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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TAF11-TSHZ2 (FusionGDB2 ID:88716)

Fusion Gene Summary for TAF11-TSHZ2

Fusion gene summary

Fusion gene information	Fusion gene name: TAF11-TSHZ2
	Fusion gene ID: 88716
		Hgene	Tgene
	Gene symbol	TAF11	TSHZ2
	Gene ID	6882	128553
	Gene name	TATA-box binding protein associated factor 11	teashirt zinc finger homeobox 2
	Synonyms	MGC:15243\|PRO2134\|TAF2I\|TAFII28	C20orf17\|OVC10-2\|TSH2\|ZABC2\|ZNF218
	Cytomap	6p21.31	20q13.2
	Type of gene	protein-coding	protein-coding
	Description	transcription initiation factor TFIID subunit 11TAF(II)28TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDaTAFII-28TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kDTFIID subunit p30-betatransc	teashirt homolog 2cell growth-inhibiting protein 7ovarian cancer-related protein 10-2serologically defined colon cancer antigen 33 liketeashirt family zinc finger 2zinc finger protein 218
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000361288, ENST00000420584,	ENST00000371497, ENST00000603338, ENST00000329613,
Fusion gene scores	* DoF score	4 X 4 X 4=64	40 X 23 X 9=8280
	# samples	4	50
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(50/8280*10)=-4.0496307677246 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TAF11 [Title/Abstract] AND TSHZ2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TAF11(34848066)-TSHZ2(51870038), # samples:1
Anticipated loss of major functional domain due to fusion event.	TAF11-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TAF11-TSHZ2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TAF11-TSHZ2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TAF11	GO:0043923	positive regulation by host of viral transcription	9108034

Fusion gene breakpoints across TAF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TSHZ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315373	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+

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Fusion Gene ORF analysis for TAF11-TSHZ2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000361288	ENST00000371497	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+
Frame-shift	ENST00000361288	ENST00000603338	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+
Frame-shift	ENST00000420584	ENST00000371497	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+
Frame-shift	ENST00000420584	ENST00000603338	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+
In-frame	ENST00000361288	ENST00000329613	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+
In-frame	ENST00000420584	ENST00000329613	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000361288

TAF11

chr6

34848066

ENST00000329613

TSHZ2

chr20

51870038

3614

540

560

3604

1014

ENST00000420584

TAF11

chr6

34848066

ENST00000329613

TSHZ2

chr20

51870038

3567

493

513

3557

1014

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361288	ENST00000329613	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+	0.004489653	0.99551034
ENST00000420584	ENST00000329613	TAF11	chr6	34848066	-	TSHZ2	chr20	51870038	+	0.004449452	0.9955505

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Fusion Genomic Features for TAF11-TSHZ2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TAF11	chr6	34848065	-	TSHZ2	chr20	51870037	+	7.36E-12	1
TAF11	chr6	34848065	-	TSHZ2	chr20	51870037	+	7.36E-12	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAF11-TSHZ2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:34848066/chr20:51870038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

13_38

1032.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

13_38

3455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

13_38

1012.6666666666666

Coiled coil

Ontology_term=ECO:0000255

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

841_911

1032.0

DNA binding

Note=Homeobox%3B atypical

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

841_911

3455.0

DNA binding

Note=Homeobox%3B atypical

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

841_911

1012.6666666666666

DNA binding

Note=Homeobox%3B atypical

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

215_239

1032.0

Zinc finger

C2H2-type 1

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

275_299

1032.0

Zinc finger

C2H2-type 2

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

380_404

1032.0

Zinc finger

C2H2-type 3%3B atypical

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

926_948

1032.0

Zinc finger

C2H2-type 4

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000329613

994_1017

1032.0

Zinc finger

C2H2-type 5

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

215_239

3455.0

Zinc finger

C2H2-type 1

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

275_299

3455.0

Zinc finger

C2H2-type 2

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

380_404

3455.0

Zinc finger

C2H2-type 3%3B atypical

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

926_948

3455.0

Zinc finger

C2H2-type 4

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000371497

994_1017

3455.0

Zinc finger

C2H2-type 5

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

215_239

1012.6666666666666

Zinc finger

C2H2-type 1

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

275_299

1012.6666666666666

Zinc finger

C2H2-type 2

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

380_404

1012.6666666666666

Zinc finger

C2H2-type 3%3B atypical

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

926_948

1012.6666666666666

Zinc finger

C2H2-type 4

Tgene

TSHZ2

chr6:34848066

chr20:51870038

ENST00000603338

994_1017

1012.6666666666666

Zinc finger

C2H2-type 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TAF11-TSHZ2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>88716_88716_1_TAF11-TSHZ2_TAF11_chr6_34848066_ENST00000361288_TSHZ2_chr20_51870038_ENST00000329613_length(transcript)=3614nt_BP=540nt
CAGGAGAGCGGTAGGGGTGATGTCATCGCTGCGCGACGACAGGAAGTAAGATCCTGGCCTGTGCAGCTCGGGTTTCCGAGCTTCTGCCTC
AGGCATCTCCGCGATCTCCTCTCCCCTCCAATCCTATCCGTGATGGACGATGCCCACGAGTCGCCCTCCGACAAAGGTGGAGAGACAGGG
GAGTCGGATGAGACGGCCGCTGTGCCCGGGGACCCGGGGGCTACCGACACCGATGGAATCCCAGAGGAAACTGACGGAGACGCAGATGTG
GACTTGAAAGAAGCTGCAGCGGAGGAAGGCGAGCTCGAGAGTCAGGATGTCTCAGATTTAACAACAGTTGAAAGGGAAGACTCATCATTA
CTTAATCCTGCAGCCAAAAAACTGAAAATAGATACCAAAGAAAAGAAAGAGAAAAAGCAGAAAGTAGATGAAGATGAGATTCAGAAGATG
CAAATCCTGGTTTCTTCTTTTTCTGAGGAGCAGCTGAACCGTTATGAAATGTATCGCCGCTCAGCTTTCCCTAAGGCAGCCATCAAAAGG
GCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAACTGCAGG
GTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGAAGTCATT
TGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGAGATGCCT
CAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAACATCCTGT
CGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGCAACAAGA
GTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTGTTCAGCT
CGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGCGCGGCCT
ATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGACCCACGA
GCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGCGACTCCT
TTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACCATTTCCT
CGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCAGATTCTT
TTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAGTTTGAGG
CCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTCACAGGTC
ACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCGTTGTCTG
AGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAGAAAGAGA
GTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCTTTAGACC
CTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAAAATACTG
TCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCTGAGGGCA
CCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAGTGGAAAG
TGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTGAAGGAGT
GTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCAGAAGCCA
AAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAGCCCACAT
CTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTCCTGAACA
ATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAGTCGAATC
TCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGCGATCAGC
CCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCTCTGTCTG
ACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTGGAAATGG
ATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAGCATCTTC
TGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAGCGTATGC
AAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGCGGGACAA
AATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTACATCAGTC
ACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATCTCCCGGG
TATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGGACATTTG
TGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTGGATGAAG

>88716_88716_1_TAF11-TSHZ2_TAF11_chr6_34848066_ENST00000361288_TSHZ2_chr20_51870038_ENST00000329613_length(amino acids)=1014AA_BP=
MKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHT
HVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQ
SSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDL
SVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQIL
KCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPE
ETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPM
GSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGP
LKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKP
VLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFED
VSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMD
KGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVK

--------------------------------------------------------------
>88716_88716_2_TAF11-TSHZ2_TAF11_chr6_34848066_ENST00000420584_TSHZ2_chr20_51870038_ENST00000329613_length(transcript)=3567nt_BP=493nt
AAGATCCTGGCCTGTGCAGCTCGGGTTTCCGAGCTTCTGCCTCAGGCATCTCCGCGATCTCCTCTCCCCTCCAATCCTATCCGTGATGGA
CGATGCCCACGAGTCGCCCTCCGACAAAGGTGGAGAGACAGGGGAGTCGGATGAGACGGCCGCTGTGCCCGGGGACCCGGGGGCTACCGA
CACCGATGGAATCCCAGAGGAAACTGACGGAGACGCAGATGTGGACTTGAAAGAAGCTGCAGCGGAGGAAGGCGAGCTCGAGAGTCAGGA
TGTCTCAGATTTAACAACAGTTGAAAGGGAAGACTCATCATTACTTAATCCTGCAGCCAAAAAACTGAAAATAGATACCAAAGAAAAGAA
AGAGAAAAAGCAGAAAGTAGATGAAGATGAGATTCAGAAGATGCAAATCCTGGTTTCTTCTTTTTCTGAGGAGCAGCTGAACCGTTATGA
AATGTATCGCCGCTCAGCTTTCCCTAAGGCAGCCATCAAAAGGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAA
GAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAACTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAG
CAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGAAGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGT
GATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGAGATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACAC
AATTGCATGGATAAAATGACCGCTGTCTACGCCAACATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAAT
AGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGCAACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAG
AACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTGTTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTC
ACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGCGCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCAC
TATCAAGATGACAACCGCAAAAAGGACAAGCTCAGACCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAG
GATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGCGACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACAT
TACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACCATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGG
CCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCAGATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGC
TATGGCTACCAAAATGGAGCCAGCTACACCTGGCAGTTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCAT
GACACCTTGCAGCAGCTCACCACCCACATGATGGTCACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTG
GTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCGTTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCA
GCATCAGATTGTACAGCCTCTACAACTGAGTTAAAGAAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTG
AAAAGCGAGGACTATGAAGATCCTCTACAAAAACCTTTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGC
TCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAAAATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGT
GCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCTGAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCT
AATCTCACCAACAAGCTGAGGCCCATTGCACCAAAGTGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAA
GTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTGAAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGT
GAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCAGAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAA
GAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAGCCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTG
CCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTCCTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCC
AGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAGTCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCA
GCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGCGATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAA
GCACAATCTTGTATGTCCCCACCTCAGAAGCACGCTCTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAG
CCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTGGAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCAT
AAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAGCATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAG
GGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAGCGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGG
CTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGCGGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGT
GACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTACATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTG
TCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATCTCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGAC
ACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGGACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAG

>88716_88716_2_TAF11-TSHZ2_TAF11_chr6_34848066_ENST00000420584_TSHZ2_chr20_51870038_ENST00000329613_length(amino acids)=1014AA_BP=
MKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHT
HVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQ
SSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDL
SVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQIL
KCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPE
ETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPM
GSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGP
LKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKP
VLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFED
VSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMD
KGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVK

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Fusion Gene PPI Analysis for TAF11-TSHZ2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TAF11-TSHZ2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TAF11-TSHZ2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source