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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SYNRG-FBXO47 (FusionGDB2 ID:88503)

Fusion Gene Summary for SYNRG-FBXO47

check button Fusion gene summary
Fusion gene informationFusion gene name: SYNRG-FBXO47
Fusion gene ID: 88503
HgeneTgene
Gene symbol

SYNRG

FBXO47

Gene ID

11276

494188

Gene namesynergin gammaF-box protein 47
SynonymsAP1GBP1|SYNG-
Cytomap

17q12

17q12|17q12

Type of geneprotein-codingprotein-coding
Descriptionsynergin gammaAP1 gamma subunit binding protein 1AP1 subunit gamma-binding protein 1adaptor-related protein complex 1 gamma subunit-binding protein 1gamma-synerginF-box only protein 47
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339208, ENST00000345615, 
ENST00000346661, ENST00000394378, 
ENST00000502449, ENST00000585472, 
ENST00000591288, ENST00000588194, 
ENST00000378079, 
Fusion gene scores* DoF score21 X 26 X 10=54606 X 6 X 4=144
# samples 216
** MAII scorelog2(21/5460*10)=-4.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYNRG [Title/Abstract] AND FBXO47 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSYNRG(35969327)-FBXO47(37107942), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SYNRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXO47 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A5A1-01ASYNRGchr17

35969327

-FBXO47chr17

37107942

-


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Fusion Gene ORF analysis for SYNRG-FBXO47

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000339208ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
In-frameENST00000345615ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
In-frameENST00000346661ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
In-frameENST00000394378ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
In-frameENST00000502449ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
In-frameENST00000585472ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
In-frameENST00000591288ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-
intron-3CDSENST00000588194ENST00000378079SYNRGchr17

35969327

-FBXO47chr17

37107942

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000339208SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-1813218861069327
ENST00000346661SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-1755160281011327
ENST00000345615SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-17281331984327
ENST00000502449SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-1703108168959263
ENST00000591288SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-1698103163954263
ENST00000394378SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-1698103163954263
ENST00000585472SYNRGchr1735969327-ENST00000378079FBXO47chr1737107942-1698103163954263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339208ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0013205220.99867946
ENST00000346661ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0015678470.9984321
ENST00000345615ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0013301080.99866986
ENST00000502449ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0014863010.99851364
ENST00000591288ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0013735520.9986265
ENST00000394378ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0013735520.9986265
ENST00000585472ENST00000378079SYNRGchr1735969327-FBXO47chr1737107942-0.0013735520.9986265

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Fusion Genomic Features for SYNRG-FBXO47


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SYNRG-FBXO47


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35969327/chr17:37107942)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122115_155251315.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120115_155251225.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121115_155251303.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121115_155251236.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120115_155251109.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122295_388251315.0DomainEH
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120295_388251225.0DomainEH
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121295_388251303.0DomainEH
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121295_388251236.0DomainEH
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120295_388251109.0DomainEH
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122457_461251315.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122690_694251315.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122775_779251315.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120457_461251225.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120690_694251225.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120775_779251225.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121457_461251303.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121690_694251303.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121775_779251303.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121457_461251236.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121690_694251236.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121775_779251236.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120457_461251109.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120690_694251109.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120775_779251109.0MotifNote=DFXDF motif 3
TgeneFBXO47chr17:35969327chr17:37107942ENST0000037807941141_91169453.0DomainF-box


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Fusion Gene Sequence for SYNRG-FBXO47


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88503_88503_1_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000339208_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1813nt_BP=218nt
AGTCACGTGGGCGCGAGGCCCCGCCCCATCGCCCGGTCCGCGGCGAGGTGGGGCCTGGTGTTTGACCCGGAAGTGGCTGTGTTCAGCTGA
CAGCTGCTGATAAGGTGGCGGCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGG
GCCGCGGGAGCTGGCGCGGGGTCCGCCGGGGGAGGCGGACCTTAACAGCAGGTTGGGATGAACTTGAGTGCCATCGCGTTTATAATTTCT
TATGCGAACTGACTAATCTCTGCCGCAAGATACAAATGGCTGTCTGCAGCAAACCAGGAAGTGCCCAAAAACTGGAGTTAAGAATCAGAC
TCTTCTGTAGGAATGTCCTCCTTGATCATTGGACACATCGAAGTGATTCTGCTTTTTGGTTGACGCGAATATTAAAACCATGGCCAATGG
TGAATCAGGCAAGATTACTGTATATCATCTTTGGGCCAATATCTCCTCAAGATGGACAGGTGGTTTGGCAGGAAATGATAGAAGAACCTA
CAGATGAATTCAGTCTGAAAGGTTTGGCTGATGCCATTAAGTTACTATATGACGCTAGCACTAAAGAGTGGACAGCAGATGATGTTATCA
GTCTTGTAGATGAACTATCAGTGGTTCCCCGTGAGTGGCTTCTAGAGAATAATGCACGTCTCCTAATGCTAAGTGGAAACAACATCTGTT
TCAGTTTCATGGCTAGTAAAGCTGTGAATGGACGCACCATTGAACTGGCAAGGCTCGTAGTCTTTTTGGCTTTGGTGTGTGAGAAAGAAC
TGTACTGCATGGATTGGACAGTTAAAATGATGCAAAAAGTCTGCAAAGTCTTTAGCACTCCAGTGGAAAGAAAGAACTTCCTGCAGAATG
TGGCAAATGCATTTGCATGTGTTATAATGGAAATGCTGCAATCAATTATGTCTGGAGACCGTGATGAAGATGACAGAAGCTTTTTGAATT
TGTTCCATCTTGTACATGCTCAGGCTAACTTCCATAAGGAGGTCCTGTATTTGACCATGAATACTCCTCTGTCTACCTAAATCCTCAGAA
AGCCTTGCCTTTAGAGAACGTCACTGAACGAATGATTAGAGGAGTGCTACTTTTTCACTCAAAAAATAGCATCCATGGGACTTTTTATCA
TCTAAGTAACCTAAGAATTCAAAAGCTGGATAGAATTTTAGAAGCAACTACGTACATCATTATTAATATAAAAATAACAGGCAGCCTCAA
GAATGTGCTGAGATTTCTCTGGAAAACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCTAACACCAAACCAAAATAGAATGTTAGCTGTTC
AAGAATCTGGGACCAGCCAACCTGTATGTATGCATTTTTGAAGCAAGAGAAAATTCCATTTTATAGTTAGACCCAAATTCACTAAATAGT
GTGTATGTTCACTTTGTTTAAGTTGTATAGACATAGCCCAGAATGTTTTGTGAAGATTTGCAATATGGTGTTTTGGAATGTGTAGAATAC
AAATCACAGTTTTTACTACCTTCTTGGCATATGCTTACAAAGAACATTATATTTTGTTCATGTTTTACATGAACTAATGGATAAAAAACA
AAGTATACATATATGTCTATATATATATATAGACACACACACACAGACATATATTTCCTTCTTTAAGGTAATCATACAAAAGGTCTATAC
ATACAGGAAGGTATATATTGTCTCAATGCAATCAAATCATCTTTTACTGGGGATTCAAATAAAATGTAGCAAATAAGAGAAAAATAAAAT

>88503_88503_1_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000339208_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=327AA_BP=30
MTAADKVAAAKAAAGREQDGAAARSWFWWRRGRGSWRGVRRGRRTLTAGWDELECHRVYNFLCELTNLCRKIQMAVCSKPGSAQKLELRI
RLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDEFSLKGLADAIKLLYDASTKEWTADDV
ISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYCMDWTVKMMQKVCKVFSTPVERKNFLQ

--------------------------------------------------------------
>88503_88503_2_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000345615_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1728nt_BP=133nt
GCTGACAGCTGCTGATAAGGTGGCGGCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCG
GCGGGGCCGCGGGAGCTGGCGCGGGGTCCGCCGGGGGAGGCGGACCTTAACAGCAGGTTGGGATGAACTTGAGTGCCATCGCGTTTATAA
TTTCTTATGCGAACTGACTAATCTCTGCCGCAAGATACAAATGGCTGTCTGCAGCAAACCAGGAAGTGCCCAAAAACTGGAGTTAAGAAT
CAGACTCTTCTGTAGGAATGTCCTCCTTGATCATTGGACACATCGAAGTGATTCTGCTTTTTGGTTGACGCGAATATTAAAACCATGGCC
AATGGTGAATCAGGCAAGATTACTGTATATCATCTTTGGGCCAATATCTCCTCAAGATGGACAGGTGGTTTGGCAGGAAATGATAGAAGA
ACCTACAGATGAATTCAGTCTGAAAGGTTTGGCTGATGCCATTAAGTTACTATATGACGCTAGCACTAAAGAGTGGACAGCAGATGATGT
TATCAGTCTTGTAGATGAACTATCAGTGGTTCCCCGTGAGTGGCTTCTAGAGAATAATGCACGTCTCCTAATGCTAAGTGGAAACAACAT
CTGTTTCAGTTTCATGGCTAGTAAAGCTGTGAATGGACGCACCATTGAACTGGCAAGGCTCGTAGTCTTTTTGGCTTTGGTGTGTGAGAA
AGAACTGTACTGCATGGATTGGACAGTTAAAATGATGCAAAAAGTCTGCAAAGTCTTTAGCACTCCAGTGGAAAGAAAGAACTTCCTGCA
GAATGTGGCAAATGCATTTGCATGTGTTATAATGGAAATGCTGCAATCAATTATGTCTGGAGACCGTGATGAAGATGACAGAAGCTTTTT
GAATTTGTTCCATCTTGTACATGCTCAGGCTAACTTCCATAAGGAGGTCCTGTATTTGACCATGAATACTCCTCTGTCTACCTAAATCCT
CAGAAAGCCTTGCCTTTAGAGAACGTCACTGAACGAATGATTAGAGGAGTGCTACTTTTTCACTCAAAAAATAGCATCCATGGGACTTTT
TATCATCTAAGTAACCTAAGAATTCAAAAGCTGGATAGAATTTTAGAAGCAACTACGTACATCATTATTAATATAAAAATAACAGGCAGC
CTCAAGAATGTGCTGAGATTTCTCTGGAAAACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCTAACACCAAACCAAAATAGAATGTTAGC
TGTTCAAGAATCTGGGACCAGCCAACCTGTATGTATGCATTTTTGAAGCAAGAGAAAATTCCATTTTATAGTTAGACCCAAATTCACTAA
ATAGTGTGTATGTTCACTTTGTTTAAGTTGTATAGACATAGCCCAGAATGTTTTGTGAAGATTTGCAATATGGTGTTTTGGAATGTGTAG
AATACAAATCACAGTTTTTACTACCTTCTTGGCATATGCTTACAAAGAACATTATATTTTGTTCATGTTTTACATGAACTAATGGATAAA
AAACAAAGTATACATATATGTCTATATATATATATAGACACACACACACAGACATATATTTCCTTCTTTAAGGTAATCATACAAAAGGTC
TATACATACAGGAAGGTATATATTGTCTCAATGCAATCAAATCATCTTTTACTGGGGATTCAAATAAAATGTAGCAAATAAGAGAAAAAT

>88503_88503_2_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000345615_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=327AA_BP=30
LTAADKVAAAKAAAGREQDGAAARSWFWWRRGRGSWRGVRRGRRTLTAGWDELECHRVYNFLCELTNLCRKIQMAVCSKPGSAQKLELRI
RLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDEFSLKGLADAIKLLYDASTKEWTADDV
ISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYCMDWTVKMMQKVCKVFSTPVERKNFLQ

--------------------------------------------------------------
>88503_88503_3_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000346661_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1755nt_BP=160nt
TGTTTGACCCGGAAGTGGCTGTGTTCAGCTGACAGCTGCTGATAAGGTGGCGGCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGC
TGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCGCCGGGGGAGGCGGACCTTAACAGCAGGTTGGGA
TGAACTTGAGTGCCATCGCGTTTATAATTTCTTATGCGAACTGACTAATCTCTGCCGCAAGATACAAATGGCTGTCTGCAGCAAACCAGG
AAGTGCCCAAAAACTGGAGTTAAGAATCAGACTCTTCTGTAGGAATGTCCTCCTTGATCATTGGACACATCGAAGTGATTCTGCTTTTTG
GTTGACGCGAATATTAAAACCATGGCCAATGGTGAATCAGGCAAGATTACTGTATATCATCTTTGGGCCAATATCTCCTCAAGATGGACA
GGTGGTTTGGCAGGAAATGATAGAAGAACCTACAGATGAATTCAGTCTGAAAGGTTTGGCTGATGCCATTAAGTTACTATATGACGCTAG
CACTAAAGAGTGGACAGCAGATGATGTTATCAGTCTTGTAGATGAACTATCAGTGGTTCCCCGTGAGTGGCTTCTAGAGAATAATGCACG
TCTCCTAATGCTAAGTGGAAACAACATCTGTTTCAGTTTCATGGCTAGTAAAGCTGTGAATGGACGCACCATTGAACTGGCAAGGCTCGT
AGTCTTTTTGGCTTTGGTGTGTGAGAAAGAACTGTACTGCATGGATTGGACAGTTAAAATGATGCAAAAAGTCTGCAAAGTCTTTAGCAC
TCCAGTGGAAAGAAAGAACTTCCTGCAGAATGTGGCAAATGCATTTGCATGTGTTATAATGGAAATGCTGCAATCAATTATGTCTGGAGA
CCGTGATGAAGATGACAGAAGCTTTTTGAATTTGTTCCATCTTGTACATGCTCAGGCTAACTTCCATAAGGAGGTCCTGTATTTGACCAT
GAATACTCCTCTGTCTACCTAAATCCTCAGAAAGCCTTGCCTTTAGAGAACGTCACTGAACGAATGATTAGAGGAGTGCTACTTTTTCAC
TCAAAAAATAGCATCCATGGGACTTTTTATCATCTAAGTAACCTAAGAATTCAAAAGCTGGATAGAATTTTAGAAGCAACTACGTACATC
ATTATTAATATAAAAATAACAGGCAGCCTCAAGAATGTGCTGAGATTTCTCTGGAAAACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCT
AACACCAAACCAAAATAGAATGTTAGCTGTTCAAGAATCTGGGACCAGCCAACCTGTATGTATGCATTTTTGAAGCAAGAGAAAATTCCA
TTTTATAGTTAGACCCAAATTCACTAAATAGTGTGTATGTTCACTTTGTTTAAGTTGTATAGACATAGCCCAGAATGTTTTGTGAAGATT
TGCAATATGGTGTTTTGGAATGTGTAGAATACAAATCACAGTTTTTACTACCTTCTTGGCATATGCTTACAAAGAACATTATATTTTGTT
CATGTTTTACATGAACTAATGGATAAAAAACAAAGTATACATATATGTCTATATATATATATAGACACACACACACAGACATATATTTCC
TTCTTTAAGGTAATCATACAAAAGGTCTATACATACAGGAAGGTATATATTGTCTCAATGCAATCAAATCATCTTTTACTGGGGATTCAA

>88503_88503_3_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000346661_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=327AA_BP=30
MTAADKVAAAKAAAGREQDGAAARSWFWWRRGRGSWRGVRRGRRTLTAGWDELECHRVYNFLCELTNLCRKIQMAVCSKPGSAQKLELRI
RLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDEFSLKGLADAIKLLYDASTKEWTADDV
ISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYCMDWTVKMMQKVCKVFSTPVERKNFLQ

--------------------------------------------------------------
>88503_88503_4_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000394378_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1698nt_BP=103nt
GAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCG
CCGGGGGAGGCGGACCTTAACAGCAGGTTGGGATGAACTTGAGTGCCATCGCGTTTATAATTTCTTATGCGAACTGACTAATCTCTGCCG
CAAGATACAAATGGCTGTCTGCAGCAAACCAGGAAGTGCCCAAAAACTGGAGTTAAGAATCAGACTCTTCTGTAGGAATGTCCTCCTTGA
TCATTGGACACATCGAAGTGATTCTGCTTTTTGGTTGACGCGAATATTAAAACCATGGCCAATGGTGAATCAGGCAAGATTACTGTATAT
CATCTTTGGGCCAATATCTCCTCAAGATGGACAGGTGGTTTGGCAGGAAATGATAGAAGAACCTACAGATGAATTCAGTCTGAAAGGTTT
GGCTGATGCCATTAAGTTACTATATGACGCTAGCACTAAAGAGTGGACAGCAGATGATGTTATCAGTCTTGTAGATGAACTATCAGTGGT
TCCCCGTGAGTGGCTTCTAGAGAATAATGCACGTCTCCTAATGCTAAGTGGAAACAACATCTGTTTCAGTTTCATGGCTAGTAAAGCTGT
GAATGGACGCACCATTGAACTGGCAAGGCTCGTAGTCTTTTTGGCTTTGGTGTGTGAGAAAGAACTGTACTGCATGGATTGGACAGTTAA
AATGATGCAAAAAGTCTGCAAAGTCTTTAGCACTCCAGTGGAAAGAAAGAACTTCCTGCAGAATGTGGCAAATGCATTTGCATGTGTTAT
AATGGAAATGCTGCAATCAATTATGTCTGGAGACCGTGATGAAGATGACAGAAGCTTTTTGAATTTGTTCCATCTTGTACATGCTCAGGC
TAACTTCCATAAGGAGGTCCTGTATTTGACCATGAATACTCCTCTGTCTACCTAAATCCTCAGAAAGCCTTGCCTTTAGAGAACGTCACT
GAACGAATGATTAGAGGAGTGCTACTTTTTCACTCAAAAAATAGCATCCATGGGACTTTTTATCATCTAAGTAACCTAAGAATTCAAAAG
CTGGATAGAATTTTAGAAGCAACTACGTACATCATTATTAATATAAAAATAACAGGCAGCCTCAAGAATGTGCTGAGATTTCTCTGGAAA
ACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCTAACACCAAACCAAAATAGAATGTTAGCTGTTCAAGAATCTGGGACCAGCCAACCTGT
ATGTATGCATTTTTGAAGCAAGAGAAAATTCCATTTTATAGTTAGACCCAAATTCACTAAATAGTGTGTATGTTCACTTTGTTTAAGTTG
TATAGACATAGCCCAGAATGTTTTGTGAAGATTTGCAATATGGTGTTTTGGAATGTGTAGAATACAAATCACAGTTTTTACTACCTTCTT
GGCATATGCTTACAAAGAACATTATATTTTGTTCATGTTTTACATGAACTAATGGATAAAAAACAAAGTATACATATATGTCTATATATA
TATATAGACACACACACACAGACATATATTTCCTTCTTTAAGGTAATCATACAAAAGGTCTATACATACAGGAAGGTATATATTGTCTCA

>88503_88503_4_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000394378_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=263AA_BP=
MTNLCRKIQMAVCSKPGSAQKLELRIRLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDE
FSLKGLADAIKLLYDASTKEWTADDVISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYC

--------------------------------------------------------------
>88503_88503_5_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000502449_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1703nt_BP=108nt
GCGGCGAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGG
GTCCGCCGGGGGAGGCGGACCTTAACAGCAGGTTGGGATGAACTTGAGTGCCATCGCGTTTATAATTTCTTATGCGAACTGACTAATCTC
TGCCGCAAGATACAAATGGCTGTCTGCAGCAAACCAGGAAGTGCCCAAAAACTGGAGTTAAGAATCAGACTCTTCTGTAGGAATGTCCTC
CTTGATCATTGGACACATCGAAGTGATTCTGCTTTTTGGTTGACGCGAATATTAAAACCATGGCCAATGGTGAATCAGGCAAGATTACTG
TATATCATCTTTGGGCCAATATCTCCTCAAGATGGACAGGTGGTTTGGCAGGAAATGATAGAAGAACCTACAGATGAATTCAGTCTGAAA
GGTTTGGCTGATGCCATTAAGTTACTATATGACGCTAGCACTAAAGAGTGGACAGCAGATGATGTTATCAGTCTTGTAGATGAACTATCA
GTGGTTCCCCGTGAGTGGCTTCTAGAGAATAATGCACGTCTCCTAATGCTAAGTGGAAACAACATCTGTTTCAGTTTCATGGCTAGTAAA
GCTGTGAATGGACGCACCATTGAACTGGCAAGGCTCGTAGTCTTTTTGGCTTTGGTGTGTGAGAAAGAACTGTACTGCATGGATTGGACA
GTTAAAATGATGCAAAAAGTCTGCAAAGTCTTTAGCACTCCAGTGGAAAGAAAGAACTTCCTGCAGAATGTGGCAAATGCATTTGCATGT
GTTATAATGGAAATGCTGCAATCAATTATGTCTGGAGACCGTGATGAAGATGACAGAAGCTTTTTGAATTTGTTCCATCTTGTACATGCT
CAGGCTAACTTCCATAAGGAGGTCCTGTATTTGACCATGAATACTCCTCTGTCTACCTAAATCCTCAGAAAGCCTTGCCTTTAGAGAACG
TCACTGAACGAATGATTAGAGGAGTGCTACTTTTTCACTCAAAAAATAGCATCCATGGGACTTTTTATCATCTAAGTAACCTAAGAATTC
AAAAGCTGGATAGAATTTTAGAAGCAACTACGTACATCATTATTAATATAAAAATAACAGGCAGCCTCAAGAATGTGCTGAGATTTCTCT
GGAAAACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCTAACACCAAACCAAAATAGAATGTTAGCTGTTCAAGAATCTGGGACCAGCCAA
CCTGTATGTATGCATTTTTGAAGCAAGAGAAAATTCCATTTTATAGTTAGACCCAAATTCACTAAATAGTGTGTATGTTCACTTTGTTTA
AGTTGTATAGACATAGCCCAGAATGTTTTGTGAAGATTTGCAATATGGTGTTTTGGAATGTGTAGAATACAAATCACAGTTTTTACTACC
TTCTTGGCATATGCTTACAAAGAACATTATATTTTGTTCATGTTTTACATGAACTAATGGATAAAAAACAAAGTATACATATATGTCTAT
ATATATATATAGACACACACACACAGACATATATTTCCTTCTTTAAGGTAATCATACAAAAGGTCTATACATACAGGAAGGTATATATTG

>88503_88503_5_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000502449_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=263AA_BP=
MTNLCRKIQMAVCSKPGSAQKLELRIRLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDE
FSLKGLADAIKLLYDASTKEWTADDVISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYC

--------------------------------------------------------------
>88503_88503_6_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000585472_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1698nt_BP=103nt
GAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCG
CCGGGGGAGGCGGACCTTAACAGCAGGTTGGGATGAACTTGAGTGCCATCGCGTTTATAATTTCTTATGCGAACTGACTAATCTCTGCCG
CAAGATACAAATGGCTGTCTGCAGCAAACCAGGAAGTGCCCAAAAACTGGAGTTAAGAATCAGACTCTTCTGTAGGAATGTCCTCCTTGA
TCATTGGACACATCGAAGTGATTCTGCTTTTTGGTTGACGCGAATATTAAAACCATGGCCAATGGTGAATCAGGCAAGATTACTGTATAT
CATCTTTGGGCCAATATCTCCTCAAGATGGACAGGTGGTTTGGCAGGAAATGATAGAAGAACCTACAGATGAATTCAGTCTGAAAGGTTT
GGCTGATGCCATTAAGTTACTATATGACGCTAGCACTAAAGAGTGGACAGCAGATGATGTTATCAGTCTTGTAGATGAACTATCAGTGGT
TCCCCGTGAGTGGCTTCTAGAGAATAATGCACGTCTCCTAATGCTAAGTGGAAACAACATCTGTTTCAGTTTCATGGCTAGTAAAGCTGT
GAATGGACGCACCATTGAACTGGCAAGGCTCGTAGTCTTTTTGGCTTTGGTGTGTGAGAAAGAACTGTACTGCATGGATTGGACAGTTAA
AATGATGCAAAAAGTCTGCAAAGTCTTTAGCACTCCAGTGGAAAGAAAGAACTTCCTGCAGAATGTGGCAAATGCATTTGCATGTGTTAT
AATGGAAATGCTGCAATCAATTATGTCTGGAGACCGTGATGAAGATGACAGAAGCTTTTTGAATTTGTTCCATCTTGTACATGCTCAGGC
TAACTTCCATAAGGAGGTCCTGTATTTGACCATGAATACTCCTCTGTCTACCTAAATCCTCAGAAAGCCTTGCCTTTAGAGAACGTCACT
GAACGAATGATTAGAGGAGTGCTACTTTTTCACTCAAAAAATAGCATCCATGGGACTTTTTATCATCTAAGTAACCTAAGAATTCAAAAG
CTGGATAGAATTTTAGAAGCAACTACGTACATCATTATTAATATAAAAATAACAGGCAGCCTCAAGAATGTGCTGAGATTTCTCTGGAAA
ACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCTAACACCAAACCAAAATAGAATGTTAGCTGTTCAAGAATCTGGGACCAGCCAACCTGT
ATGTATGCATTTTTGAAGCAAGAGAAAATTCCATTTTATAGTTAGACCCAAATTCACTAAATAGTGTGTATGTTCACTTTGTTTAAGTTG
TATAGACATAGCCCAGAATGTTTTGTGAAGATTTGCAATATGGTGTTTTGGAATGTGTAGAATACAAATCACAGTTTTTACTACCTTCTT
GGCATATGCTTACAAAGAACATTATATTTTGTTCATGTTTTACATGAACTAATGGATAAAAAACAAAGTATACATATATGTCTATATATA
TATATAGACACACACACACAGACATATATTTCCTTCTTTAAGGTAATCATACAAAAGGTCTATACATACAGGAAGGTATATATTGTCTCA

>88503_88503_6_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000585472_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=263AA_BP=
MTNLCRKIQMAVCSKPGSAQKLELRIRLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDE
FSLKGLADAIKLLYDASTKEWTADDVISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYC

--------------------------------------------------------------
>88503_88503_7_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000591288_FBXO47_chr17_37107942_ENST00000378079_length(transcript)=1698nt_BP=103nt
GAAGGCAGCGGCAGGTCGGGAGCAAGATGGCGCTGCGGCCAGGAGCTGGTTCTGGTGGCGGCGGGGCCGCGGGAGCTGGCGCGGGGTCCG
CCGGGGGAGGCGGACCTTAACAGCAGGTTGGGATGAACTTGAGTGCCATCGCGTTTATAATTTCTTATGCGAACTGACTAATCTCTGCCG
CAAGATACAAATGGCTGTCTGCAGCAAACCAGGAAGTGCCCAAAAACTGGAGTTAAGAATCAGACTCTTCTGTAGGAATGTCCTCCTTGA
TCATTGGACACATCGAAGTGATTCTGCTTTTTGGTTGACGCGAATATTAAAACCATGGCCAATGGTGAATCAGGCAAGATTACTGTATAT
CATCTTTGGGCCAATATCTCCTCAAGATGGACAGGTGGTTTGGCAGGAAATGATAGAAGAACCTACAGATGAATTCAGTCTGAAAGGTTT
GGCTGATGCCATTAAGTTACTATATGACGCTAGCACTAAAGAGTGGACAGCAGATGATGTTATCAGTCTTGTAGATGAACTATCAGTGGT
TCCCCGTGAGTGGCTTCTAGAGAATAATGCACGTCTCCTAATGCTAAGTGGAAACAACATCTGTTTCAGTTTCATGGCTAGTAAAGCTGT
GAATGGACGCACCATTGAACTGGCAAGGCTCGTAGTCTTTTTGGCTTTGGTGTGTGAGAAAGAACTGTACTGCATGGATTGGACAGTTAA
AATGATGCAAAAAGTCTGCAAAGTCTTTAGCACTCCAGTGGAAAGAAAGAACTTCCTGCAGAATGTGGCAAATGCATTTGCATGTGTTAT
AATGGAAATGCTGCAATCAATTATGTCTGGAGACCGTGATGAAGATGACAGAAGCTTTTTGAATTTGTTCCATCTTGTACATGCTCAGGC
TAACTTCCATAAGGAGGTCCTGTATTTGACCATGAATACTCCTCTGTCTACCTAAATCCTCAGAAAGCCTTGCCTTTAGAGAACGTCACT
GAACGAATGATTAGAGGAGTGCTACTTTTTCACTCAAAAAATAGCATCCATGGGACTTTTTATCATCTAAGTAACCTAAGAATTCAAAAG
CTGGATAGAATTTTAGAAGCAACTACGTACATCATTATTAATATAAAAATAACAGGCAGCCTCAAGAATGTGCTGAGATTTCTCTGGAAA
ACAAGCTCTGCCTCTCCGGGTTTTAGTCAACCTAACACCAAACCAAAATAGAATGTTAGCTGTTCAAGAATCTGGGACCAGCCAACCTGT
ATGTATGCATTTTTGAAGCAAGAGAAAATTCCATTTTATAGTTAGACCCAAATTCACTAAATAGTGTGTATGTTCACTTTGTTTAAGTTG
TATAGACATAGCCCAGAATGTTTTGTGAAGATTTGCAATATGGTGTTTTGGAATGTGTAGAATACAAATCACAGTTTTTACTACCTTCTT
GGCATATGCTTACAAAGAACATTATATTTTGTTCATGTTTTACATGAACTAATGGATAAAAAACAAAGTATACATATATGTCTATATATA
TATATAGACACACACACACAGACATATATTTCCTTCTTTAAGGTAATCATACAAAAGGTCTATACATACAGGAAGGTATATATTGTCTCA

>88503_88503_7_SYNRG-FBXO47_SYNRG_chr17_35969327_ENST00000591288_FBXO47_chr17_37107942_ENST00000378079_length(amino acids)=263AA_BP=
MTNLCRKIQMAVCSKPGSAQKLELRIRLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDE
FSLKGLADAIKLLYDASTKEWTADDVISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SYNRG-FBXO47


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122666_67825.6666666666666681315.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120666_67825.6666666666666681225.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121666_67825.6666666666666681303.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121666_67825.6666666666666681236.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120666_67825.6666666666666681109.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000339208-122518_78625.6666666666666681315.0AP1G1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000345615-120518_78625.6666666666666681225.0AP1G1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000346661-121518_78625.6666666666666681303.0AP1G1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000585472-121518_78625.6666666666666681236.0AP1G1
HgeneSYNRGchr17:35969327chr17:37107942ENST00000591288-120518_78625.6666666666666681109.0AP1G1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SYNRG-FBXO47


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SYNRG-FBXO47


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource