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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TAF11-ANKS1A (FusionGDB2 ID:88714)

Fusion Gene Summary for TAF11-ANKS1A

Fusion gene summary

Fusion gene information	Fusion gene name: TAF11-ANKS1A
	Fusion gene ID: 88714
		Hgene	Tgene
	Gene symbol	TAF11	ANKS1A
	Gene ID	6882	23294
	Gene name	TATA-box binding protein associated factor 11	ankyrin repeat and sterile alpha motif domain containing 1A
	Synonyms	MGC:15243\|PRO2134\|TAF2I\|TAFII28	ANKS1
	Cytomap	6p21.31	6p21.31
	Type of gene	protein-coding	protein-coding
	Description	transcription initiation factor TFIID subunit 11TAF(II)28TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDaTAFII-28TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kDTFIID subunit p30-betatransc	ankyrin repeat and SAM domain-containing protein 1AOdinankyrin repeat and SAM domain containing 1
	Modification date	20200313	20200327
	UniProtAcc	.	Q92625
	Ensembl transtripts involved in fusion gene	ENST00000361288, ENST00000420584,	ENST00000470698, ENST00000535627, ENST00000360359,
Fusion gene scores	* DoF score	4 X 4 X 4=64	36 X 13 X 15=7020
	# samples	4	36
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(36/7020*10)=-4.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TAF11 [Title/Abstract] AND ANKS1A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TAF11(34855563)-ANKS1A(35021875), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TAF11	GO:0043923	positive regulation by host of viral transcription	9108034

Fusion gene breakpoints across TAF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKS1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-AA64	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+

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Fusion Gene ORF analysis for TAF11-ANKS1A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000361288	ENST00000470698	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+
5CDS-intron	ENST00000361288	ENST00000535627	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+
5CDS-intron	ENST00000420584	ENST00000470698	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+
5CDS-intron	ENST00000420584	ENST00000535627	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+
In-frame	ENST00000361288	ENST00000360359	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+
In-frame	ENST00000420584	ENST00000360359	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000361288

TAF11

chr6

34855563

ENST00000360359

ANKS1A

chr6

35021875

4491

303

132

1697

521

ENST00000420584

TAF11

chr6

34855563

ENST00000360359

ANKS1A

chr6

35021875

4444

256

1650

521

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361288	ENST00000360359	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+	0.008364609	0.99163544
ENST00000420584	ENST00000360359	TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+	0.008783882	0.99121606

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Fusion Genomic Features for TAF11-ANKS1A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+	8.08E-08	0.9999999
TAF11	chr6	34855563	-	ANKS1A	chr6	35021875	+	8.08E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAF11-ANKS1A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:34855563/chr6:35021875)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ANKS1A Q92625
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269\|PubMed:17875921}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

696_762

670

1135.0

Domain

SAM 1

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

770_837

670

1135.0

Domain

SAM 2

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

936_1091

670

1135.0

Domain

PID

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

2_55

670

1135.0

Compositional bias

Note=Gly-rich

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

112_141

670

1135.0

Repeat

Note=ANK 2

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

148_177

670

1135.0

Repeat

Note=ANK 3

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

181_210

670

1135.0

Repeat

Note=ANK 4

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

214_243

670

1135.0

Repeat

Note=ANK 5

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

246_275

670

1135.0

Repeat

Note=ANK 6

Tgene

ANKS1A

chr6:34855563

chr6:35021875

ENST00000360359

79_108

670

1135.0

Repeat

Note=ANK 1

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Fusion Gene Sequence for TAF11-ANKS1A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>88714_88714_1_TAF11-ANKS1A_TAF11_chr6_34855563_ENST00000361288_ANKS1A_chr6_35021875_ENST00000360359_length(transcript)=4491nt_BP=303nt
CAGGAGAGCGGTAGGGGTGATGTCATCGCTGCGCGACGACAGGAAGTAAGATCCTGGCCTGTGCAGCTCGGGTTTCCGAGCTTCTGCCTC
AGGCATCTCCGCGATCTCCTCTCCCCTCCAATCCTATCCGTGATGGACGATGCCCACGAGTCGCCCTCCGACAAAGGTGGAGAGACAGGG
GAGTCGGATGAGACGGCCGCTGTGCCCGGGGACCCGGGGGCTACCGACACCGATGGAATCCCAGAGGAAACTGACGGAGACGCAGATGTG
GACTTGAAAGAAGCTGCAGCGGAGGAAGGCGAGATTGAGAAAATCATGAGTTCTATTGGAGAAGGGATTGACTTTTCTCAGGAACGGCAG
AAGATCTCAGGTTTACGGACGCTGGAGCAGAGTGTCGGGGAGTGGCTGGAGTCGATTGGGCTGCAGCAGTATGAGAGCAAGTTGCTTCTG
AATGGCTTTGACGATGTCCACTTCCTGGGGTCTAATGTGATGGAAGAGCAGGACCTGCGGGACATCGGCATCAGCGACCCACAGCACCGG
CGGAAGCTGCTCCAGGCGGCACGCTCCCTACCCAAGGTGAAGGCTCTGGGTTATGACGGGAACAGCCCCCCTAGCGTGCCCTCCTGGCTG
GACTCCCTGGGGCTGCAGGACTACGTCCATTCCTTCTTGTCAAGTGGTTACAGCTCCATTGACACCGTGAAGAACCTCTGGGAGCTAGAG
CTCGTCAATGTCCTGAAGGTCCAGCTGCTCGGCCATCGCAAGCGCATCATCGCCTCCCTCGCAGACAGACCGTACGAGGAGCCGCCCCAG
AAGCCCCCCAGATTCTCCCAGCTGAGGTGCCAAGATTTGCTCTCCCAGACGTCATCCCCACTGAGTCAGAATGATTCCTGCACTGGGCGG
TCGGCAGATCTGCTGCTGCCTCCAGGGGACACAGGCAGGAGGCGCCATGACAGTCTCCATGACCCTGCGGCACCCTCCCGAGCGGAGCGC
TTCAGGATCCAGGAGGAGCACCGTGAGGCCAAGCTGACCCTGCGGCCCCCGAGCCTGGCAGCCCCCTACGCCCCAGTGCAGAGTTGGCAA
CACCAGCCAGAGAAACTCATCTTCGAGTCCTGTGGTTATGAAGCCAATTATCTGGGCTCCATGCTGATCAAAGATCTGCGAGGGACAGAA
TCCACGCAAGACGCCTGTGCCAAGATGCGGAAATCTACGGAGCACATGAAGAAGATCCCCACCATCATCCTGTCCATCACATACAAAGGT
GTCAAGTTCATCGATGCCTCCAACAAGAACGTCATTGCAGAGCACGAGATCCGGAACATTTCCTGTGCGGCCCAGGACCCGGAGGACCTC
TGTACCTTTGCCTACATCACCAAGGACCTGCAGACCAGCCACCACTATTGCCATGTGTTCAGCACCGTGGATGTGAACCTGACCTACGAG
ATCATCCTGACGCTGGGGCAGGCCTTCGAAGTGGCCTATCAGTTGGCCCTGCAGGCCCAGAAGTCCAGGGCGACGGGCGCCTCTGCAGCT
GAGATGATTGAAACAAAATCTTCCAAACCGGTGCCTAAGCCTCGGGTCGGCGTGAGGAAATCCGCACTGGAACCACCTGATATGGACCAA
GATGCCCAATCCCATGCCAGTGTCTCCTGGGTTGTGGACCCCAAACCAGACTCTAAGCGGAGCCTCAGCACCAACTGAGCCACTGAGGAA
CCACACTGTGCTGCGGAAACATAGACGTGGGGGCATAGGCTCCCACTGCCACCACCGCCATCGCCTCACCTGCAGCTCTGAAGACCCAGG
CCTCACCTCCGCCTGCAGGACCTCCTCTTGGCCACTTGGCCTGGGCCTGCCACCACCACGTCCTGCAGAACGAGCCCTGCCTTGGCTGTG
GAGAAGCACTCCAGGCCGCTAGCAGATGGGACTGGCATTCCAGAGGGTCAAGAAGTGACTTGTTCAGAACACATTGTTTTTAACAGAAAA
AAAATCTTTTTATAAAATGAACTTTTAACACTTGGCTCAAACCTCTAGGTCATACTGCCAATCTTTAGACAAATGGCCATGGGGCAGAGG
ACAGGGGAGCTGAGGTTGGTTCAGAGGCCAGCCTGCATAGCCTCTGTCCTCAGGACGGAACTTGGGTGCAGCTCAGTGGGTCGGAAGAGA
AGGCGGTGGCCTGTGGGTGAGGGGAACGGAGCAGGCTCAGGCAGAATTGAGTACGGTGCGTCTGCTTTTCAAACCCAACCATATCAGCTG
CTGCTCTTTATGAACTGCCCAACTTCCTGTCCCTTTCAGGGGCTAGACACAGGCTTCTCGTAAGAACACAGCCTTAGAGGCACCTGAGCA
ACTCAAAGGTTTCCGGTCCATTTCTGGGGTTCCCGATGGGAAGGTTCAGTGGCCAAATGAAGATAAGTGTGCAGTTTCTAGTGCTGGGAA
GTCTTAGCCAGCACCAGAGCGCCAGGCCTCTCCCTGGCCTCTTACCTGTCAGTGATCGGAGCACTGCCCTGGGCTGGCCGGCGCCGTACT
GCCTGCGTTGTGTCAGAGAATAGGAAAAGCAGCTTTGTTTGGGGCATTAATGCTTGGAGTGGGGTCAGCTAAGGTTGCTACTTGCCAATT
TGTGATTTGTCTAATCAGCCTGTGTGATTGGGGCTCATTTTGATTCTCTGAATTATCGGTTTGACGGTTACACTTGGCTGCTGGGCCCAT
CCCTGGCCCCCGGTGTGGAAAAGGCTAAATAAGGTGACAGTGCATCGATGCTCCCCCGCGTGGCCTTTGGGGCAGGCTGGCATCCCGGTG
CGCCTCTGCTTCTTAAGCTTTCCTGCTGCTCGCTTTGTTTTTAAAAGTAACTTGGGTTGCATTCTTCCCTCTGGACTAGAGTAGAAATGC
AGGGGAAACTGCTGTGGATTTGAGAGGCAAAGTTGGCTCAGCTGTGTGCCCAGTTCCTCCTGTGGGCACTTTAGCAGGCTCCGAGCTTTC
CTGGCATAGGTCAATCAGGTCCCAGGATGAATAATCCAGGCTTCAGCAACACTCCTCTTTCCCAGCCAGCAAAGGCTGTGAATTTGAATT
CTTTGTTGGTATGTATGTGCAGGGAGTACTGTTAGGCACATTCTTAACCCATGTGGTTGGCCAGAAATCAGAAGTGGGGCTGTGTCTCTG
ACTGGCTAGAGGCCAGGCCTTGTGGGTTTCTATCTGCTAAGCACCCAGCAGGTTGGGGCCTGGGACTCAGCTCTCTCTGCGGTAGAGGCA
GGCCCTCCTCCACTTCTTGGTACTAAACGAAGATCTCGACACCTTGCAGTTTTACTTCATTTCCTGCCCCTTTCAGGGCCTGTGAGGATG
CCCATGAGCTACCGCTGTACAGTTCTCGGCCCCGGCTTTCTTCCAAGAGTTGACCAGGAACCCTAAAGCATCCAGAGTAGACTGCGCTGC
CACTGCGCACATGCTGGTGCCCGTCTTCCTCCTAAGGGGCCAGGCCACATCCAAGTGGGCCTCTGTCGGGGGCGGGGCGGTAGGTCCGAA
AGAAACCGCAGACACTACGATGCACTCCTCAAGCTGTCTTTTGTGCTTAGATCATCCATAGGTGTTTCTTCTGCTTGAAGCTGCTATATC
ATCTTTATTTATTCAGGGTATTTTCATATTGGAAGCCTTGGCTAGTCTGCTCTAGCTCTGGGTTCTGTTTAGAGATTGGTTTATTTCTGA
ATATTCAAGAAAGGAAAATGACTGGGCCTTTCTTTCTTTTCTTCTCCTCTGGGATGGGTAGTCTCCCTTTCCTAGAAAGGTTATTATAAC
TTTAAGGACAGGCTTCAAGTGGGAAGGCCCCTACTTTTGCACTTCTCCAAGTGCAGGTCACACCAGGGGCAGACCCTGTCGCTGCGTTTC
TGAACTGTGAAGGAGCCCATTCGGGTGGGAGACTTCAGATGGGCTCAGTACCTGTCCCAGCCACAGGCTTCTTGTCCACCTCTTCTCCCC
TGCCCACCAGCTGCTCAGCGCATAAGACCTTCCCGACAGGCTCTGCGTGTGCAGCTCTCTGCGTCCCTCCTGGGCCCTCCAGCGTCAGAC
ACTAATGGGAGTTCCCGAGATGCTCGGGTTTGAGCAGGGAGCAGGCAGAGCTGCAGTCAGAGACATTAGAAAACCAGTCTGAATTGGGTC
TGTCTTTGAGATGCCCAGGCCAGCAGAAAGCAGCTCAGAAGTATTGTTGCTCATGGTGTGGCAATGGACTGAACTGTAATGAAAATGTTA
TTTAATCTTTGTCTCTGTATTTTGATACTTGAATGACTTTCCCTTTTGTTTTACTGTATATAAAATTGTTAATCTGTCTGATTTTGTCTG
AATTATAAACACTTTGAGGTACCAAACATAACCAATCTGTGCAACAACATAGACTGACCTCAGTACCCAAGAGAGTGTAAATATTTCTGG

>88714_88714_1_TAF11-ANKS1A_TAF11_chr6_34855563_ENST00000361288_ANKS1A_chr6_35021875_ENST00000360359_length(amino acids)=521AA_BP=57
MDDAHESPSDKGGETGESDETAAVPGDPGATDTDGIPEETDGDADVDLKEAAAEEGEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGE
WLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLS
SGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRR
RHDSLHDPAAPSRAERFRIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTE
HMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQ

--------------------------------------------------------------
>88714_88714_2_TAF11-ANKS1A_TAF11_chr6_34855563_ENST00000420584_ANKS1A_chr6_35021875_ENST00000360359_length(transcript)=4444nt_BP=256nt
AAGATCCTGGCCTGTGCAGCTCGGGTTTCCGAGCTTCTGCCTCAGGCATCTCCGCGATCTCCTCTCCCCTCCAATCCTATCCGTGATGGA
CGATGCCCACGAGTCGCCCTCCGACAAAGGTGGAGAGACAGGGGAGTCGGATGAGACGGCCGCTGTGCCCGGGGACCCGGGGGCTACCGA
CACCGATGGAATCCCAGAGGAAACTGACGGAGACGCAGATGTGGACTTGAAAGAAGCTGCAGCGGAGGAAGGCGAGATTGAGAAAATCAT
GAGTTCTATTGGAGAAGGGATTGACTTTTCTCAGGAACGGCAGAAGATCTCAGGTTTACGGACGCTGGAGCAGAGTGTCGGGGAGTGGCT
GGAGTCGATTGGGCTGCAGCAGTATGAGAGCAAGTTGCTTCTGAATGGCTTTGACGATGTCCACTTCCTGGGGTCTAATGTGATGGAAGA
GCAGGACCTGCGGGACATCGGCATCAGCGACCCACAGCACCGGCGGAAGCTGCTCCAGGCGGCACGCTCCCTACCCAAGGTGAAGGCTCT
GGGTTATGACGGGAACAGCCCCCCTAGCGTGCCCTCCTGGCTGGACTCCCTGGGGCTGCAGGACTACGTCCATTCCTTCTTGTCAAGTGG
TTACAGCTCCATTGACACCGTGAAGAACCTCTGGGAGCTAGAGCTCGTCAATGTCCTGAAGGTCCAGCTGCTCGGCCATCGCAAGCGCAT
CATCGCCTCCCTCGCAGACAGACCGTACGAGGAGCCGCCCCAGAAGCCCCCCAGATTCTCCCAGCTGAGGTGCCAAGATTTGCTCTCCCA
GACGTCATCCCCACTGAGTCAGAATGATTCCTGCACTGGGCGGTCGGCAGATCTGCTGCTGCCTCCAGGGGACACAGGCAGGAGGCGCCA
TGACAGTCTCCATGACCCTGCGGCACCCTCCCGAGCGGAGCGCTTCAGGATCCAGGAGGAGCACCGTGAGGCCAAGCTGACCCTGCGGCC
CCCGAGCCTGGCAGCCCCCTACGCCCCAGTGCAGAGTTGGCAACACCAGCCAGAGAAACTCATCTTCGAGTCCTGTGGTTATGAAGCCAA
TTATCTGGGCTCCATGCTGATCAAAGATCTGCGAGGGACAGAATCCACGCAAGACGCCTGTGCCAAGATGCGGAAATCTACGGAGCACAT
GAAGAAGATCCCCACCATCATCCTGTCCATCACATACAAAGGTGTCAAGTTCATCGATGCCTCCAACAAGAACGTCATTGCAGAGCACGA
GATCCGGAACATTTCCTGTGCGGCCCAGGACCCGGAGGACCTCTGTACCTTTGCCTACATCACCAAGGACCTGCAGACCAGCCACCACTA
TTGCCATGTGTTCAGCACCGTGGATGTGAACCTGACCTACGAGATCATCCTGACGCTGGGGCAGGCCTTCGAAGTGGCCTATCAGTTGGC
CCTGCAGGCCCAGAAGTCCAGGGCGACGGGCGCCTCTGCAGCTGAGATGATTGAAACAAAATCTTCCAAACCGGTGCCTAAGCCTCGGGT
CGGCGTGAGGAAATCCGCACTGGAACCACCTGATATGGACCAAGATGCCCAATCCCATGCCAGTGTCTCCTGGGTTGTGGACCCCAAACC
AGACTCTAAGCGGAGCCTCAGCACCAACTGAGCCACTGAGGAACCACACTGTGCTGCGGAAACATAGACGTGGGGGCATAGGCTCCCACT
GCCACCACCGCCATCGCCTCACCTGCAGCTCTGAAGACCCAGGCCTCACCTCCGCCTGCAGGACCTCCTCTTGGCCACTTGGCCTGGGCC
TGCCACCACCACGTCCTGCAGAACGAGCCCTGCCTTGGCTGTGGAGAAGCACTCCAGGCCGCTAGCAGATGGGACTGGCATTCCAGAGGG
TCAAGAAGTGACTTGTTCAGAACACATTGTTTTTAACAGAAAAAAAATCTTTTTATAAAATGAACTTTTAACACTTGGCTCAAACCTCTA
GGTCATACTGCCAATCTTTAGACAAATGGCCATGGGGCAGAGGACAGGGGAGCTGAGGTTGGTTCAGAGGCCAGCCTGCATAGCCTCTGT
CCTCAGGACGGAACTTGGGTGCAGCTCAGTGGGTCGGAAGAGAAGGCGGTGGCCTGTGGGTGAGGGGAACGGAGCAGGCTCAGGCAGAAT
TGAGTACGGTGCGTCTGCTTTTCAAACCCAACCATATCAGCTGCTGCTCTTTATGAACTGCCCAACTTCCTGTCCCTTTCAGGGGCTAGA
CACAGGCTTCTCGTAAGAACACAGCCTTAGAGGCACCTGAGCAACTCAAAGGTTTCCGGTCCATTTCTGGGGTTCCCGATGGGAAGGTTC
AGTGGCCAAATGAAGATAAGTGTGCAGTTTCTAGTGCTGGGAAGTCTTAGCCAGCACCAGAGCGCCAGGCCTCTCCCTGGCCTCTTACCT
GTCAGTGATCGGAGCACTGCCCTGGGCTGGCCGGCGCCGTACTGCCTGCGTTGTGTCAGAGAATAGGAAAAGCAGCTTTGTTTGGGGCAT
TAATGCTTGGAGTGGGGTCAGCTAAGGTTGCTACTTGCCAATTTGTGATTTGTCTAATCAGCCTGTGTGATTGGGGCTCATTTTGATTCT
CTGAATTATCGGTTTGACGGTTACACTTGGCTGCTGGGCCCATCCCTGGCCCCCGGTGTGGAAAAGGCTAAATAAGGTGACAGTGCATCG
ATGCTCCCCCGCGTGGCCTTTGGGGCAGGCTGGCATCCCGGTGCGCCTCTGCTTCTTAAGCTTTCCTGCTGCTCGCTTTGTTTTTAAAAG
TAACTTGGGTTGCATTCTTCCCTCTGGACTAGAGTAGAAATGCAGGGGAAACTGCTGTGGATTTGAGAGGCAAAGTTGGCTCAGCTGTGT
GCCCAGTTCCTCCTGTGGGCACTTTAGCAGGCTCCGAGCTTTCCTGGCATAGGTCAATCAGGTCCCAGGATGAATAATCCAGGCTTCAGC
AACACTCCTCTTTCCCAGCCAGCAAAGGCTGTGAATTTGAATTCTTTGTTGGTATGTATGTGCAGGGAGTACTGTTAGGCACATTCTTAA
CCCATGTGGTTGGCCAGAAATCAGAAGTGGGGCTGTGTCTCTGACTGGCTAGAGGCCAGGCCTTGTGGGTTTCTATCTGCTAAGCACCCA
GCAGGTTGGGGCCTGGGACTCAGCTCTCTCTGCGGTAGAGGCAGGCCCTCCTCCACTTCTTGGTACTAAACGAAGATCTCGACACCTTGC
AGTTTTACTTCATTTCCTGCCCCTTTCAGGGCCTGTGAGGATGCCCATGAGCTACCGCTGTACAGTTCTCGGCCCCGGCTTTCTTCCAAG
AGTTGACCAGGAACCCTAAAGCATCCAGAGTAGACTGCGCTGCCACTGCGCACATGCTGGTGCCCGTCTTCCTCCTAAGGGGCCAGGCCA
CATCCAAGTGGGCCTCTGTCGGGGGCGGGGCGGTAGGTCCGAAAGAAACCGCAGACACTACGATGCACTCCTCAAGCTGTCTTTTGTGCT
TAGATCATCCATAGGTGTTTCTTCTGCTTGAAGCTGCTATATCATCTTTATTTATTCAGGGTATTTTCATATTGGAAGCCTTGGCTAGTC
TGCTCTAGCTCTGGGTTCTGTTTAGAGATTGGTTTATTTCTGAATATTCAAGAAAGGAAAATGACTGGGCCTTTCTTTCTTTTCTTCTCC
TCTGGGATGGGTAGTCTCCCTTTCCTAGAAAGGTTATTATAACTTTAAGGACAGGCTTCAAGTGGGAAGGCCCCTACTTTTGCACTTCTC
CAAGTGCAGGTCACACCAGGGGCAGACCCTGTCGCTGCGTTTCTGAACTGTGAAGGAGCCCATTCGGGTGGGAGACTTCAGATGGGCTCA
GTACCTGTCCCAGCCACAGGCTTCTTGTCCACCTCTTCTCCCCTGCCCACCAGCTGCTCAGCGCATAAGACCTTCCCGACAGGCTCTGCG
TGTGCAGCTCTCTGCGTCCCTCCTGGGCCCTCCAGCGTCAGACACTAATGGGAGTTCCCGAGATGCTCGGGTTTGAGCAGGGAGCAGGCA
GAGCTGCAGTCAGAGACATTAGAAAACCAGTCTGAATTGGGTCTGTCTTTGAGATGCCCAGGCCAGCAGAAAGCAGCTCAGAAGTATTGT
TGCTCATGGTGTGGCAATGGACTGAACTGTAATGAAAATGTTATTTAATCTTTGTCTCTGTATTTTGATACTTGAATGACTTTCCCTTTT
GTTTTACTGTATATAAAATTGTTAATCTGTCTGATTTTGTCTGAATTATAAACACTTTGAGGTACCAAACATAACCAATCTGTGCAACAA
CATAGACTGACCTCAGTACCCAAGAGAGTGTAAATATTTCTGGGCTTCCAGCTTTGGTTTTGTTATTTTCATAACTGTACACAACTTAGA

>88714_88714_2_TAF11-ANKS1A_TAF11_chr6_34855563_ENST00000420584_ANKS1A_chr6_35021875_ENST00000360359_length(amino acids)=521AA_BP=57
MDDAHESPSDKGGETGESDETAAVPGDPGATDTDGIPEETDGDADVDLKEAAAEEGEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGE
WLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLS
SGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRR
RHDSLHDPAAPSRAERFRIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTE
HMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQ

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Fusion Gene PPI Analysis for TAF11-ANKS1A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TAF11-ANKS1A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TAF11-ANKS1A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source