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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TAX1BP1-JAZF1 (FusionGDB2 ID:89176)

Fusion Gene Summary for TAX1BP1-JAZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TAX1BP1-JAZF1
Fusion gene ID: 89176
HgeneTgene
Gene symbol

TAX1BP1

JAZF1

Gene ID

8887

221895

Gene nameTax1 binding protein 1JAZF zinc finger 1
SynonymsCALCOCO3|T6BP|TXBP151TIP27|ZNF802
Cytomap

7p15.2

7p15.2-p15.1

Type of geneprotein-codingprotein-coding
Descriptiontax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1juxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802
Modification date2020032720200313
UniProtAcc.

Q86VZ6

Ensembl transtripts involved in fusion geneENST00000265393, ENST00000396319, 
ENST00000409980, ENST00000543117, 
ENST00000433216, ENST00000494033, 
ENST00000466516, ENST00000283928, 
Fusion gene scores* DoF score17 X 11 X 11=20579 X 6 X 5=270
# samples 199
** MAII scorelog2(19/2057*10)=-3.43647047019399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAX1BP1 [Title/Abstract] AND JAZF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointJAZF1(27880317)-TAX1BP1(27867357), # samples:5
TAX1BP1(27797752)-JAZF1(28031600), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJAZF1

GO:0000122

negative regulation of transcription by RNA polymerase II

15302918


check buttonFusion gene breakpoints across TAX1BP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across JAZF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1424-01ATAX1BP1chr7

27797752

-JAZF1chr7

28031600

-
ChimerDB4OVTCGA-24-1424-01ATAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
ChimerDB4OVTCGA-24-1424TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-


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Fusion Gene ORF analysis for TAX1BP1-JAZF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265393ENST00000466516TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
5CDS-intronENST00000396319ENST00000466516TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
5CDS-intronENST00000409980ENST00000466516TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
5CDS-intronENST00000543117ENST00000466516TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
5UTR-3CDSENST00000433216ENST00000283928TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
5UTR-intronENST00000433216ENST00000466516TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
In-frameENST00000265393ENST00000283928TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
In-frameENST00000396319ENST00000283928TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
In-frameENST00000409980ENST00000283928TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
In-frameENST00000543117ENST00000283928TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
intron-3CDSENST00000494033ENST00000283928TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-
intron-intronENST00000494033ENST00000466516TAX1BP1chr7

27797752

+JAZF1chr7

28031600

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543117TAX1BP1chr727797752+ENST00000283928JAZF1chr728031600-32944501851066293
ENST00000265393TAX1BP1chr727797752+ENST00000283928JAZF1chr728031600-32914471821063293
ENST00000409980TAX1BP1chr727797752+ENST00000283928JAZF1chr728031600-32444001351016293
ENST00000396319TAX1BP1chr727797752+ENST00000283928JAZF1chr728031600-319735388969293

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543117ENST00000283928TAX1BP1chr727797752+JAZF1chr728031600-0.0006516740.99934834
ENST00000265393ENST00000283928TAX1BP1chr727797752+JAZF1chr728031600-0.0005688110.9994312
ENST00000409980ENST00000283928TAX1BP1chr727797752+JAZF1chr728031600-0.0005506450.9994493
ENST00000396319ENST00000283928TAX1BP1chr727797752+JAZF1chr728031600-0.0005728830.9994272

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Fusion Genomic Features for TAX1BP1-JAZF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAX1BP1-JAZF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:27880317/chr7:27867357)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.JAZF1

Q86VZ6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneJAZF1chr7:27797752chr7:28031600ENST0000028392805173_19838244.0Zinc fingerNote=C2H2-type 2
TgeneJAZF1chr7:27797752chr7:28031600ENST0000028392805208_23038244.0Zinc fingerNote=C2H2-type 3%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000265393+317144_59988748.0Coiled coilOntology_term=ECO:0000255
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000396319+317144_59988790.0Coiled coilOntology_term=ECO:0000255
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000433216+316144_5990591.0Coiled coilOntology_term=ECO:0000255
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000543117+317144_59988748.0Coiled coilOntology_term=ECO:0000255
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000265393+317320_42088748.0RegionNote=Oligomerization
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000396319+317320_42088790.0RegionNote=Oligomerization
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000433216+316320_4200591.0RegionNote=Oligomerization
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000543117+317320_42088748.0RegionNote=Oligomerization
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000265393+317727_75388748.0Zinc fingerUBZ1-type 1
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000265393+317754_78088748.0Zinc fingerUBZ1-type 2
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000396319+317727_75388790.0Zinc fingerUBZ1-type 1
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000396319+317754_78088790.0Zinc fingerUBZ1-type 2
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000433216+316727_7530591.0Zinc fingerUBZ1-type 1
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000433216+316754_7800591.0Zinc fingerUBZ1-type 2
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000543117+317727_75388748.0Zinc fingerUBZ1-type 1
HgeneTAX1BP1chr7:27797752chr7:28031600ENST00000543117+317754_78088748.0Zinc fingerUBZ1-type 2
TgeneJAZF1chr7:27797752chr7:28031600ENST000002839280512_3738244.0Zinc fingerNote=C2H2-type 1


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Fusion Gene Sequence for TAX1BP1-JAZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89176_89176_1_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000265393_JAZF1_chr7_28031600_ENST00000283928_length(transcript)=3291nt_BP=447nt
GGAAGAGACCGCCCCGTGGGCGGAAGTGACGCAAGGCCTACTGTCGGCTGGGAGGGGAGGTGTAGCCGGTCTTTGGGGGTAGGCGGTAGT
GGCGGAAGAGGTTCGGCGGCTGATGGCGGATCAGGATCGGAAGCCTGCGTAACTTTCTCCCTTGATCCGGGAGTCTTTCCACTGGATTCA
CAATGACATCCTTTCAAGAAGTCCCATTGCAGACTTCCAACTTTGCCCATGTCATCTTTCAAAATGTGGCCAAGAGTTACCTTCCTAATG
CACACCTGGAATGTCATTACACCTTAACTCCATATATTCATCCACATCCAAAAGATTGGGTTGGTATATTCAAGGTTGGATGGAGTACTG
CTCGTGATTATTACACGTTTTTATGGTCCCCTATGCCTGAACATTATGTGGAAGGATCAACAGTCAATTGTGTACTAGCATTCCAAGATA
CAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCC
GCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTC
CCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCA
GCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCC
TCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCA
TAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTC
AGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCTGAGATTATCAGGAAGATGCAGCAATAACATGCTGGTCATAACT
GTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCACCTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAAAGAAAAAGA
ATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTATCTTTGTAGAGTTAATGATTTTGTACATTTGCACATGTAATCAT
CATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGCTCTAGGTTCTTCAGCACATTTCCCCCAAAACAAAATAAAATTG
AGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTGGGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTTCAAGATTGT
AATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACCAAAATAATACCTTCATTATCAAACTGGTTACCATGCCTTACAT
AATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATATAAATAAGAAAGAATGTTTAACATAATATGCTAAAAATATTTT
CATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATTATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGAAAATCTTGC
CATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACAAAATAGTCTATTCAGTTCGTTCATTCATTTAACACACATTGAT
TGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATCTGCGGACCAAGATACCCATTTAGTGAAATACTTTTTTCCCTGA
AATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTGTGTGAAGTTTAGTTATATCTTCATCTTCAGATGAAGTTTTAAA
GCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGCCAATTCTTGCAACCACTGCCCTACCAAACCTGTGGGTTGCAAA
TCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTAAGACCCCTATTGCCTCTTCTTCATGCTCATTTTTTACTTTTTT
TAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCATTGGAAATGTCTGTTTAGCTTTATAAAACAAACACTTTGCTGAA
ATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGTGGTCAAAGAAAAGCATGACTAATACGACCTATTAGAGTAATCT
ACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCATGCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCCTTAAACACG
AGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATAGCTAACTGCCCATAAAACAAACTCAAATTGCTTATAAAGTTTC
TTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGGGAAGCAGGGGTCCCTCCTCAATTTTCAGACATTTTGAAAGGAT
GACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCTAAAATCCTTCATTATGAGGGATTCAAAGTATTTATAAAAACAC
TGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGAATATACAGTGTTATCCTATGTTTAAAAGGGTGATCCAGACATG
AGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCATATCTACCTACAATTGACCAAAAAAAATTTTTTAGGCCAGCAAT
TATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGATCAGTAGTTCAACAGCTAAACAGTCATAAAATAGTCATTGTGCA
TGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATTTACTTATTCATTGTGACAGTATTACTAAACAGGTAAGGATGGG
AATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGTGAAAACTGTGCTTTAAATTATATTTTCATATGTTTTGTTGGGG
ACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTGAAGGCAATTTAATCAAAATTCCTGTCAAGAAAAGCTGCTTATA

>89176_89176_1_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000265393_JAZF1_chr7_28031600_ENST00000283928_length(amino acids)=293AA_BP=88
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQDT
DPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGS
EYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQ

--------------------------------------------------------------
>89176_89176_2_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000396319_JAZF1_chr7_28031600_ENST00000283928_length(transcript)=3197nt_BP=353nt
GAAGAGGTTCGGCGGCTGATGGCGGATCAGGATCGGAAGCCTGCGTAACTTTCTCCCTTGATCCGGGAGTCTTTCCACTGGATTCACAAT
GACATCCTTTCAAGAAGTCCCATTGCAGACTTCCAACTTTGCCCATGTCATCTTTCAAAATGTGGCCAAGAGTTACCTTCCTAATGCACA
CCTGGAATGTCATTACACCTTAACTCCATATATTCATCCACATCCAAAAGATTGGGTTGGTATATTCAAGGTTGGATGGAGTACTGCTCG
TGATTATTACACGTTTTTATGGTCCCCTATGCCTGAACATTATGTGGAAGGATCAACAGTCAATTGTGTACTAGCATTCCAAGATACAGA
TCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCG
AGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCC
ACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGA
GTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAG
CTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAA
GTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGG
CCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCTGAGATTATCAGGAAGATGCAGCAATAACATGCTGGTCATAACTGTGC
CAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCACCTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAAAGAAAAAGAATTA
AATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTATCTTTGTAGAGTTAATGATTTTGTACATTTGCACATGTAATCATCATA
CCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGCTCTAGGTTCTTCAGCACATTTCCCCCAAAACAAAATAAAATTGAGGG
CATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTGGGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTTCAAGATTGTAATG
TGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACCAAAATAATACCTTCATTATCAAACTGGTTACCATGCCTTACATAATG
GAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATATAAATAAGAAAGAATGTTTAACATAATATGCTAAAAATATTTTCATA
TTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATTATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGAAAATCTTGCCATC
TGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACAAAATAGTCTATTCAGTTCGTTCATTCATTTAACACACATTGATTGAG
TGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATCTGCGGACCAAGATACCCATTTAGTGAAATACTTTTTTCCCTGAAATC
TGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTGTGTGAAGTTTAGTTATATCTTCATCTTCAGATGAAGTTTTAAAGCAC
TTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGCCAATTCTTGCAACCACTGCCCTACCAAACCTGTGGGTTGCAAATCAG
AACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTAAGACCCCTATTGCCTCTTCTTCATGCTCATTTTTTACTTTTTTTAAA
AGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCATTGGAAATGTCTGTTTAGCTTTATAAAACAAACACTTTGCTGAAATAG
GAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGTGGTCAAAGAAAAGCATGACTAATACGACCTATTAGAGTAATCTACAT
CTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCATGCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCCTTAAACACGAGAG
TTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATAGCTAACTGCCCATAAAACAAACTCAAATTGCTTATAAAGTTTCTTCC
CATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGGGAAGCAGGGGTCCCTCCTCAATTTTCAGACATTTTGAAAGGATGACA
GTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCTAAAATCCTTCATTATGAGGGATTCAAAGTATTTATAAAAACACTGCC
CTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGAATATACAGTGTTATCCTATGTTTAAAAGGGTGATCCAGACATGAGAC
GCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCATATCTACCTACAATTGACCAAAAAAAATTTTTTAGGCCAGCAATTATT
ATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGATCAGTAGTTCAACAGCTAAACAGTCATAAAATAGTCATTGTGCATGTT
AAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATTTACTTATTCATTGTGACAGTATTACTAAACAGGTAAGGATGGGAATA
TTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGTGAAAACTGTGCTTTAAATTATATTTTCATATGTTTTGTTGGGGACAG
AGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTGAAGGCAATTTAATCAAAATTCCTGTCAAGAAAAGCTGCTTATAAATG

>89176_89176_2_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000396319_JAZF1_chr7_28031600_ENST00000283928_length(amino acids)=293AA_BP=88
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQDT
DPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGS
EYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQ

--------------------------------------------------------------
>89176_89176_3_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000409980_JAZF1_chr7_28031600_ENST00000283928_length(transcript)=3244nt_BP=400nt
CTGGGAGGGGAGGTGTAGCCGGTCTTTGGGGGTAGGCGGTAGTGGCGGAAGAGGTTCGGCGGCTGATGGCGGATCAGGATCGGAAGCCTG
CGTAACTTTCTCCCTTGATCCGGGAGTCTTTCCACTGGATTCACAATGACATCCTTTCAAGAAGTCCCATTGCAGACTTCCAACTTTGCC
CATGTCATCTTTCAAAATGTGGCCAAGAGTTACCTTCCTAATGCACACCTGGAATGTCATTACACCTTAACTCCATATATTCATCCACAT
CCAAAAGATTGGGTTGGTATATTCAAGGTTGGATGGAGTACTGCTCGTGATTATTACACGTTTTTATGGTCCCCTATGCCTGAACATTAT
GTGGAAGGATCAACAGTCAATTGTGTACTAGCATTCCAAGATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTAT
GTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCG
CTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCC
ATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGAT
GAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGC
CCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGC
AAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCT
GAGATTATCAGGAAGATGCAGCAATAACATGCTGGTCATAACTGTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCAC
CTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAAAGAAAAAGAATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTAT
CTTTGTAGAGTTAATGATTTTGTACATTTGCACATGTAATCATCATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGC
TCTAGGTTCTTCAGCACATTTCCCCCAAAACAAAATAAAATTGAGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTG
GGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTTCAAGATTGTAATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACC
AAAATAATACCTTCATTATCAAACTGGTTACCATGCCTTACATAATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATA
TAAATAAGAAAGAATGTTTAACATAATATGCTAAAAATATTTTCATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATT
ATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGAAAATCTTGCCATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACA
AAATAGTCTATTCAGTTCGTTCATTCATTTAACACACATTGATTGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATC
TGCGGACCAAGATACCCATTTAGTGAAATACTTTTTTCCCTGAAATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTG
TGTGAAGTTTAGTTATATCTTCATCTTCAGATGAAGTTTTAAAGCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGC
CAATTCTTGCAACCACTGCCCTACCAAACCTGTGGGTTGCAAATCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTA
AGACCCCTATTGCCTCTTCTTCATGCTCATTTTTTACTTTTTTTAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCAT
TGGAAATGTCTGTTTAGCTTTATAAAACAAACACTTTGCTGAAATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGT
GGTCAAAGAAAAGCATGACTAATACGACCTATTAGAGTAATCTACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCAT
GCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCCTTAAACACGAGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATA
GCTAACTGCCCATAAAACAAACTCAAATTGCTTATAAAGTTTCTTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGG
GAAGCAGGGGTCCCTCCTCAATTTTCAGACATTTTGAAAGGATGACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCT
AAAATCCTTCATTATGAGGGATTCAAAGTATTTATAAAAACACTGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGA
ATATACAGTGTTATCCTATGTTTAAAAGGGTGATCCAGACATGAGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCAT
ATCTACCTACAATTGACCAAAAAAAATTTTTTAGGCCAGCAATTATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGAT
CAGTAGTTCAACAGCTAAACAGTCATAAAATAGTCATTGTGCATGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATT
TACTTATTCATTGTGACAGTATTACTAAACAGGTAAGGATGGGAATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGT
GAAAACTGTGCTTTAAATTATATTTTCATATGTTTTGTTGGGGACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTG
AAGGCAATTTAATCAAAATTCCTGTCAAGAAAAGCTGCTTATAAATGTAAATGAAATCACATTTAAAATAAACTGCCTCTGACCCAAAAA

>89176_89176_3_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000409980_JAZF1_chr7_28031600_ENST00000283928_length(amino acids)=293AA_BP=88
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQDT
DPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGS
EYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQ

--------------------------------------------------------------
>89176_89176_4_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000543117_JAZF1_chr7_28031600_ENST00000283928_length(transcript)=3294nt_BP=450nt
ACGGCAACAGAAGACTATGATGAATTCGAATGGGACACATTTGCTTCTGTGGAGTTACGATTCAAACTGAATGTCCAATATAGGAAGGCA
ACATATACAACAAGCAAAAGTGATTTTAGAAATAACAGAACGCGGGAGAAAATTCACACACGGAAAATGATACGGATAACAAAAGCAGAT
TCACAATGACATCCTTTCAAGAAGTCCCATTGCAGACTTCCAACTTTGCCCATGTCATCTTTCAAAATGTGGCCAAGAGTTACCTTCCTA
ATGCACACCTGGAATGTCATTACACCTTAACTCCATATATTCATCCACATCCAAAAGATTGGGTTGGTATATTCAAGGTTGGATGGAGTA
CTGCTCGTGATTATTACACGTTTTTATGGTCCCCTATGCCTGAACATTATGTGGAAGGATCAACAGTCAATTGTGTACTAGCATTCCAAG
ATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTG
CCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCA
CTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAG
GCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCA
TCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATG
GCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAG
CTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCTGAGATTATCAGGAAGATGCAGCAATAACATGCTGGTCATA
ACTGTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCACCTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAAAGAAAA
AGAATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTATCTTTGTAGAGTTAATGATTTTGTACATTTGCACATGTAAT
CATCATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGCTCTAGGTTCTTCAGCACATTTCCCCCAAAACAAAATAAAA
TTGAGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTGGGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTTCAAGAT
TGTAATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACCAAAATAATACCTTCATTATCAAACTGGTTACCATGCCTTA
CATAATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATATAAATAAGAAAGAATGTTTAACATAATATGCTAAAAATAT
TTTCATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATTATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGAAAATCT
TGCCATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACAAAATAGTCTATTCAGTTCGTTCATTCATTTAACACACATT
GATTGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATCTGCGGACCAAGATACCCATTTAGTGAAATACTTTTTTCCC
TGAAATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTGTGTGAAGTTTAGTTATATCTTCATCTTCAGATGAAGTTTT
AAAGCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGCCAATTCTTGCAACCACTGCCCTACCAAACCTGTGGGTTGC
AAATCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTAAGACCCCTATTGCCTCTTCTTCATGCTCATTTTTTACTTT
TTTTAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCATTGGAAATGTCTGTTTAGCTTTATAAAACAAACACTTTGCT
GAAATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGTGGTCAAAGAAAAGCATGACTAATACGACCTATTAGAGTAA
TCTACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCATGCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCCTTAAAC
ACGAGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATAGCTAACTGCCCATAAAACAAACTCAAATTGCTTATAAAGT
TTCTTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGGGAAGCAGGGGTCCCTCCTCAATTTTCAGACATTTTGAAAG
GATGACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCTAAAATCCTTCATTATGAGGGATTCAAAGTATTTATAAAAA
CACTGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGAATATACAGTGTTATCCTATGTTTAAAAGGGTGATCCAGAC
ATGAGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCATATCTACCTACAATTGACCAAAAAAAATTTTTTAGGCCAGC
AATTATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGATCAGTAGTTCAACAGCTAAACAGTCATAAAATAGTCATTGT
GCATGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATTTACTTATTCATTGTGACAGTATTACTAAACAGGTAAGGAT
GGGAATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGTGAAAACTGTGCTTTAAATTATATTTTCATATGTTTTGTTG
GGGACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTGAAGGCAATTTAATCAAAATTCCTGTCAAGAAAAGCTGCTT

>89176_89176_4_TAX1BP1-JAZF1_TAX1BP1_chr7_27797752_ENST00000543117_JAZF1_chr7_28031600_ENST00000283928_length(amino acids)=293AA_BP=88
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQDT
DPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGS
EYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TAX1BP1-JAZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAX1BP1-JAZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAX1BP1-JAZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource