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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAG6-FEM1B (FusionGDB2 ID:8870)

Fusion Gene Summary for BAG6-FEM1B

check button Fusion gene summary
Fusion gene informationFusion gene name: BAG6-FEM1B
Fusion gene ID: 8870
HgeneTgene
Gene symbol

BAG6

FEM1B

Gene ID

7917

10116

Gene nameBAG cochaperone 6fem-1 homolog B
SynonymsBAG-6|BAT3|D6S52E|G3F1A-ALPHA|F1AA|FEM1-beta
Cytomap

6p21.33

15q23

Type of geneprotein-codingprotein-coding
Descriptionlarge proline-rich protein BAG6BAG family molecular chaperone regulator 6BCL2 associated athanogene 6HLA-B-associated transcript 3large proline-rich protein BAT3protein G3protein Scythescytheprotein fem-1 homolog BFEM-1-like death receptor binding proteinfem-1-like death receptor-binding protein alphafem-1-like in apoptotic pathway protein alpha
Modification date2020031320200313
UniProtAcc

P46379

Q9UK73

Ensembl transtripts involved in fusion geneENST00000211379, ENST00000375964, 
ENST00000375976, ENST00000404765, 
ENST00000439687, ENST00000361076, 
ENST00000362049, ENST00000383446, 
ENST00000383448, ENST00000412012, 
ENST00000413922, ENST00000415345, 
ENST00000415373, ENST00000417144, 
ENST00000419847, ENST00000422756, 
ENST00000425649, ENST00000434446, 
ENST00000442479, ENST00000443182, 
ENST00000444402, ENST00000449450, 
ENST00000451932, ENST00000454478, 
ENST00000460147, ENST00000460429, 
ENST00000461852, ENST00000463220, 
ENST00000470875, ENST00000471376, 
ENST00000497694, ENST00000546462, 
ENST00000550393, ENST00000551350, 
ENST00000552116, ENST00000552467, 
ENST00000552605, 		ENST00000306917, 
Fusion gene scores* DoF score9 X 14 X 3=3786 X 5 X 3=90
# samples 106
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAG6 [Title/Abstract] AND FEM1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAG6(31606805)-FEM1B(68575832), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAG6

GO:0002429

immune response-activating cell surface receptor signaling pathway

18852879

HgeneBAG6

GO:0006915

apoptotic process

14960581

HgeneBAG6

GO:0018393

internal peptidyl-lysine acetylation

17403783

HgeneBAG6

GO:0030101

natural killer cell activation

18852879

HgeneBAG6

GO:0030433

ubiquitin-dependent ERAD pathway

23129660|24981174

HgeneBAG6

GO:0071712

ER-associated misfolded protein catabolic process

23129660|24981174

HgeneBAG6

GO:0071816

tail-anchored membrane protein insertion into ER membrane

20676083|25535373


check buttonFusion gene breakpoints across BAG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FEM1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM015948BAG6chr6

31606805

-FEM1Bchr15

68575832

+


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Fusion Gene ORF analysis for BAG6-FEM1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000211379ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
5CDS-intronENST00000375964ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
5CDS-intronENST00000375976ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
5CDS-intronENST00000404765ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
5CDS-intronENST00000439687ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000361076ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000362049ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000383446ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000383448ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000412012ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000413922ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000415345ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000415373ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000417144ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000419847ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000422756ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000425649ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000434446ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000442479ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000443182ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000444402ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000449450ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000451932ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000454478ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000460147ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000460429ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000461852ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000463220ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000470875ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000471376ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000497694ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000546462ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000550393ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000551350ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000552116ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000552467ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+
intron-intronENST00000552605ENST00000306917BAG6chr6

31606805

-FEM1Bchr15

68575832

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BAG6-FEM1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAG6-FEM1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31606805/:68575832)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAG6

P46379

FEM1B

Q9UK73

FUNCTION: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.FUNCTION: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. {ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BAG6-FEM1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BAG6-FEM1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAG6-FEM1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAG6-FEM1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource