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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TACC2-MICU1 (FusionGDB2 ID:88663)

Fusion Gene Summary for TACC2-MICU1

check button Fusion gene summary
Fusion gene informationFusion gene name: TACC2-MICU1
Fusion gene ID: 88663
HgeneTgene
Gene symbol

TACC2

MICU1

Gene ID

10579

10367

Gene nametransforming acidic coiled-coil containing protein 2mitochondrial calcium uptake 1
SynonymsAZU-1|ECTACCCALC|CBARA1|EFHA3|MPXPS|ara CALC
Cytomap

10q26.13

10q22.1

Type of geneprotein-codingprotein-coding
Descriptiontransforming acidic coiled-coil-containing protein 2anti zuai-1calcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
Modification date2020031320200313
UniProtAcc.

Q9BPX6

Ensembl transtripts involved in fusion geneENST00000369005, ENST00000513429, 
ENST00000515273, ENST00000515603, 
ENST00000260733, ENST00000334433, 
ENST00000358010, ENST00000360561, 
ENST00000368999, ENST00000369000, 
ENST00000369001, ENST00000369004, 
ENST00000453444, ENST00000493951, 
ENST00000361114, ENST00000398761, 
ENST00000398763, ENST00000401998, 
ENST00000418483, ENST00000604025, 
Fusion gene scores* DoF score15 X 17 X 7=178522 X 15 X 11=3630
# samples 2030
** MAII scorelog2(20/1785*10)=-3.15785216914174
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/3630*10)=-3.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TACC2 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTACC2(123749003)-MICU1(74135630), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMICU1

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

TgeneMICU1

GO:0051260

protein homooligomerization

24514027

TgeneMICU1

GO:0051561

positive regulation of mitochondrial calcium ion concentration

24560927

TgeneMICU1

GO:0070509

calcium ion import

20693986


check buttonFusion gene breakpoints across TACC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CL-01ATACC2chr10

123749003

-MICU1chr10

74135630

-
ChimerDB4BRCATCGA-A2-A0CL-01ATACC2chr10

123749003

+MICU1chr10

74135630

-


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Fusion Gene ORF analysis for TACC2-MICU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000369005ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000369005ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000369005ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000369005ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000369005ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000513429ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000513429ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000513429ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000513429ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000513429ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515273ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515273ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515273ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515273ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515273ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515603ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515603ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515603ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515603ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-3CDSENST00000515603ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-intronENST00000369005ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-intronENST00000513429ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-intronENST00000515273ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
5UTR-intronENST00000515603ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000260733ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000260733ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000260733ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000260733ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000260733ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000334433ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000334433ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000334433ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000334433ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000334433ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000358010ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000358010ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000358010ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000358010ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000358010ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000360561ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000360561ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000360561ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000360561ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000360561ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000368999ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000368999ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000368999ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000368999ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000368999ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369000ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369000ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369000ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369000ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369000ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369001ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369001ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369001ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369001ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369001ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369004ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369004ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369004ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369004ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000369004ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000453444ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000453444ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000453444ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000453444ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000453444ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000493951ENST00000361114TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000493951ENST00000398761TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000493951ENST00000398763TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000493951ENST00000401998TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-3CDSENST00000493951ENST00000418483TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000260733ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000334433ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000358010ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000360561ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000368999ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000369000ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000369001ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000369004ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000453444ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-
intron-intronENST00000493951ENST00000604025TACC2chr10

123749003

+MICU1chr10

74135630

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TACC2-MICU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TACC2-MICU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:123749003/:74135630)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MICU1

Q9BPX6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221, ECO:0000269|PubMed:27099988}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TACC2-MICU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TACC2-MICU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TACC2-MICU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TACC2-MICU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource