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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TATDN1-TAF2 (FusionGDB2 ID:89155)

Fusion Gene Summary for TATDN1-TAF2

Fusion gene summary

Fusion gene information	Fusion gene name: TATDN1-TAF2
	Fusion gene ID: 89155
		Hgene	Tgene
	Gene symbol	TATDN1	TAF2
	Gene ID	83940	6873
	Gene name	TatD DNase domain containing 1	TATA-box binding protein associated factor 2
	Synonyms	CDA11	CIF150\|MRT40\|TAF2B\|TAFII150
	Cytomap	8q24.13	8q24.12
	Type of gene	protein-coding	protein-coding
	Description	putative deoxyribonuclease TATDN1hepatocarcinoma high expression protein	transcription initiation factor TFIID subunit 2150 kDa cofactor of initiator functionRNA polymerase II TBP-associated factor subunit BTAF(II)150TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDaTATA box binding protein (
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000276692, ENST00000605953, ENST00000519548, ENST00000517678, ENST00000521546,	ENST00000519355, ENST00000378164,
Fusion gene scores	* DoF score	9 X 5 X 6=270	5 X 6 X 3=90
	# samples	9	6
	** MAII score	log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TATDN1 [Title/Abstract] AND TAF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TATDN1(125551265)-TAF2(120831746), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TAF2	GO:0006367	transcription initiation from RNA polymerase II promoter	9418870

Fusion gene breakpoints across TATDN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TAF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-DJ-A2Q9	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-

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Fusion Gene ORF analysis for TATDN1-TAF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000276692	ENST00000519355	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
5CDS-intron	ENST00000605953	ENST00000519355	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
5UTR-3CDS	ENST00000519548	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
5UTR-intron	ENST00000519548	ENST00000519355	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
In-frame	ENST00000276692	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
In-frame	ENST00000605953	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
intron-3CDS	ENST00000517678	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
intron-3CDS	ENST00000521546	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
intron-intron	ENST00000517678	ENST00000519355	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-
intron-intron	ENST00000521546	ENST00000519355	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000276692	TATDN1	chr8	125551265	-	ENST00000378164	TAF2	chr8	120831746	-	4671	60	72	3521	1149
ENST00000605953	TATDN1	chr8	125551265	-	ENST00000378164	TAF2	chr8	120831746	-	4669	58	70	3519	1149

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000276692	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-	0.000142457	0.99985754
ENST00000605953	ENST00000378164	TATDN1	chr8	125551265	-	TAF2	chr8	120831746	-	0.000141796	0.99985814

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Fusion Genomic Features for TATDN1-TAF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TATDN1-TAF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:125551265/chr8:120831746)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TAF2

chr8:125551265

chr8:120831746

ENST00000378164

1143_1171

1200.0

Compositional bias

Note=His-rich

Tgene

TAF2

chr8:125551265

chr8:120831746

ENST00000378164

1155_1178

1200.0

Compositional bias

Note=Lys-rich

Tgene

TAF2

chr8:125551265

chr8:120831746

ENST00000378164

600_603

1200.0

Compositional bias

Note=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TATDN1-TAF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89155_89155_1_TATDN1-TAF2_TATDN1_chr8_125551265_ENST00000276692_TAF2_chr8_120831746_ENST00000378164_length(transcript)=4671nt_BP=60nt
ACTTCCGCTTCCGCTGGGGAGGTCCTCCATGCGCAGTCATGAGTCGCTTCAAGTTTATCGGGATTTGTGGAACTGACTATATTTCCCACA
GTTGCAAACTTGAATAGAATCAAGTTGAACAGCAAACAGTGTAGAATATACCGAGTAAGGATCAATGATTTAGAGGCTGCTTTTATTTAT
AATGACCCAACCTTGGAAGTTTGTCACAGTGAATCAAAACAGAGAAACCTCAATTATTTTTCCAATGCTTATGCAGCTGCAGTTAGTGCT
GTGGACCCTGATGCAGGAAATGGAGAACTTTGCATTAAGGTTCCATCAGAGCTATGGAAACACGTTGATGAGTTAAAGGTCCTGAAGATA
CACATCAATTTTTCTTTGGATCAGCCCAAAGGAGGTCTTCATTTTGTGGTACCCAGTGTAGAGGGAAGTATGGCAGAGAGAGGTGCTCAT
GTTTTCTCTTGTGGGTATCAAAATTCTACAAGATTTTGGTTCCCTTGTGTTGATTCATACTCTGAATTGTGTACATGGAAATTAGAATTT
ACAGTAGATGCTGCAATGGTTGCTGTTTCTAATGGCGATTTGGTGGAGACAGTGTATACTCATGATATGAGGAAGAAAACTTTCCATTAT
ATGCTTACCATTCCTACAGCAGCGTCAAATATCTCCTTGGCCATTGGACCATTTGAAATACTGGTAGATCCATACATGCATGAGGTTACT
CATTTTTGTTTGCCCCAACTTCTTCCATTGCTGAAACATACCACATCATACCTTCATGAAGTCTTTGAATTTTATGAAGAAATTCTTACA
TGTCGTTACCCATACTCCTGTTTTAAGACTGTCTTCATTGATGAGGCTTATGTTGAAGTGGCTGCTTATGCTTCCATGAGCATTTTTAGC
ACAAATCTTTTACACAGTGCCATGATTATAGATGAGACACCTTTGACTAGAAGGTGTTTAGCCCAATCCTTGGCCCAGCAGTTTTTTGGT
TGTTTCATATCTAGAATGTCTTGGTCTGATGAATGGGTGCTGAAGGGAATTTCAGGCTATATCTATGGACTTTGGATGAAAAAAACTTTT
GGTGTTAATGAGTACCGCCATTGGATTAAAGAGGAGCTAGACAAAATAGTGGCATATGAACTAAAAACTGGTGGGGTTTTACTACATCCC
ATATTTGGTGGAGGAAAAGAGAAGGATAATCCGGCTTCCCATCTACACTTTTCAATAAAGCATCCACATACACTGTCCTGGGAATACTAC
AGTATGTTTCAGTGTAAAGCCCACCTTGTGATGAGATTGATTGAAAATAGGATCAGTATGGAATTTATGCTACAAGTTTTCAATAAACTG
CTAAGTCTGGCTAGTACTGCTTCATCTCAGAAGTTCCAGTCACATATGTGGAGTCAGATGTTGGTTTCCACATCTGGGTTTTTGAAATCC
ATTTCAAATGTCTCTGGCAAAGATATTCAGCCGTTAATAAAGCAGTGGGTAGATCAGAGTGGAGTGGTAAAATTTTATGGAAGTTTTGCA
TTTAATAGAAAACGAAATGTCTTGGAACTGGAAATAAAACAGGACTATACATCTCCTGGAACTCAGAAATACGTGGGACCACTTAAAGTG
ACAGTGCAGGAGTTAGATGGATCCTTCAATCATACACTGCAAATTGAAGAAAACAGCCTTAAACATGATATACCCTGCCATTCCAAAAGT
AGAAGGAATAAAAAGAAAAAAATCCCACTGATGAATGGAGAAGAAGTTGATATGGATCTTTCTGCAATGGATGCTGATTCCCCTTTGCTG
TGGATAAGGATAGACCCAGATATGTCAGTATTGAGGAAGGTAGAATTTGAGCAAGCTGATTTTATGTGGCAGTATCAGCTCCGCTATGAG
AGAGATGTTGTTGCACAGCAGGAATCCATTTTGGCTTTGGAAAAATTCCCTACTCCAGCATCTCGGCTTGCACTCACTGATATATTAGAA
CAAGAGCAGTGTTTCTACAGAGTAAGAATGTCAGCTTGCTTCTGTCTTGCAAAGATTGCAAATTCAATGGTGAGCACATGGACAGGACCA
CCAGCCATGAAGTCACTCTTCACTAGGATGTTTTGTTGTAAAAGTTGTCCAAACATTGTGAAAACAAACAACTTTATGAGCTTTCAAAGC
TATTTTCTACAGAAGACTATGCCAGTTGCAATGGCTTTATTAAGAGATGTTCATAATCTTTGTCCTAAAGAAGTCTTAACATTTATTTTA
GACTTAATCAAGTACAATGACAACAGGAAAAATAAGTTTTCAGATAACTATTATCGTGCAGAAATGATTGATGCCCTGGCCAACTCTGTT
ACACCTGCAGTCAGTGTGAATAATGAAGTTAGAACTTTGGATAACTTAAATCCTGATGTGCGACTCATTCTTGAAGAAATCACCAGATTT
TTGAATATGGAAAAACTTCTTCCGAGTTACAGGCATACCATCACTGTCAGTTGTTTGAGAGCCATACGGGTACTTCAGAAGAACGGACAT
GTGCCAAGTGATCCAGCTCTTTTTAAATCTTATGCTGAATATGGCCACTTTGTGGACATTAGGATAGCAGCTTTGGAAGCAGTTGTTGAT
TATACTAAAGTGGACAGAAGTTATGAAGAACTGCAATGGCTACTTAATATGATTCAGAATGACCCTGTACCCTATGTAAGGCATAAGATT
CTCAACATGTTGACTAAGAACCCACCATTTACTAAGAACATGGAGTCTCCCTTATGCAATGAAGCCCTGGTAGATCAACTTTGGAAACTT
ATGAATTCTGGTACTTCACATGACTGGAGGTTACGGTGTGGTGCTGTGGACTTGTACTTCACACTTTTTGGCCTCAGTAGACCTTCCTGT
TTACCCTTGCCAGAGCTTGGGTTGGTTCTTAATCTAAAGGAGAAAAAAGCTGTCTTGAATCCTACCATAATTCCAGAGTCAGTAGCAGGC
AACCAAGAAGCTGCAAATAATCCAAGCAGTCACCCACAGCTAGTTGGATTTCAGAACCCTTTTTCCAGTTCTCAAGATGAGGAGGAGATT
GATATGGATACTGTTCATGATAGCCAGGCCTTCATTTCCCATCATTTAAACATGCTTGAAAGGCCGTCAACTCCAGGGCTCTCGAAATAT
CGGCCAGCTAGCTCCCGATCTGCTTTAATACCCCAGCACTCAGCAGGCTGTGACAGCACACCCACCACAAAACCCCAGTGGAGTTTGGAA
CTTGCACGGAAGGGAACAGGTAAAGAACAAGCACCTTTGGAGATGAGTATGCATCCAGCGGCAAGCGCTCCACTCTCAGTCTTTACTAAG
GAATCTACAGCCTCCAAACACAGTGACCACCATCACCACCATCACCATGAGCACAAGAAAAAGAAGAAGAAGCATAAACATAAGCACAAA
CACAAGCATAAGCATGACAGTAAAGAAAAGGACAAGGAGCCTTTCACTTTCTCCAGCCCTGCCAGTGGCAGGTCTATTCGTTCTCCTTCC
CTTTCAGACTGAGAAGGGGACAAAAAGACCTTTCCTTTCATGTCCAGAAGAATGTATGTAACTAAAGCTTTGTCCTCTGTGAAGAATTAT
AAAAGGGAGGGGGGAAAGGATTCGCCTCTCCTACAGAAATTCTGAATTCATTTAAGTTCTAAGCATTTGATTTATGTTATTTATACAGTT
GGGATCTAATTAGGAAAATGTGTTTTGTAGTTCTGGATAAACTATTTCATCCGCTGTTTCCTCCCCAAAACACACACACAGAGCAAACTC
CCTTTCATAAAAGCCCTCATATCCACTGGCAGTCCCCGTTCGCATCATGGTCTCCATGTGTACCGCCAAAGTCAATTATGTTTGAAAGCC
TTTGGTGGATGTTATGGGGCAAAGTTATGATTTACACAGAAGCAACTGCCAAATCTGTGGTGCAACCACTATCTCCAGTGAAATATTGTA
TAACACCATTTGGAACTACTGAAAAGACAGTGGCTTTTCTACAGTACTCTTCCTTATTGCACCATTTTTGTATTAACGTAGAAACTAAGC
ATCAGAATTTATGAACAAAGAATATGTTATTTTTCCTTTTGCTCTAAAATACTGAGATTTGGGGAAGCAATTCTTTTTTAAAAAAATTTT
GAATAACTATCTTTTGATAACACATTCGGCGGTTACGATGTTGGAATTTAGCAGAACTATCAAATCCAAAATTATTTTCAAATCAAGATG
TTTAAATTATAAGTTTTTTTGTTTTGTTTTCCAGTAAGTATAAATGAAAATATTCATATGTAAAATATGTTTTGCTTAATGTGGACAATT
TACACACCCAACACATACTGTTTCCAAAATTATTTCTATATGACACAAAGTATGATACCTTTAAAAAGGTGAGCTTATATATTGTTTATT
AACCTGGAAATAGACAATTTGGCTCTCATACCATAAGCATTTAAAAACATATGAAATATTTTGATTTCTTTATATGGTGGTGTGTTTTTA
TTTCTGAATTTTCCATGTGCTTTAATATTTGTTTAAGAATATTTTTTATATCTGTTCAATTTTTATCATTCCCCTTATCATTAGAAAGTT

>89155_89155_1_TATDN1-TAF2_TATDN1_chr8_125551265_ENST00000276692_TAF2_chr8_120831746_ENST00000378164_length(amino acids)=1149AA_BP=
MTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDE
LKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMR
KKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYA
SMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTG
GVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVST
SGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDI
PCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLA
LTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKE
VLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRV
LQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALV
DQLWKLMNSGTSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEAANNPSSHPQLVGFQNPFSSS
QDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPASSRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAP

--------------------------------------------------------------
>89155_89155_2_TATDN1-TAF2_TATDN1_chr8_125551265_ENST00000605953_TAF2_chr8_120831746_ENST00000378164_length(transcript)=4669nt_BP=58nt
TTCCGCTTCCGCTGGGGAGGTCCTCCATGCGCAGTCATGAGTCGCTTCAAGTTTATCGGGATTTGTGGAACTGACTATATTTCCCACAGT
TGCAAACTTGAATAGAATCAAGTTGAACAGCAAACAGTGTAGAATATACCGAGTAAGGATCAATGATTTAGAGGCTGCTTTTATTTATAA
TGACCCAACCTTGGAAGTTTGTCACAGTGAATCAAAACAGAGAAACCTCAATTATTTTTCCAATGCTTATGCAGCTGCAGTTAGTGCTGT
GGACCCTGATGCAGGAAATGGAGAACTTTGCATTAAGGTTCCATCAGAGCTATGGAAACACGTTGATGAGTTAAAGGTCCTGAAGATACA
CATCAATTTTTCTTTGGATCAGCCCAAAGGAGGTCTTCATTTTGTGGTACCCAGTGTAGAGGGAAGTATGGCAGAGAGAGGTGCTCATGT
TTTCTCTTGTGGGTATCAAAATTCTACAAGATTTTGGTTCCCTTGTGTTGATTCATACTCTGAATTGTGTACATGGAAATTAGAATTTAC
AGTAGATGCTGCAATGGTTGCTGTTTCTAATGGCGATTTGGTGGAGACAGTGTATACTCATGATATGAGGAAGAAAACTTTCCATTATAT
GCTTACCATTCCTACAGCAGCGTCAAATATCTCCTTGGCCATTGGACCATTTGAAATACTGGTAGATCCATACATGCATGAGGTTACTCA
TTTTTGTTTGCCCCAACTTCTTCCATTGCTGAAACATACCACATCATACCTTCATGAAGTCTTTGAATTTTATGAAGAAATTCTTACATG
TCGTTACCCATACTCCTGTTTTAAGACTGTCTTCATTGATGAGGCTTATGTTGAAGTGGCTGCTTATGCTTCCATGAGCATTTTTAGCAC
AAATCTTTTACACAGTGCCATGATTATAGATGAGACACCTTTGACTAGAAGGTGTTTAGCCCAATCCTTGGCCCAGCAGTTTTTTGGTTG
TTTCATATCTAGAATGTCTTGGTCTGATGAATGGGTGCTGAAGGGAATTTCAGGCTATATCTATGGACTTTGGATGAAAAAAACTTTTGG
TGTTAATGAGTACCGCCATTGGATTAAAGAGGAGCTAGACAAAATAGTGGCATATGAACTAAAAACTGGTGGGGTTTTACTACATCCCAT
ATTTGGTGGAGGAAAAGAGAAGGATAATCCGGCTTCCCATCTACACTTTTCAATAAAGCATCCACATACACTGTCCTGGGAATACTACAG
TATGTTTCAGTGTAAAGCCCACCTTGTGATGAGATTGATTGAAAATAGGATCAGTATGGAATTTATGCTACAAGTTTTCAATAAACTGCT
AAGTCTGGCTAGTACTGCTTCATCTCAGAAGTTCCAGTCACATATGTGGAGTCAGATGTTGGTTTCCACATCTGGGTTTTTGAAATCCAT
TTCAAATGTCTCTGGCAAAGATATTCAGCCGTTAATAAAGCAGTGGGTAGATCAGAGTGGAGTGGTAAAATTTTATGGAAGTTTTGCATT
TAATAGAAAACGAAATGTCTTGGAACTGGAAATAAAACAGGACTATACATCTCCTGGAACTCAGAAATACGTGGGACCACTTAAAGTGAC
AGTGCAGGAGTTAGATGGATCCTTCAATCATACACTGCAAATTGAAGAAAACAGCCTTAAACATGATATACCCTGCCATTCCAAAAGTAG
AAGGAATAAAAAGAAAAAAATCCCACTGATGAATGGAGAAGAAGTTGATATGGATCTTTCTGCAATGGATGCTGATTCCCCTTTGCTGTG
GATAAGGATAGACCCAGATATGTCAGTATTGAGGAAGGTAGAATTTGAGCAAGCTGATTTTATGTGGCAGTATCAGCTCCGCTATGAGAG
AGATGTTGTTGCACAGCAGGAATCCATTTTGGCTTTGGAAAAATTCCCTACTCCAGCATCTCGGCTTGCACTCACTGATATATTAGAACA
AGAGCAGTGTTTCTACAGAGTAAGAATGTCAGCTTGCTTCTGTCTTGCAAAGATTGCAAATTCAATGGTGAGCACATGGACAGGACCACC
AGCCATGAAGTCACTCTTCACTAGGATGTTTTGTTGTAAAAGTTGTCCAAACATTGTGAAAACAAACAACTTTATGAGCTTTCAAAGCTA
TTTTCTACAGAAGACTATGCCAGTTGCAATGGCTTTATTAAGAGATGTTCATAATCTTTGTCCTAAAGAAGTCTTAACATTTATTTTAGA
CTTAATCAAGTACAATGACAACAGGAAAAATAAGTTTTCAGATAACTATTATCGTGCAGAAATGATTGATGCCCTGGCCAACTCTGTTAC
ACCTGCAGTCAGTGTGAATAATGAAGTTAGAACTTTGGATAACTTAAATCCTGATGTGCGACTCATTCTTGAAGAAATCACCAGATTTTT
GAATATGGAAAAACTTCTTCCGAGTTACAGGCATACCATCACTGTCAGTTGTTTGAGAGCCATACGGGTACTTCAGAAGAACGGACATGT
GCCAAGTGATCCAGCTCTTTTTAAATCTTATGCTGAATATGGCCACTTTGTGGACATTAGGATAGCAGCTTTGGAAGCAGTTGTTGATTA
TACTAAAGTGGACAGAAGTTATGAAGAACTGCAATGGCTACTTAATATGATTCAGAATGACCCTGTACCCTATGTAAGGCATAAGATTCT
CAACATGTTGACTAAGAACCCACCATTTACTAAGAACATGGAGTCTCCCTTATGCAATGAAGCCCTGGTAGATCAACTTTGGAAACTTAT
GAATTCTGGTACTTCACATGACTGGAGGTTACGGTGTGGTGCTGTGGACTTGTACTTCACACTTTTTGGCCTCAGTAGACCTTCCTGTTT
ACCCTTGCCAGAGCTTGGGTTGGTTCTTAATCTAAAGGAGAAAAAAGCTGTCTTGAATCCTACCATAATTCCAGAGTCAGTAGCAGGCAA
CCAAGAAGCTGCAAATAATCCAAGCAGTCACCCACAGCTAGTTGGATTTCAGAACCCTTTTTCCAGTTCTCAAGATGAGGAGGAGATTGA
TATGGATACTGTTCATGATAGCCAGGCCTTCATTTCCCATCATTTAAACATGCTTGAAAGGCCGTCAACTCCAGGGCTCTCGAAATATCG
GCCAGCTAGCTCCCGATCTGCTTTAATACCCCAGCACTCAGCAGGCTGTGACAGCACACCCACCACAAAACCCCAGTGGAGTTTGGAACT
TGCACGGAAGGGAACAGGTAAAGAACAAGCACCTTTGGAGATGAGTATGCATCCAGCGGCAAGCGCTCCACTCTCAGTCTTTACTAAGGA
ATCTACAGCCTCCAAACACAGTGACCACCATCACCACCATCACCATGAGCACAAGAAAAAGAAGAAGAAGCATAAACATAAGCACAAACA
CAAGCATAAGCATGACAGTAAAGAAAAGGACAAGGAGCCTTTCACTTTCTCCAGCCCTGCCAGTGGCAGGTCTATTCGTTCTCCTTCCCT
TTCAGACTGAGAAGGGGACAAAAAGACCTTTCCTTTCATGTCCAGAAGAATGTATGTAACTAAAGCTTTGTCCTCTGTGAAGAATTATAA
AAGGGAGGGGGGAAAGGATTCGCCTCTCCTACAGAAATTCTGAATTCATTTAAGTTCTAAGCATTTGATTTATGTTATTTATACAGTTGG
GATCTAATTAGGAAAATGTGTTTTGTAGTTCTGGATAAACTATTTCATCCGCTGTTTCCTCCCCAAAACACACACACAGAGCAAACTCCC
TTTCATAAAAGCCCTCATATCCACTGGCAGTCCCCGTTCGCATCATGGTCTCCATGTGTACCGCCAAAGTCAATTATGTTTGAAAGCCTT
TGGTGGATGTTATGGGGCAAAGTTATGATTTACACAGAAGCAACTGCCAAATCTGTGGTGCAACCACTATCTCCAGTGAAATATTGTATA
ACACCATTTGGAACTACTGAAAAGACAGTGGCTTTTCTACAGTACTCTTCCTTATTGCACCATTTTTGTATTAACGTAGAAACTAAGCAT
CAGAATTTATGAACAAAGAATATGTTATTTTTCCTTTTGCTCTAAAATACTGAGATTTGGGGAAGCAATTCTTTTTTAAAAAAATTTTGA
ATAACTATCTTTTGATAACACATTCGGCGGTTACGATGTTGGAATTTAGCAGAACTATCAAATCCAAAATTATTTTCAAATCAAGATGTT
TAAATTATAAGTTTTTTTGTTTTGTTTTCCAGTAAGTATAAATGAAAATATTCATATGTAAAATATGTTTTGCTTAATGTGGACAATTTA
CACACCCAACACATACTGTTTCCAAAATTATTTCTATATGACACAAAGTATGATACCTTTAAAAAGGTGAGCTTATATATTGTTTATTAA
CCTGGAAATAGACAATTTGGCTCTCATACCATAAGCATTTAAAAACATATGAAATATTTTGATTTCTTTATATGGTGGTGTGTTTTTATT
TCTGAATTTTCCATGTGCTTTAATATTTGTTTAAGAATATTTTTTATATCTGTTCAATTTTTATCATTCCCCTTATCATTAGAAAGTTTG

>89155_89155_2_TATDN1-TAF2_TATDN1_chr8_125551265_ENST00000605953_TAF2_chr8_120831746_ENST00000378164_length(amino acids)=1149AA_BP=
MTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDE
LKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMR
KKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYA
SMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTG
GVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVST
SGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDI
PCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLA
LTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKE
VLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRV
LQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALV
DQLWKLMNSGTSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEAANNPSSHPQLVGFQNPFSSS
QDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPASSRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAP

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Fusion Gene PPI Analysis for TATDN1-TAF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TATDN1-TAF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TATDN1-TAF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source