FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SYTL2-EED (FusionGDB2 ID:88580)

Fusion Gene Summary for SYTL2-EED

check button Fusion gene summary
Fusion gene informationFusion gene name: SYTL2-EED
Fusion gene ID: 88580
HgeneTgene
Gene symbol

SYTL2

EED

Gene ID

54843

8726

Gene namesynaptotagmin like 2embryonic ectoderm development
SynonymsCHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2ACOGIS|HEED|WAIT1
Cytomap

11q14.1

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionsynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151polycomb protein EEDWD protein associating with integrin cytoplasmic tails 1embryonic ectoderm development protein
Modification date2020032020200313
UniProtAcc.

O75530

Ensembl transtripts involved in fusion geneENST00000316356, ENST00000354566, 
ENST00000359152, ENST00000389958, 
ENST00000389960, ENST00000524452, 
ENST00000525423, ENST00000527523, 
ENST00000528231, ENST00000528566, 
ENST00000529581, ENST00000533892, 
ENST00000525702, 		ENST00000527888, 
ENST00000263360, ENST00000327320, 
ENST00000351625, ENST00000528180, 
Fusion gene scores* DoF score7 X 8 X 5=28010 X 8 X 5=400
# samples 913
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/400*10)=-1.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYTL2 [Title/Abstract] AND EED [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSYTL2(85429833)-EED(85988022), # samples:1
Anticipated loss of major functional domain due to fusion event.SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYTL2

GO:0006887

exocytosis

18812475

HgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

HgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across SYTL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EED (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J5-01ASYTL2chr11

85429833

-EEDchr11

85988022

+


Top

Fusion Gene ORF analysis for SYTL2-EED

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000316356ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000354566ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000359152ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000389958ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000389960ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000524452ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000525423ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000527523ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5CDS-5UTRENST00000528231ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000528566ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000528566ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000528566ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000528566ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000529581ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000529581ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000529581ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000529581ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000533892ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000533892ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000533892ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-3CDSENST00000533892ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-5UTRENST00000528566ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-5UTRENST00000529581ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
5UTR-5UTRENST00000533892ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000316356ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000316356ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000316356ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000316356ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000354566ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000354566ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000354566ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000354566ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000359152ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000359152ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000359152ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000359152ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000389960ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000389960ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000389960ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000389960ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000524452ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000524452ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000524452ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000524452ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000525423ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000525423ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000525423ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000525423ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000528231ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000528231ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000528231ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
Frame-shiftENST00000528231ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000389958ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000389958ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000389958ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000389958ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000527523ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000527523ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000527523ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
In-frameENST00000527523ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
intron-3CDSENST00000525702ENST00000263360SYTL2chr11

85429833

-EEDchr11

85988022

+
intron-3CDSENST00000525702ENST00000327320SYTL2chr11

85429833

-EEDchr11

85988022

+
intron-3CDSENST00000525702ENST00000351625SYTL2chr11

85429833

-EEDchr11

85988022

+
intron-3CDSENST00000525702ENST00000528180SYTL2chr11

85429833

-EEDchr11

85988022

+
intron-5UTRENST00000525702ENST00000527888SYTL2chr11

85429833

-EEDchr11

85988022

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000527523SYTL2chr1185429833-ENST00000263360EEDchr1185988022+227317021921709505
ENST00000527523SYTL2chr1185429833-ENST00000528180EEDchr1185988022+224417021921709505
ENST00000527523SYTL2chr1185429833-ENST00000327320EEDchr1185988022+267917021921709505
ENST00000527523SYTL2chr1185429833-ENST00000351625EEDchr1185988022+235017021921709505
ENST00000389958SYTL2chr1185429833-ENST00000263360EEDchr1185988022+950379370738122
ENST00000389958SYTL2chr1185429833-ENST00000528180EEDchr1185988022+921379370738122
ENST00000389958SYTL2chr1185429833-ENST00000327320EEDchr1185988022+135637955830783
ENST00000389958SYTL2chr1185429833-ENST00000351625EEDchr1185988022+1027379370738122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000527523ENST00000263360SYTL2chr1185429833-EEDchr1185988022+0.0035390290.996461
ENST00000527523ENST00000528180SYTL2chr1185429833-EEDchr1185988022+0.0039742550.9960258
ENST00000527523ENST00000327320SYTL2chr1185429833-EEDchr1185988022+0.001901570.99809843
ENST00000527523ENST00000351625SYTL2chr1185429833-EEDchr1185988022+0.0029146330.9970854
ENST00000389958ENST00000263360SYTL2chr1185429833-EEDchr1185988022+0.095720780.90427923
ENST00000389958ENST00000528180SYTL2chr1185429833-EEDchr1185988022+0.074620690.92537934
ENST00000389958ENST00000327320SYTL2chr1185429833-EEDchr1185988022+0.200635980.7993641
ENST00000389958ENST00000351625SYTL2chr1185429833-EEDchr1185988022+0.1039218750.89607817

Top

Fusion Genomic Features for SYTL2-EED


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SYTL2chr1185429832-EEDchr1185988021+3.57E-050.99996436
SYTL2chr1185429832-EEDchr1185988021+3.57E-050.99996436

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for SYTL2-EED


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85429833/chr11:85988022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EED

O75530

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-313579_6198601273.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-312579_6198601257.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-10191_57539936.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-3131_578601273.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-313628_7538601273.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-10191_57538911.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-9181_57538911.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-3121_578601257.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-312628_7538601257.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-9191_57490903.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-9181_57538935.0DomainRabBD
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812359_399322442.0RepeatNote=WD 6
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812408_441322442.0RepeatNote=WD 7
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811359_399322401.0RepeatNote=WD 6
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811408_441322401.0RepeatNote=WD 7
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913359_399347467.0RepeatNote=WD 6
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913408_441347467.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-1019579_619539936.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-19579_6191366.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-1019579_619538911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-918579_619538911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-19579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-919579_619490903.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-918579_619538935.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-212579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-211579_6190337.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-1019628_753539936.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-1019768_897539936.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-313768_8978601273.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-191_571366.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-19628_7531366.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-19768_8971366.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-1019628_753538911.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-1019768_897538911.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-918628_753538911.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-918768_897538911.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-312768_8978601257.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-191_570377.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-19628_7530377.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-19768_8970377.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-919628_753490903.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-919768_897490903.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-918628_753538935.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-918768_897538935.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-2121_570377.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-212628_7530377.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-212768_8970377.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-2111_570337.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-211628_7530337.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-211768_8970337.0DomainC2 2
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812142_185322442.0RepeatNote=WD 2
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812188_228322442.0RepeatNote=WD 3
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812234_275322442.0RepeatNote=WD 4
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812304_341322442.0RepeatNote=WD 5
TgeneEEDchr11:85429833chr11:85988022ENST0000026336081291_134322442.0RepeatNote=WD 1
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811142_185322401.0RepeatNote=WD 2
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811188_228322401.0RepeatNote=WD 3
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811234_275322401.0RepeatNote=WD 4
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811304_341322401.0RepeatNote=WD 5
TgeneEEDchr11:85429833chr11:85988022ENST0000032732081191_134322401.0RepeatNote=WD 1
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913142_185347467.0RepeatNote=WD 2
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913188_228347467.0RepeatNote=WD 3
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913234_275347467.0RepeatNote=WD 4
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913304_341347467.0RepeatNote=WD 5
TgeneEEDchr11:85429833chr11:85988022ENST0000035162591391_134347467.0RepeatNote=WD 1


Top

Fusion Gene Sequence for SYTL2-EED


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88580_88580_1_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000263360_length(transcript)=950nt_BP=379nt
ACAGAAGAATAGAGAGGCTGTTGCAGCCCCGTGCTTTCTCCTGCTGCTGGCCGATTGCTTGCTCTGAACTAACCCTCTAACCCTTGGGAG
TCTGTGTGCAGCAGTGATGTGAGCTGCATCCGGGCTGAAATGGGAGCTCCCGCTATGGCACTGGCTCAAGGAGCTAATCTAAAGAGAAAG
TATTTTGGGGAAGACATCTTGGTTGCACCCCTCATTGCATCTTGACTAATTGCTTCCAACTCCGGGGGCTTCCAGGGACAATCTCATTGT
TCTTTTCTCTCCAAGGGTCAGCCATGTTAACCATTTGTTAATTTCTTCTGAACAGATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTA
GTGCGTAGTGCTGAAGATGTCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAG
TGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGAT
GCTTGCATTGGGCAATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCA
TCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCG
CTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAG
TAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGT

>88580_88580_1_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000263360_length(amino acids)=122AA_BP=3
MKMSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC

--------------------------------------------------------------
>88580_88580_2_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000327320_length(transcript)=1356nt_BP=379nt
ACAGAAGAATAGAGAGGCTGTTGCAGCCCCGTGCTTTCTCCTGCTGCTGGCCGATTGCTTGCTCTGAACTAACCCTCTAACCCTTGGGAG
TCTGTGTGCAGCAGTGATGTGAGCTGCATCCGGGCTGAAATGGGAGCTCCCGCTATGGCACTGGCTCAAGGAGCTAATCTAAAGAGAAAG
TATTTTGGGGAAGACATCTTGGTTGCACCCCTCATTGCATCTTGACTAATTGCTTCCAACTCCGGGGGCTTCCAGGGACAATCTCATTGT
TCTTTTCTCTCCAAGGGTCAGCCATGTTAACCATTTGTTAATTTCTTCTGAACAGATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTA
GTGCGTAGTGCTGAAGATGTCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAG
TGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGAT
GCTTGCATTGGGCAATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAGTAAGTATTTAGAAATTT
CTGTTCAAAATTTCAGGCTTTTTCTCCACACTTGTATGCCAATGTAGAGAAGATCATTTATATTTGCAGTGCCATCCTTAAGTCATTTTT
AACATTTACTGTTTTCAGAGTTAAAGTTATTCTTTTTTATTCCAATAATTTTTGTTTTTCCTAAGTACCTTGGTGACAAGTCATTTCTTG
TTTTTATACAAATTATGTAGTGCTTGTTGAACTTAAAATATATCTAAATTTTATAAAATTTGAGACTGAGCTCTTAGTGAAGTATATTCT
GGTTTTAAGTGCTTTTCGTATGACTTGGAACATCTGCTTATTTTCTAATCCGCTGTTTTAGGGTAGACACTGACAACGTTATGTGTGGTC
TTTAACCTGTTGTCATGTTTTTTCCCTAGATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGG
GATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTA
GAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAAT
CAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGTACTGTCTTCCTGCTCAGACTCTACTGCTTTTAATAAAAATTTA

>88580_88580_2_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000327320_length(amino acids)=83AA_BP=1

--------------------------------------------------------------
>88580_88580_3_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000351625_length(transcript)=1027nt_BP=379nt
ACAGAAGAATAGAGAGGCTGTTGCAGCCCCGTGCTTTCTCCTGCTGCTGGCCGATTGCTTGCTCTGAACTAACCCTCTAACCCTTGGGAG
TCTGTGTGCAGCAGTGATGTGAGCTGCATCCGGGCTGAAATGGGAGCTCCCGCTATGGCACTGGCTCAAGGAGCTAATCTAAAGAGAAAG
TATTTTGGGGAAGACATCTTGGTTGCACCCCTCATTGCATCTTGACTAATTGCTTCCAACTCCGGGGGCTTCCAGGGACAATCTCATTGT
TCTTTTCTCTCCAAGGGTCAGCCATGTTAACCATTTGTTAATTTCTTCTGAACAGATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTA
GTGCGTAGTGCTGAAGATGTCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAG
TGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGAT
GCTTGCATTGGGCAATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCA
TCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCG
CTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAG
TAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGT
ACTGTCTTCCTGCTCAGACTCTACTGCTTTTAATAAAAATTTATTTTTGTAAAGCTGTGTGTTTAGTTACTTTCATTGTGGTGAAAAAAA

>88580_88580_3_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000351625_length(amino acids)=122AA_BP=3
MKMSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC

--------------------------------------------------------------
>88580_88580_4_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000528180_length(transcript)=921nt_BP=379nt
ACAGAAGAATAGAGAGGCTGTTGCAGCCCCGTGCTTTCTCCTGCTGCTGGCCGATTGCTTGCTCTGAACTAACCCTCTAACCCTTGGGAG
TCTGTGTGCAGCAGTGATGTGAGCTGCATCCGGGCTGAAATGGGAGCTCCCGCTATGGCACTGGCTCAAGGAGCTAATCTAAAGAGAAAG
TATTTTGGGGAAGACATCTTGGTTGCACCCCTCATTGCATCTTGACTAATTGCTTCCAACTCCGGGGGCTTCCAGGGACAATCTCATTGT
TCTTTTCTCTCCAAGGGTCAGCCATGTTAACCATTTGTTAATTTCTTCTGAACAGATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTA
GTGCGTAGTGCTGAAGATGTCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAG
TGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGAT
GCTTGCATTGGGCAATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCA
TCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCG
CTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAG
TAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGT

>88580_88580_4_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000528180_length(amino acids)=122AA_BP=3
MKMSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC

--------------------------------------------------------------
>88580_88580_5_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000263360_length(transcript)=2273nt_BP=1702nt
AGTGCCGGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGC
GCCCGGGGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCG
ACTCGGAGACATTTGCCTGAAAAAATTAAGGATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAAAGG
CACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATCTATGAGAAAGAAGAGGCCCCAGATAGCAGCTGAGCAGAGTAAAGACAGA
GAAAATGGGGCAAAGGAAAGCTGGGTGAATAATGTCAACAAAGATGCTTTCCTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCAGAA
GAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTGATTGATATGTCCCAGGAAAACACAAGGAAACCA
AATGTGTCTCCAGAGAAGAGGAAGAATCCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACAAACTAAAAATGAACAGTCA
AAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCAAAAGAAAAGTCAACTGTCGCAGATACTTCAATC
CAAAAGTTAGAGAAATCAAAGCAGACTTTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATGATC
TACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACAGACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGG
ATCCTCAAGCGCAACTCCAGTTCCAGTAGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTGTCA
CCTGGCCTAACCATCCATGAGAGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAACTCTTCCCCAAACTCCCTGGAGCCATTAAAGCAT
GTGAGATTCTCTGCAGTGAAGGATGAGCTTCCACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAATCT
GACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGAAGAGTTTCAGAGTGACCCTAAGCCTTCTCAATACAGAAAGCCTTCGCTT
TTTCATCAATCAACCTCAAGCCCATATGTATCAAAAAGTGAAACACATCAGCCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTGCAT
TCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATCAATGAACCCAAAGATAAATCATCAGAATTAACA
AGGCTTGAATCTGTATTACCCAGAAGCCCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCAGGTGCCAGGTGGCAGTTCT
AGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGCCTTCCAAAAGT
CTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTCTTGTGA
AAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCG
ATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAAGTTGGCAA
ACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACA
AACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTT
TGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTG
TCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGTACTGTCTTCCTGCTCAGACTCTACTGC

>88580_88580_5_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000263360_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------
>88580_88580_6_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000327320_length(transcript)=2679nt_BP=1702nt
AGTGCCGGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGC
GCCCGGGGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCG
ACTCGGAGACATTTGCCTGAAAAAATTAAGGATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAAAGG
CACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATCTATGAGAAAGAAGAGGCCCCAGATAGCAGCTGAGCAGAGTAAAGACAGA
GAAAATGGGGCAAAGGAAAGCTGGGTGAATAATGTCAACAAAGATGCTTTCCTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCAGAA
GAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTGATTGATATGTCCCAGGAAAACACAAGGAAACCA
AATGTGTCTCCAGAGAAGAGGAAGAATCCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACAAACTAAAAATGAACAGTCA
AAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCAAAAGAAAAGTCAACTGTCGCAGATACTTCAATC
CAAAAGTTAGAGAAATCAAAGCAGACTTTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATGATC
TACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACAGACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGG
ATCCTCAAGCGCAACTCCAGTTCCAGTAGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTGTCA
CCTGGCCTAACCATCCATGAGAGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAACTCTTCCCCAAACTCCCTGGAGCCATTAAAGCAT
GTGAGATTCTCTGCAGTGAAGGATGAGCTTCCACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAATCT
GACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGAAGAGTTTCAGAGTGACCCTAAGCCTTCTCAATACAGAAAGCCTTCGCTT
TTTCATCAATCAACCTCAAGCCCATATGTATCAAAAAGTGAAACACATCAGCCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTGCAT
TCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATCAATGAACCCAAAGATAAATCATCAGAATTAACA
AGGCTTGAATCTGTATTACCCAGAAGCCCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCAGGTGCCAGGTGGCAGTTCT
AGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGCCTTCCAAAAGT
CTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTCTTGTGA
AAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCG
ATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAAGTTGGCAA
ACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAGTAAGTATTTAGAAATTTCTGTTCAAAATTTCAGGCTTTTTCTCC
ACACTTGTATGCCAATGTAGAGAAGATCATTTATATTTGCAGTGCCATCCTTAAGTCATTTTTAACATTTACTGTTTTCAGAGTTAAAGT
TATTCTTTTTTATTCCAATAATTTTTGTTTTTCCTAAGTACCTTGGTGACAAGTCATTTCTTGTTTTTATACAAATTATGTAGTGCTTGT
TGAACTTAAAATATATCTAAATTTTATAAAATTTGAGACTGAGCTCTTAGTGAAGTATATTCTGGTTTTAAGTGCTTTTCGTATGACTTG
GAACATCTGCTTATTTTCTAATCCGCTGTTTTAGGGTAGACACTGACAACGTTATGTGTGGTCTTTAACCTGTTGTCATGTTTTTTCCCT
AGATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGT
GATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATA
GAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTT

>88580_88580_6_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000327320_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------
>88580_88580_7_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000351625_length(transcript)=2350nt_BP=1702nt
AGTGCCGGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGC
GCCCGGGGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCG
ACTCGGAGACATTTGCCTGAAAAAATTAAGGATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAAAGG
CACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATCTATGAGAAAGAAGAGGCCCCAGATAGCAGCTGAGCAGAGTAAAGACAGA
GAAAATGGGGCAAAGGAAAGCTGGGTGAATAATGTCAACAAAGATGCTTTCCTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCAGAA
GAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTGATTGATATGTCCCAGGAAAACACAAGGAAACCA
AATGTGTCTCCAGAGAAGAGGAAGAATCCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACAAACTAAAAATGAACAGTCA
AAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCAAAAGAAAAGTCAACTGTCGCAGATACTTCAATC
CAAAAGTTAGAGAAATCAAAGCAGACTTTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATGATC
TACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACAGACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGG
ATCCTCAAGCGCAACTCCAGTTCCAGTAGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTGTCA
CCTGGCCTAACCATCCATGAGAGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAACTCTTCCCCAAACTCCCTGGAGCCATTAAAGCAT
GTGAGATTCTCTGCAGTGAAGGATGAGCTTCCACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAATCT
GACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGAAGAGTTTCAGAGTGACCCTAAGCCTTCTCAATACAGAAAGCCTTCGCTT
TTTCATCAATCAACCTCAAGCCCATATGTATCAAAAAGTGAAACACATCAGCCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTGCAT
TCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATCAATGAACCCAAAGATAAATCATCAGAATTAACA
AGGCTTGAATCTGTATTACCCAGAAGCCCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCAGGTGCCAGGTGGCAGTTCT
AGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGCCTTCCAAAAGT
CTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTCTTGTGA
AAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCG
ATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAAGTTGGCAA
ACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACA
AACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTT
TGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTG
TCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGTACTGTCTTCCTGCTCAGACTCTACTGC
TTTTAATAAAAATTTATTTTTGTAAAGCTGTGTGTTTAGTTACTTTCATTGTGGTGAAAAAAAGTTAAAAGTAATAAAATTATGCCTTAT

>88580_88580_7_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000351625_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------
>88580_88580_8_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000528180_length(transcript)=2244nt_BP=1702nt
AGTGCCGGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGC
GCCCGGGGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCG
ACTCGGAGACATTTGCCTGAAAAAATTAAGGATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAAAGG
CACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATCTATGAGAAAGAAGAGGCCCCAGATAGCAGCTGAGCAGAGTAAAGACAGA
GAAAATGGGGCAAAGGAAAGCTGGGTGAATAATGTCAACAAAGATGCTTTCCTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCAGAA
GAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTGATTGATATGTCCCAGGAAAACACAAGGAAACCA
AATGTGTCTCCAGAGAAGAGGAAGAATCCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACAAACTAAAAATGAACAGTCA
AAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCAAAAGAAAAGTCAACTGTCGCAGATACTTCAATC
CAAAAGTTAGAGAAATCAAAGCAGACTTTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATGATC
TACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACAGACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGG
ATCCTCAAGCGCAACTCCAGTTCCAGTAGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTGTCA
CCTGGCCTAACCATCCATGAGAGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAACTCTTCCCCAAACTCCCTGGAGCCATTAAAGCAT
GTGAGATTCTCTGCAGTGAAGGATGAGCTTCCACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAATCT
GACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGAAGAGTTTCAGAGTGACCCTAAGCCTTCTCAATACAGAAAGCCTTCGCTT
TTTCATCAATCAACCTCAAGCCCATATGTATCAAAAAGTGAAACACATCAGCCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTGCAT
TCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATCAATGAACCCAAAGATAAATCATCAGAATTAACA
AGGCTTGAATCTGTATTACCCAGAAGCCCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCAGGTGCCAGGTGGCAGTTCT
AGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGCCTTCCAAAAGT
CTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTCTTGTGA
AAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCG
ATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAAGTTGGCAA
ACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACA
AACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTT
TGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTG

>88580_88580_8_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000528180_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SYTL2-EED


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEEDchr11:85429833chr11:85988022ENST0000026336081281_441322.0442.0EZH2
TgeneEEDchr11:85429833chr11:85988022ENST0000032732081181_441322.0401.0EZH2
TgeneEEDchr11:85429833chr11:85988022ENST0000035162591381_441347.0467.0EZH2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SYTL2-EED


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SYTL2-EED


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource