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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TAF6-FLT3LG (FusionGDB2 ID:88813)

Fusion Gene Summary for TAF6-FLT3LG

Fusion gene summary

Fusion gene information	Fusion gene name: TAF6-FLT3LG
	Fusion gene ID: 88813
		Hgene	Tgene
	Gene symbol	TAF6	FLT3LG
	Gene ID	6878	2323
	Gene name	TATA-box binding protein associated factor 6	fms related receptor tyrosine kinase 3 ligand
	Synonyms	ALYUS\|MGC:8964\|TAF(II)70\|TAF(II)80\|TAF2E\|TAFII-70\|TAFII-80\|TAFII70\|TAFII80\|TAFII85	FL\|FLG3L\|FLT3L
	Cytomap	7q22.1	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	transcription initiation factor TFIID subunit 6RNA polymerase II TBP-associated factor subunit ETAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85	fms-related tyrosine kinase 3 ligandflt3 ligandfms related tyrosine kinase 3 ligand
	Modification date	20200313	20200313
	UniProtAcc	.	P49771
	Ensembl transtripts involved in fusion gene	ENST00000453269, ENST00000497233, ENST00000344095, ENST00000418432, ENST00000437822, ENST00000452041, ENST00000472509,	ENST00000204637, ENST00000344019, ENST00000594009, ENST00000595510, ENST00000596435, ENST00000597551, ENST00000600429,
Fusion gene scores	* DoF score	4 X 5 X 3=60	7 X 8 X 7=392
	# samples	5	10
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/392*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TAF6 [Title/Abstract] AND FLT3LG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TAF6(99716827)-FLT3LG(49982166), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TAF6	GO:0006352	DNA-templated transcription, initiation	9603525
Hgene	TAF6	GO:0006367	transcription initiation from RNA polymerase II promoter	9603525
Hgene	TAF6	GO:0045786	negative regulation of cell cycle	15328371
Tgene	FLT3LG	GO:0008284	positive regulation of cell proliferation	8180375
Tgene	FLT3LG	GO:0035162	embryonic hemopoiesis	21149635

Fusion gene breakpoints across TAF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FLT3LG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-8534-01A	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+

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Fusion Gene ORF analysis for TAF6-FLT3LG

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-intron	ENST00000453269	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000453269	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000453269	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000453269	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000453269	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000453269	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000453269	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
5UTR-intron	ENST00000497233	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000344095	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000418432	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000437822	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000452041	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000204637	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000344019	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000594009	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000595510	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000596435	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000597551	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+
intron-intron	ENST00000472509	ENST00000600429	TAF6	chr7	99716827	-	FLT3LG	chr19	49982166	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for TAF6-FLT3LG

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TAF6	chr7	99716826	-	FLT3LG	chr19	49982165	+	3.07E-09	1
TAF6	chr7	99716826	-	FLT3LG	chr19	49982165	+	3.07E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAF6-FLT3LG

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:99716827/:49982166)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FLT3LG P49771
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TAF6-FLT3LG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TAF6-FLT3LG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TAF6-FLT3LG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TAF6-FLT3LG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source