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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:BAG6-CERK (FusionGDB2 ID:8868) |
Fusion Gene Summary for BAG6-CERK |
Fusion gene summary |
Fusion gene information | Fusion gene name: BAG6-CERK | Fusion gene ID: 8868 | Hgene | Tgene | Gene symbol | BAG6 | CERK | Gene ID | 7917 | 64781 |
Gene name | BAG cochaperone 6 | ceramide kinase | |
Synonyms | BAG-6|BAT3|D6S52E|G3 | LK4|dA59H18.2|dA59H18.3|hCERK | |
Cytomap | 6p21.33 | 22q13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | large proline-rich protein BAG6BAG family molecular chaperone regulator 6BCL2 associated athanogene 6HLA-B-associated transcript 3large proline-rich protein BAT3protein G3protein Scythescythe | ceramide kinaseacylsphingosine kinaselipid kinase 4lipid kinase LK4 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P46379 | Q49MI3 | |
Ensembl transtripts involved in fusion gene | ENST00000362049, ENST00000211379, ENST00000361076, ENST00000375964, ENST00000375976, ENST00000383446, ENST00000383448, ENST00000404765, ENST00000412012, ENST00000413922, ENST00000415345, ENST00000415373, ENST00000417144, ENST00000419847, ENST00000422756, ENST00000425649, ENST00000434446, ENST00000439687, ENST00000442479, ENST00000443182, ENST00000444402, ENST00000449450, ENST00000451932, ENST00000454478, ENST00000460147, ENST00000460429, ENST00000461852, ENST00000463220, ENST00000470875, ENST00000471376, ENST00000497694, ENST00000546462, ENST00000550393, ENST00000551350, ENST00000552116, ENST00000552467, ENST00000552605, | ENST00000216264, ENST00000471929, ENST00000541677, | |
Fusion gene scores | * DoF score | 9 X 14 X 3=378 | 16 X 13 X 6=1248 |
# samples | 10 | 17 | |
** MAII score | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1248*10)=-2.87601128272455 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BAG6 [Title/Abstract] AND CERK [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BAG6(31606818)-CERK(47100721), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BAG6 | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 18852879 |
Hgene | BAG6 | GO:0006915 | apoptotic process | 14960581 |
Hgene | BAG6 | GO:0018393 | internal peptidyl-lysine acetylation | 17403783 |
Hgene | BAG6 | GO:0030101 | natural killer cell activation | 18852879 |
Hgene | BAG6 | GO:0030433 | ubiquitin-dependent ERAD pathway | 23129660|24981174 |
Hgene | BAG6 | GO:0071712 | ER-associated misfolded protein catabolic process | 23129660|24981174 |
Hgene | BAG6 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane | 20676083|25535373 |
Tgene | CERK | GO:0006672 | ceramide metabolic process | 19501188 |
Fusion gene breakpoints across BAG6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CERK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | BG661049 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
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Fusion Gene ORF analysis for BAG6-CERK |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000362049 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
5CDS-intron | ENST00000362049 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
5CDS-intron | ENST00000362049 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000211379 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000211379 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000211379 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000361076 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000361076 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000361076 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000375964 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000375964 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000375964 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000375976 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000375976 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000375976 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000383446 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000383446 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000383446 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000383448 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000383448 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000383448 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000404765 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000404765 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000404765 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000412012 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000412012 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000412012 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000413922 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000413922 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000413922 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000415345 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000415345 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000415345 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000415373 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000415373 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000415373 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000417144 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000417144 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000417144 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000419847 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000419847 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000419847 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000422756 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000422756 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000422756 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000425649 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000425649 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000425649 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000434446 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000434446 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000434446 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000439687 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000439687 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000439687 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000442479 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000442479 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000442479 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000443182 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000443182 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000443182 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000444402 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000444402 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000444402 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000449450 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000449450 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000449450 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000451932 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000451932 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000451932 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000454478 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000454478 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000454478 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000460147 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000460147 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000460147 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000460429 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000460429 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000460429 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000461852 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000461852 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000461852 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000463220 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000463220 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000463220 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000470875 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000470875 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000470875 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000471376 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000471376 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000471376 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000497694 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000497694 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000497694 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000546462 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000546462 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000546462 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000550393 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000550393 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000550393 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000551350 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000551350 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000551350 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552116 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552116 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552116 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552467 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552467 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552467 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552605 | ENST00000216264 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552605 | ENST00000471929 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
intron-intron | ENST00000552605 | ENST00000541677 | BAG6 | chr6 | 31606818 | - | CERK | chr22 | 47100721 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BAG6-CERK |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for BAG6-CERK |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31606818/:47100721) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
BAG6 | CERK |
FUNCTION: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. | FUNCTION: Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. {ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for BAG6-CERK |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for BAG6-CERK |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BAG6-CERK |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BAG6-CERK |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |