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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TARDBP-LRCH3 (FusionGDB2 ID:89102)

Fusion Gene Summary for TARDBP-LRCH3

check button Fusion gene summary
Fusion gene informationFusion gene name: TARDBP-LRCH3
Fusion gene ID: 89102
HgeneTgene
Gene symbol

TARDBP

LRCH3

Gene ID

23435

84859

Gene nameTAR DNA binding proteinleucine rich repeats and calponin homology domain containing 3
SynonymsALS10|TDP-43-
Cytomap

1p36.22

3q29

Type of geneprotein-codingprotein-coding
DescriptionTAR DNA-binding protein 43TAR DNA-binding protein-43DISP complex protein LRCH3leucine-rich repeat and calponin homology domain-containing protein 3leucine-rich repeats and calponin homology (CH) domain containing 3
Modification date2020032920200313
UniProtAcc.

Q96II8

Ensembl transtripts involved in fusion geneENST00000240185, ENST00000315091, 
ENST00000439080, ENST00000480464, 
ENST00000536618, ENST00000334859, 
ENST00000414675, ENST00000425562, 
ENST00000441090, ENST00000493726, 
ENST00000438796, 
Fusion gene scores* DoF score8 X 8 X 4=25611 X 12 X 5=660
# samples 813
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TARDBP [Title/Abstract] AND LRCH3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTARDBP(11073830)-LRCH3(197562617), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTARDBP

GO:0008380

RNA splicing

11285240

HgeneTARDBP

GO:0043922

negative regulation by host of viral transcription

7745706

HgeneTARDBP

GO:0061158

3'-UTR-mediated mRNA destabilization

28335005

HgeneTARDBP

GO:0070935

3'-UTR-mediated mRNA stabilization

17481916


check buttonFusion gene breakpoints across TARDBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRCH3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA652289TARDBPchr1

11073830

+LRCH3chr3

197562617

+


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Fusion Gene ORF analysis for TARDBP-LRCH3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000240185ENST00000536618TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-5UTRENST00000315091ENST00000536618TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000240185ENST00000334859TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000240185ENST00000414675TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000240185ENST00000425562TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000240185ENST00000441090TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000240185ENST00000493726TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000315091ENST00000334859TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000315091ENST00000414675TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000315091ENST00000425562TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000315091ENST00000441090TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5CDS-intronENST00000315091ENST00000493726TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-3CDSENST00000439080ENST00000438796TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-5UTRENST00000439080ENST00000536618TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-intronENST00000439080ENST00000334859TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-intronENST00000439080ENST00000414675TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-intronENST00000439080ENST00000425562TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-intronENST00000439080ENST00000441090TARDBPchr1

11073830

+LRCH3chr3

197562617

+
5UTR-intronENST00000439080ENST00000493726TARDBPchr1

11073830

+LRCH3chr3

197562617

+
In-frameENST00000240185ENST00000438796TARDBPchr1

11073830

+LRCH3chr3

197562617

+
In-frameENST00000315091ENST00000438796TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-3CDSENST00000480464ENST00000438796TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-5UTRENST00000480464ENST00000536618TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-intronENST00000480464ENST00000334859TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-intronENST00000480464ENST00000414675TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-intronENST00000480464ENST00000425562TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-intronENST00000480464ENST00000441090TARDBPchr1

11073830

+LRCH3chr3

197562617

+
intron-intronENST00000480464ENST00000493726TARDBPchr1

11073830

+LRCH3chr3

197562617

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000240185TARDBPchr111073830+ENST00000438796LRCH3chr3197562617+64692942561530424
ENST00000315091TARDBPchr111073830+ENST00000438796LRCH3chr3197562617+63671921541428424

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000240185ENST00000438796TARDBPchr111073830+LRCH3chr3197562617+0.0033707160.9966293
ENST00000315091ENST00000438796TARDBPchr111073830+LRCH3chr3197562617+0.0032156960.9967843

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Fusion Genomic Features for TARDBP-LRCH3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TARDBP-LRCH3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:11073830/chr3:197562617)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRCH3

Q96II8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019384_3890713.0Compositional biasNote=Poly-Glu
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021384_3890778.0Compositional biasNote=Poly-Glu
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022384_38902334.0Compositional biasNote=Poly-Glu
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019652_7650713.0DomainCalponin-homology (CH)
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021652_7650778.0DomainCalponin-homology (CH)
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022652_76502334.0DomainCalponin-homology (CH)
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019105_1270713.0RepeatLRR 3
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019128_1500713.0RepeatLRR 4
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019152_1720713.0RepeatLRR 5
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019173_1950713.0RepeatLRR 6
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019196_2180713.0RepeatLRR 7
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019220_2390713.0RepeatLRR 8
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019240_2640713.0RepeatLRR 9
TgeneLRCH3chr1:11073830chr3:197562617ENST00000334859019266_2900713.0RepeatLRR 10
TgeneLRCH3chr1:11073830chr3:197562617ENST0000033485901956_790713.0RepeatLRR 1
TgeneLRCH3chr1:11073830chr3:197562617ENST0000033485901981_1040713.0RepeatLRR 2
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021105_1270778.0RepeatLRR 3
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021128_1500778.0RepeatLRR 4
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021152_1720778.0RepeatLRR 5
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021173_1950778.0RepeatLRR 6
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021196_2180778.0RepeatLRR 7
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021220_2390778.0RepeatLRR 8
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021240_2640778.0RepeatLRR 9
TgeneLRCH3chr1:11073830chr3:197562617ENST00000425562021266_2900778.0RepeatLRR 10
TgeneLRCH3chr1:11073830chr3:197562617ENST0000042556202156_790778.0RepeatLRR 1
TgeneLRCH3chr1:11073830chr3:197562617ENST0000042556202181_1040778.0RepeatLRR 2
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022105_12702334.0RepeatLRR 3
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022128_15002334.0RepeatLRR 4
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022152_17202334.0RepeatLRR 5
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022173_19502334.0RepeatLRR 6
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022196_21802334.0RepeatLRR 7
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022220_23902334.0RepeatLRR 8
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022240_26402334.0RepeatLRR 9
TgeneLRCH3chr1:11073830chr3:197562617ENST00000438796022266_29002334.0RepeatLRR 10
TgeneLRCH3chr1:11073830chr3:197562617ENST0000043879602256_7902334.0RepeatLRR 1
TgeneLRCH3chr1:11073830chr3:197562617ENST0000043879602281_10402334.0RepeatLRR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTARDBPchr1:11073830chr3:197562617ENST00000240185+16274_4130415.0Compositional biasNote=Gly-rich
HgeneTARDBPchr1:11073830chr3:197562617ENST00000240185+16104_2000415.0DomainRRM 1
HgeneTARDBPchr1:11073830chr3:197562617ENST00000240185+16191_2620415.0DomainRRM 2
HgeneTARDBPchr1:11073830chr3:197562617ENST00000240185+16239_2500415.0MotifNuclear export signal
HgeneTARDBPchr1:11073830chr3:197562617ENST00000240185+1682_980415.0MotifNuclear localization signal


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Fusion Gene Sequence for TARDBP-LRCH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89102_89102_1_TARDBP-LRCH3_TARDBP_chr1_11073830_ENST00000240185_LRCH3_chr3_197562617_ENST00000438796_length(transcript)=6469nt_BP=294nt
GGCCCTAGCGCCATTTTGTGGGAGCGAAGCGGTGGCTGGGCTGCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCA
GCGGCCTAGCGGTTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTC
GCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGG
TGTATGTTGTCAACTATCCAAAAGGCCCAAGGGACCAGACCCAGACAGCCTTAGTTCACAGTTTATGGCGTATATTGAACAGCGGCGAAT
CTCTCATGAGGGTTCACCAGTAAAGCCAGTAGCCATTAGGGAGTTTCAAAAAACAGAAGATATGAGAAGATATTTACATCAAAACAGGGT
TCCAGCTGAGCCATCTTCCCTCCTGTCACTATCAGCAAGTCACAATCAGCTGTCACACACAGACCTGGAACTTCATCAGAGAAGGGAGCA
GTTAGTAGAGCGCACTCGGAGAGAGGCTCAGCTTGCTGCCCTGCAGTATGAGGAGGAGAAAATAAGGACCAAGCAGATCCAGAGAGATGC
TGTCCTGGACTTTGTCAAACAAAAAGCATCACAAAGTCCACAAAAACAGCACCCGCTCCTAGATGGCGTAGATGGTGAGTGCCCCTTCCC
ATCCAGAAGGTCTCAGCACACTGATGATAGTGCCTTGTGCATGTCGCTGTCAGGGTTGAATCAAGTGGGCTGTGCTGCTACCCTGCCTCA
TTCTTCTGCCTTCACGCCTCTTAAGAGTGATGACAGACCTAATGCTCTATTAAGTTCACCTGCAACAGAAACAGTTCATCATTCCCCTGC
ATATTCTTTTCCTGCTGCTATCCAGAGAAATCAGCCTCAGCGCCCTGAAAGCTTCCTTTTCCGAGCAGGTGTCAGGGCAGAAACCAACAA
AGGTCATGCTTCACCCCTTCCTCCATCTGCTGCACCTACCACTGATTCTACAGATTCCATAACAGGACAGAATTCAAGACAGAGAGAAGA
AGAGCTGGAATTAATAGACCAACTGCGTAAACATATTGAGTACCGGTTGAAAGTGTCTCTACCTTGTGATCTCGGAGCAGCTCTAACTGA
CGGTGTTGTTCTTTGCCATTTGGCCAATCATGTGCGACCTCGATCTGTCCCAAGCATTCATGTTCCCTCACCAGCTGTACCTAAATTAAC
AATGGCGAAATGCAGGCGAAATGTGGAAAATTTCCTAGAAGCTTGCAGAAAAATTGGTGTACCTCAGGACAATCTTTGTTCCCCTTCCGA
CATCCTTCAGCTAAACCTCAGCGTTAAAAGAACTGTTGAAACGCTCCTTTCTCTTGGGGCACACTCAGAAGAATCCAGTTTTGTCTGTCT
CTCTCTGCAGCTTCTGGGTTTTGTGGCATTTTACTGTACTGTGATGTTAACTCTCTGTGTGCTTTATTACTGGCTCTTCCCCGCTCGCTG
AAAGATTGCACTCCGGTGACTTTCTGCCTCATTCCTGTGCTTGGAGCAATTATGTTTGCCTCTCCACATTTTAGAAGAGAAAGGTTTGAG
CCAGGTTGCAGTGACGGTCCAGGCTCTCCTGGAACTTGCCCCACCCAAGCAACAGCAGCACCAGTTATCTGCTGTTTGAGGATCCCCAGG
ACGGTGGGCACTGGCCTGGCCAAAACAAGGAACAGGACACCGTGATTGCTGCTGCCAGCTGTCTGCTTAAACAAAGCTCTTGTGTGTTCT
CAGAAGGGACCGTTCCCATGATTCCTAACAGGAATATTTTGCTTCATTTCTCCATTTTAGGGGAGGTTATTTCCATTTCCATTGAATTTT
TTTACGAAGACACCATTGGTTTTCTCAGATGAAACTTCTCTTACTGAAAACCCAGCACCTAACTTGGCTGTGTTTTCCTGGAGAGCAGGC
GTGTTTCACGTGCCAGAAAGCACATCTTCTGTGTTAGGCACAAGCATGCTGTGCCATTGTTTTTACCTGGTCTCAAGACAACTGGTCTGC
TGGTTTCTAAACTTGGTTGTTCATTAGACTCTCCTGGAGTATTTGTTAAAATACAGATTCACATTCAGTAGAGCTGGGGTAAGGCCTAGG
AATCTGCATTTTCAACAACCATTGCACATGTTTTTGTTTTTGTTGGAGAAGGAGTTCTGCTCAGTCGCCCAGGCTAGAGTGCAGTGGCAT
AATCTCAGCTCACTGCAACCTCCGCCTCCCGGGCTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACAACAGGTGCCCGCCA
CCATGCCTGGCTAATTTTCTTGTATTTTTAGTAGAGATGGGATTTTGTCATGTTGGCCAGGCTGGTCTCAAACTCCTGACTTCAAGTGAT
CCACCTGCCTCGGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCCCAGAGTGCTGGGATGACAGGCGTGAGCC
CCCGCGCCCGGCCTCCGAGAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCTGAGGGTGCTGGGATTACAGGCGTGAGCCAC
TGCGCCCGGCGCCCGGCCCATTGCACGTGTTTTTCATGTAGTGGAACCACTGTTCAAAGCTAGATATTTGTATGTTTGCGGGGGAGGGTA
ATGGCCCCCTGCATTTTTCACCCACATTTAAAATCAAAAGCTATATTATGAGGAGTTGGACTGTTCTGTCAAAGGCAAAACAAAAATAAT
ATAGAAGGCCTAGGTTTTGCATAGTCTTCTTTTTTTTAAGAGTTGGGGTCTTGCCGTATTGCCCAGGCTGGTCTGAAACTCCTGGGCTCA
ACTGATCCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACTGGAGTGAGCCATCGGGCCTGGCCCAGATTTTGCATAGTAAAACAGTGA
AACAGATAGAGTTGTATTTAAGGTCAGTATTCTAGGCCTCCCTTCAACTGCAGTCATACCATCATAGAAGATAGTTCTATGTCATCCTGT
TATCTGGACATTATAATAAACAACAAGCCCTCTATACACAGGTTCCAAACCCCGTTATCTAGACATTATCAACAACAAGCCCTCTCTCTA
TACAGAGTTTCCAAATTCTGAAGCTGATAGCGCACTTGGTCTCACTGAGCCTCCCTCCCCGCCCTCCTGCTGCTCCTCAGACATCTGGGC
CTGCAGACACATTGCAGTTACAGCACATACACTTCTAGCTCGGAAAAGCCTAGTTTCTTGTATTTCTTTCAGGTAACTGCCAGTTTCTGT
GGCTGAATTTAAGCACTTACAGCATCTTCCTAGCTGGGTGTGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCTGAGGCGGGCAG
ATCACCTGAAGTTGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGG
TGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGTGGTGAGCCAAGATCGTG
CCATTGCACCCCAGCCTGGGCAACAAAAGCGAAATTCCATCTCAAAAAAAGAAAACGCGCCCCATCTCGCTCCACCACAAGCGCCTTTAT
ATACTCAATGATGGGTGGAGGAAAAGGGCCCAAGGGCTCACACCGCACAGGAGCCTTTACTCAAGTTTCAGCTAGTTTTCCTTCCCCTGC
ATTTTGAACTCCTTTTAGTTGTTGGTGATATCCTTTGGTGTTCACTGCCTTTGTAAAACAAGTAAATAAAGTAAGCGGAAGATATCTCTT
TTGTTTCTGTAGTTGTTAACTGTTCTGGATTTTCTTTACAATGCATCCATTTGGGCATAATGTTATCCCTCTTTTTATCAGGTAAATGTA
GCATCTAAAAGTAGCTTTGGATCAAATCATGTTGAATACCTGGTCAAAGTAATGTTTTCTTCCTTGTTCTTGCAGAGAAACAAATTCATC
AGAACATTACCACTTGACCAGGTTTAAAATTGTATAACAGGCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAG
GCAAGAGGATCACTTGAGCCCAGGAGTTTGAGAGCAGCCTGGGCAACATAGCAAGACCCTGTCTCCCAAAAATTAAAAAAAAAAAAAAAA
AACCAGGTGTGGTGGCACCTGCCTGTACTCCCAGCTACTCAGGAGGCTGGGGTGGGAGGATCACTTGAGCCTGGGAGGTTGAGGCTACAG
TGAGCCATGGCTGCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCCATCTCTAAAAATAAATTGTACAACATCTAACTTCAATG
CCCAATCTTATAGAACAAAAGTAAAATGTCTTTATGTAAGACCCCATTATATTTACAGTTCCCAACAGACCCACCAACTCTTATATACCC
TTATATAACTTGTTTAGAATTTAGCCATGTGCATTTTTAAACTGTGTTTGTCAACATTAAGCCTCAGTACAGTCTCCAAATTATATGCCA
CCAGAAATGAAATTCAGCAAAGGACAGGATTGTTTTTAACATACGCAAGCCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAAA
TACAAAAATTAGCTGGGCGTGGTGGTGGGCACCTGTAATCCCAGCTACTTGGGTGGCTGAGGCACAAGAATCGCTTCAACCTGGAAGCCG
AAGGTTGCAGTGGGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAACC
CACCAAACCAAAAATATACTATGCAAGGAATAATTCTAGAAGACATTACATAATGCAATACTTGCAACATTTGCAACTAATTTTCCCATA
GGGATAAATGGAAATTTCAACTTATTTCAAATTTTGCACATATTATGAAACCTTATTAATGTATTTTTATCAAACTAAATCAGATTTGTA
TTTGAATTGTTAGGAAAAACCATGTGCAGTTTTGGCTGATAATTGAAGGAAAAATATCAAATGCTTTGAATTTTTTTTCTCTTTTTTCAA
ACCCTCTGCAGAGGTAGGAAGGTATGAATTTCTTTTTTATGTCAAGATGCAAAAACAAATCATGATGCTTTTGTTGGGAGAATTTTTGTA
TTCAGTATTTTGTATGTACCTTTTTTTTTTTAAATTGGAAAGCACAATTCGGTTTAACATTTAGCTTTGCTTGACTCCAGTGTAAGATGA
AGATGACCTTGTCACAGCTCCCCTGACCTGAAGCAGAGCCCTTCCCATCACTGACAGTGTTGGGGGTTGAGAGCCCCCCAGCAGAGCCCT
TCCCATCACTGACAGTGTGTCGGCAGCTGAGAGCTCCCCCAGCAGAGCCCTTCCCATCACTGAACAGTGTTGGCGGCTGAGAGCCCCCCA
GCAGAGCCCTTCCCATCACTGACAGTGTTGGGGGCTGAGAGCCCCCCAGCAGAGCCCTTCCCATCACTGAACAGTGTTGGCGGCTGAGAG
CCCCCCAGCAGAGCCCTTCCCATCACTGACAGTGTTGGGGGCTGAGAGCCCCCCTAGCAGAGCCCTTCCCATCACTGACAGTGTCTGGGG
CTGAGAGCCCCCCCTAGCAGAGCCCTTCCCATCACTGACAGTGTTGGGGGCTGAGAGCCCCCCAGCAGAGCCCTTCCCATCACTGACAGT
GTCTGGGGCTGAGAGCCCCCCAGCAGAGCCCTTCCCATCACTGACAGTGTCTGGGGCTGAGAGCCCCCCCTAGCAGAGCCCTTCCCATCA
CTGACAGTGTCGGGTTGAGAGCCACCCCCAGCAGAGCCCTTGCCACGTACAGAGATTTTCTGTCAGCAGTTTCCCAGTATTTCAGACTCA
TAATCTGTGTTTAGCACTCCAGTGTTCTCTTGTAATAGCCAGGTCTGGAAACGACCCATGGAAAGAGGGGCCTTTGTATTCTGCTAGAAC
ACAGAGCATAGTAGTAGATCACTTTTCTGAAGAGCTTTTTAAAATACAGCTAATCAAGGAGTTTGCGATTTCTCTTACTTTCTACAGCTC
AGCAGTGACTAATGATGTGTGACTATGCGAATGAGTTTGATGAATTCGTAAAAACTAAGCGCTTAAATGGTTATAGAAATGAAAACATGG
ATATTTAGAAGCCTTTCTATATACACAGTGCAGTTGAGATGGTTTACAGCAAATTTCGTTTTATTTCTGAAAATGTTGTAAACATGTAAT
TAGTGAAAGATTTTGTAAAACATTGTCCTGTATTTTTGTCTGTAAATATATTGCATAAGTTCTAAGTATAAATATGTCAGTATCATGTAT

>89102_89102_1_TARDBP-LRCH3_TARDBP_chr1_11073830_ENST00000240185_LRCH3_chr3_197562617_ENST00000438796_length(amino acids)=424AA_BP=13
MGKSGVCCQLSKRPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELH
QRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCA
ATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNS
RQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNL

--------------------------------------------------------------
>89102_89102_2_TARDBP-LRCH3_TARDBP_chr1_11073830_ENST00000315091_LRCH3_chr3_197562617_ENST00000438796_length(transcript)=6367nt_BP=192nt
TTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTCGCTACAGGAATC
CAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCA
ACTATCCAAAAGGCCCAAGGGACCAGACCCAGACAGCCTTAGTTCACAGTTTATGGCGTATATTGAACAGCGGCGAATCTCTCATGAGGG
TTCACCAGTAAAGCCAGTAGCCATTAGGGAGTTTCAAAAAACAGAAGATATGAGAAGATATTTACATCAAAACAGGGTTCCAGCTGAGCC
ATCTTCCCTCCTGTCACTATCAGCAAGTCACAATCAGCTGTCACACACAGACCTGGAACTTCATCAGAGAAGGGAGCAGTTAGTAGAGCG
CACTCGGAGAGAGGCTCAGCTTGCTGCCCTGCAGTATGAGGAGGAGAAAATAAGGACCAAGCAGATCCAGAGAGATGCTGTCCTGGACTT
TGTCAAACAAAAAGCATCACAAAGTCCACAAAAACAGCACCCGCTCCTAGATGGCGTAGATGGTGAGTGCCCCTTCCCATCCAGAAGGTC
TCAGCACACTGATGATAGTGCCTTGTGCATGTCGCTGTCAGGGTTGAATCAAGTGGGCTGTGCTGCTACCCTGCCTCATTCTTCTGCCTT
CACGCCTCTTAAGAGTGATGACAGACCTAATGCTCTATTAAGTTCACCTGCAACAGAAACAGTTCATCATTCCCCTGCATATTCTTTTCC
TGCTGCTATCCAGAGAAATCAGCCTCAGCGCCCTGAAAGCTTCCTTTTCCGAGCAGGTGTCAGGGCAGAAACCAACAAAGGTCATGCTTC
ACCCCTTCCTCCATCTGCTGCACCTACCACTGATTCTACAGATTCCATAACAGGACAGAATTCAAGACAGAGAGAAGAAGAGCTGGAATT
AATAGACCAACTGCGTAAACATATTGAGTACCGGTTGAAAGTGTCTCTACCTTGTGATCTCGGAGCAGCTCTAACTGACGGTGTTGTTCT
TTGCCATTTGGCCAATCATGTGCGACCTCGATCTGTCCCAAGCATTCATGTTCCCTCACCAGCTGTACCTAAATTAACAATGGCGAAATG
CAGGCGAAATGTGGAAAATTTCCTAGAAGCTTGCAGAAAAATTGGTGTACCTCAGGACAATCTTTGTTCCCCTTCCGACATCCTTCAGCT
AAACCTCAGCGTTAAAAGAACTGTTGAAACGCTCCTTTCTCTTGGGGCACACTCAGAAGAATCCAGTTTTGTCTGTCTCTCTCTGCAGCT
TCTGGGTTTTGTGGCATTTTACTGTACTGTGATGTTAACTCTCTGTGTGCTTTATTACTGGCTCTTCCCCGCTCGCTGAAAGATTGCACT
CCGGTGACTTTCTGCCTCATTCCTGTGCTTGGAGCAATTATGTTTGCCTCTCCACATTTTAGAAGAGAAAGGTTTGAGCCAGGTTGCAGT
GACGGTCCAGGCTCTCCTGGAACTTGCCCCACCCAAGCAACAGCAGCACCAGTTATCTGCTGTTTGAGGATCCCCAGGACGGTGGGCACT
GGCCTGGCCAAAACAAGGAACAGGACACCGTGATTGCTGCTGCCAGCTGTCTGCTTAAACAAAGCTCTTGTGTGTTCTCAGAAGGGACCG
TTCCCATGATTCCTAACAGGAATATTTTGCTTCATTTCTCCATTTTAGGGGAGGTTATTTCCATTTCCATTGAATTTTTTTACGAAGACA
CCATTGGTTTTCTCAGATGAAACTTCTCTTACTGAAAACCCAGCACCTAACTTGGCTGTGTTTTCCTGGAGAGCAGGCGTGTTTCACGTG
CCAGAAAGCACATCTTCTGTGTTAGGCACAAGCATGCTGTGCCATTGTTTTTACCTGGTCTCAAGACAACTGGTCTGCTGGTTTCTAAAC
TTGGTTGTTCATTAGACTCTCCTGGAGTATTTGTTAAAATACAGATTCACATTCAGTAGAGCTGGGGTAAGGCCTAGGAATCTGCATTTT
CAACAACCATTGCACATGTTTTTGTTTTTGTTGGAGAAGGAGTTCTGCTCAGTCGCCCAGGCTAGAGTGCAGTGGCATAATCTCAGCTCA
CTGCAACCTCCGCCTCCCGGGCTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACAACAGGTGCCCGCCACCATGCCTGGCT
AATTTTCTTGTATTTTTAGTAGAGATGGGATTTTGTCATGTTGGCCAGGCTGGTCTCAAACTCCTGACTTCAAGTGATCCACCTGCCTCG
GCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCCCAGAGTGCTGGGATGACAGGCGTGAGCCCCCGCGCCCGGC
CTCCGAGAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCTGAGGGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCGC
CCGGCCCATTGCACGTGTTTTTCATGTAGTGGAACCACTGTTCAAAGCTAGATATTTGTATGTTTGCGGGGGAGGGTAATGGCCCCCTGC
ATTTTTCACCCACATTTAAAATCAAAAGCTATATTATGAGGAGTTGGACTGTTCTGTCAAAGGCAAAACAAAAATAATATAGAAGGCCTA
GGTTTTGCATAGTCTTCTTTTTTTTAAGAGTTGGGGTCTTGCCGTATTGCCCAGGCTGGTCTGAAACTCCTGGGCTCAACTGATCCTCCC
GCCTCAGCCTCCCAAAGTGCTGGGATTACTGGAGTGAGCCATCGGGCCTGGCCCAGATTTTGCATAGTAAAACAGTGAAACAGATAGAGT
TGTATTTAAGGTCAGTATTCTAGGCCTCCCTTCAACTGCAGTCATACCATCATAGAAGATAGTTCTATGTCATCCTGTTATCTGGACATT
ATAATAAACAACAAGCCCTCTATACACAGGTTCCAAACCCCGTTATCTAGACATTATCAACAACAAGCCCTCTCTCTATACAGAGTTTCC
AAATTCTGAAGCTGATAGCGCACTTGGTCTCACTGAGCCTCCCTCCCCGCCCTCCTGCTGCTCCTCAGACATCTGGGCCTGCAGACACAT
TGCAGTTACAGCACATACACTTCTAGCTCGGAAAAGCCTAGTTTCTTGTATTTCTTTCAGGTAACTGCCAGTTTCTGTGGCTGAATTTAA
GCACTTACAGCATCTTCCTAGCTGGGTGTGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAAGT
TGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGTGCATGCCTGTA
ATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACCCC
AGCCTGGGCAACAAAAGCGAAATTCCATCTCAAAAAAAGAAAACGCGCCCCATCTCGCTCCACCACAAGCGCCTTTATATACTCAATGAT
GGGTGGAGGAAAAGGGCCCAAGGGCTCACACCGCACAGGAGCCTTTACTCAAGTTTCAGCTAGTTTTCCTTCCCCTGCATTTTGAACTCC
TTTTAGTTGTTGGTGATATCCTTTGGTGTTCACTGCCTTTGTAAAACAAGTAAATAAAGTAAGCGGAAGATATCTCTTTTGTTTCTGTAG
TTGTTAACTGTTCTGGATTTTCTTTACAATGCATCCATTTGGGCATAATGTTATCCCTCTTTTTATCAGGTAAATGTAGCATCTAAAAGT
AGCTTTGGATCAAATCATGTTGAATACCTGGTCAAAGTAATGTTTTCTTCCTTGTTCTTGCAGAGAAACAAATTCATCAGAACATTACCA
CTTGACCAGGTTTAAAATTGTATAACAGGCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCAAGAGGATCA
CTTGAGCCCAGGAGTTTGAGAGCAGCCTGGGCAACATAGCAAGACCCTGTCTCCCAAAAATTAAAAAAAAAAAAAAAAAACCAGGTGTGG
TGGCACCTGCCTGTACTCCCAGCTACTCAGGAGGCTGGGGTGGGAGGATCACTTGAGCCTGGGAGGTTGAGGCTACAGTGAGCCATGGCT
GCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCCATCTCTAAAAATAAATTGTACAACATCTAACTTCAATGCCCAATCTTATA
GAACAAAAGTAAAATGTCTTTATGTAAGACCCCATTATATTTACAGTTCCCAACAGACCCACCAACTCTTATATACCCTTATATAACTTG
TTTAGAATTTAGCCATGTGCATTTTTAAACTGTGTTTGTCAACATTAAGCCTCAGTACAGTCTCCAAATTATATGCCACCAGAAATGAAA
TTCAGCAAAGGACAGGATTGTTTTTAACATACGCAAGCCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTAG
CTGGGCGTGGTGGTGGGCACCTGTAATCCCAGCTACTTGGGTGGCTGAGGCACAAGAATCGCTTCAACCTGGAAGCCGAAGGTTGCAGTG
GGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAACCCACCAAACCAAA
AATATACTATGCAAGGAATAATTCTAGAAGACATTACATAATGCAATACTTGCAACATTTGCAACTAATTTTCCCATAGGGATAAATGGA
AATTTCAACTTATTTCAAATTTTGCACATATTATGAAACCTTATTAATGTATTTTTATCAAACTAAATCAGATTTGTATTTGAATTGTTA
GGAAAAACCATGTGCAGTTTTGGCTGATAATTGAAGGAAAAATATCAAATGCTTTGAATTTTTTTTCTCTTTTTTCAAACCCTCTGCAGA
GGTAGGAAGGTATGAATTTCTTTTTTATGTCAAGATGCAAAAACAAATCATGATGCTTTTGTTGGGAGAATTTTTGTATTCAGTATTTTG
TATGTACCTTTTTTTTTTTAAATTGGAAAGCACAATTCGGTTTAACATTTAGCTTTGCTTGACTCCAGTGTAAGATGAAGATGACCTTGT
CACAGCTCCCCTGACCTGAAGCAGAGCCCTTCCCATCACTGACAGTGTTGGGGGTTGAGAGCCCCCCAGCAGAGCCCTTCCCATCACTGA
CAGTGTGTCGGCAGCTGAGAGCTCCCCCAGCAGAGCCCTTCCCATCACTGAACAGTGTTGGCGGCTGAGAGCCCCCCAGCAGAGCCCTTC
CCATCACTGACAGTGTTGGGGGCTGAGAGCCCCCCAGCAGAGCCCTTCCCATCACTGAACAGTGTTGGCGGCTGAGAGCCCCCCAGCAGA
GCCCTTCCCATCACTGACAGTGTTGGGGGCTGAGAGCCCCCCTAGCAGAGCCCTTCCCATCACTGACAGTGTCTGGGGCTGAGAGCCCCC
CCTAGCAGAGCCCTTCCCATCACTGACAGTGTTGGGGGCTGAGAGCCCCCCAGCAGAGCCCTTCCCATCACTGACAGTGTCTGGGGCTGA
GAGCCCCCCAGCAGAGCCCTTCCCATCACTGACAGTGTCTGGGGCTGAGAGCCCCCCCTAGCAGAGCCCTTCCCATCACTGACAGTGTCG
GGTTGAGAGCCACCCCCAGCAGAGCCCTTGCCACGTACAGAGATTTTCTGTCAGCAGTTTCCCAGTATTTCAGACTCATAATCTGTGTTT
AGCACTCCAGTGTTCTCTTGTAATAGCCAGGTCTGGAAACGACCCATGGAAAGAGGGGCCTTTGTATTCTGCTAGAACACAGAGCATAGT
AGTAGATCACTTTTCTGAAGAGCTTTTTAAAATACAGCTAATCAAGGAGTTTGCGATTTCTCTTACTTTCTACAGCTCAGCAGTGACTAA
TGATGTGTGACTATGCGAATGAGTTTGATGAATTCGTAAAAACTAAGCGCTTAAATGGTTATAGAAATGAAAACATGGATATTTAGAAGC
CTTTCTATATACACAGTGCAGTTGAGATGGTTTACAGCAAATTTCGTTTTATTTCTGAAAATGTTGTAAACATGTAATTAGTGAAAGATT
TTGTAAAACATTGTCCTGTATTTTTGTCTGTAAATATATTGCATAAGTTCTAAGTATAAATATGTCAGTATCATGTATGTTATTTTAAAT

>89102_89102_2_TARDBP-LRCH3_TARDBP_chr1_11073830_ENST00000315091_LRCH3_chr3_197562617_ENST00000438796_length(amino acids)=424AA_BP=13
MGKSGVCCQLSKRPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELH
QRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCA
ATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNS
RQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TARDBP-LRCH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTARDBPchr1:11073830chr3:197562617ENST00000240185+16216_4140415.0UBQLN2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TARDBP-LRCH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TARDBP-LRCH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource