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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TAF3-APP (FusionGDB2 ID:88780)

Fusion Gene Summary for TAF3-APP

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF3-APP
Fusion gene ID: 88780
HgeneTgene
Gene symbol

TAF3

APP

Gene ID

83860

351

Gene nameTATA-box binding protein associated factor 3amyloid beta precursor protein
SynonymsTAF140|TAFII-140|TAFII140AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

10p14

21q21.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription initiation factor TFIID subunit 3140 kDa TATA box-binding protein-associated factorRNA polymerase II transcription factor TAFII140TAF(II)140TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDaTBP-associated famyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020031320200329
UniProtAcc.

Q8NEU8

Ensembl transtripts involved in fusion geneENST00000344293, ENST00000474136, 
ENST00000346798, ENST00000348990, 
ENST00000354192, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000439274, ENST00000440126, 
ENST00000448388, 
Fusion gene scores* DoF score11 X 6 X 7=46225 X 18 X 10=4500
# samples 1227
** MAII scorelog2(12/462*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAF3 [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAF3(8019286)-APP(27394358), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAF3

GO:0000122

negative regulation of transcription by RNA polymerase II

18549481

HgeneTAF3

GO:0043433

negative regulation of DNA-binding transcription factor activity

18549481

HgeneTAF3

GO:0051457

maintenance of protein location in nucleus

15870280

TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across TAF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA87-01ATAF3chr10

8019286

-APPchr21

27394358

-


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Fusion Gene ORF analysis for TAF3-APP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344293ENST00000474136TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000346798TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000348990TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000354192TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000357903TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000358918TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000359726TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000439274TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000440126TAF3chr10

8019286

-APPchr21

27394358

-
In-frameENST00000344293ENST00000448388TAF3chr10

8019286

-APPchr21

27394358

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344293TAF3chr108019286-ENST00000346798APPchr2127394358-5292252113741711344
ENST00000344293TAF3chr108019286-ENST00000354192APPchr2127394358-5067252113739461269
ENST00000344293TAF3chr108019286-ENST00000348990APPchr2127394358-5067252113739461269
ENST00000344293TAF3chr108019286-ENST00000357903APPchr2127394358-5235252113741141325
ENST00000344293TAF3chr108019286-ENST00000358918APPchr2127394358-5237252113741171326
ENST00000344293TAF3chr108019286-ENST00000359726APPchr2127394358-5123252113740031288
ENST00000344293TAF3chr108019286-ENST00000448388APPchr2127394358-4290252113739461269
ENST00000344293TAF3chr108019286-ENST00000440126APPchr2127394358-4454252113741141325
ENST00000344293TAF3chr108019286-ENST00000439274APPchr2127394358-4510252113741711344

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344293ENST00000346798TAF3chr108019286-APPchr2127394358-0.0009509060.9990491
ENST00000344293ENST00000354192TAF3chr108019286-APPchr2127394358-0.0006805240.99931943
ENST00000344293ENST00000348990TAF3chr108019286-APPchr2127394358-0.0006805240.99931943
ENST00000344293ENST00000357903TAF3chr108019286-APPchr2127394358-0.0013148390.9986852
ENST00000344293ENST00000358918TAF3chr108019286-APPchr2127394358-0.0010064150.9989936
ENST00000344293ENST00000359726TAF3chr108019286-APPchr2127394358-0.0006271890.9993728
ENST00000344293ENST00000448388TAF3chr108019286-APPchr2127394358-0.0015802790.99841976
ENST00000344293ENST00000440126TAF3chr108019286-APPchr2127394358-0.0026567270.99734324
ENST00000344293ENST00000439274TAF3chr108019286-APPchr2127394358-0.0019952230.99800473

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Fusion Genomic Features for TAF3-APP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAF3-APP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:8019286/chr21:27394358)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.APP

Q8NEU8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAF3chr10:8019286chr21:27394358ENST00000344293-47136_141771930.0Compositional biasNote=Poly-Glu
HgeneTAF3chr10:8019286chr21:27394358ENST00000344293-47163_168771930.0Compositional biasNote=Poly-Glu
HgeneTAF3chr10:8019286chr21:27394358ENST00000344293-47507_746771930.0Compositional biasNote=Lys-rich
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418230_260220771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418274_280220771.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416230_260220696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416274_280220696.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315230_260164640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315274_280164640.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417230_260220752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417274_280220752.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417230_260220753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417274_280220753.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417230_260220715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417274_280220715.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417230_260215747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417274_280215747.0Compositional biasNote=Poly-Thr
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418374_565220771.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416374_565220696.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315374_565164640.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417374_565220752.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417374_565220753.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417374_565220715.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417374_565215747.0DomainE2
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418344_365220771.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418724_734220771.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416344_365220696.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416724_734220696.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315344_365164640.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315724_734164640.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417344_365220752.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417724_734220752.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417344_365220753.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417724_734220753.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417344_365220715.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417724_734220715.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417344_365215747.0MotifOX-2
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417724_734215747.0MotifNote=Basolateral sorting signal
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418391_423220771.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418491_522220771.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418523_540220771.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416391_423220696.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416491_522220696.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416523_540220696.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315181_188164640.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315391_423164640.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315491_522164640.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315523_540164640.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417391_423220752.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417491_522220752.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417523_540220752.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417391_423220753.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417491_522220753.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417523_540220753.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417391_423220715.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417491_522220715.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417523_540220715.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417391_423215747.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417491_522215747.0RegionNote=Heparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417523_540215747.0RegionCollagen-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418723_770220771.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416723_770220696.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315723_770164640.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417723_770220752.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417723_770220753.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417723_770220715.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417723_770215747.0Topological domainCytoplasmic
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418702_722220771.0TransmembraneHelical
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416702_722220696.0TransmembraneHelical
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315702_722164640.0TransmembraneHelical
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417702_722220752.0TransmembraneHelical
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417702_722220753.0TransmembraneHelical
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417702_722220715.0TransmembraneHelical
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417702_722215747.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAF3chr10:8019286chr21:27394358ENST00000344293-47779_833771930.0Compositional biasNote=Pro-rich
HgeneTAF3chr10:8019286chr21:27394358ENST00000344293-47865_915771930.0Zinc fingerPHD-type
TgeneAPPchr10:8019286chr21:27394358ENST0000034679841828_189220771.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST0000034899041628_189220696.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST0000035419231528_189164640.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST0000035790341728_189220752.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST0000035891841728_189220753.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST0000035972641728_189220715.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST0000044012641728_189215747.0DomainE1
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418131_189220771.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418181_188220771.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000034679841828_123220771.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000034679841896_110220771.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416131_189220696.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416181_188220696.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000034899041628_123220696.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000034899041696_110220696.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315131_189164640.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000035419231528_123164640.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000035419231596_110164640.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417131_189220752.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417181_188220752.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000035790341728_123220752.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000035790341796_110220752.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417131_189220753.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417181_188220753.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000035891841728_123220753.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000035891841796_110220753.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417131_189220715.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417181_188220715.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000035972641728_123220715.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000035972641796_110220715.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417131_189215747.0RegionCuBD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417181_188215747.0RegionNote=Zinc-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000044012641728_123215747.0RegionGFLD subdomain
TgeneAPPchr10:8019286chr21:27394358ENST0000044012641796_110215747.0RegionHeparin-binding
TgeneAPPchr10:8019286chr21:27394358ENST0000034679841818_701220771.0Topological domainExtracellular
TgeneAPPchr10:8019286chr21:27394358ENST0000034899041618_701220696.0Topological domainExtracellular
TgeneAPPchr10:8019286chr21:27394358ENST0000035419231518_701164640.0Topological domainExtracellular
TgeneAPPchr10:8019286chr21:27394358ENST0000035790341718_701220752.0Topological domainExtracellular
TgeneAPPchr10:8019286chr21:27394358ENST0000035891841718_701220753.0Topological domainExtracellular
TgeneAPPchr10:8019286chr21:27394358ENST0000035972641718_701220715.0Topological domainExtracellular
TgeneAPPchr10:8019286chr21:27394358ENST0000044012641718_701215747.0Topological domainExtracellular


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Fusion Gene Sequence for TAF3-APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88780_88780_1_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000346798_length(transcript)=5292nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATG
TGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGT
GTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTA
CCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCA
AGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAG
TTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAG
TGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGT
TCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCA
AGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACG
TGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGA
TTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATG
GAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTG
ATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGA
TGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTG
CAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCA
TTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAA
CCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATC
GGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAG
TAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTT
TTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGT
ATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGT
TCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAG
ATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTT
CTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAA
AAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAA
TTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCC
GGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTA
ACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCC

>88780_88780_1_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000346798_length(amino acids)=1344AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQ

--------------------------------------------------------------
>88780_88780_2_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000348990_length(transcript)=5067nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA
ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG
CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG
CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT
ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC
AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG
TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC
TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT
CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG
CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTT
CTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATC
AAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGA
TCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGG
AGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAG
CAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTA
TGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCT
ATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAAT
AGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACAT
ATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGC
ATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCT
GCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAA
GCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGA
GGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATC
GCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATC
GAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGG
AAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCAT

>88780_88780_2_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000348990_length(amino acids)=1269AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK
HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF
NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI
SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKM
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPT

--------------------------------------------------------------
>88780_88780_3_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000354192_length(transcript)=5067nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA
ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG
CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG
CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT
ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC
AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG
TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC
TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT
CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG
CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTT
CTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATC
AAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGA
TCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGG
AGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAG
CAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTA
TGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCT
ATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAAT
AGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACAT
ATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGC
ATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCT
GCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAA
GCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGA
GGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATC
GCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATC
GAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGG
AAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCAT

>88780_88780_3_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000354192_length(amino acids)=1269AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK
HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF
NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI
SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKM
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPT

--------------------------------------------------------------
>88780_88780_4_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000357903_length(transcript)=5235nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATG
TGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGT
GTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCC
ATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAG
CAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGA
GACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTC
TGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAA
AGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGC
GCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGC
AAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAA
CGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGC
CAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAA
ATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGT
TCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCT
TGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGT
CCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAG
TTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCAT
TATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTAC
ATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCT
GATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAA
TCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTA
AACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTG
ATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTT
TTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGC
TGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACT
GTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTG
GGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATAT
AAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATAC

>88780_88780_4_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000357903_length(amino acids)=1325AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ
IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL
DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL

--------------------------------------------------------------
>88780_88780_5_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000358918_length(transcript)=5237nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATG
TGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGT
GTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTA
CCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCA
AGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAG
TTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAG
TGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGT
TCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCA
AGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACG
TGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGA
TTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATG
GAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGGTTCTGGGTTGA
CAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGG
TGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCA
CCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACC
TGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTG
AAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACT
CATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTT
TACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCT
CCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAA
GAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAG
TTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTT
GTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTT
TTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTC
TGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTAC
ACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATT
TTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAA
TATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAA

>88780_88780_5_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000358918_length(amino acids)=1326AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG

--------------------------------------------------------------
>88780_88780_6_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000359726_length(transcript)=5123nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAA
CAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGA
GGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTG
ATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACAC
ACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGC
CTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCA
TGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCC
TGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCT
TGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCC
TTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAG
TTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCT
CTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTT
CAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAAC
AGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCT
ACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCT
TCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTG
CTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACAT
TATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCC
TTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGT
GAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGA
TGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATAC
ACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTC
TTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAAT
TCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAA
TAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATT
CAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGC

>88780_88780_6_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000359726_length(amino acids)=1288AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETP
GDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLA
LENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEV
DELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTT
RPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAV

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>88780_88780_7_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000439274_length(transcript)=4510nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATG
TGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGT
GTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTA
CCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCA
AGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAG
TTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAG
TGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGT
TCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCA
AGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACG
TGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGA
TTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATG
GAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTG
ATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGA
TGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTG
CAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCA
TTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAA
CCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATC
GGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAG
TAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTT
TTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGT

>88780_88780_7_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000439274_length(amino acids)=1344AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQ

--------------------------------------------------------------
>88780_88780_8_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000440126_length(transcript)=4454nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATG
TGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGT
GTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCC
ATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAG
CAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGA
GACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTC
TGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAA
AGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGC
GCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGC
AAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAA
CGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGC
CAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAA
ATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGT
TCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCT
TGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGT
CCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAG
TTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCAT
TATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTAC
ATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCT

>88780_88780_8_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000440126_length(amino acids)=1325AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ
IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL
DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL

--------------------------------------------------------------
>88780_88780_9_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000448388_length(transcript)=4290nt_BP=2521nt
CAGCGGGAGGCGGAGCGAGTCCAAAATGGCGGCTCTCAGGCTGGCGCGCTCCGTGCTGCTGGGGCTTTGAGGTGGTCGCCGGGGGTCCGG
GGGACCCTTTCCCCGCCGCGGAAGCCCTAGAGGATGAATCGGGGACCCTGCTAAGGTCTGGCGGCGGGGCTGGAGAGCAGTGGCAGCAAG
GGCTGCGGTGGCGTCCACGCAGCGGGATGTGCGAGAGTTACTCCAGGTCGTTGTTGAGGGTCTCGGTGGCGCAGATCTGCCAGGCGCTGG
GCTGGGACTCGGTGCAGCTCAGCGCCTGCCACCTCCTCACGGACGTGCTGCAGCGCTATCTGCAGCAGCTGGGCCGGGGCTGCCATCGGT
ACTCTGAGCTCTATGGCCGAACAGACCCAATTTTGGATGATGTTGGTGAAGCTTTCCAGCTGATGGGGGTTAGTCTACATGAACTAGAAG
ACTATATTCACAACATTGAGCCTGTCACCTTCCCACACCAAATTCCGTCATTTCCTGTTAGCAAGAACAATGTACTTCAGTTTCCTCAAC
CTGGAAGTAAAGATGCAGAGGAAAGAAAAGAATACATTCCTGATTACCTGCCACCCATTGTGTCTTCTCAAGAAGAAGAAGAAGAAGAGC
AGGTGCCCACTGATGGAGGCACATCAGCAGAAGCCATGCAGGTTCCCTTGGAAGAAGATGATGAATTGGAGGAGGAAGAAATTATTAATG
ATGAGAATTTCCTGGGCAAGAGACCACTGGATAGTCCTGAAGCTGAAGAACTGCCAGCCATGAAGCGGCCTCGGCTATTAAGCACTAAAG
GGGACACGCTAGATGTTGTGTTATTGGAAGCTCGAGAGCCACTCAGCTCAATAAATACTCAAAAGATCCCACCAATGCTTTCTCCAGTCC
ATGTACAGGACAGTACAGACTTGGCACCTCCCTCACCCGAGCCGCCAATGTTGGCTCCAGTTGCAAAATCACAAATGCCAACTGCAAAAC
CATTAGAAACAAAGTCATTTACACCTAAAACAAAGACTAAAACTAGCTCTCCAGGACAGAAGACTAAATCACCTAAAACCGCCCAGTCAC
CAGCAATGGTCGGAAGTCCTATTCGATCACCAAAAACTGTATCCAAAGAAAAGAAATCACCTGGACGTTCCAAGAGCCCCAAGAGTCCCA
AGAGCCCCAAGGTCACGACTCACATTCCCCAAACACCTGTGAGACCTGAAACGCCCAACAGGACTCCTTCAGCTACACTCAGTGAAAAAA
TCAGTAAAGAGACTATCCAGGTAAAACAAATACAGACACCCCCTGATGCTGGGAAACTGAACAGTGAGAATCAGCCGAAAAAGGCTGTGG
TAGCAGATAAAACGATTGAGGCCTCTATCGATGCTGTGATTGCACGAGCCTGTGCTGAGCGAGAGCCAGATCCTTTCGAATTTTCTTCTG
GATCGGAATCTGAAGGAGACATTTTTACTAGCCCTAAGAGAATTTCAGGCCCGGAGTGTACTACTCCCAAAGCTTCCACTTCCGCGAACA
ATTTCACAAAGTCAGGATCCACTCCTCTGCCTCTTTCCGGTGGAACCTCAAGTTCCGATAACTCATGGACAATGGATGCCTCCATTGATG
AGGTTGTACGTAAAGCAAAACTGGGAACACCTTCAAATATGCCCCCCAACTTTCCTTATATCTCTTCTCCGTCAGTGTCTCCTCCCACTC
CCGAACCTCTCCACAAGGTGTATGAGGAGAAAACCAAGCTGCCTTCCTCCGTGGAGGTAAAGAAGAAGTTGAAAAAGGAACTAAAGACTA
AAATGAAAAAGAAAGAAAAGCAGAGAGATAGGGAGAGGGAAAAAGACAAGAACAAGGACAAAAGTAAGGAGAAGGATAAAGTGAAAGAGA
AAGAGAAAGACAAGGAAACTGGCAGGGAAACAAAGTATCCCTGGAAGGAATTTCTTAAAGAGGAAGAGGCAGATCCCTACAAGTTTAAAA
TCAAAGAATTTGAAGATGTTGATCCCAAAGTGAAATTGAAAGATGGACTTGTGAGGAAGGAGAAAGAGAAGCATAAAGATAAGAAGAAAG
ATAGAGAGAAAGGCAAGAAAGATAAAGATAAGAGAGAGAAAGAAAAAGTGAAAGATAAAGGCAGAGAAGATAAGATGAAAGCCCCAGCAC
CCCCACTGGTGTTGCCCCCAAAAGAGTTGGCCCTGCCCTTGTTCAGCCCTGCCACAGCCTCCAGGGTCCCAGCCATGCTGCCATCTTTGT
TGCCAGTGCTTCCGGAAAAACTGTTTGAGGAGAAAGAGAAGGTGAAGGAGAAAGAAAAGAAAAAGGACAAAAAGGAGAAGAAGAAAAAGA
AGGAAAAAGAGAAGGAGAAGAAGGAGAAGGAAAGAGAGAAAGAGAAGAGAGAGCGAGAGAAGAGAGAAAAAGAGAAGGAGAAACACAAGC
ATGAAAAAATAAAAGTGGAACCAGTCGCTCTGGCCCCGAGTCCAGTTATCCCCAGATTAACTCTCCGAGTCGGTGCTGGCCAAGACAAGA
TTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATG
GTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAG
AGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA
ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG
CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG
CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT
ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC
AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG
TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC
TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT
CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG
CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTT
CTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATC
AAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGA
TCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGG
AGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAG
CAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTA
TGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCT
ATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAAT

>88780_88780_9_TAF3-APP_TAF3_chr10_8019286_ENST00000344293_APP_chr21_27394358_ENST00000448388_length(amino acids)=1269AA_BP=795
MLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVG
EAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVP
LEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPP
MLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRP
ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRIS
GPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS
SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDG
LVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK
EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK
HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF
NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI
SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKM
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TAF3-APP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418732_751220.66666666666666771.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416732_751220.66666666666666696.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315732_751164.66666666666666640.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417732_751220.66666666666666752.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417732_751220.66666666666666753.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417732_751220.66666666666666715.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417732_751215.66666666666666747.0G(o)-alpha
TgeneAPPchr10:8019286chr21:27394358ENST00000346798418695_722220.66666666666666771.0PSEN1
TgeneAPPchr10:8019286chr21:27394358ENST00000348990416695_722220.66666666666666696.0PSEN1
TgeneAPPchr10:8019286chr21:27394358ENST00000354192315695_722164.66666666666666640.0PSEN1
TgeneAPPchr10:8019286chr21:27394358ENST00000357903417695_722220.66666666666666752.0PSEN1
TgeneAPPchr10:8019286chr21:27394358ENST00000358918417695_722220.66666666666666753.0PSEN1
TgeneAPPchr10:8019286chr21:27394358ENST00000359726417695_722220.66666666666666715.0PSEN1
TgeneAPPchr10:8019286chr21:27394358ENST00000440126417695_722215.66666666666666747.0PSEN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAF3-APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAF3-APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource