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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TAF1C-TSTA3 (FusionGDB2 ID:88751)

Fusion Gene Summary for TAF1C-TSTA3

Fusion gene summary

Fusion gene information	Fusion gene name: TAF1C-TSTA3
	Fusion gene ID: 88751
		Hgene	Tgene
	Gene symbol	TAF1C	TSTA3
	Gene ID	9013	7264
	Gene name	TATA-box binding protein associated factor, RNA polymerase I subunit C	tissue specific transplantation antigen P35B
	Synonyms	MGC:39976\|SL1\|TAFI110\|TAFI95	FX\|P35B\|SDR4E1
	Cytomap	16q24.1	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	TATA box-binding protein-associated factor RNA polymerase I subunit CRNA polymerase I-specific TBP-associated factor 110 kDaSL1, 110kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDTATA box binding protein (TBP)-as	GDP-L-fucose synthase3-5 epimerase/4-reductaseGDP-4-keto-6-deoxy-D-mannose epimerase-reductaseGDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductasered cell NADP(H)-binding proteinshort chain dehydrogenase/reductase family 4E, member 1testis tissue
	Modification date	20200320	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000570117, ENST00000378541, ENST00000341690, ENST00000541676, ENST00000566732, ENST00000567759, ENST00000565544,	ENST00000425753, ENST00000529064,
Fusion gene scores	* DoF score	2 X 1 X 2=4	5 X 3 X 3=45
	# samples	2	7
	** MAII score	log2(2/4*10)=2.32192809488736	log2(7/45*10)=0.637429920615292 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TAF1C [Title/Abstract] AND TSTA3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TAF1C(84215807)-TSTA3(144695465), # samples:1
Anticipated loss of major functional domain due to fusion event.	TAF1C-TSTA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TAF1C-TSTA3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TSTA3	GO:0019673	GDP-mannose metabolic process	9525924
Tgene	TSTA3	GO:0042351	'de novo' GDP-L-fucose biosynthetic process	9525924

Fusion gene breakpoints across TAF1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TSTA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0913	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-

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Fusion Gene ORF analysis for TAF1C-TSTA3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000570117	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
5UTR-3CDS	ENST00000570117	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
Frame-shift	ENST00000378541	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
Frame-shift	ENST00000378541	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000341690	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000341690	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000541676	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000541676	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000566732	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000566732	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000567759	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
In-frame	ENST00000567759	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
intron-3CDS	ENST00000565544	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-
intron-3CDS	ENST00000565544	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341690	TAF1C	chr16	84215807	-	ENST00000529064	TSTA3	chr8	144695465	-	1229	781	833	192	213
ENST00000341690	TAF1C	chr16	84215807	-	ENST00000425753	TSTA3	chr8	144695465	-	1229	781	833	192	213
ENST00000567759	TAF1C	chr16	84215807	-	ENST00000529064	TSTA3	chr8	144695465	-	1352	904	165	908	247
ENST00000567759	TAF1C	chr16	84215807	-	ENST00000425753	TSTA3	chr8	144695465	-	1352	904	165	908	247
ENST00000541676	TAF1C	chr16	84215807	-	ENST00000529064	TSTA3	chr8	144695465	-	1236	788	840	199	213
ENST00000541676	TAF1C	chr16	84215807	-	ENST00000425753	TSTA3	chr8	144695465	-	1236	788	840	199	213
ENST00000566732	TAF1C	chr16	84215807	-	ENST00000529064	TSTA3	chr8	144695465	-	1380	932	193	936	247
ENST00000566732	TAF1C	chr16	84215807	-	ENST00000425753	TSTA3	chr8	144695465	-	1380	932	193	936	247

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341690	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.12243798	0.877562
ENST00000341690	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.12243798	0.877562
ENST00000567759	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.1313832	0.8686168
ENST00000567759	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.1313832	0.8686168
ENST00000541676	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.11509563	0.8849044
ENST00000541676	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.11509563	0.8849044
ENST00000566732	ENST00000529064	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.14178954	0.85821044
ENST00000566732	ENST00000425753	TAF1C	chr16	84215807	-	TSTA3	chr8	144695465	-	0.14178954	0.85821044

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Fusion Genomic Features for TAF1C-TSTA3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAF1C-TSTA3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:84215807/chr8:144695465)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TSTA3

chr16:84215807

chr8:144695465

ENST00000425753

14_20

270

322.0

Nucleotide binding

NADP

Tgene

TSTA3

chr16:84215807

chr8:144695465

ENST00000425753

170_173

270

322.0

Nucleotide binding

NADP

Tgene

TSTA3

chr16:84215807

chr8:144695465

ENST00000529064

14_20

270

322.0

Nucleotide binding

NADP

Tgene

TSTA3

chr16:84215807

chr8:144695465

ENST00000529064

170_173

270

322.0

Nucleotide binding

NADP

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Fusion Gene Sequence for TAF1C-TSTA3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>88751_88751_1_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000341690_TSTA3_chr8_144695465_ENST00000425753_length(transcript)=1229nt_BP=781nt
CCGGAAGACCGTGGGTAGCTGCGGCGGGGCTGACCCGTCCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGTGCCAGGG
TCCGGCGAGCATCACGCCGAGGCCCATTTTCCAGACGACCACGACGAGGCCGGGGTCACCTGGCGAGACGCACTGACTCTGCCAGAGGCC
CAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAGCCGGCAACCCCTGGGCCTCTCCCCATGCTGCCT
CCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGAGGGTGCCGGTATCGGAAGCGGCCCCGAGTCGTG
CTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTTGCGCCCCTGGGGAAGCTGATGCTGGAGAATTTC
AAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAGCTGCTCCAGGACCTCGGTGGACACCAGCCCTGG
GGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGCCCCATCCTGGGCACGTCGGTGGCGAGCCACTTG
GCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAGGCCTGCACTGGGGGCGCGCTGGCCTGGGTTCCT
GGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGGCTGCTTTGATACAACCAAGTCGGATGGGCAGTT
TAAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCACACCCTTCAAGCAGGCGGTGAAGGAGACCTGTGC
TTGGTTCACTGACAACTACGAGCAGGCCCGGAAGTGAAGCTGGAAGACAGGATCAGGTGCCAGCGGACCATCGGCTGGCAGAGCCCAGCG
GCCACCACCCGTCAACCCTGCCAGGAGCTGAGGGCACCACCCAGCAACCTGGGCCTGCATTCCATCCGCTCTGCAGCCCCAAGCATCTTT
CCAGTGGGGCCCCCATTCACGTTGGTCCTCAGGGAAACCAGGGTCCCGGGCAGGCCCGGCGCTTTGCTCCCCACACCAGCCCCCTGCGCG

>88751_88751_1_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000341690_TSTA3_chr8_144695465_ENST00000425753_length(amino acids)=213AA_BP=1
MLLLAVFLNCPSDLVVSKQPVLGASSRVDQLPELGCPSRNPGQRAPSAGLIQKQLLPPQHQLLVQQLCQVARHRRAQDGAPEDREAALSV
AEVSPGTPPGLVSTEVLEQLLHTDHCLLLSAAPRSLQLEILQHQLPQGRKGYVSMIQEEPADLLSHIQHDSGPLPIPAPSAEKQVPGSQA

--------------------------------------------------------------
>88751_88751_2_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000341690_TSTA3_chr8_144695465_ENST00000529064_length(transcript)=1229nt_BP=781nt
CCGGAAGACCGTGGGTAGCTGCGGCGGGGCTGACCCGTCCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGTGCCAGGG
TCCGGCGAGCATCACGCCGAGGCCCATTTTCCAGACGACCACGACGAGGCCGGGGTCACCTGGCGAGACGCACTGACTCTGCCAGAGGCC
CAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAGCCGGCAACCCCTGGGCCTCTCCCCATGCTGCCT
CCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGAGGGTGCCGGTATCGGAAGCGGCCCCGAGTCGTG
CTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTTGCGCCCCTGGGGAAGCTGATGCTGGAGAATTTC
AAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAGCTGCTCCAGGACCTCGGTGGACACCAGCCCTGG
GGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGCCCCATCCTGGGCACGTCGGTGGCGAGCCACTTG
GCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAGGCCTGCACTGGGGGCGCGCTGGCCTGGGTTCCT
GGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGGCTGCTTTGATACAACCAAGTCGGATGGGCAGTT
TAAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCACACCCTTCAAGCAGGCGGTGAAGGAGACCTGTGC
TTGGTTCACTGACAACTACGAGCAGGCCCGGAAGTGAAGCTGGAAGACAGGATCAGGTGCCAGCGGACCATCGGCTGGCAGAGCCCAGCG
GCCACCACCCGTCAACCCTGCCAGGAGCTGAGGGCACCACCCAGCAACCTGGGCCTGCATTCCATCCGCTCTGCAGCCCCAAGCATCTTT
CCAGTGGGGCCCCCATTCACGTTGGTCCTCAGGGAAACCAGGGTCCCGGGCAGGCCCGGCGCTTTGCTCCCCACACCAGCCCCCTGCGCG

>88751_88751_2_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000341690_TSTA3_chr8_144695465_ENST00000529064_length(amino acids)=213AA_BP=1
MLLLAVFLNCPSDLVVSKQPVLGASSRVDQLPELGCPSRNPGQRAPSAGLIQKQLLPPQHQLLVQQLCQVARHRRAQDGAPEDREAALSV
AEVSPGTPPGLVSTEVLEQLLHTDHCLLLSAAPRSLQLEILQHQLPQGRKGYVSMIQEEPADLLSHIQHDSGPLPIPAPSAEKQVPGSQA

--------------------------------------------------------------
>88751_88751_3_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000541676_TSTA3_chr8_144695465_ENST00000425753_length(transcript)=1236nt_BP=788nt
GTCCAAACCGGAAGACCGTGGGTAGCTGCGGCGGGGCTGACCCGTCCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGT
GCCAGGGTCCGGCGAGCATCACGCCGAGGCCCATTTTCCAGACGACCACGACGAGGCCGGGGTCACCTGGCGAGACGCACTGACTCTGCC
AGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAGCCGGCAACCCCTGGGCCTCTCCCCAT
GCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGAGGGTGCCGGTATCGGAAGCGGCCCCG
AGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTTGCGCCCCTGGGGAAGCTGATGCTGGA
GAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAGCTGCTCCAGGACCTCGGTGGACACCA
GCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGCCCCATCCTGGGCACGTCGGTGGCGAG
CCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAGGCCTGCACTGGGGGCGCGCTGGCCTG
GGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGGCTGCTTTGATACAACCAAGTCGGATG
GGCAGTTTAAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCACACCCTTCAAGCAGGCGGTGAAGGAGA
CCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCCGGAAGTGAAGCTGGAAGACAGGATCAGGTGCCAGCGGACCATCGGCTGGCAGAG
CCCAGCGGCCACCACCCGTCAACCCTGCCAGGAGCTGAGGGCACCACCCAGCAACCTGGGCCTGCATTCCATCCGCTCTGCAGCCCCAAG
CATCTTTCCAGTGGGGCCCCCATTCACGTTGGTCCTCAGGGAAACCAGGGTCCCGGGCAGGCCCGGCGCTTTGCTCCCCACACCAGCCCC

>88751_88751_3_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000541676_TSTA3_chr8_144695465_ENST00000425753_length(amino acids)=213AA_BP=1
MLLLAVFLNCPSDLVVSKQPVLGASSRVDQLPELGCPSRNPGQRAPSAGLIQKQLLPPQHQLLVQQLCQVARHRRAQDGAPEDREAALSV
AEVSPGTPPGLVSTEVLEQLLHTDHCLLLSAAPRSLQLEILQHQLPQGRKGYVSMIQEEPADLLSHIQHDSGPLPIPAPSAEKQVPGSQA

--------------------------------------------------------------
>88751_88751_4_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000541676_TSTA3_chr8_144695465_ENST00000529064_length(transcript)=1236nt_BP=788nt
GTCCAAACCGGAAGACCGTGGGTAGCTGCGGCGGGGCTGACCCGTCCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGT
GCCAGGGTCCGGCGAGCATCACGCCGAGGCCCATTTTCCAGACGACCACGACGAGGCCGGGGTCACCTGGCGAGACGCACTGACTCTGCC
AGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAGCCGGCAACCCCTGGGCCTCTCCCCAT
GCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGAGGGTGCCGGTATCGGAAGCGGCCCCG
AGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTTGCGCCCCTGGGGAAGCTGATGCTGGA
GAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAGCTGCTCCAGGACCTCGGTGGACACCA
GCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGCCCCATCCTGGGCACGTCGGTGGCGAG
CCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAGGCCTGCACTGGGGGCGCGCTGGCCTG
GGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGGCTGCTTTGATACAACCAAGTCGGATG
GGCAGTTTAAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCACACCCTTCAAGCAGGCGGTGAAGGAGA
CCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCCGGAAGTGAAGCTGGAAGACAGGATCAGGTGCCAGCGGACCATCGGCTGGCAGAG
CCCAGCGGCCACCACCCGTCAACCCTGCCAGGAGCTGAGGGCACCACCCAGCAACCTGGGCCTGCATTCCATCCGCTCTGCAGCCCCAAG
CATCTTTCCAGTGGGGCCCCCATTCACGTTGGTCCTCAGGGAAACCAGGGTCCCGGGCAGGCCCGGCGCTTTGCTCCCCACACCAGCCCC

>88751_88751_4_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000541676_TSTA3_chr8_144695465_ENST00000529064_length(amino acids)=213AA_BP=1
MLLLAVFLNCPSDLVVSKQPVLGASSRVDQLPELGCPSRNPGQRAPSAGLIQKQLLPPQHQLLVQQLCQVARHRRAQDGAPEDREAALSV
AEVSPGTPPGLVSTEVLEQLLHTDHCLLLSAAPRSLQLEILQHQLPQGRKGYVSMIQEEPADLLSHIQHDSGPLPIPAPSAEKQVPGSQA

--------------------------------------------------------------
>88751_88751_5_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000566732_TSTA3_chr8_144695465_ENST00000425753_length(transcript)=1380nt_BP=932nt
GTGGGTAGCTGCGGCGGGGCTGACCCGTCCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGTGCCAGGGTCCGGCGAGC
ATCACGCCGAGGCCCATTTTCCAGACGACCACGACGAGGCCGGGGTCACGAACTCTGGCGCCCCTTACCAGCTTCCAGTCTCTCGAGGTG
GCCAGTGTGGTGCTTGGTCCTTGTTTCCAGGATGGACTTCCCCAGCTCCCTCCGCCCTGCATTGTTTCTGACCGGCCCCCTTGGTCTGAG
CGACGTCCCTGACCTCTCTTTCATGTGCAGCTGGCGAGACGCACTGACTCTGCCAGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACT
GCATGTGACCAAGGACCTGCTGTGGGAGCCGGCAACCCCTGGGCCTCTCCCCATGCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCT
GACTGCCCGGGACCTGCTTTTCCGCGGAGGGTGCCGGTATCGGAAGCGGCCCCGAGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTT
CCTCTTGGATCATGGAGACGTAGCCTTTGCGCCCCTGGGGAAGCTGATGCTGGAGAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAA
GAAGAAGACAGTGGTCAGTGTGAAGAAGCTGCTCCAGGACCTCGGTGGACACCAGCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCG
ACAGCGCCGCTTCTCTATCCTCGGGGGCCCCATCCTGGGCACGTCGGTGGCGAGCCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCT
GCGGTGGGAGCAGCTGCTTCTGGATGAGGCCTGCACTGGGGGCGCGCTGGCCTGGGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGT
CTACCCTGCTGGAGGCGCCCAGGACAGGCTGCTTTGATACAACCAAGTCGGATGGGCAGTTTAAGAAGACAGCCAGTAACAGCAAGCTGA
GGACCTACCTGCCCGACTTCCGGTTCACACCCTTCAAGCAGGCGGTGAAGGAGACCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCC
GGAAGTGAAGCTGGAAGACAGGATCAGGTGCCAGCGGACCATCGGCTGGCAGAGCCCAGCGGCCACCACCCGTCAACCCTGCCAGGAGCT
GAGGGCACCACCCAGCAACCTGGGCCTGCATTCCATCCGCTCTGCAGCCCCAAGCATCTTTCCAGTGGGGCCCCCATTCACGTTGGTCCT
CAGGGAAACCAGGGTCCCGGGCAGGCCCGGCGCTTTGCTCCCCACACCAGCCCCCTGCGCGTGTCCACTCTGATCCTGCATCCCACTCCC

>88751_88751_5_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000566732_TSTA3_chr8_144695465_ENST00000425753_length(amino acids)=247AA_BP=
MVLVSRMDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARD
LLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRF

--------------------------------------------------------------
>88751_88751_6_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000566732_TSTA3_chr8_144695465_ENST00000529064_length(transcript)=1380nt_BP=932nt
GTGGGTAGCTGCGGCGGGGCTGACCCGTCCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGTGCCAGGGTCCGGCGAGC
ATCACGCCGAGGCCCATTTTCCAGACGACCACGACGAGGCCGGGGTCACGAACTCTGGCGCCCCTTACCAGCTTCCAGTCTCTCGAGGTG
GCCAGTGTGGTGCTTGGTCCTTGTTTCCAGGATGGACTTCCCCAGCTCCCTCCGCCCTGCATTGTTTCTGACCGGCCCCCTTGGTCTGAG
CGACGTCCCTGACCTCTCTTTCATGTGCAGCTGGCGAGACGCACTGACTCTGCCAGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACT
GCATGTGACCAAGGACCTGCTGTGGGAGCCGGCAACCCCTGGGCCTCTCCCCATGCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCT
GACTGCCCGGGACCTGCTTTTCCGCGGAGGGTGCCGGTATCGGAAGCGGCCCCGAGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTT
CCTCTTGGATCATGGAGACGTAGCCTTTGCGCCCCTGGGGAAGCTGATGCTGGAGAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAA
GAAGAAGACAGTGGTCAGTGTGAAGAAGCTGCTCCAGGACCTCGGTGGACACCAGCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCG
ACAGCGCCGCTTCTCTATCCTCGGGGGCCCCATCCTGGGCACGTCGGTGGCGAGCCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCT
GCGGTGGGAGCAGCTGCTTCTGGATGAGGCCTGCACTGGGGGCGCGCTGGCCTGGGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGT
CTACCCTGCTGGAGGCGCCCAGGACAGGCTGCTTTGATACAACCAAGTCGGATGGGCAGTTTAAGAAGACAGCCAGTAACAGCAAGCTGA
GGACCTACCTGCCCGACTTCCGGTTCACACCCTTCAAGCAGGCGGTGAAGGAGACCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCC
GGAAGTGAAGCTGGAAGACAGGATCAGGTGCCAGCGGACCATCGGCTGGCAGAGCCCAGCGGCCACCACCCGTCAACCCTGCCAGGAGCT
GAGGGCACCACCCAGCAACCTGGGCCTGCATTCCATCCGCTCTGCAGCCCCAAGCATCTTTCCAGTGGGGCCCCCATTCACGTTGGTCCT
CAGGGAAACCAGGGTCCCGGGCAGGCCCGGCGCTTTGCTCCCCACACCAGCCCCCTGCGCGTGTCCACTCTGATCCTGCATCCCACTCCC

>88751_88751_6_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000566732_TSTA3_chr8_144695465_ENST00000529064_length(amino acids)=247AA_BP=
MVLVSRMDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARD
LLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRF

--------------------------------------------------------------
>88751_88751_7_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000567759_TSTA3_chr8_144695465_ENST00000425753_length(transcript)=1352nt_BP=904nt
CCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGTGCCAGGGTCCGGCGAGCATCACGCCGAGGCCCATTTTCCAGACGA
CCACGACGAGGCCGGGGTCACGAACTCTGGCGCCCCTTACCAGCTTCCAGTCTCTCGAGGTGGCCAGTGTGGTGCTTGGTCCTTGTTTCC
AGGATGGACTTCCCCAGCTCCCTCCGCCCTGCATTGTTTCTGACCGGCCCCCTTGGTCTGAGCGACGTCCCTGACCTCTCTTTCATGTGC
AGCTGGCGAGACGCACTGACTCTGCCAGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAG
CCGGCAACCCCTGGGCCTCTCCCCATGCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGA
GGGTGCCGGTATCGGAAGCGGCCCCGAGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTT
GCGCCCCTGGGGAAGCTGATGCTGGAGAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAG
CTGCTCCAGGACCTCGGTGGACACCAGCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGC
CCCATCCTGGGCACGTCGGTGGCGAGCCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAG
GCCTGCACTGGGGGCGCGCTGGCCTGGGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGG
CTGCTTTGATACAACCAAGTCGGATGGGCAGTTTAAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCAC
ACCCTTCAAGCAGGCGGTGAAGGAGACCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCCGGAAGTGAAGCTGGAAGACAGGATCAGG
TGCCAGCGGACCATCGGCTGGCAGAGCCCAGCGGCCACCACCCGTCAACCCTGCCAGGAGCTGAGGGCACCACCCAGCAACCTGGGCCTG
CATTCCATCCGCTCTGCAGCCCCAAGCATCTTTCCAGTGGGGCCCCCATTCACGTTGGTCCTCAGGGAAACCAGGGTCCCGGGCAGGCCC
GGCGCTTTGCTCCCCACACCAGCCCCCTGCGCGTGTCCACTCTGATCCTGCATCCCACTCCCTGGGAGCCAATAAAGTGCATTTTCACAG

>88751_88751_7_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000567759_TSTA3_chr8_144695465_ENST00000425753_length(amino acids)=247AA_BP=
MVLVSRMDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARD
LLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRF

--------------------------------------------------------------
>88751_88751_8_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000567759_TSTA3_chr8_144695465_ENST00000529064_length(transcript)=1352nt_BP=904nt
CCCGAGTGCCAAAGCTGGGGTTCTACTTGAGATTTCCCTCGTGGTGCCAGGGTCCGGCGAGCATCACGCCGAGGCCCATTTTCCAGACGA
CCACGACGAGGCCGGGGTCACGAACTCTGGCGCCCCTTACCAGCTTCCAGTCTCTCGAGGTGGCCAGTGTGGTGCTTGGTCCTTGTTTCC
AGGATGGACTTCCCCAGCTCCCTCCGCCCTGCATTGTTTCTGACCGGCCCCCTTGGTCTGAGCGACGTCCCTGACCTCTCTTTCATGTGC
AGCTGGCGAGACGCACTGACTCTGCCAGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAG
CCGGCAACCCCTGGGCCTCTCCCCATGCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGA
GGGTGCCGGTATCGGAAGCGGCCCCGAGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTT
GCGCCCCTGGGGAAGCTGATGCTGGAGAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAG
CTGCTCCAGGACCTCGGTGGACACCAGCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGC
CCCATCCTGGGCACGTCGGTGGCGAGCCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAG
GCCTGCACTGGGGGCGCGCTGGCCTGGGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGG
CTGCTTTGATACAACCAAGTCGGATGGGCAGTTTAAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCAC
ACCCTTCAAGCAGGCGGTGAAGGAGACCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCCGGAAGTGAAGCTGGAAGACAGGATCAGG
TGCCAGCGGACCATCGGCTGGCAGAGCCCAGCGGCCACCACCCGTCAACCCTGCCAGGAGCTGAGGGCACCACCCAGCAACCTGGGCCTG
CATTCCATCCGCTCTGCAGCCCCAAGCATCTTTCCAGTGGGGCCCCCATTCACGTTGGTCCTCAGGGAAACCAGGGTCCCGGGCAGGCCC
GGCGCTTTGCTCCCCACACCAGCCCCCTGCGCGTGTCCACTCTGATCCTGCATCCCACTCCCTGGGAGCCAATAAAGTGCATTTTCACAG

>88751_88751_8_TAF1C-TSTA3_TAF1C_chr16_84215807_ENST00000567759_TSTA3_chr8_144695465_ENST00000529064_length(amino acids)=247AA_BP=
MVLVSRMDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARD
LLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TAF1C-TSTA3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TAF1C-TSTA3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TAF1C-TSTA3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source