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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SYTL2-TMEM135 (FusionGDB2 ID:88585)

Fusion Gene Summary for SYTL2-TMEM135

check button Fusion gene summary
Fusion gene informationFusion gene name: SYTL2-TMEM135
Fusion gene ID: 88585
HgeneTgene
Gene symbol

SYTL2

TMEM135

Gene ID

54843

65084

Gene namesynaptotagmin like 2transmembrane protein 135
SynonymsCHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2APMP52
Cytomap

11q14.1

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionsynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151transmembrane protein 135peroxisomal membrane protein 52
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000316356, ENST00000389960, 
ENST00000524452, ENST00000528231, 
ENST00000527523, ENST00000354566, 
ENST00000359152, ENST00000389958, 
ENST00000525423, ENST00000525702, 
ENST00000528566, ENST00000529581, 
ENST00000533892, 		ENST00000355734, 
ENST00000305494, ENST00000340353, 
ENST00000532959, ENST00000535167, 
Fusion gene scores* DoF score7 X 8 X 5=28011 X 9 X 7=693
# samples 912
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYTL2 [Title/Abstract] AND TMEM135 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSYTL2(85468668)-TMEM135(87006824), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYTL2

GO:0006887

exocytosis

18812475

HgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

HgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across SYTL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM135 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FD-01ASYTL2chr11

85468668

-TMEM135chr11

87006824

+
ChimerDB4BRCATCGA-BH-A1FD-01ASYTL2chr11

85521997

-TMEM135chr11

87006824

+


Top

Fusion Gene ORF analysis for SYTL2-TMEM135

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316356ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
5CDS-intronENST00000389960ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
5CDS-intronENST00000524452ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
5CDS-intronENST00000528231ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000316356ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000316356ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000316356ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000316356ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000389960ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000389960ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000389960ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000389960ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000527523ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000527523ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000527523ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-3CDSENST00000527523ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-intronENST00000316356ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-intronENST00000389960ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
5UTR-intronENST00000527523ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
Frame-shiftENST00000524452ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000524452ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000524452ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000524452ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000528231ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000528231ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000528231ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
Frame-shiftENST00000528231ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000316356ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000316356ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000316356ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000316356ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000389960ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000389960ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000389960ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
In-frameENST00000389960ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000354566ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000359152ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000389958ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000524452ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000524452ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000524452ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000524452ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525423ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000525702ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000527523ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000527523ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000527523ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000527523ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000528231ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528231ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528231ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528231ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000528566ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000529581ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000305494SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000305494SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000340353SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000340353SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000532959SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000532959SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000535167SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-3CDSENST00000533892ENST00000535167SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000354566ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000354566ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000359152ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000359152ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000389958ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000389958ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000524452ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000525423ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000525423ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000525702ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000525702ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000527523ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000528231ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000528566ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000528566ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000529581ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000529581ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+
intron-intronENST00000533892ENST00000355734SYTL2chr11

85468668

-TMEM135chr11

87006824

+
intron-intronENST00000533892ENST00000355734SYTL2chr11

85521997

-TMEM135chr11

87006824

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389960SYTL2chr1185468668-ENST00000340353TMEM135chr1187006824+39656725081539343
ENST00000389960SYTL2chr1185468668-ENST00000532959TMEM135chr1187006824+15666725081539343
ENST00000389960SYTL2chr1185468668-ENST00000305494TMEM135chr1187006824+25576725081539343
ENST00000389960SYTL2chr1185468668-ENST00000535167TMEM135chr1187006824+16936725081539343
ENST00000316356SYTL2chr1185468668-ENST00000340353TMEM135chr1187006824+39596665021533343
ENST00000316356SYTL2chr1185468668-ENST00000532959TMEM135chr1187006824+15606665021533343
ENST00000316356SYTL2chr1185468668-ENST00000305494TMEM135chr1187006824+25516665021533343
ENST00000316356SYTL2chr1185468668-ENST00000535167TMEM135chr1187006824+16876665021533343

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389960ENST00000340353SYTL2chr1185468668-TMEM135chr1187006824+0.000337450.9996625
ENST00000389960ENST00000532959SYTL2chr1185468668-TMEM135chr1187006824+0.0011849150.99881506
ENST00000389960ENST00000305494SYTL2chr1185468668-TMEM135chr1187006824+0.0004944350.9995055
ENST00000389960ENST00000535167SYTL2chr1185468668-TMEM135chr1187006824+0.0011504520.9988495
ENST00000316356ENST00000340353SYTL2chr1185468668-TMEM135chr1187006824+0.0003394020.9996606
ENST00000316356ENST00000532959SYTL2chr1185468668-TMEM135chr1187006824+0.0012009160.9987991
ENST00000316356ENST00000305494SYTL2chr1185468668-TMEM135chr1187006824+0.0005130710.9994869
ENST00000316356ENST00000535167SYTL2chr1185468668-TMEM135chr1187006824+0.0011611050.99883896

Top

Fusion Genomic Features for SYTL2-TMEM135


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SYTL2chr1185521996-TMEM135chr1187006823+6.38E-050.9999362
SYTL2chr1185468667-TMEM135chr1187006823+6.68E-070.9999993
SYTL2chr1185521996-TMEM135chr1187006823+6.38E-050.9999362
SYTL2chr1185468667-TMEM135chr1187006823+6.68E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SYTL2-TMEM135


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85468668/chr11:87006824)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM135chr11:85468668chr11:87006824ENST00000305494515298_318169459.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST00000305494515331_351169459.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST00000305494515380_400169459.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST00000340353414149_169147437.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST00000340353414298_318147437.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST00000340353414331_351147437.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST00000340353414380_400147437.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYTL2chr11:85468668chr11:87006824ENST00000316356-219579_61933936.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000354566-113579_61901273.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389958-19579_6190366.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389960-219579_61933911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000524452-118579_61933911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525423-112579_61901257.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525702-19579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000527523-119579_6190903.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000528231-118579_61933935.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000529581-112579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000533892-111579_6190337.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:87006824ENST00000316356-2191_5733936.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000316356-219628_75333936.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000316356-219768_89733936.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000354566-1131_5701273.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000354566-113628_75301273.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000354566-113768_89701273.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389958-191_570366.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389958-19628_7530366.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389958-19768_8970366.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389960-2191_5733911.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389960-219628_75333911.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000389960-219768_89733911.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000524452-1181_5733911.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000524452-118628_75333911.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000524452-118768_89733911.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525423-1121_5701257.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525423-112628_75301257.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525423-112768_89701257.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525702-191_570377.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525702-19628_7530377.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000525702-19768_8970377.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000527523-1191_570903.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000527523-119628_7530903.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000527523-119768_8970903.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000528231-1181_5733935.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000528231-118628_75333935.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000528231-118768_89733935.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000529581-1121_570377.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000529581-112628_7530377.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000529581-112768_8970377.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:87006824ENST00000533892-1111_570337.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:87006824ENST00000533892-111628_7530337.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:87006824ENST00000533892-111768_8970337.0DomainC2 2
TgeneTMEM135chr11:85468668chr11:87006824ENST00000305494515149_169169459.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST0000030549451568_88169459.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST0000030549451596_116169459.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST0000034035341468_88147437.0TransmembraneHelical
TgeneTMEM135chr11:85468668chr11:87006824ENST0000034035341496_116147437.0TransmembraneHelical


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Fusion Gene Sequence for SYTL2-TMEM135


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88585_88585_1_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000305494_length(transcript)=2551nt_BP=666nt
CACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGGGGCTGC
GCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGGAGGTAG
GTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAGTGAGTG
TGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACC
AGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACT
GAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCT
ATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGA
TGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGG
GAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGG
AAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGA
TAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATT
TAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGT
TAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGG
TATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGC
AGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCA
GACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGG
TACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTC
CTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGA
ACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTT
GCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCA
CAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAA
TATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTA
AAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAA
TTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAAC
TAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGG
AAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACT
TCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCA
AAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAA

>88585_88585_1_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000305494_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_2_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000340353_length(transcript)=3959nt_BP=666nt
CACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGGGGCTGC
GCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGGAGGTAG
GTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAGTGAGTG
TGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACC
AGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACT
GAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCT
ATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGA
TGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGG
GAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGG
AAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGA
TAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATT
TAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGT
TAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGG
TATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGC
AGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCA
GACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGG
TACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTC
CTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGA
ACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTT
GCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCA
CAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAA
TATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTA
AAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAA
TTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAAC
TAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGG
AAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACT
TCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCA
AAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAA
ACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATTTGTCACTAATTCCATTCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCA
CCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAAGTCCTGCTGATAATGAGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCG
CTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTATGTTAATAAAGAGCTGAAGTGGTCTACAGTTAATGTGACATGTAGGGATGAT
GATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTTAGGCCAGTGCAAATTATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACC
CATACTTTAAAAATGCTTAATCCCTCATATTCAATTTCATCAAGCCTTGTATACTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATG
GCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACTATGGTAACAGAGCCACTTTATCATTTGGTCAAAATTTGGCATTATGATTAGC
TTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAAAGGATCATTTCGGTTTCAGACTTCAAAGTTGATTAATAAATTTAATCTTAAC
TTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGTGTTTACTGTTTAAAATGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTC
TTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGGTTTAAAAAGATGTTTTAATTCATAAATTATTGTTTTCATTGACATTAAAAGA
CTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGATTGTTTAGTAAAATTTTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTT
TTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTATGTAAAATGTAAAATGAAATAGCTATCATGAAGCAGAATACAATGATGAATG
TATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATTGAGAAGTCCAGTTTGATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGA
GCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCAGAATGATTACCTTTCTACCTCTAACTAATCAGGTATTGATTGACAACTTTTT
GGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCAAAATATGTTTTTTAGTTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTG
GAACTGATTACAGTAAACAATAATATGTCCCCTTAGTCTTTCTGACATTTTTATATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAG

>88585_88585_2_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000340353_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_3_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000532959_length(transcript)=1560nt_BP=666nt
CACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGGGGCTGC
GCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGGAGGTAG
GTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAGTGAGTG
TGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACC
AGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACT
GAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCT
ATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGA
TGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGG
GAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGG
AAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGA
TAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATT
TAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGT
TAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGG
TATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGC
AGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCA
GACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGG
TACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTC

>88585_88585_3_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000532959_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_4_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000535167_length(transcript)=1687nt_BP=666nt
CACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGGGGCTGC
GCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGGAGGTAG
GTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAGTGAGTG
TGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACC
AGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACT
GAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCT
ATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGA
TGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGG
GAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGG
AAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGA
TAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATT
TAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGT
TAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGG
TATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGC
AGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCA
GACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGG
TACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTC
CTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGA

>88585_88585_4_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000316356_TMEM135_chr11_87006824_ENST00000535167_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_5_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000305494_length(transcript)=2557nt_BP=672nt
GGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGG
GGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGG
AGGTAGGTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAG
TGAGTGTGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCA
CAGACCAGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGC
AGAACTGAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTT
GTTGCTATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCA
GCGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCAT
TGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAA
ACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTA
TGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTC
TGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTC
TTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTT
GGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCAT
TGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGA
AGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGT
TTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGA
GTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAA
GCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAA
GATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTA
TGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCA
TTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATT
TTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCA
ATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTT
TTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGC
AAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTT
TAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAG
GGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCAC

>88585_88585_5_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000305494_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_6_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000340353_length(transcript)=3965nt_BP=672nt
GGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGG
GGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGG
AGGTAGGTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAG
TGAGTGTGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCA
CAGACCAGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGC
AGAACTGAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTT
GTTGCTATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCA
GCGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCAT
TGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAA
ACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTA
TGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTC
TGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTC
TTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTT
GGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCAT
TGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGA
AGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGT
TTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGA
GTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAA
GCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAA
GATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTA
TGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCA
TTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATT
TTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCA
ATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTT
TTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGC
AAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTT
TAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAG
GGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCAC
CTGAAAACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATTTGTCACTAATTCCATTCAGGTTCTCCAACCTTCTTCTTGAATATCA
TTGTCACCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAAGTCCTGCTGATAATGAGAGTAGTTCAGGACAGCTGTGATTGAAATA
TGGTCGCTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTATGTTAATAAAGAGCTGAAGTGGTCTACAGTTAATGTGACATGTAGG
GATGATGATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTTAGGCCAGTGCAAATTATGCAGTAGAACTTGTGTTGCAAAAGGAATT
ATAACCCATACTTTAAAAATGCTTAATCCCTCATATTCAATTTCATCAAGCCTTGTATACTTCTGCTTAAATGTAATTCAATCCTTGGTT
GTTATGGCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACTATGGTAACAGAGCCACTTTATCATTTGGTCAAAATTTGGCATTATG
ATTAGCTTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAAAGGATCATTTCGGTTTCAGACTTCAAAGTTGATTAATAAATTTAAT
CTTAACTTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGTGTTTACTGTTTAAAATGAAGTACTAAAGCCCTGAGAACTGCACCTC
ATTTTCTTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGGTTTAAAAAGATGTTTTAATTCATAAATTATTGTTTTCATTGACATT
AAAAGACTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGATTGTTTAGTAAAATTTTGCTGGTCAAAAAGGTGTATTTCTACAATT
TACCTTTTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTATGTAAAATGTAAAATGAAATAGCTATCATGAAGCAGAATACAATGA
TGAATGTATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATTGAGAAGTCCAGTTTGATTTCATTGGGACAGACTGCAAAGTGTAGTT
GTTTGAGCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCAGAATGATTACCTTTCTACCTCTAACTAATCAGGTATTGATTGACAA
CTTTTTGGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCAAAATATGTTTTTTAGTTTATTTATATCCTGAAGAAATGGTAAGTTT
TCACTGGAACTGATTACAGTAAACAATAATATGTCCCCTTAGTCTTTCTGACATTTTTATATAGATTGAGATTGAAAAACCGTGCATTTG
GGGCAGTGGTATTATGGTCATTTCGTTGCTATTTTCTGTTTTAATAAAATCCTAGAACTAGTAGCAACCGAGTAAAGATTGAGTTTGCAA

>88585_88585_6_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000340353_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_7_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000532959_length(transcript)=1566nt_BP=672nt
GGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGG
GGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGG
AGGTAGGTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAG
TGAGTGTGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCA
CAGACCAGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGC
AGAACTGAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTT
GTTGCTATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCA
GCGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCAT
TGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAA
ACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTA
TGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTC
TGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTC
TTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTT
GGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCAT
TGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGA
AGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGT
TTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGA

>88585_88585_7_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000532959_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------
>88585_88585_8_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000535167_length(transcript)=1693nt_BP=672nt
GGGCGACACCCGGGCCGTGCCGCCAGCGTCCGTCGGGAGAGTGAAGGCTCGCAACGCCTTGCCCGGGGGAAGGTAACGCGCCGCGCCCGG
GGCTGCGCGGTTTGCACCGCCAGGCCGAGGGCTGGGGGCCAGAAGACAAGAGAGACGGCGAGGCGCGCTCCCTGCCCGGCAGCGACTCGG
AGGTAGGTGATGCTCTGATGCTGCTGCCTCTTATGAATTGACGACAGGTGCAGAGAGAGAATAAACTGTGTCTAAGACTGGACCAGAGAG
TGAGTGTGCTGGAAGCCACCATAGGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCA
CAGACCAGGACTTCCTCATGGGAAAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGC
AGAACTGAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTT
GTTGCTATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCA
GCGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCAT
TGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAA
ACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTA
TGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTC
TGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTC
TTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTT
GGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCAT
TGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGA
AGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGT
TTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGA
GTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAA

>88585_88585_8_SYTL2-TMEM135_SYTL2_chr11_85468668_ENST00000389960_TMEM135_chr11_87006824_ENST00000535167_length(amino acids)=343AA_BP=54
MFSPENFEPHLLLLFLHALFKMIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAK
VEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK
ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSIS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SYTL2-TMEM135


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SYTL2-TMEM135


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SYTL2-TMEM135


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource