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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBC1D15-E2F5 (FusionGDB2 ID:89221)

Fusion Gene Summary for TBC1D15-E2F5

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D15-E2F5
Fusion gene ID: 89221
HgeneTgene
Gene symbol

TBC1D15

E2F5

Gene ID

64786

1875

Gene nameTBC1 domain family member 15E2F transcription factor 5
SynonymsRAB7-GAPE2F-5
Cytomap

12q21.1

8q21.2

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 15GAP for RAB7GTPase-activating protein RAB7Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15Tre2/Bub2/Cdc16 domain family member 15transcription factor E2F5E2F transcription factor 5, p130-binding
Modification date2020031320200313
UniProtAcc.

Q15329

Ensembl transtripts involved in fusion geneENST00000485960, ENST00000550746, 
ENST00000319106, ENST00000393309, 
ENST00000548679, 		ENST00000519128, 
ENST00000517476, ENST00000521429, 
ENST00000256117, ENST00000416274, 
ENST00000418930, 
Fusion gene scores* DoF score24 X 12 X 13=37446 X 6 X 4=144
# samples 367
** MAII scorelog2(36/3744*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D15 [Title/Abstract] AND E2F5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBC1D15(72233591)-E2F5(86114381), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TBC1D15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across E2F5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-3P-A9WATBC1D15chr12

72233591

+E2F5chr8

86114381

+


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Fusion Gene ORF analysis for TBC1D15-E2F5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000485960ENST00000519128TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5CDS-3UTRENST00000550746ENST00000519128TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5CDS-5UTRENST00000485960ENST00000517476TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5CDS-5UTRENST00000485960ENST00000521429TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5CDS-5UTRENST00000550746ENST00000517476TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5CDS-5UTRENST00000550746ENST00000521429TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3CDSENST00000319106ENST00000256117TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3CDSENST00000319106ENST00000416274TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3CDSENST00000319106ENST00000418930TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3CDSENST00000393309ENST00000256117TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3CDSENST00000393309ENST00000416274TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3CDSENST00000393309ENST00000418930TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3UTRENST00000319106ENST00000519128TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-3UTRENST00000393309ENST00000519128TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-5UTRENST00000319106ENST00000517476TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-5UTRENST00000319106ENST00000521429TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-5UTRENST00000393309ENST00000517476TBC1D15chr12

72233591

+E2F5chr8

86114381

+
5UTR-5UTRENST00000393309ENST00000521429TBC1D15chr12

72233591

+E2F5chr8

86114381

+
In-frameENST00000485960ENST00000256117TBC1D15chr12

72233591

+E2F5chr8

86114381

+
In-frameENST00000485960ENST00000416274TBC1D15chr12

72233591

+E2F5chr8

86114381

+
In-frameENST00000485960ENST00000418930TBC1D15chr12

72233591

+E2F5chr8

86114381

+
In-frameENST00000550746ENST00000256117TBC1D15chr12

72233591

+E2F5chr8

86114381

+
In-frameENST00000550746ENST00000416274TBC1D15chr12

72233591

+E2F5chr8

86114381

+
In-frameENST00000550746ENST00000418930TBC1D15chr12

72233591

+E2F5chr8

86114381

+
intron-3CDSENST00000548679ENST00000256117TBC1D15chr12

72233591

+E2F5chr8

86114381

+
intron-3CDSENST00000548679ENST00000416274TBC1D15chr12

72233591

+E2F5chr8

86114381

+
intron-3CDSENST00000548679ENST00000418930TBC1D15chr12

72233591

+E2F5chr8

86114381

+
intron-3UTRENST00000548679ENST00000519128TBC1D15chr12

72233591

+E2F5chr8

86114381

+
intron-5UTRENST00000548679ENST00000517476TBC1D15chr12

72233591

+E2F5chr8

86114381

+
intron-5UTRENST00000548679ENST00000521429TBC1D15chr12

72233591

+E2F5chr8

86114381

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000550746TBC1D15chr1272233591+ENST00000418930E2F5chr886114381+1554941897298
ENST00000550746TBC1D15chr1272233591+ENST00000256117E2F5chr886114381+1558941903300
ENST00000550746TBC1D15chr1272233591+ENST00000416274E2F5chr886114381+1554941900299
ENST00000485960TBC1D15chr1272233591+ENST00000418930E2F5chr886114381+15135323856277
ENST00000485960TBC1D15chr1272233591+ENST00000256117E2F5chr886114381+15175323862279
ENST00000485960TBC1D15chr1272233591+ENST00000416274E2F5chr886114381+15135323859278

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000550746ENST00000418930TBC1D15chr1272233591+E2F5chr886114381+0.0001318790.99986815
ENST00000550746ENST00000256117TBC1D15chr1272233591+E2F5chr886114381+0.0001396270.9998604
ENST00000550746ENST00000416274TBC1D15chr1272233591+E2F5chr886114381+0.0001052070.99989474
ENST00000485960ENST00000418930TBC1D15chr1272233591+E2F5chr886114381+0.0001427440.9998572
ENST00000485960ENST00000256117TBC1D15chr1272233591+E2F5chr886114381+0.0001481280.9998518
ENST00000485960ENST00000416274TBC1D15chr1272233591+E2F5chr886114381+0.0001154130.9998846

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Fusion Genomic Features for TBC1D15-E2F5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBC1D15chr1272233591+E2F5chr886114381+7.88E-070.99999917
TBC1D15chr1272233591+E2F5chr886114381+7.88E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TBC1D15-E2F5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:72233591/chr8:86114381)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.E2F5

Q15329

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneE2F5chr12:72233591chr8:86114381ENST0000041627408233_23678347.0Compositional biasNote=Poly-Ser
TgeneE2F5chr12:72233591chr8:86114381ENST0000041893008233_23678346.0Compositional biasNote=Poly-Ser
TgeneE2F5chr12:72233591chr8:86114381ENST0000051747608233_2360186.0Compositional biasNote=Poly-Ser
TgeneE2F5chr12:72233591chr8:86114381ENST000005174760833_390186.0Compositional biasNote=Poly-Pro
TgeneE2F5chr12:72233591chr8:86114381ENST000005174760847_1180186.0DNA bindingOntology_term=ECO:0000255
TgeneE2F5chr12:72233591chr8:86114381ENST000004162740881_11878347.0MotifNote=DEF box
TgeneE2F5chr12:72233591chr8:86114381ENST000004189300881_11878346.0MotifNote=DEF box
TgeneE2F5chr12:72233591chr8:86114381ENST000005174760881_1180186.0MotifNote=DEF box
TgeneE2F5chr12:72233591chr8:86114381ENST0000041627408119_21578347.0RegionDimerization
TgeneE2F5chr12:72233591chr8:86114381ENST0000041627408287_34678347.0RegionTransactivation
TgeneE2F5chr12:72233591chr8:86114381ENST0000041627408323_34078347.0RegionRBL2 association
TgeneE2F5chr12:72233591chr8:86114381ENST000004162740876_9878347.0RegionNote=Leucine-zipper
TgeneE2F5chr12:72233591chr8:86114381ENST0000041893008119_21578346.0RegionDimerization
TgeneE2F5chr12:72233591chr8:86114381ENST0000041893008287_34678346.0RegionTransactivation
TgeneE2F5chr12:72233591chr8:86114381ENST0000041893008323_34078346.0RegionRBL2 association
TgeneE2F5chr12:72233591chr8:86114381ENST000004189300876_9878346.0RegionNote=Leucine-zipper
TgeneE2F5chr12:72233591chr8:86114381ENST0000051747608119_2150186.0RegionDimerization
TgeneE2F5chr12:72233591chr8:86114381ENST0000051747608287_3460186.0RegionTransactivation
TgeneE2F5chr12:72233591chr8:86114381ENST0000051747608323_3400186.0RegionRBL2 association
TgeneE2F5chr12:72233591chr8:86114381ENST000005174760876_980186.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D15chr12:72233591chr8:86114381ENST00000319106+118346_5560683.0DomainRab-GAP TBC
HgeneTBC1D15chr12:72233591chr8:86114381ENST00000485960+117346_55610675.0DomainRab-GAP TBC
HgeneTBC1D15chr12:72233591chr8:86114381ENST00000550746+118346_55610692.0DomainRab-GAP TBC
TgeneE2F5chr12:72233591chr8:86114381ENST000004162740833_3978347.0Compositional biasNote=Poly-Pro
TgeneE2F5chr12:72233591chr8:86114381ENST000004189300833_3978346.0Compositional biasNote=Poly-Pro
TgeneE2F5chr12:72233591chr8:86114381ENST000004162740847_11878347.0DNA bindingOntology_term=ECO:0000255
TgeneE2F5chr12:72233591chr8:86114381ENST000004189300847_11878346.0DNA bindingOntology_term=ECO:0000255


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Fusion Gene Sequence for TBC1D15-E2F5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89221_89221_1_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000485960_E2F5_chr8_86114381_ENST00000256117_length(transcript)=1517nt_BP=53nt
ATTACCAGGCACGCGCAGGAAACATGGCGGCGGCGGGTGTTGTGAGCGGGAAGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAA
TTTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAAGTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGCT
GTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAATTGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGA
AGTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAATAATAGAACATTTTCCTATGTAACTCATGAAGACATCTGTA
ATTGCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTACACAACTGGAGGTACCCATTCCAGAAATGGGTCAGAATGGAC
AAAAGAAATACCAGATCAATCTAAAGAGTCATTCAGGACCTATCCATGTGCTGCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGG
TTTTTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTCCTTGACTCCAGTGACTCCACAGAAATCCAGCATGGCAACTC
AAAATCTGCCTGAGCAACATGTCTCTGAAAGAAGCCAGGCTCTGCAGCAGACATCAGCTACAGATATATCTTCAGCAGGATCTATTAGTG
GAGATATCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAGGCTTTCTCCTACCCCGGCAGATGACTACAACTTTAATTTAG
ATGATAACGAAGGAGTTTGTGATCTGTTTGATGTCCAGATACTAAATTATTAGATTCCATGGAAACTTGGGACTGTTATCTACCTCTAAC
TGTGTAACATTTTAGACTTCTTAATAACCTAAATATTTAAAATAATGAATGTAACACCTTTTTTAGTTCACTGATTCTGAAGTGTTCTTC
CCTAATACTTTCTTTACTTCACAAAACTTCAACCATAAAAACAAAGGGCTCTGATTGCTTTAGGGGATAAGTGATTTAATATCCACAAAC
GTCCCCACTCCCAAAAGTAACTATATTCTGGATTTCAACTTTTCTTCTAATTGTGAATCCTTCTGTTTTTTCTTCTTAAGGAGGAAAGTT
AAAGGACACTACAGGTCATCAAAAACAAGTTGGCCAAGGACTCATTACTTGTCTTATATTTTTACTGCCACTAAACTGCCTGTATTTCTG
TATGTCCTTCTATCCAAACAGACGTTCACTGCCACTTGTAAAGTGAAGGATGTAAACGAGGATATATAACTGTTTCAGTGAACAGATTTT
GTGAAGTGCCTTCTGTTTTAGCACTTTAAGTTTATCACATTTTGTTGACTTCTGACATTCCACTTTCCTAGGTTATAGGAAAGATCTGTT

>89221_89221_1_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000485960_E2F5_chr8_86114381_ENST00000256117_length(amino acids)=279AA_BP=10
MAAAGVVSGKAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSI
KNVMDDSINNRTFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVVFPVPPPD
DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCD

--------------------------------------------------------------
>89221_89221_2_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000485960_E2F5_chr8_86114381_ENST00000416274_length(transcript)=1513nt_BP=53nt
ATTACCAGGCACGCGCAGGAAACATGGCGGCGGCGGGTGTTGTGAGCGGGAAGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAA
TTTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAAGTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGCT
GTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAATTGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGA
AGTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAATAATAGATTTTCCTATGTAACTCATGAAGACATCTGTAATT
GCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTACACAACTGGAGGTACCCATTCCAGAAATGGGTCAGAATGGACAAA
AGAAATACCAGATCAATCTAAAGAGTCATTCAGGACCTATCCATGTGCTGCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGGTTT
TTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTCCTTGACTCCAGTGACTCCACAGAAATCCAGCATGGCAACTCAAA
ATCTGCCTGAGCAACATGTCTCTGAAAGAAGCCAGGCTCTGCAGCAGACATCAGCTACAGATATATCTTCAGCAGGATCTATTAGTGGAG
ATATCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAGGCTTTCTCCTACCCCGGCAGATGACTACAACTTTAATTTAGATG
ATAACGAAGGAGTTTGTGATCTGTTTGATGTCCAGATACTAAATTATTAGATTCCATGGAAACTTGGGACTGTTATCTACCTCTAACTGT
GTAACATTTTAGACTTCTTAATAACCTAAATATTTAAAATAATGAATGTAACACCTTTTTTAGTTCACTGATTCTGAAGTGTTCTTCCCT
AATACTTTCTTTACTTCACAAAACTTCAACCATAAAAACAAAGGGCTCTGATTGCTTTAGGGGATAAGTGATTTAATATCCACAAACGTC
CCCACTCCCAAAAGTAACTATATTCTGGATTTCAACTTTTCTTCTAATTGTGAATCCTTCTGTTTTTTCTTCTTAAGGAGGAAAGTTAAA
GGACACTACAGGTCATCAAAAACAAGTTGGCCAAGGACTCATTACTTGTCTTATATTTTTACTGCCACTAAACTGCCTGTATTTCTGTAT
GTCCTTCTATCCAAACAGACGTTCACTGCCACTTGTAAAGTGAAGGATGTAAACGAGGATATATAACTGTTTCAGTGAACAGATTTTGTG
AAGTGCCTTCTGTTTTAGCACTTTAAGTTTATCACATTTTGTTGACTTCTGACATTCCACTTTCCTAGGTTATAGGAAAGATCTGTTTAT

>89221_89221_2_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000485960_E2F5_chr8_86114381_ENST00000416274_length(amino acids)=278AA_BP=10
MAAAGVVSGKAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSI
KNVMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVVFPVPPPDD
LTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDL

--------------------------------------------------------------
>89221_89221_3_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000485960_E2F5_chr8_86114381_ENST00000418930_length(transcript)=1513nt_BP=53nt
ATTACCAGGCACGCGCAGGAAACATGGCGGCGGCGGGTGTTGTGAGCGGGAAGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAA
TTTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAAGTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGCT
GTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAATTGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGA
AGTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAATAATAGATTTTCCTATGTAACTCATGAAGACATCTGTAATT
GCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTACACAACTGGAGGTACCCATTCCAGAAATGGGTCAGAATGGACAAA
AGAAATACCAGATCAATCTAAAGAGTCATTCAGGACCTATCCATGTGCTGCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGGTTT
TTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTCCTTGACTCCAGTGACTCCACAGAAATCCAGCATGGCAACTCAAA
ATCTGCCTGAGCAACATGTCTCTGAAAGAAGCCAGGCTCTGCAGCAGACATCAGCTACAGATATATCTTCAGGATCTATTAGTGGAGATA
TCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAGGCTTTCTCCTACCCCGGCAGATGACTACAACTTTAATTTAGATGATA
ACGAAGGAGTTTGTGATCTGTTTGATGTCCAGATACTAAATTATTAGATTCCATGGAAACTTGGGACTGTTATCTACCTCTAACTGTGTA
ACATTTTAGACTTCTTAATAACCTAAATATTTAAAATAATGAATGTAACACCTTTTTTAGTTCACTGATTCTGAAGTGTTCTTCCCTAAT
ACTTTCTTTACTTCACAAAACTTCAACCATAAAAACAAAGGGCTCTGATTGCTTTAGGGGATAAGTGATTTAATATCCACAAACGTCCCC
ACTCCCAAAAGTAACTATATTCTGGATTTCAACTTTTCTTCTAATTGTGAATCCTTCTGTTTTTTCTTCTTAAGGAGGAAAGTTAAAGGA
CACTACAGGTCATCAAAAACAAGTTGGCCAAGGACTCATTACTTGTCTTATATTTTTACTGCCACTAAACTGCCTGTATTTCTGTATGTC
CTTCTATCCAAACAGACGTTCACTGCCACTTGTAAAGTGAAGGATGTAAACGAGGATATATAACTGTTTCAGTGAACAGATTTTGTGAAG
TGCCTTCTGTTTTAGCACTTTAAGTTTATCACATTTTGTTGACTTCTGACATTCCACTTTCCTAGGTTATAGGAAAGATCTGTTTATGTA

>89221_89221_3_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000485960_E2F5_chr8_86114381_ENST00000418930_length(amino acids)=277AA_BP=10
MAAAGVVSGKAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSI
KNVMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVVFPVPPPDD
LTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLF

--------------------------------------------------------------
>89221_89221_4_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000550746_E2F5_chr8_86114381_ENST00000256117_length(transcript)=1558nt_BP=94nt
GTTGTTGTATGTCCGAGAGACACGTGAGGTTCTGCTACGTCATTACCAGGCACGCGCAGGAAACATGGCGGCGGCGGGTGTTGTGAGCGG
GAAGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAATTTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAA
GTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGCTGTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAAT
TGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGAAGTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAA
TAATAGAACATTTTCCTATGTAACTCATGAAGACATCTGTAATTGCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTAC
ACAACTGGAGGTACCCATTCCAGAAATGGGTCAGAATGGACAAAAGAAATACCAGATCAATCTAAAGAGTCATTCAGGACCTATCCATGT
GCTGCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGGTTTTTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTC
CTTGACTCCAGTGACTCCACAGAAATCCAGCATGGCAACTCAAAATCTGCCTGAGCAACATGTCTCTGAAAGAAGCCAGGCTCTGCAGCA
GACATCAGCTACAGATATATCTTCAGCAGGATCTATTAGTGGAGATATCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAG
GCTTTCTCCTACCCCGGCAGATGACTACAACTTTAATTTAGATGATAACGAAGGAGTTTGTGATCTGTTTGATGTCCAGATACTAAATTA
TTAGATTCCATGGAAACTTGGGACTGTTATCTACCTCTAACTGTGTAACATTTTAGACTTCTTAATAACCTAAATATTTAAAATAATGAA
TGTAACACCTTTTTTAGTTCACTGATTCTGAAGTGTTCTTCCCTAATACTTTCTTTACTTCACAAAACTTCAACCATAAAAACAAAGGGC
TCTGATTGCTTTAGGGGATAAGTGATTTAATATCCACAAACGTCCCCACTCCCAAAAGTAACTATATTCTGGATTTCAACTTTTCTTCTA
ATTGTGAATCCTTCTGTTTTTTCTTCTTAAGGAGGAAAGTTAAAGGACACTACAGGTCATCAAAAACAAGTTGGCCAAGGACTCATTACT
TGTCTTATATTTTTACTGCCACTAAACTGCCTGTATTTCTGTATGTCCTTCTATCCAAACAGACGTTCACTGCCACTTGTAAAGTGAAGG
ATGTAAACGAGGATATATAACTGTTTCAGTGAACAGATTTTGTGAAGTGCCTTCTGTTTTAGCACTTTAAGTTTATCACATTTTGTTGAC
TTCTGACATTCCACTTTCCTAGGTTATAGGAAAGATCTGTTTATGTAGTTTGTTTTTAAAATGTGCCAATGCCTGTACATTAACAAGATT

>89221_89221_4_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000550746_E2F5_chr8_86114381_ENST00000256117_length(amino acids)=300AA_BP=31
LLYVRETREVLLRHYQARAGNMAAAGVVSGKAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEI
EDLELKERELDQQKLWLQQSIKNVMDDSINNRTFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHV
LLINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLR

--------------------------------------------------------------
>89221_89221_5_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000550746_E2F5_chr8_86114381_ENST00000416274_length(transcript)=1554nt_BP=94nt
GTTGTTGTATGTCCGAGAGACACGTGAGGTTCTGCTACGTCATTACCAGGCACGCGCAGGAAACATGGCGGCGGCGGGTGTTGTGAGCGG
GAAGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAATTTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAA
GTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGCTGTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAAT
TGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGAAGTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAA
TAATAGATTTTCCTATGTAACTCATGAAGACATCTGTAATTGCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTACACA
ACTGGAGGTACCCATTCCAGAAATGGGTCAGAATGGACAAAAGAAATACCAGATCAATCTAAAGAGTCATTCAGGACCTATCCATGTGCT
GCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGGTTTTTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTCCTT
GACTCCAGTGACTCCACAGAAATCCAGCATGGCAACTCAAAATCTGCCTGAGCAACATGTCTCTGAAAGAAGCCAGGCTCTGCAGCAGAC
ATCAGCTACAGATATATCTTCAGCAGGATCTATTAGTGGAGATATCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAGGCT
TTCTCCTACCCCGGCAGATGACTACAACTTTAATTTAGATGATAACGAAGGAGTTTGTGATCTGTTTGATGTCCAGATACTAAATTATTA
GATTCCATGGAAACTTGGGACTGTTATCTACCTCTAACTGTGTAACATTTTAGACTTCTTAATAACCTAAATATTTAAAATAATGAATGT
AACACCTTTTTTAGTTCACTGATTCTGAAGTGTTCTTCCCTAATACTTTCTTTACTTCACAAAACTTCAACCATAAAAACAAAGGGCTCT
GATTGCTTTAGGGGATAAGTGATTTAATATCCACAAACGTCCCCACTCCCAAAAGTAACTATATTCTGGATTTCAACTTTTCTTCTAATT
GTGAATCCTTCTGTTTTTTCTTCTTAAGGAGGAAAGTTAAAGGACACTACAGGTCATCAAAAACAAGTTGGCCAAGGACTCATTACTTGT
CTTATATTTTTACTGCCACTAAACTGCCTGTATTTCTGTATGTCCTTCTATCCAAACAGACGTTCACTGCCACTTGTAAAGTGAAGGATG
TAAACGAGGATATATAACTGTTTCAGTGAACAGATTTTGTGAAGTGCCTTCTGTTTTAGCACTTTAAGTTTATCACATTTTGTTGACTTC
TGACATTCCACTTTCCTAGGTTATAGGAAAGATCTGTTTATGTAGTTTGTTTTTAAAATGTGCCAATGCCTGTACATTAACAAGATTTTT

>89221_89221_5_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000550746_E2F5_chr8_86114381_ENST00000416274_length(amino acids)=299AA_BP=31
LLYVRETREVLLRHYQARAGNMAAAGVVSGKAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEI
EDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVL
LINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRL

--------------------------------------------------------------
>89221_89221_6_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000550746_E2F5_chr8_86114381_ENST00000418930_length(transcript)=1554nt_BP=94nt
GTTGTTGTATGTCCGAGAGACACGTGAGGTTCTGCTACGTCATTACCAGGCACGCGCAGGAAACATGGCGGCGGCGGGTGTTGTGAGCGG
GAAGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAATTTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAA
GTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGCTGTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAAT
TGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGAAGTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAA
TAATAGATTTTCCTATGTAACTCATGAAGACATCTGTAATTGCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTACACA
ACTGGAGGTACCCATTCCAGAAATGGGTCAGAATGGACAAAAGAAATACCAGATCAATCTAAAGAGTCATTCAGGACCTATCCATGTGCT
GCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGGTTTTTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTCCTT
GACTCCAGTGACTCCACAGAAATCCAGCATGGCAACTCAAAATCTGCCTGAGCAACATGTCTCTGAAAGAAGCCAGGCTCTGCAGCAGAC
ATCAGCTACAGATATATCTTCAGGATCTATTAGTGGAGATATCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAGGCTTTC
TCCTACCCCGGCAGATGACTACAACTTTAATTTAGATGATAACGAAGGAGTTTGTGATCTGTTTGATGTCCAGATACTAAATTATTAGAT
TCCATGGAAACTTGGGACTGTTATCTACCTCTAACTGTGTAACATTTTAGACTTCTTAATAACCTAAATATTTAAAATAATGAATGTAAC
ACCTTTTTTAGTTCACTGATTCTGAAGTGTTCTTCCCTAATACTTTCTTTACTTCACAAAACTTCAACCATAAAAACAAAGGGCTCTGAT
TGCTTTAGGGGATAAGTGATTTAATATCCACAAACGTCCCCACTCCCAAAAGTAACTATATTCTGGATTTCAACTTTTCTTCTAATTGTG
AATCCTTCTGTTTTTTCTTCTTAAGGAGGAAAGTTAAAGGACACTACAGGTCATCAAAAACAAGTTGGCCAAGGACTCATTACTTGTCTT
ATATTTTTACTGCCACTAAACTGCCTGTATTTCTGTATGTCCTTCTATCCAAACAGACGTTCACTGCCACTTGTAAAGTGAAGGATGTAA
ACGAGGATATATAACTGTTTCAGTGAACAGATTTTGTGAAGTGCCTTCTGTTTTAGCACTTTAAGTTTATCACATTTTGTTGACTTCTGA
CATTCCACTTTCCTAGGTTATAGGAAAGATCTGTTTATGTAGTTTGTTTTTAAAATGTGCCAATGCCTGTACATTAACAAGATTTTTAAA

>89221_89221_6_TBC1D15-E2F5_TBC1D15_chr12_72233591_ENST00000550746_E2F5_chr8_86114381_ENST00000418930_length(amino acids)=298AA_BP=31
LLYVRETREVLLRHYQARAGNMAAAGVVSGKAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEI
EDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVL
LINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSGSISGDIIDELMSSDVFPLLRLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBC1D15-E2F5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBC1D15-E2F5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBC1D15-E2F5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource