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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAG4-NEDD8 (FusionGDB2 ID:8860)

Fusion Gene Summary for BAG4-NEDD8

check button Fusion gene summary
Fusion gene informationFusion gene name: BAG4-NEDD8
Fusion gene ID: 8860
HgeneTgene
Gene symbol

BAG4

NEDD8

Gene ID

9530

4738

Gene nameBAG cochaperone 4NEDD8 ubiquitin like modifier
SynonymsBAG-4|SODDNEDD-8
Cytomap

8p11.23

14q12

Type of geneprotein-codingprotein-coding
DescriptionBAG family molecular chaperone regulator 4BCL2 associated athanogene 4bcl-2-associated athanogene 4silencer of death domainsNEDD8neddylinneural precursor cell expressed, developmentally down-regulated 8ubiquitin-like protein Nedd8
Modification date2020031320200327
UniProtAcc

O95429

UBE2F

Ensembl transtripts involved in fusion geneENST00000521282, ENST00000287322, 
ENST00000432471, 
ENST00000250495, 
ENST00000524927, ENST00000533242, 
Fusion gene scores* DoF score12 X 5 X 7=4203 X 2 X 3=18
# samples 153
** MAII scorelog2(15/420*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BAG4 [Title/Abstract] AND NEDD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAG4(38034657)-NEDD8(24687637), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAG4

GO:0071356

cellular response to tumor necrosis factor

21712384

TgeneNEDD8

GO:0045116

protein neddylation

10500095


check buttonFusion gene breakpoints across BAG4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NEDD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1PH-01ABAG4chr8

38034657

-NEDD8chr14

24687637

-
ChimerDB4BRCATCGA-EW-A1PH-01ABAG4chr8

38034657

+NEDD8chr14

24687637

-


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Fusion Gene ORF analysis for BAG4-NEDD8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000521282ENST00000250495BAG4chr8

38034657

+NEDD8chr14

24687637

-
3UTR-3CDSENST00000521282ENST00000524927BAG4chr8

38034657

+NEDD8chr14

24687637

-
3UTR-intronENST00000521282ENST00000533242BAG4chr8

38034657

+NEDD8chr14

24687637

-
5CDS-intronENST00000287322ENST00000533242BAG4chr8

38034657

+NEDD8chr14

24687637

-
5CDS-intronENST00000432471ENST00000533242BAG4chr8

38034657

+NEDD8chr14

24687637

-
In-frameENST00000287322ENST00000250495BAG4chr8

38034657

+NEDD8chr14

24687637

-
In-frameENST00000287322ENST00000524927BAG4chr8

38034657

+NEDD8chr14

24687637

-
In-frameENST00000432471ENST00000250495BAG4chr8

38034657

+NEDD8chr14

24687637

-
In-frameENST00000432471ENST00000524927BAG4chr8

38034657

+NEDD8chr14

24687637

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000432471BAG4chr838034657+ENST00000250495NEDD8chr1424687637-1055552159779206
ENST00000432471BAG4chr838034657+ENST00000524927NEDD8chr1424687637-1100552159686175
ENST00000287322BAG4chr838034657+ENST00000250495NEDD8chr1424687637-1044541148768206
ENST00000287322BAG4chr838034657+ENST00000524927NEDD8chr1424687637-1089541148675175

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432471ENST00000250495BAG4chr838034657+NEDD8chr1424687637-0.026853340.9731467
ENST00000432471ENST00000524927BAG4chr838034657+NEDD8chr1424687637-0.0578472950.9421527
ENST00000287322ENST00000250495BAG4chr838034657+NEDD8chr1424687637-0.0224118870.97758806
ENST00000287322ENST00000524927BAG4chr838034657+NEDD8chr1424687637-0.0611728240.9388272

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Fusion Genomic Features for BAG4-NEDD8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAG4-NEDD8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38034657/chr14:24687637)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAG4

O95429

NEDD8

UBE2F

FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}.185

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAG4chr8:38034657chr14:24687637ENST00000287322+15379_45690458.0DomainBAG
HgeneBAG4chr8:38034657chr14:24687637ENST00000432471+14379_45690422.0DomainBAG


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Fusion Gene Sequence for BAG4-NEDD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8860_8860_1_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000287322_NEDD8_chr14_24687637_ENST00000250495_length(transcript)=1044nt_BP=541nt
AACTCCATTGGATAAATGGCGAGGAAACGTATACTCCCTCTTAAGGAACACGGTGTCTTCCTTCGTCTCCGGGTTCCCGAGACCCCAGAG
TCACTGACCTCCGTCCCTCAGCTTTCGGGGTTCGGCAGCAGAAGGGGCGGGCCCGGGCCTGGGATTGGCTGGCGTCGTCCGACCCCCTTC
GCTGCTCTCCATTCGCAATCGCCCGCGGGCGCCTGCGCGATGGGTCGGCCGTGGGGAGCGGGGCGGGAAGCGCTTCAGGGCAGCGGATCC
CATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGT
ACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGAC
CACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCA
GACGCTGACCGGAAAGGAGATTGAGATTGACATTGAACCTACAGACAAGGTGGAGCGAATCAAGGAGCGTGTGGAGGAGAAAGAGGGAAT
CCCCCCACAACAGCAGAGGCTCATCTACAGTGGCAAGCAGATGAATGATGAGAAGACAGCAGCTGATTACAAGATTTTAGGTGGTTCAGT
CCTTCACCTGGTGTTGGCTCTGAGAGGAGGAGGTGGTCTTAGGCAGTGATGGACCCTCCATTTTACCTCTTTACCCTGTCGCTCATAATG
AGGCATCATATATCCTCTCACTCTCTGGGACACCATAGCCACTGCCCCCTCCCCTGGATGCCCAGTAATGTATGTCTACTGGTGGGAGAC
TGTGAGGATCCCAGGATTCAGTATTCCTGGCCCAGAGGGCCCTTGCTGGCTACTGGGTGTTAGTTTGCAGTCCTGTGTGCTTCCCTCTCT

>8860_8860_1_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000287322_NEDD8_chr14_24687637_ENST00000250495_length(amino acids)=206AA_BP=130
MGLAGVVRPPSLLSIRNRPRAPARWVGRGERGGKRFRAADPMSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPIS
WRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKT

--------------------------------------------------------------
>8860_8860_2_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000287322_NEDD8_chr14_24687637_ENST00000524927_length(transcript)=1089nt_BP=541nt
AACTCCATTGGATAAATGGCGAGGAAACGTATACTCCCTCTTAAGGAACACGGTGTCTTCCTTCGTCTCCGGGTTCCCGAGACCCCAGAG
TCACTGACCTCCGTCCCTCAGCTTTCGGGGTTCGGCAGCAGAAGGGGCGGGCCCGGGCCTGGGATTGGCTGGCGTCGTCCGACCCCCTTC
GCTGCTCTCCATTCGCAATCGCCCGCGGGCGCCTGCGCGATGGGTCGGCCGTGGGGAGCGGGGCGGGAAGCGCTTCAGGGCAGCGGATCC
CATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGT
ACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGAC
CACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCA
GACGCTGACCGGAAAGGAGATTGAGATTGACATTGAACCTACAGACAAGGTGGAGCGAATCAAGGAGCGTGTGGAGGAGAAAGAGGGAAT
CCCCCCACAACAGCAGAGGCTCATCTACAGTGGCAAGCAGATGTGAGTTTGGAGTGAGAATGACAGCATGGCGATCTTATGTGAAGATGA
GAAGAGGAGAGGGGGCACGTACTGAGGTGGATCAGGGGTGCCTCTTGTTTTTGGTGCCTAAGACTCTTTGGCAATCTGGTGAAGCCTCTA
AGCCCCTTCTCAGAATAAGATTTTTTCAGGCATAAAACAAAATATATAGAATTAAAGGAAAACTAATTATATTGAAATAGTTATTAAAAT
ACTAAAACAAATTTGTGATATAGTAATATATGTACTTTTTTATTAATGCATAAGATCTAATGGTAGGTCTAATATGACCATAATTTTGAA
ATATTTTCAAGATACCTATAAATGATCATGATAGAAAATAGTTAATTGCTATTGTTAACAAGTTACCTATATTGCTAATACTACTGTGGT

>8860_8860_2_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000287322_NEDD8_chr14_24687637_ENST00000524927_length(amino acids)=175AA_BP=130
MGLAGVVRPPSLLSIRNRPRAPARWVGRGERGGKRFRAADPMSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPIS

--------------------------------------------------------------
>8860_8860_3_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000432471_NEDD8_chr14_24687637_ENST00000250495_length(transcript)=1055nt_BP=552nt
AGGTAAGAGGAAACTCCATTGGATAAATGGCGAGGAAACGTATACTCCCTCTTAAGGAACACGGTGTCTTCCTTCGTCTCCGGGTTCCCG
AGACCCCAGAGTCACTGACCTCCGTCCCTCAGCTTTCGGGGTTCGGCAGCAGAAGGGGCGGGCCCGGGCCTGGGATTGGCTGGCGTCGTC
CGACCCCCTTCGCTGCTCTCCATTCGCAATCGCCCGCGGGCGCCTGCGCGATGGGTCGGCCGTGGGGAGCGGGGCGGGAAGCGCTTCAGG
GCAGCGGATCCCATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGA
GATGTGCCGGTACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGC
CCGGCGGAGACCACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGA
GGAAGCCACCAGACGCTGACCGGAAAGGAGATTGAGATTGACATTGAACCTACAGACAAGGTGGAGCGAATCAAGGAGCGTGTGGAGGAG
AAAGAGGGAATCCCCCCACAACAGCAGAGGCTCATCTACAGTGGCAAGCAGATGAATGATGAGAAGACAGCAGCTGATTACAAGATTTTA
GGTGGTTCAGTCCTTCACCTGGTGTTGGCTCTGAGAGGAGGAGGTGGTCTTAGGCAGTGATGGACCCTCCATTTTACCTCTTTACCCTGT
CGCTCATAATGAGGCATCATATATCCTCTCACTCTCTGGGACACCATAGCCACTGCCCCCTCCCCTGGATGCCCAGTAATGTATGTCTAC
TGGTGGGAGACTGTGAGGATCCCAGGATTCAGTATTCCTGGCCCAGAGGGCCCTTGCTGGCTACTGGGTGTTAGTTTGCAGTCCTGTGTG

>8860_8860_3_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000432471_NEDD8_chr14_24687637_ENST00000250495_length(amino acids)=206AA_BP=130
MGLAGVVRPPSLLSIRNRPRAPARWVGRGERGGKRFRAADPMSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPIS
WRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKT

--------------------------------------------------------------
>8860_8860_4_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000432471_NEDD8_chr14_24687637_ENST00000524927_length(transcript)=1100nt_BP=552nt
AGGTAAGAGGAAACTCCATTGGATAAATGGCGAGGAAACGTATACTCCCTCTTAAGGAACACGGTGTCTTCCTTCGTCTCCGGGTTCCCG
AGACCCCAGAGTCACTGACCTCCGTCCCTCAGCTTTCGGGGTTCGGCAGCAGAAGGGGCGGGCCCGGGCCTGGGATTGGCTGGCGTCGTC
CGACCCCCTTCGCTGCTCTCCATTCGCAATCGCCCGCGGGCGCCTGCGCGATGGGTCGGCCGTGGGGAGCGGGGCGGGAAGCGCTTCAGG
GCAGCGGATCCCATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGA
GATGTGCCGGTACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGC
CCGGCGGAGACCACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGA
GGAAGCCACCAGACGCTGACCGGAAAGGAGATTGAGATTGACATTGAACCTACAGACAAGGTGGAGCGAATCAAGGAGCGTGTGGAGGAG
AAAGAGGGAATCCCCCCACAACAGCAGAGGCTCATCTACAGTGGCAAGCAGATGTGAGTTTGGAGTGAGAATGACAGCATGGCGATCTTA
TGTGAAGATGAGAAGAGGAGAGGGGGCACGTACTGAGGTGGATCAGGGGTGCCTCTTGTTTTTGGTGCCTAAGACTCTTTGGCAATCTGG
TGAAGCCTCTAAGCCCCTTCTCAGAATAAGATTTTTTCAGGCATAAAACAAAATATATAGAATTAAAGGAAAACTAATTATATTGAAATA
GTTATTAAAATACTAAAACAAATTTGTGATATAGTAATATATGTACTTTTTTATTAATGCATAAGATCTAATGGTAGGTCTAATATGACC
ATAATTTTGAAATATTTTCAAGATACCTATAAATGATCATGATAGAAAATAGTTAATTGCTATTGTTAACAAGTTACCTATATTGCTAAT

>8860_8860_4_BAG4-NEDD8_BAG4_chr8_38034657_ENST00000432471_NEDD8_chr14_24687637_ENST00000524927_length(amino acids)=175AA_BP=130
MGLAGVVRPPSLLSIRNRPRAPARWVGRGERGGKRFRAADPMSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPIS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BAG4-NEDD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNEDD8chr8:38034657chr14:24687637ENST000002504950470_726.082.0UBE1C


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAG4-NEDD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAG4-NEDD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource