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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TAX1BP1-CHN2 (FusionGDB2 ID:89173)

Fusion Gene Summary for TAX1BP1-CHN2

check button Fusion gene summary
Fusion gene informationFusion gene name: TAX1BP1-CHN2
Fusion gene ID: 89173
HgeneTgene
Gene symbol

TAX1BP1

CHN2

Gene ID

8887

4359

Gene nameTax1 binding protein 1myelin protein zero
SynonymsCALCOCO3|T6BP|TXBP151CHM|CHN2|CMT1|CMT1B|CMT2I|CMT2J|CMT4E|CMTDI3|CMTDID|DSS|HMSNIB|MPP|P0
Cytomap

7p15.2

1q23.3

Type of geneprotein-codingprotein-coding
Descriptiontax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1myelin protein P0Charcot-Marie-Tooth neuropathy 1Bmyelin peripheral protein
Modification date2020032720200328
UniProtAcc.

P52757

Ensembl transtripts involved in fusion geneENST00000265393, ENST00000396319, 
ENST00000409980, ENST00000433216, 
ENST00000543117, ENST00000494033, 
ENST00000409041, ENST00000410098, 
ENST00000421775, ENST00000424025, 
ENST00000439711, ENST00000222792, 
ENST00000435288, ENST00000495789, 
ENST00000539389, ENST00000539406, 
ENST00000546235, 
Fusion gene scores* DoF score17 X 11 X 11=20577 X 7 X 4=196
# samples 199
** MAII scorelog2(19/2057*10)=-3.43647047019399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAX1BP1 [Title/Abstract] AND CHN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAX1BP1(27827222)-CHN2(29394241), # samples:3
CHN2(29234606)-TAX1BP1(27824782), # samples:1
CHN2(29234606)-TAX1BP1(27824781), # samples:1
Anticipated loss of major functional domain due to fusion event.CHN2-TAX1BP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TAX1BP1-CHN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TAX1BP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CHN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FH-01ATAX1BP1chr7

27827222

-CHN2chr7

29394241

+
ChimerDB4ESCATCGA-JY-A6FH-01ATAX1BP1chr7

27827222

+CHN2chr7

29394241

+
ChimerDB4ESCATCGA-JY-A6FHTAX1BP1chr7

27827222

+CHN2chr7

29394240

+
ChimerDB4ESCATCGA-JY-A6FHTAX1BP1chr7

27827222

+CHN2chr7

29394241

+


Top

Fusion Gene ORF analysis for TAX1BP1-CHN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265393ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000265393ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000265393ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000265393ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000265393ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000265393ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000265393ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000265393ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000265393ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000265393ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000396319ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000396319ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000396319ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000396319ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000396319ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000396319ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000396319ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000396319ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000396319ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000396319ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000409980ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000409980ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000409980ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000409980ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000409980ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000409980ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000409980ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000409980ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000409980ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000409980ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000433216ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000433216ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000433216ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000433216ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000433216ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000433216ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000433216ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000433216ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000433216ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000433216ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000543117ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000543117ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000543117ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000543117ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000543117ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000543117ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000543117ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000543117ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
5CDS-intronENST00000543117ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
5CDS-intronENST00000543117ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000265393ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000265393ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000265393ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000265393ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000265393ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000265393ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000265393ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000265393ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000265393ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000265393ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000265393ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000265393ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000396319ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000396319ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000396319ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000396319ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000396319ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000396319ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000396319ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000396319ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000396319ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000396319ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000396319ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000396319ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000409980ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000409980ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000409980ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000409980ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000409980ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000409980ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000409980ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000409980ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000409980ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000409980ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000409980ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000409980ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000433216ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000433216ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000433216ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000433216ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000433216ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000433216ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000433216ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000433216ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000433216ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000433216ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000433216ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000433216ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000543117ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000543117ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000543117ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000543117ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000543117ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000543117ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000543117ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000543117ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000543117ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000543117ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
Frame-shiftENST00000543117ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
Frame-shiftENST00000543117ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-3CDSENST00000494033ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-3CDSENST00000494033ENST00000222792TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-3CDSENST00000494033ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-3CDSENST00000494033ENST00000435288TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-3CDSENST00000494033ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-3CDSENST00000494033ENST00000495789TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-3CDSENST00000494033ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-3CDSENST00000494033ENST00000539389TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-3CDSENST00000494033ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-3CDSENST00000494033ENST00000539406TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-3CDSENST00000494033ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-3CDSENST00000494033ENST00000546235TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-intronENST00000494033ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-intronENST00000494033ENST00000409041TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-intronENST00000494033ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-intronENST00000494033ENST00000410098TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-intronENST00000494033ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-intronENST00000494033ENST00000421775TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-intronENST00000494033ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-intronENST00000494033ENST00000424025TAX1BP1chr7

27827222

+CHN2chr7

29394240

+
intron-intronENST00000494033ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394241

+
intron-intronENST00000494033ENST00000439711TAX1BP1chr7

27827222

+CHN2chr7

29394240

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TAX1BP1-CHN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TAX1BP1chr727827222+CHN2chr729394240+4.69E-050.99995303
TAX1BP1chr727827222+CHN2chr729394240+4.69E-050.99995303
TAX1BP1chr727827222+CHN2chr729394240+4.69E-050.99995303
TAX1BP1chr727827222+CHN2chr729394240+4.69E-050.99995303

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TAX1BP1-CHN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27827222/:29394241)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHN2

P52757

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TAX1BP1-CHN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TAX1BP1-CHN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAX1BP1-CHN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAX1BP1-CHN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource