGAAACGATTTGAACAGCAGCAAAAACTCTTAGAAGAAGAAAGAAAAAGACGCCAGTTTGAAGAGCAGAAGCAAAAGCTCAGACTTT
TGAGCAGTGTGAAACCCAAGACAGGAGAGAAGAGTAGAGATGATGCTTTGGAAGCCATAAAAGGAAATTTAGATGGGTTTTCCAGAGATG
CAAAAATGCACCCTACTCCAGCATCGCACCCCAAGAAACCAGGCCCTTCCTTGGAGGAGAAGTTCCTAGTATCTTGTGATATAAGTACAT
CTGGGCAGGAACAAATTAAATTAAATACTTCTGAAGTTGGCCACAAAGCCCTAGGCCCAGGTTCCAGTAAGAAGTATCCCAGTTTAATGG
CCAGTAACGGGGTTGCTGTAGATGGATGTGTAAGTGGTACCACCACTGCAGAGGCAGAAAATACTTCAGATCAAAACCTGTCAATTGAAG
AGAGTGGTGTGGGAGTATTTCCCTCACAGGATCCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTCCAGATGCCT
ATAAGAAAATCTTAGAAACCACAATGACTCCAACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGCTTCCCAGGG
AAACTCTTGGACAGATATGGGCCTTAGCTAATCGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAGCCATGATAG
CGGTAACACAGAGGGGCGTTCCTGCAATGAGTCCTGATGCTTTAAACCAGTTCCCAGCAGCTCCTATTCCAACTTTAAGTGGCTTTTCTA
TGACTCTGCCTACACCGGTGAGTCAGCCAACTGTGATACCTTCAGGTCCTGCGGGCTCCATGCCCCTCAGCCTTGGACAGCCAGTCATGG
GCATTAACCTTGTTGGACCAGTGGGTGGAGCTGCAGCCCAGGCTTCTAGTGGTTTCATACCAACCTACCCTGCAAATCAGGTAGTAAAGC
CAGAAGAAGATGACTTCCAGGATTTTCAAGATGCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGTTGCCTGCTT
CTTCAAAAACAAGTAACTCCCAGCATGGAAACAGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTTCAATGGACA
AATATGCTGTGTTTAAAGGAATTGCAGCTGACAAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATAGTGCTTTCA
GAGAACTTGAACAGACAGCAGAGAATAAACCTTTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTAT
GCCTGTGTCAAGATGAGGTCACGGACGATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGG
ACGTGCGGAACTTTAAAGCCTGGTTCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGA
CCTATATCTATTTCAAGAGGCTCAAGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTC
CCTTCTGGGCCTACAGCGCGGCCAAGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCA
GTGGCATGCTCCTACTTCTTTGCATCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCC
TTCTCATCAGCAAGCTGTCCTGTGTGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGA
GCAGCAGTGAGCAAGCGATGCGATGCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCT
TTCTGGTCCCCCTGCTGGCCATGAGCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCA
TCAAGGTGATCATCGCTGTGGTCGTGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCA
ACATCACCAGTAGCACCTGTGAGCTCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCA
ACCCTTTCTTGTACGCCTTCATCGGCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGC
TCCGGCAGTGGTCTTCCTGTCGGCACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTC
TTCTGCCTGGACTAGAGGGACCTCTCCCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAG
CTGCTCAGGGAAAAGCAGCTCTCCCCTCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGC
CAAAAAAAGACAGGGCTGATAAGCTAACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAA
AGTCCAGAAACTGTTCCCACCTGCTGGAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAAT
GAACCTTCTGGCCTCCCACAGACTCAAATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGAC
TTCTTGGCTTGGTGAGGAAAAGCGGACATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAG
CCAGCGGGAATGGCAGCTGCCACGCCGCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGA
GTGTGGTGTTTCCTGCAGGCCAGGCCAGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCT
CTTGGCTCCACTGGGATGGGAGGAGAGGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTC
TTTGTTCTTTGTCACAGGGACTGAAAACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAA

>88499_88499_3_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000346661_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=945AA_BP=568
MLIRWRRRRQRQVGSKMALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQ
GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKS
RDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVS
GTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANR
TTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAA
AQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADK
SSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPI
MYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISID
RYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCY
LVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKF

--------------------------------------------------------------
>88499_88499_4_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000394378_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3555nt_BP=1455nt
GAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCG
CCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAGGTGGGATAAGACCCCCTCAAGCAGGCCTGATGCCGATGCAGCAACAAGGATTTCCTA
TGGTCTCTGTCATGCAGCCTAATATGCAAGGCATTATGGGAATGAATTACAGCTCTCAGATGTCCCAAGGACCTATTGCTATGCAGGCAG
GAATACCAATGGGACCAATGCCAGCAGCGGGAATGCCTTACCTAGGACAAGCACCCTTCCTGGGCATGCGTCCTCCAGGCCCACAGTACA
CTCCAGACATGCAGAAGCAGTTTGCCGAAGAGCAGCAGAAACGATTTGAACAGCAGCAAAAACTCTTAGAAGAAGAAAGAAAAAGACGCC
AGTTTGAAGAGCAGAAGCAAAAGCTCAGACTTTTGAGCAGTGTGAAACCCAAGACAGGAGAGAAGAGTAGAGATGATGCTTTGGAAGCCA
TAAAAGGAAATTTAGATGGGTTTTCCAGAGATGCAAAAATGCACCCTACTCCAGCATCGCACCCCAAGAAACCAGGTGTGGGAGTATTTC
CCTCACAGGATCCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTCCAGATGCCTATAAGAAAATCTTAGAAACCA
CAATGACTCCAACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGCTTCCCAGGGAAACTCTTGGACAGATATGGG
CCTTAGCTAATCGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAGCCATGATAGCGGTAACACAGAGGGGCGTTC
CTGCAATGAGTCCTGATGCTTTAAACCAGTTCCCAGCAGCTCCTATTCCAACTTTAAGTGGCTTTTCTATGACTCTGCCTACACCGGTGA
GTCAGCCAACTGTGATACCTTCAGGTCCTGCGGGCTCCATGCCCCTCAGCCTTGGACAGCCAGTCATGGGCATTAACCTTGTTGGACCAG
TGGGTGGAGCTGCAGCCCAGGCTTCTAGTGGTTTCATACCAACCTACCCTGCAAATCAGGTAGTAAAGCCAGAAGAAGATGACTTCCAGG
ATTTTCAAGATGCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGTTGCCTGCTTCTTCAAAAACAAGTAACTCCC
AGCATGGAAACAGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTTCAATGGACAAATATGCTGTGTTTAAAGGAA
TTGCAGCTGACAAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATAGTGCTTTCAGAGAACTTGAACAGACAGCAG
AGAATAAACCTTTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGAGGTCA
CGGACGATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAAAGCCT
GGTTCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAAGAGGC
TCAAGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAGCGCGG
CCAAGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACTTCTTT
GCATCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCTGTCCT
GTGTGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGCGATGC
GATGCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCTGGCCA
TGAGCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGCTGTGG
TCGTGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCACCTGTG
AGCTCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGCCTTCA
TCGGCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTCCTGTC
GGCACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTCTTCTGCCTGGACTAGAGGGAC
CTCTCCCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAGCTGCTCAGGGAAAAGCAGCTC
TCCCCTCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGCCAAAAAAAGACAGGGCTGATA
AGCTAACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAAAGTCCAGAAACTGTTCCCACC
TGCTGGAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAATGAACCTTCTGGCCTCCCACAG
ACTCAAATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGACTTCTTGGCTTGGTGAGGAAAA
GCGGACATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAGCCAGCGGGAATGGCAGCTGCC
ACGCCGCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGAGTGTGGTGTTTCCTGCAGGCC
AGGCCAGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCTCTTGGCTCCACTGGGATGGGA
GGAGAGGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTCTTTGTTCTTTGTCACAGGGAC
TGAAAACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAAGTTTTCCCTTGAGGAAACAAC

>88499_88499_4_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000394378_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=851AA_BP=474
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPA
AGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFS
RDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPG
KLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQAS
SGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSEN
TVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSI
ICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVA
IVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVII
RTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDL

--------------------------------------------------------------
>88499_88499_5_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000502449_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3560nt_BP=1460nt
GCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGG
GTCCGCCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAGGTGGGATAAGACCCCCTCAAGCAGGCCTGATGCCGATGCAGCAACAAGGATT
TCCTATGGTCTCTGTCATGCAGCCTAATATGCAAGGCATTATGGGAATGAATTACAGCTCTCAGATGTCCCAAGGACCTATTGCTATGCA
GGCAGGAATACCAATGGGACCAATGCCAGCAGCGGGAATGCCTTACCTAGGACAAGCACCCTTCCTGGGCATGCGTCCTCCAGGCCCACA
GTACACTCCAGACATGCAGAAGCAGTTTGCCGAAGAGCAGCAGAAACGATTTGAACAGCAGCAAAAACTCTTAGAAGAAGAAAGAAAAAG
ACGCCAGTTTGAAGAGCAGAAGCAAAAGCTCAGACTTTTGAGCAGTGTGAAACCCAAGACAGGAGAGAAGAGTAGAGATGATGCTTTGGA
AGCCATAAAAGGAAATTTAGATGGGTTTTCCAGAGATGCAAAAATGCACCCTACTCCAGCATCGCACCCCAAGAAACCAGGTGTGGGAGT
ATTTCCCTCACAGGATCCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTCCAGATGCCTATAAGAAAATCTTAGA
AACCACAATGACTCCAACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGCTTCCCAGGGAAACTCTTGGACAGAT
ATGGGCCTTAGCTAATCGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAGCCATGATAGCGGTAACACAGAGGGG
CGTTCCTGCAATGAGTCCTGATGCTTTAAACCAGTTCCCAGCAGCTCCTATTCCAACTTTAAGTGGCTTTTCTATGACTCTGCCTACACC
GGTGAGTCAGCCAACTGTGATACCTTCAGGTCCTGCGGGCTCCATGCCCCTCAGCCTTGGACAGCCAGTCATGGGCATTAACCTTGTTGG
ACCAGTGGGTGGAGCTGCAGCCCAGGCTTCTAGTGGTTTCATACCAACCTACCCTGCAAATCAGGTAGTAAAGCCAGAAGAAGATGACTT
CCAGGATTTTCAAGATGCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGTTGCCTGCTTCTTCAAAAACAAGTAA
CTCCCAGCATGGAAACAGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTTCAATGGACAAATATGCTGTGTTTAA
AGGAATTGCAGCTGACAAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATAGTGCTTTCAGAGAACTTGAACAGAC
AGCAGAGAATAAACCTTTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGA
GGTCACGGACGATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAA
AGCCTGGTTCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAA
GAGGCTCAAGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAG
CGCGGCCAAGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACT
TCTTTGCATCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCT
GTCCTGTGTGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGC
GATGCGATGCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCT
GGCCATGAGCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGC
TGTGGTCGTGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCAC
CTGTGAGCTCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGC
CTTCATCGGCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTC
CTGTCGGCACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTCTTCTGCCTGGACTAGA
GGGACCTCTCCCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAGCTGCTCAGGGAAAAGC
AGCTCTCCCCTCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGCCAAAAAAAGACAGGGC
TGATAAGCTAACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAAAGTCCAGAAACTGTTC
CCACCTGCTGGAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAATGAACCTTCTGGCCTCC
CACAGACTCAAATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGACTTCTTGGCTTGGTGAG
GAAAAGCGGACATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAGCCAGCGGGAATGGCAG
CTGCCACGCCGCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGAGTGTGGTGTTTCCTGC
AGGCCAGGCCAGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCTCTTGGCTCCACTGGGA
TGGGAGGAGAGGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTCTTTGTTCTTTGTCACA
GGGACTGAAAACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAAGTTTTCCCTTGAGGAA

>88499_88499_5_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000502449_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=851AA_BP=474
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPA
AGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFS
RDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPG
KLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQAS
SGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSEN
TVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSI
ICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVA
IVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVII
RTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDL

--------------------------------------------------------------
>88499_88499_6_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000585472_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3552nt_BP=1452nt
GAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCG
CCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAGGTGGGATAAGACCCCCTCAAGGCCTGATGCCGATGCAGCAACAAGGATTTCCTATGG
TCTCTGTCATGCAGCCTAATATGCAAGGCATTATGGGAATGAATTACAGCTCTCAGATGTCCCAAGGACCTATTGCTATGCAGGCAGGAA
TACCAATGGGACCAATGCCAGCAGCGGGAATGCCTTACCTAGGACAAGCACCCTTCCTGGGCATGCGTCCTCCAGGCCCACAGTACACTC
CAGACATGCAGAAGCAGTTTGCCGAAGAGCAGCAGAAACGATTTGAACAGCAGCAAAAACTCTTAGAAGAAGAAAGAAAAAGACGCCAGT
TTGAAGAGCAGAAGCAAAAGCTCAGACTTTTGAGCAGTGTGAAACCCAAGACAGGAGAGAAGAGTAGAGATGATGCTTTGGAAGCCATAA
AAGGAAATTTAGATGGGTTTTCCAGAGATGCAAAAATGCACCCTACTCCAGCATCGCACCCCAAGAAACCAGGTGTGGGAGTATTTCCCT
CACAGGATCCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTCCAGATGCCTATAAGAAAATCTTAGAAACCACAA
TGACTCCAACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGCTTCCCAGGGAAACTCTTGGACAGATATGGGCCT
TAGCTAATCGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAGCCATGATAGCGGTAACACAGAGGGGCGTTCCTG
CAATGAGTCCTGATGCTTTAAACCAGTTCCCAGCAGCTCCTATTCCAACTTTAAGTGGCTTTTCTATGACTCTGCCTACACCGGTGAGTC
AGCCAACTGTGATACCTTCAGGTCCTGCGGGCTCCATGCCCCTCAGCCTTGGACAGCCAGTCATGGGCATTAACCTTGTTGGACCAGTGG
GTGGAGCTGCAGCCCAGGCTTCTAGTGGTTTCATACCAACCTACCCTGCAAATCAGGTAGTAAAGCCAGAAGAAGATGACTTCCAGGATT
TTCAAGATGCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGTTGCCTGCTTCTTCAAAAACAAGTAACTCCCAGC
ATGGAAACAGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTTCAATGGACAAATATGCTGTGTTTAAAGGAATTG
CAGCTGACAAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATAGTGCTTTCAGAGAACTTGAACAGACAGCAGAGA
ATAAACCTTTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGAGGTCACGG
ACGATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAAAGCCTGGT
TCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAAGAGGCTCA
AGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAGCGCGGCCA
AGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACTTCTTTGCA
TCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCTGTCCTGTG
TGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGCGATGCGAT
GCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCTGGCCATGA
GCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGCTGTGGTCG
TGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCACCTGTGAGC
TCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGCCTTCATCG
GCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTCCTGTCGGC
ACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTCTTCTGCCTGGACTAGAGGGACCTC
TCCCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAGCTGCTCAGGGAAAAGCAGCTCTCC
CCTCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGCCAAAAAAAGACAGGGCTGATAAGC
TAACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAAAGTCCAGAAACTGTTCCCACCTGC
TGGAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAATGAACCTTCTGGCCTCCCACAGACT
CAAATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGACTTCTTGGCTTGGTGAGGAAAAGCG
GACATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAGCCAGCGGGAATGGCAGCTGCCACG
CCGCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGAGTGTGGTGTTTCCTGCAGGCCAGG
CCAGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCTCTTGGCTCCACTGGGATGGGAGGA
GAGGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTCTTTGTTCTTTGTCACAGGGACTGA
AAACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAAGTTTTCCCTTGAGGAAACAACAGC

>88499_88499_6_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000585472_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=850AA_BP=473
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAA
GMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSR
DAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGK
LTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASS
GFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSENT
VPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSII
CFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAI
VQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIR
TLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLF

--------------------------------------------------------------
>88499_88499_7_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000591288_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3306nt_BP=1206nt
GAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCG
CCGGGGGAGGCGGCTTCATGTTTCCTGTTGCAGGTGGGATAAGACCCCCTCAAGCAGGCCTGATGCCGATGCAGCAACAAGGATTTCCTA
TGGTCTCTGTCATGCAGCCTAATATGCAAGGCATTATGGGAATGAATTACAGCTCTCAGATGTCCCAAGGACCTATTGCTATGCAGGCAG
GAATACCAATGGGACCAATGCCAGCAGCGGGAATGCCTTACCTAGGACAAGCACCCTTCCTGGGCATGCGTCCTCCAGGCCCACAGTACA
CTCCAGACATGCAGAAGCAGTTTGCCGAAGAGCAGCAGAAACGATTTGAACAGCAGCAAAAACTCTTAGAAGAAGAAAGAAAAAGACGCC
AGTTTGAAGAGCAGAAGCAAAAGCTCAGACTTTTGAGCAGTGTGAAACCCAAGACAGGAGAGAAGAGTAGAGATGATGCTTTGGAAGCCA
TAAAAGGAAATTTAGATGGGTTTTCCAGAGATGCAAAAATGCACCCTACTCCAGCATCGCACCCCAAGAAACCAGGTGTGGGAGTATTTC
CCTCACAGGATCCTGCTCAGCCCAGAATGCCTCCTTGGATTTACAATGAGAGTTTGGTTCCAGATGCCTATAAGAAAATCTTAGAAACCA
CAATGACTCCAACTGGAATAGATACTGCCAAACTGTATCCCATTCTGATGTCATCTGGGCTTCCCAGGGAAACTCTTGGACAGATATGGG
CCTTAGCTAATCGAACTACACCTGGCAAACTTACAAAAGAAGAACTTTATACCGTTCTAGCCATGATAGCGGTAACACAGGTAGTAAAGC
CAGAAGAAGATGACTTCCAGGATTTTCAAGATGCTTCTAAGTCAGGATCCCTTGATGACTCATTCAGTGATTTCCAAGAGTTGCCTGCTT
CTTCAAAAACAAGTAACTCCCAGCATGGAAACAGTGCCCCTTCTTTGTTGATGCCACTTCCTGGAACTAAAGCATTGCCTTCAATGGACA
AATATGCTGTGTTTAAAGGAATTGCAGCTGACAAGTCCTCTGAAAATACTGTTCCACCTGGAGATCCTGGTGATAAATATAGTGCTTTCA
GAGAACTTGAACAGACAGCAGAGAATAAACCTTTAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTAT
GCCTGTGTCAAGATGAGGTCACGGACGATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGG
ACGTGCGGAACTTTAAAGCCTGGTTCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGA
CCTATATCTATTTCAAGAGGCTCAAGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTC
CCTTCTGGGCCTACAGCGCGGCCAAGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCA
GTGGCATGCTCCTACTTCTTTGCATCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCC
TTCTCATCAGCAAGCTGTCCTGTGTGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGA
GCAGCAGTGAGCAAGCGATGCGATGCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCT
TTCTGGTCCCCCTGCTGGCCATGAGCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCA
TCAAGGTGATCATCGCTGTGGTCGTGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCA
ACATCACCAGTAGCACCTGTGAGCTCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCA
ACCCTTTCTTGTACGCCTTCATCGGCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGC
TCCGGCAGTGGTCTTCCTGTCGGCACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTC
TTCTGCCTGGACTAGAGGGACCTCTCCCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAG
CTGCTCAGGGAAAAGCAGCTCTCCCCTCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGC
CAAAAAAAGACAGGGCTGATAAGCTAACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAA
AGTCCAGAAACTGTTCCCACCTGCTGGAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAAT
GAACCTTCTGGCCTCCCACAGACTCAAATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGAC
TTCTTGGCTTGGTGAGGAAAAGCGGACATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAG
CCAGCGGGAATGGCAGCTGCCACGCCGCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGA
GTGTGGTGTTTCCTGCAGGCCAGGCCAGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCT
CTTGGCTCCACTGGGATGGGAGGAGAGGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTC
TTTGTTCTTTGTCACAGGGACTGAAAACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAA

>88499_88499_7_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000591288_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=768AA_BP=391
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPA
AGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFS
RDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPG
KLTKEELYTVLAMIAVTQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIA
ADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWF
LPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCI
SIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMS
FCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SYNRG-CCR7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322666_678554.33333333333341315.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220666_678476.33333333333331225.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321666_678554.33333333333341303.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221666_678475.33333333333331236.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120666_678393.33333333333331109.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322518_786554.33333333333341315.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220518_786476.33333333333331225.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321518_786554.33333333333341303.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221518_786475.33333333333331236.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120518_786393.33333333333331109.0AP1G1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SYNRG-CCR7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SYNRG-CCR7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource