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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TARDBP-XRN2 (FusionGDB2 ID:89104)

Fusion Gene Summary for TARDBP-XRN2

Fusion gene summary

Fusion gene information	Fusion gene name: TARDBP-XRN2
	Fusion gene ID: 89104
		Hgene	Tgene
	Gene symbol	TARDBP	XRN2
	Gene ID	23435	22803
	Gene name	TAR DNA binding protein	5'-3' exoribonuclease 2
	Synonyms	ALS10\|TDP-43	-
	Cytomap	1p36.22	20p11.22
	Type of gene	protein-coding	protein-coding
	Description	TAR DNA-binding protein 43TAR DNA-binding protein-43	5'-3' exoribonuclease 2DHP proteinDhm1-like protein
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000240185, ENST00000439080, ENST00000315091, ENST00000480464,	ENST00000377191, ENST00000430571, ENST00000539513,
Fusion gene scores	* DoF score	8 X 8 X 4=256	12 X 12 X 5=720
	# samples	8	12
	** MAII score	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TARDBP [Title/Abstract] AND XRN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TARDBP(11082553)-XRN2(21314397), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TARDBP	GO:0008380	RNA splicing	11285240
Hgene	TARDBP	GO:0043922	negative regulation by host of viral transcription	7745706
Hgene	TARDBP	GO:0061158	3'-UTR-mediated mRNA destabilization	28335005
Hgene	TARDBP	GO:0070935	3'-UTR-mediated mRNA stabilization	17481916
Tgene	XRN2	GO:0000738	DNA catabolic process, exonucleolytic	15565158

Fusion gene breakpoints across TARDBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across XRN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF356570	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+

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Fusion Gene ORF analysis for TARDBP-XRN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000240185	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000240185	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000240185	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000439080	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000439080	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000439080	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000315091	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000315091	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000315091	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000480464	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000480464	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000480464	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000240185	TARDBP	chr1	11082553	+	ENST00000377191	XRN2	chr20	21314397	+	4726	2375	2289	4238	649
ENST00000240185	TARDBP	chr1	11082553	+	ENST00000430571	XRN2	chr20	21314397	+	4526	2375	2289	4238	649
ENST00000240185	TARDBP	chr1	11082553	+	ENST00000539513	XRN2	chr20	21314397	+	4726	2375	2289	4238	649
ENST00000439080	TARDBP	chr1	11082553	+	ENST00000377191	XRN2	chr20	21314397	+	3335	984	970	2847	625
ENST00000439080	TARDBP	chr1	11082553	+	ENST00000430571	XRN2	chr20	21314397	+	3135	984	970	2847	625
ENST00000439080	TARDBP	chr1	11082553	+	ENST00000539513	XRN2	chr20	21314397	+	3335	984	970	2847	625

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000240185	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+	0.00025433	0.99974567
ENST00000240185	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+	0.000249087	0.9997509
ENST00000240185	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+	0.00025433	0.99974567
ENST00000439080	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+	0.000389389	0.9996106
ENST00000439080	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+	0.000399548	0.99960047
ENST00000439080	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+	0.000389389	0.9996106

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Fusion Genomic Features for TARDBP-XRN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TARDBP-XRN2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:11082553/chr20:21314397)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

XRN2

chr1:11082553

chr20:21314397

ENST00000377191

262_278

951.0

Zinc finger

Note=CCHC-type

Tgene

XRN2

chr1:11082553

chr20:21314397

ENST00000430571

262_278

875.0

Zinc finger

Note=CCHC-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TARDBP

chr1:11082553

chr20:21314397

ENST00000240185

274_413

415.0

Compositional bias

Note=Gly-rich

Hgene

TARDBP

chr1:11082553

chr20:21314397

ENST00000240185

104_200

415.0

Domain

RRM 1

Hgene

TARDBP

chr1:11082553

chr20:21314397

ENST00000240185

191_262

415.0

Domain

RRM 2

Hgene

TARDBP

chr1:11082553

chr20:21314397

ENST00000240185

239_250

415.0

Motif

Nuclear export signal

Hgene

TARDBP

chr1:11082553

chr20:21314397

ENST00000240185

82_98

415.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for TARDBP-XRN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89104_89104_1_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000240185_XRN2_chr20_21314397_ENST00000377191_length(transcript)=4726nt_BP=2375nt
GGCCCTAGCGCCATTTTGTGGGAGCGAAGCGGTGGCTGGGCTGCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCA
GCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGAC
GATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGA
GGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGATAACAAA
AGAAAAATGGATGAGACAGATGCTTCATCAGCAGTGAAAGTGAAAAGAGCAGTCCAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCA
TGGAAAACAACCGAACAGGACCTGAAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGGTGCAGGTCAAGAAAGATCTTAAGACTGGT
CATTCAAAGGGGTTTGGCTTTGTTCGTTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGG
TGTGACTGCAAACTTCCTAATTCTAAGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATG
ACTGAGGATGAGCTGCGGGAGTTCTTCTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTT
ACATTTGCAGATGATCAGCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGAT
CAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAG
TGGGGTTGTGGTTGGTTGGTATAGAATGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGA
ATTTTCAAAATTGGTTTGTTCAGTGTGGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTA
TAAGTTTTGTTACATGAAAGGTTGAAATATTGAGTGGTTGAAAGTGAACTGCTGTTTGCCTGATTGGTAAACCAACACACTACAATTGAT
ATCAAAAGGTTTCTCCTGTAATATTTTATCCCTGGACTTGTCAAGTGAATTCTTTGCATGTTCAAAACGGAAACCATTGATTAGAACTAC
ATTCTTTACCCCTTGTTTTAATTTGAACCCCACCATATGGATTTTTTTCCTTAAGAAAATCTCCTTTTAGGAGATCATGGTGTCACAGTG
TTTGGTTCTTTTGTTTTGTTTTTTAACACTTGTCTCCCCTCATACACAAAAGTACAATATGAAGCCTTCATTTAATCTCTGCAGTTCATC
TCATTTCAAATGTTTATGGAAGAAGCACTTCATTGAAAGTAGTGCTGTAAATATTCTGCCATAGGAATACTGTCTACATGCTTTCTCATT
CAAGAATTCGTCATCACGCATCACAGGCCGCGTCTTTGACGGTGGGTGTCCCATTTTTATCCGCTACTCTTTATTTCATGGAGTCGTATC
AACGCTATGAACGCAAGGCTGTGATATGGAACCAGAAGGCTGTCTGAACTTTTGAAACCTTGTGTGGGATTGATGGTGGTGCCGAGGCAT
GAAAGGCTAGTATGAGCGAGAAAAGGAGAGAGCGCGTGCAGAGACTTGGTGGTGCATAATGGATATTTTTTAACTTGGCGAGATGTGTCT
CTCAATCCTGTGGCTTTGGTGAGAGAGTGTGCAGAGAGCAATGATAGCAAATAATGTACGAATGTTTTTTGCATTCAAAGGACATCCACA
TCTGTTGGAAGACTTTTAAGTGAGTTTTTGTTCTTAGATAACCCACATTAGATGAATGTGTTAAGTGAAATGATACTTGTACTCCCCCTA
CCCCTTTGTCAACTGCTGTGAATGCTGTATGGTGTGTGTTCTCTTCTGTTACTGATATGTAAGTGTGGCAATGTGAACTGAAGCTGATGG
GCTGAGAACATGGACTGAGCTTGTGGTGTGCTTTGCAGGAGGACTTGAAGCAGAGTTCACCAGTGAGCTCAGGTGTCTCAAAGAAGGGTG
GAAGTTCTAATGTCTGTTAGCTACCCATAAGAATGCTGTTTGCTGCAGTTCTGTGTCCTGTGCTTGGATGCTTTTTATAAGAGTTGTCAT
TGTTGGAAATTCTTAAATAAAACTGATTTAAATAAGAGCATTGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCT
CATTTGCCATCGTTAGAGATTAGGGAAAATGCAATTGACCGTTTGGTTAACATATACAAAAATGTGGTACACAAAACTGGGGGTTACCTT
ACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGATCATGTTAGCAGTTGGTGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAG
GATGATGAGGACAGTTTTAGAAGACGACAGAAAGAAAAAAGAAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTA
ACTCCTCATGCCTTGGGTTCAAGAAATTCACCAGGTTCTCAAGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCAGAAT
AACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATCTGATGGCTCCCCGTCTCCATTAGGAGGAATTAAGCGAAAAGCAGAAGAC
AGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATGGGAAGCTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGAT
GCAGCTGATGAGAAATTCCGTCGGAAAGTTGTGCAGTCGTACGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCT
TCCTGGAAGTGGTATTATCCATTTCATTATGCACCATTTGCTTCAGACTTTGAAGGCATTGCAGACATGCCATCTGATTTTGAGAAGGGT
ACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATTTCCAGCTGCAAGTGGTAATTTTCTACCTCCATCATGGCGGAAGCTCATG
AGTGATCCTGATTCTAGTATAATTGACTTCTATCCTGAAGATTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCT
CTCTTGCCATTCGTGGATGAGCGAAGGCTACGAGCTGCCCTAGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAACAGC
CTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACTCCATGACTTCATTTTAGAGCTGTACCAGACAGGTTCCACAGAGCCAGTG
GAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTTTTCTTTGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCT
GTTCCTATGTTAAGGGATCTGACACAGAACACTGTAGTCAGTATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCT
GTAATGCTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAAACCTAGTGACTGGGAAAAATCCAGCAATGGACGGCAGTGGAAGCCTCAG
CTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCAGGCAGCCTTCAGGACTTTGGGCCATGTGATGCCAAGAGGCTCAGGAACT
GGCATTTACAGCAATGCTGCACCACCACCTGTGACTTACCAGGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAA
CTTATGTCAAATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAA
CCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTTCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTAT
CCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAGAAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAAT
TGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCTACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTA
GTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGTATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAA
GATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTATAAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGT
TAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGATCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTT
TGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAGTATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAA

>89104_89104_1_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000240185_XRN2_chr20_21314397_ENST00000377191_length(amino acids)=649AA_BP=29
MLQFCVLCLDAFYKSCHCWKFLNKTDLNKSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQM
IMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFT
SDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPF
ASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAA
LEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVV
SINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTY
QGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGY

--------------------------------------------------------------
>89104_89104_2_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000240185_XRN2_chr20_21314397_ENST00000430571_length(transcript)=4526nt_BP=2375nt
GGCCCTAGCGCCATTTTGTGGGAGCGAAGCGGTGGCTGGGCTGCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCA
GCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGAC
GATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGA
GGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGATAACAAA
AGAAAAATGGATGAGACAGATGCTTCATCAGCAGTGAAAGTGAAAAGAGCAGTCCAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCA
TGGAAAACAACCGAACAGGACCTGAAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGGTGCAGGTCAAGAAAGATCTTAAGACTGGT
CATTCAAAGGGGTTTGGCTTTGTTCGTTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGG
TGTGACTGCAAACTTCCTAATTCTAAGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATG
ACTGAGGATGAGCTGCGGGAGTTCTTCTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTT
ACATTTGCAGATGATCAGCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGAT
CAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAG
TGGGGTTGTGGTTGGTTGGTATAGAATGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGA
ATTTTCAAAATTGGTTTGTTCAGTGTGGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTA
TAAGTTTTGTTACATGAAAGGTTGAAATATTGAGTGGTTGAAAGTGAACTGCTGTTTGCCTGATTGGTAAACCAACACACTACAATTGAT
ATCAAAAGGTTTCTCCTGTAATATTTTATCCCTGGACTTGTCAAGTGAATTCTTTGCATGTTCAAAACGGAAACCATTGATTAGAACTAC
ATTCTTTACCCCTTGTTTTAATTTGAACCCCACCATATGGATTTTTTTCCTTAAGAAAATCTCCTTTTAGGAGATCATGGTGTCACAGTG
TTTGGTTCTTTTGTTTTGTTTTTTAACACTTGTCTCCCCTCATACACAAAAGTACAATATGAAGCCTTCATTTAATCTCTGCAGTTCATC
TCATTTCAAATGTTTATGGAAGAAGCACTTCATTGAAAGTAGTGCTGTAAATATTCTGCCATAGGAATACTGTCTACATGCTTTCTCATT
CAAGAATTCGTCATCACGCATCACAGGCCGCGTCTTTGACGGTGGGTGTCCCATTTTTATCCGCTACTCTTTATTTCATGGAGTCGTATC
AACGCTATGAACGCAAGGCTGTGATATGGAACCAGAAGGCTGTCTGAACTTTTGAAACCTTGTGTGGGATTGATGGTGGTGCCGAGGCAT
GAAAGGCTAGTATGAGCGAGAAAAGGAGAGAGCGCGTGCAGAGACTTGGTGGTGCATAATGGATATTTTTTAACTTGGCGAGATGTGTCT
CTCAATCCTGTGGCTTTGGTGAGAGAGTGTGCAGAGAGCAATGATAGCAAATAATGTACGAATGTTTTTTGCATTCAAAGGACATCCACA
TCTGTTGGAAGACTTTTAAGTGAGTTTTTGTTCTTAGATAACCCACATTAGATGAATGTGTTAAGTGAAATGATACTTGTACTCCCCCTA
CCCCTTTGTCAACTGCTGTGAATGCTGTATGGTGTGTGTTCTCTTCTGTTACTGATATGTAAGTGTGGCAATGTGAACTGAAGCTGATGG
GCTGAGAACATGGACTGAGCTTGTGGTGTGCTTTGCAGGAGGACTTGAAGCAGAGTTCACCAGTGAGCTCAGGTGTCTCAAAGAAGGGTG
GAAGTTCTAATGTCTGTTAGCTACCCATAAGAATGCTGTTTGCTGCAGTTCTGTGTCCTGTGCTTGGATGCTTTTTATAAGAGTTGTCAT
TGTTGGAAATTCTTAAATAAAACTGATTTAAATAAGAGCATTGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCT
CATTTGCCATCGTTAGAGATTAGGGAAAATGCAATTGACCGTTTGGTTAACATATACAAAAATGTGGTACACAAAACTGGGGGTTACCTT
ACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGATCATGTTAGCAGTTGGTGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAG
GATGATGAGGACAGTTTTAGAAGACGACAGAAAGAAAAAAGAAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTA
ACTCCTCATGCCTTGGGTTCAAGAAATTCACCAGGTTCTCAAGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCAGAAT
AACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATCTGATGGCTCCCCGTCTCCATTAGGAGGAATTAAGCGAAAAGCAGAAGAC
AGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATGGGAAGCTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGAT
GCAGCTGATGAGAAATTCCGTCGGAAAGTTGTGCAGTCGTACGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCT
TCCTGGAAGTGGTATTATCCATTTCATTATGCACCATTTGCTTCAGACTTTGAAGGCATTGCAGACATGCCATCTGATTTTGAGAAGGGT
ACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATTTCCAGCTGCAAGTGGTAATTTTCTACCTCCATCATGGCGGAAGCTCATG
AGTGATCCTGATTCTAGTATAATTGACTTCTATCCTGAAGATTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCT
CTCTTGCCATTCGTGGATGAGCGAAGGCTACGAGCTGCCCTAGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAACAGC
CTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACTCCATGACTTCATTTTAGAGCTGTACCAGACAGGTTCCACAGAGCCAGTG
GAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTTTTCTTTGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCT
GTTCCTATGTTAAGGGATCTGACACAGAACACTGTAGTCAGTATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCT
GTAATGCTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAAACCTAGTGACTGGGAAAAATCCAGCAATGGACGGCAGTGGAAGCCTCAG
CTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCAGGCAGCCTTCAGGACTTTGGGCCATGTGATGCCAAGAGGCTCAGGAACT
GGCATTTACAGCAATGCTGCACCACCACCTGTGACTTACCAGGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAA
CTTATGTCAAATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAA
CCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTTCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTAT
CCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAGAAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAAT
TGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCTACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTA
GTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGTATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAA
GATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTATAAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGT

>89104_89104_2_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000240185_XRN2_chr20_21314397_ENST00000430571_length(amino acids)=649AA_BP=29
MLQFCVLCLDAFYKSCHCWKFLNKTDLNKSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQM
IMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFT
SDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPF
ASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAA
LEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVV
SINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTY
QGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGY

--------------------------------------------------------------
>89104_89104_3_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000240185_XRN2_chr20_21314397_ENST00000539513_length(transcript)=4726nt_BP=2375nt
GGCCCTAGCGCCATTTTGTGGGAGCGAAGCGGTGGCTGGGCTGCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCA
GCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGAC
GATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGA
GGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGATAACAAA
AGAAAAATGGATGAGACAGATGCTTCATCAGCAGTGAAAGTGAAAAGAGCAGTCCAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCA
TGGAAAACAACCGAACAGGACCTGAAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGGTGCAGGTCAAGAAAGATCTTAAGACTGGT
CATTCAAAGGGGTTTGGCTTTGTTCGTTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGG
TGTGACTGCAAACTTCCTAATTCTAAGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATG
ACTGAGGATGAGCTGCGGGAGTTCTTCTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTT
ACATTTGCAGATGATCAGCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGAT
CAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAG
TGGGGTTGTGGTTGGTTGGTATAGAATGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGA
ATTTTCAAAATTGGTTTGTTCAGTGTGGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTA
TAAGTTTTGTTACATGAAAGGTTGAAATATTGAGTGGTTGAAAGTGAACTGCTGTTTGCCTGATTGGTAAACCAACACACTACAATTGAT
ATCAAAAGGTTTCTCCTGTAATATTTTATCCCTGGACTTGTCAAGTGAATTCTTTGCATGTTCAAAACGGAAACCATTGATTAGAACTAC
ATTCTTTACCCCTTGTTTTAATTTGAACCCCACCATATGGATTTTTTTCCTTAAGAAAATCTCCTTTTAGGAGATCATGGTGTCACAGTG
TTTGGTTCTTTTGTTTTGTTTTTTAACACTTGTCTCCCCTCATACACAAAAGTACAATATGAAGCCTTCATTTAATCTCTGCAGTTCATC
TCATTTCAAATGTTTATGGAAGAAGCACTTCATTGAAAGTAGTGCTGTAAATATTCTGCCATAGGAATACTGTCTACATGCTTTCTCATT
CAAGAATTCGTCATCACGCATCACAGGCCGCGTCTTTGACGGTGGGTGTCCCATTTTTATCCGCTACTCTTTATTTCATGGAGTCGTATC
AACGCTATGAACGCAAGGCTGTGATATGGAACCAGAAGGCTGTCTGAACTTTTGAAACCTTGTGTGGGATTGATGGTGGTGCCGAGGCAT
GAAAGGCTAGTATGAGCGAGAAAAGGAGAGAGCGCGTGCAGAGACTTGGTGGTGCATAATGGATATTTTTTAACTTGGCGAGATGTGTCT
CTCAATCCTGTGGCTTTGGTGAGAGAGTGTGCAGAGAGCAATGATAGCAAATAATGTACGAATGTTTTTTGCATTCAAAGGACATCCACA
TCTGTTGGAAGACTTTTAAGTGAGTTTTTGTTCTTAGATAACCCACATTAGATGAATGTGTTAAGTGAAATGATACTTGTACTCCCCCTA
CCCCTTTGTCAACTGCTGTGAATGCTGTATGGTGTGTGTTCTCTTCTGTTACTGATATGTAAGTGTGGCAATGTGAACTGAAGCTGATGG
GCTGAGAACATGGACTGAGCTTGTGGTGTGCTTTGCAGGAGGACTTGAAGCAGAGTTCACCAGTGAGCTCAGGTGTCTCAAAGAAGGGTG
GAAGTTCTAATGTCTGTTAGCTACCCATAAGAATGCTGTTTGCTGCAGTTCTGTGTCCTGTGCTTGGATGCTTTTTATAAGAGTTGTCAT
TGTTGGAAATTCTTAAATAAAACTGATTTAAATAAGAGCATTGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCT
CATTTGCCATCGTTAGAGATTAGGGAAAATGCAATTGACCGTTTGGTTAACATATACAAAAATGTGGTACACAAAACTGGGGGTTACCTT
ACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGATCATGTTAGCAGTTGGTGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAG
GATGATGAGGACAGTTTTAGAAGACGACAGAAAGAAAAAAGAAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTA
ACTCCTCATGCCTTGGGTTCAAGAAATTCACCAGGTTCTCAAGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCAGAAT
AACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATCTGATGGCTCCCCGTCTCCATTAGGAGGAATTAAGCGAAAAGCAGAAGAC
AGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATGGGAAGCTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGAT
GCAGCTGATGAGAAATTCCGTCGGAAAGTTGTGCAGTCGTACGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCT
TCCTGGAAGTGGTATTATCCATTTCATTATGCACCATTTGCTTCAGACTTTGAAGGCATTGCAGACATGCCATCTGATTTTGAGAAGGGT
ACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATTTCCAGCTGCAAGTGGTAATTTTCTACCTCCATCATGGCGGAAGCTCATG
AGTGATCCTGATTCTAGTATAATTGACTTCTATCCTGAAGATTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCT
CTCTTGCCATTCGTGGATGAGCGAAGGCTACGAGCTGCCCTAGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAACAGC
CTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACTCCATGACTTCATTTTAGAGCTGTACCAGACAGGTTCCACAGAGCCAGTG
GAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTTTTCTTTGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCT
GTTCCTATGTTAAGGGATCTGACACAGAACACTGTAGTCAGTATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCT
GTAATGCTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAAACCTAGTGACTGGGAAAAATCCAGCAATGGACGGCAGTGGAAGCCTCAG
CTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCAGGCAGCCTTCAGGACTTTGGGCCATGTGATGCCAAGAGGCTCAGGAACT
GGCATTTACAGCAATGCTGCACCACCACCTGTGACTTACCAGGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAA
CTTATGTCAAATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAA
CCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTTCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTAT
CCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAGAAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAAT
TGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCTACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTA
GTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGTATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAA
GATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTATAAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGT
TAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGATCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTT
TGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAGTATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAA

>89104_89104_3_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000240185_XRN2_chr20_21314397_ENST00000539513_length(amino acids)=649AA_BP=29
MLQFCVLCLDAFYKSCHCWKFLNKTDLNKSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQM
IMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFT
SDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPF
ASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAA
LEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVV
SINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTY
QGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGY

--------------------------------------------------------------
>89104_89104_4_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000439080_XRN2_chr20_21314397_ENST00000377191_length(transcript)=3335nt_BP=984nt
GCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCAGCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGG
GTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCA
GGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCT
GGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGGTCAAGAAAGATCTTAAGACTGGTCATTCAAAGGGGTTTGGCTTTGTTCG
TTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGGTGTGACTGCAAACTTCCTAATTCTAA
GCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATGACTGAGGATGAGCTGCGGGAGTTCTT
CTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTACATTTGCAGATGATCAGCAAACCAG
GCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGT
GGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAGTGGGGTTGTGGTTGGTTGGTATAGAA
TGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGAATTTTCAAAATTGGTTTGTTCAGTGT
GGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTATAAGTTTTGTTACATGAAAGGAGCAT
TGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCTCATTTGCCATCGTTAGAGATTAGGGAAAATGCAATTGACCG
TTTGGTTAACATATACAAAAATGTGGTACACAAAACTGGGGGTTACCTTACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGAT
CATGTTAGCAGTTGGTGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAGGATGATGAGGACAGTTTTAGAAGACGACAGAAAGAAAAAAG
AAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTAACTCCTCATGCCTTGGGTTCAAGAAATTCACCAGGTTCTCA
AGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCAGAATAACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATC
TGATGGCTCCCCGTCTCCATTAGGAGGAATTAAGCGAAAAGCAGAAGACAGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATG
GGAAGCTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGATGCAGCTGATGAGAAATTCCGTCGGAAAGTTGTGCAGTCGTA
CGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCTTCCTGGAAGTGGTATTATCCATTTCATTATGCACCATTTGC
TTCAGACTTTGAAGGCATTGCAGACATGCCATCTGATTTTGAGAAGGGTACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATT
TCCAGCTGCAAGTGGTAATTTTCTACCTCCATCATGGCGGAAGCTCATGAGTGATCCTGATTCTAGTATAATTGACTTCTATCCTGAAGA
TTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCTCTCTTGCCATTCGTGGATGAGCGAAGGCTACGAGCTGCCCT
AGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAACAGCCTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACT
CCATGACTTCATTTTAGAGCTGTACCAGACAGGTTCCACAGAGCCAGTGGAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTT
TTCTTTGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCTGTTCCTATGTTAAGGGATCTGACACAGAACACTGTAGTCAG
TATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCTGTAATGCTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAA
ACCTAGTGACTGGGAAAAATCCAGCAATGGACGGCAGTGGAAGCCTCAGCTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCA
GGCAGCCTTCAGGACTTTGGGCCATGTGATGCCAAGAGGCTCAGGAACTGGCATTTACAGCAATGCTGCACCACCACCTGTGACTTACCA
GGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAACTTATGTCAAATATGAGGCCCCAGGATTCCTGGCGAGGTCC
TCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGC
AGCCTTCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCC
CAGAGAAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATC
ATTCTACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAAC
TGTGTATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTG
CTTATAAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATT
CTAGATCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTG
TTCAGTATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAATTTCTGAACTTTAGTAAAAAAAAATAAAGTTAAACTTTTAA

>89104_89104_4_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000439080_XRN2_chr20_21314397_ENST00000377191_length(amino acids)=625AA_BP=3
MLHERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFR
RRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEP
EDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPL
EQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLF
VGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGAR
KPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRP

--------------------------------------------------------------
>89104_89104_5_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000439080_XRN2_chr20_21314397_ENST00000430571_length(transcript)=3135nt_BP=984nt
GCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCAGCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGG
GTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCA
GGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCT
GGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGGTCAAGAAAGATCTTAAGACTGGTCATTCAAAGGGGTTTGGCTTTGTTCG
TTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGGTGTGACTGCAAACTTCCTAATTCTAA
GCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATGACTGAGGATGAGCTGCGGGAGTTCTT
CTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTACATTTGCAGATGATCAGCAAACCAG
GCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGT
GGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAGTGGGGTTGTGGTTGGTTGGTATAGAA
TGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGAATTTTCAAAATTGGTTTGTTCAGTGT
GGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTATAAGTTTTGTTACATGAAAGGAGCAT
TGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCTCATTTGCCATCGTTAGAGATTAGGGAAAATGCAATTGACCG
TTTGGTTAACATATACAAAAATGTGGTACACAAAACTGGGGGTTACCTTACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGAT
CATGTTAGCAGTTGGTGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAGGATGATGAGGACAGTTTTAGAAGACGACAGAAAGAAAAAAG
AAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTAACTCCTCATGCCTTGGGTTCAAGAAATTCACCAGGTTCTCA
AGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCAGAATAACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATC
TGATGGCTCCCCGTCTCCATTAGGAGGAATTAAGCGAAAAGCAGAAGACAGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATG
GGAAGCTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGATGCAGCTGATGAGAAATTCCGTCGGAAAGTTGTGCAGTCGTA
CGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCTTCCTGGAAGTGGTATTATCCATTTCATTATGCACCATTTGC
TTCAGACTTTGAAGGCATTGCAGACATGCCATCTGATTTTGAGAAGGGTACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATT
TCCAGCTGCAAGTGGTAATTTTCTACCTCCATCATGGCGGAAGCTCATGAGTGATCCTGATTCTAGTATAATTGACTTCTATCCTGAAGA
TTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCTCTCTTGCCATTCGTGGATGAGCGAAGGCTACGAGCTGCCCT
AGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAACAGCCTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACT
CCATGACTTCATTTTAGAGCTGTACCAGACAGGTTCCACAGAGCCAGTGGAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTT
TTCTTTGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCTGTTCCTATGTTAAGGGATCTGACACAGAACACTGTAGTCAG
TATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCTGTAATGCTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAA
ACCTAGTGACTGGGAAAAATCCAGCAATGGACGGCAGTGGAAGCCTCAGCTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCA
GGCAGCCTTCAGGACTTTGGGCCATGTGATGCCAAGAGGCTCAGGAACTGGCATTTACAGCAATGCTGCACCACCACCTGTGACTTACCA
GGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAACTTATGTCAAATATGAGGCCCCAGGATTCCTGGCGAGGTCC
TCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGC
AGCCTTCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCC
CAGAGAAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATC
ATTCTACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAAC
TGTGTATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTG

>89104_89104_5_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000439080_XRN2_chr20_21314397_ENST00000430571_length(amino acids)=625AA_BP=3
MLHERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFR
RRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEP
EDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPL
EQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLF
VGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGAR
KPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRP

--------------------------------------------------------------
>89104_89104_6_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000439080_XRN2_chr20_21314397_ENST00000539513_length(transcript)=3335nt_BP=984nt
GCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCAGCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGG
GTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCA
GGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCT
GGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGGTCAAGAAAGATCTTAAGACTGGTCATTCAAAGGGGTTTGGCTTTGTTCG
TTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGGTGTGACTGCAAACTTCCTAATTCTAA
GCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATGACTGAGGATGAGCTGCGGGAGTTCTT
CTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTACATTTGCAGATGATCAGCAAACCAG
GCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGT
GGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAGTGGGGTTGTGGTTGGTTGGTATAGAA
TGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGAATTTTCAAAATTGGTTTGTTCAGTGT
GGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTATAAGTTTTGTTACATGAAAGGAGCAT
TGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCTCATTTGCCATCGTTAGAGATTAGGGAAAATGCAATTGACCG
TTTGGTTAACATATACAAAAATGTGGTACACAAAACTGGGGGTTACCTTACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGAT
CATGTTAGCAGTTGGTGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAGGATGATGAGGACAGTTTTAGAAGACGACAGAAAGAAAAAAG
AAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTAACTCCTCATGCCTTGGGTTCAAGAAATTCACCAGGTTCTCA
AGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCAGAATAACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATC
TGATGGCTCCCCGTCTCCATTAGGAGGAATTAAGCGAAAAGCAGAAGACAGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATG
GGAAGCTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGATGCAGCTGATGAGAAATTCCGTCGGAAAGTTGTGCAGTCGTA
CGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCTTCCTGGAAGTGGTATTATCCATTTCATTATGCACCATTTGC
TTCAGACTTTGAAGGCATTGCAGACATGCCATCTGATTTTGAGAAGGGTACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATT
TCCAGCTGCAAGTGGTAATTTTCTACCTCCATCATGGCGGAAGCTCATGAGTGATCCTGATTCTAGTATAATTGACTTCTATCCTGAAGA
TTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCTCTCTTGCCATTCGTGGATGAGCGAAGGCTACGAGCTGCCCT
AGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAACAGCCTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACT
CCATGACTTCATTTTAGAGCTGTACCAGACAGGTTCCACAGAGCCAGTGGAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTT
TTCTTTGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCTGTTCCTATGTTAAGGGATCTGACACAGAACACTGTAGTCAG
TATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCTGTAATGCTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAA
ACCTAGTGACTGGGAAAAATCCAGCAATGGACGGCAGTGGAAGCCTCAGCTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCA
GGCAGCCTTCAGGACTTTGGGCCATGTGATGCCAAGAGGCTCAGGAACTGGCATTTACAGCAATGCTGCACCACCACCTGTGACTTACCA
GGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAACTTATGTCAAATATGAGGCCCCAGGATTCCTGGCGAGGTCC
TCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGC
AGCCTTCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCC
CAGAGAAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATC
ATTCTACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAAC
TGTGTATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTG
CTTATAAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATT
CTAGATCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTG
TTCAGTATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAATTTCTGAACTTTAGTAAAAAAAAATAAAGTTAAACTTTTAA

>89104_89104_6_TARDBP-XRN2_TARDBP_chr1_11082553_ENST00000439080_XRN2_chr20_21314397_ENST00000539513_length(amino acids)=625AA_BP=3
MLHERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFR
RRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEP
EDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPL
EQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLF
VGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGAR
KPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TARDBP-XRN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TARDBP	chr1:11082553	chr20:21314397	ENST00000240185	+	1	6	216_414	0	415.0	UBQLN2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TARDBP-XRN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TARDBP-XRN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source