FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TBC1D22A-POLDIP3 (FusionGDB2 ID:89303)

Fusion Gene Summary for TBC1D22A-POLDIP3

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D22A-POLDIP3
Fusion gene ID: 89303
HgeneTgene
Gene symbol

TBC1D22A

POLDIP3

Gene ID

25771

84271

Gene nameTBC1 domain family member 22ADNA polymerase delta interacting protein 3
SynonymsC22orf4|HSC79E021PDIP3|PDIP46|SKAR
Cytomap

22q13.31

22q13.2

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 22Aputative GTPase activatorpolymerase delta-interacting protein 346 kDa DNA polymerase delta interaction proteinRNA-binding protein P46S6K1 Aly/REF-like targetpolymerase (DNA) delta interacting protein 3polymerase (DNA-directed), delta interacting protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337137, ENST00000380995, 
ENST00000406733, ENST00000355704, 
ENST00000407381, ENST00000472791, 
ENST00000491021, ENST00000339677, 
ENST00000451060, ENST00000252115, 
ENST00000348657, 
Fusion gene scores* DoF score34 X 18 X 14=856811 X 7 X 4=308
# samples 3711
** MAII scorelog2(37/8568*10)=-4.53336130423394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/308*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D22A [Title/Abstract] AND POLDIP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBC1D22A(47193517)-POLDIP3(42983578), # samples:4
Anticipated loss of major functional domain due to fusion event.TBC1D22A-POLDIP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLDIP3

GO:0016973

poly(A)+ mRNA export from nucleus

22928037


check buttonFusion gene breakpoints across TBC1D22A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLDIP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1434-01ATBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
ChimerDB4OVTCGA-24-1434-01ATBC1D22Achr22

47193517

-POLDIP3chr22

42983578

-
ChimerDB4OVTCGA-24-1434-01ATBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
ChimerDB4OVTCGA-24-1434TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-


Top

Fusion Gene ORF analysis for TBC1D22A-POLDIP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337137ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-5UTRENST00000337137ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-5UTRENST00000380995ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-5UTRENST00000380995ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-5UTRENST00000406733ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-5UTRENST00000406733ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-intronENST00000337137ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-intronENST00000337137ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-intronENST00000337137ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-intronENST00000337137ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-intronENST00000380995ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-intronENST00000380995ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-intronENST00000380995ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-intronENST00000380995ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-intronENST00000406733ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-intronENST00000406733ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
5CDS-intronENST00000406733ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
5CDS-intronENST00000406733ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
Frame-shiftENST00000337137ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
Frame-shiftENST00000380995ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
Frame-shiftENST00000406733ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
In-frameENST00000337137ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
In-frameENST00000337137ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
In-frameENST00000337137ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
In-frameENST00000380995ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
In-frameENST00000380995ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
In-frameENST00000380995ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
In-frameENST00000406733ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
In-frameENST00000406733ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
In-frameENST00000406733ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-3CDSENST00000355704ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-3CDSENST00000355704ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-3CDSENST00000355704ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-3CDSENST00000355704ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-3CDSENST00000407381ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-3CDSENST00000407381ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-3CDSENST00000407381ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-3CDSENST00000407381ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-3CDSENST00000472791ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-3CDSENST00000472791ENST00000252115TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-3CDSENST00000472791ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-3CDSENST00000472791ENST00000348657TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-5UTRENST00000355704ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-5UTRENST00000355704ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-5UTRENST00000407381ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-5UTRENST00000407381ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-5UTRENST00000472791ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-5UTRENST00000472791ENST00000491021TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-intronENST00000355704ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-intronENST00000355704ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-intronENST00000355704ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-intronENST00000355704ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-intronENST00000407381ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-intronENST00000407381ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-intronENST00000407381ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-intronENST00000407381ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-intronENST00000472791ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-intronENST00000472791ENST00000339677TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-
intron-intronENST00000472791ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42981974

-
intron-intronENST00000472791ENST00000451060TBC1D22Achr22

47193517

+POLDIP3chr22

42983578

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337137TBC1D22Achr2247193517+ENST00000348657POLDIP3chr2242983578-31188031661047293
ENST00000337137TBC1D22Achr2247193517+ENST00000252115POLDIP3chr2242983578-31188031661047293
ENST00000380995TBC1D22Achr2247193517+ENST00000348657POLDIP3chr2242983578-31077921551036293
ENST00000380995TBC1D22Achr2247193517+ENST00000252115POLDIP3chr2242983578-31077921551036293
ENST00000406733TBC1D22Achr2247193517+ENST00000348657POLDIP3chr2242983578-31998842411128295
ENST00000406733TBC1D22Achr2247193517+ENST00000252115POLDIP3chr2242983578-31998842411128295
ENST00000337137TBC1D22Achr2247193517+ENST00000348657POLDIP3chr2242981974-3051803166810214
ENST00000380995TBC1D22Achr2247193517+ENST00000348657POLDIP3chr2242981974-3040792155799214
ENST00000406733TBC1D22Achr2247193517+ENST00000348657POLDIP3chr2242981974-3132884241891216

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337137ENST00000348657TBC1D22Achr2247193517+POLDIP3chr2242983578-0.0149554230.98504454
ENST00000337137ENST00000252115TBC1D22Achr2247193517+POLDIP3chr2242983578-0.0149554230.98504454
ENST00000380995ENST00000348657TBC1D22Achr2247193517+POLDIP3chr2242983578-0.0150904220.9849096
ENST00000380995ENST00000252115TBC1D22Achr2247193517+POLDIP3chr2242983578-0.0150904220.9849096
ENST00000406733ENST00000348657TBC1D22Achr2247193517+POLDIP3chr2242983578-0.0178216580.9821783
ENST00000406733ENST00000252115TBC1D22Achr2247193517+POLDIP3chr2242983578-0.0178216580.9821783
ENST00000337137ENST00000348657TBC1D22Achr2247193517+POLDIP3chr2242981974-0.0335488360.9664512
ENST00000380995ENST00000348657TBC1D22Achr2247193517+POLDIP3chr2242981974-0.0346654020.9653346
ENST00000406733ENST00000348657TBC1D22Achr2247193517+POLDIP3chr2242981974-0.0318024980.96819746

Top

Fusion Genomic Features for TBC1D22A-POLDIP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TBC1D22A-POLDIP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:47193517/chr22:42983578)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D22Achr22:47193517chr22:42981974ENST00000337137+413222_446212518.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:42981974ENST00000355704+111222_4460440.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:42981974ENST00000380995+49222_446165325.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:42983578ENST00000337137+413222_446212518.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:42983578ENST00000355704+111222_4460440.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:42983578ENST00000380995+49222_446165325.0DomainRab-GAP TBC
TgenePOLDIP3chr22:47193517chr22:42981974ENST0000025211579280_351362422.0DomainRRM
TgenePOLDIP3chr22:47193517chr22:42981974ENST0000034865768280_351333393.0DomainRRM
TgenePOLDIP3chr22:47193517chr22:42983578ENST0000025211569280_351340422.0DomainRRM
TgenePOLDIP3chr22:47193517chr22:42983578ENST0000034865758280_351311393.0DomainRRM


Top

Fusion Gene Sequence for TBC1D22A-POLDIP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89303_89303_1_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000337137_POLDIP3_chr22_42981974_ENST00000348657_length(transcript)=3051nt_BP=803nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGCGGCTG
AGTGACAGCCCATCAATGAAAAAGGAGAGCGAGCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCT
GACACCATCCTGAAGGCACTCTTCAAGTCCTCAGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAG
TGAGGCAGCCAGAAGTGGGGGCAGAGGAGGGTGGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCT
GATTGTGGGAAGGGTTGCCAGGGATAAAGAGCTTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTC
TACGTTAACGTTTCCTGTAGTATGTTTCTTCATCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCC
AAGCTGATTTCTTATCTGGAAATGGTACACTGAATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAG
GACCCTGCTTTTTCCAGGGGCCGAGGGGCTGCCTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGT
CCTGACGGGAGCCAGGTCGGCCTGAGAGCTGTGCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCT
TGTCCTCTCCCCAGTGGCTCCAGGCCTCACTAGTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTT
GGAGTCCCGTGTCGTCTCCACCCAGAGGAAGTTCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTC
TCTTTCCCTTCTGGGTGTCTTTGCTGGGAGGGGGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGT
TTTGTGTAGCCGCCAGCTCTCTTCTGGTTGGGCCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATG
GAAGAGGTCAGTTTGTTCCTGGCTCTCCATTTCTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCT
GCCACCAAGGGGCACTGTTTGTTCCCACTTATGTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGG
AGGAGTCAAGGGAGCAGGGCAGCTCTACCAGGCAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCA
GTCCCTGAATGACCAGGCCAGTGTTGTCACTGAGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGT
TGGGGAGCACGGTTCTGGGAGCTCTGCAAAATCAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTG
CTTGAGGCTAGCCCAGTGAAAAAAACCAGAGACTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCT
TCAGTGTGCAGGCTCTGAGGCTGCCCAGGACGGGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTG
CTTTTTATTCTCCTAACCCTTTCAAGTGGGTGCAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCA
AGAGAGCATCCAGAAGGCAGTAGGACCTGGTTTTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGT
AAATATCCTCCCTGCATGGCTTTATCCTCCCTCTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAG
CCACGTGGCCATCTGGAGCTGGTGCTATAGGTGACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCT
TGGGAGACCGGGAGGAGAAGGTGGTGGGCTAGTCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCA

>89303_89303_1_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000337137_POLDIP3_chr22_42981974_ENST00000348657_length(amino acids)=214AA_BP=
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS

--------------------------------------------------------------
>89303_89303_2_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000337137_POLDIP3_chr22_42983578_ENST00000252115_length(transcript)=3118nt_BP=803nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGGCAGCC
GATGAAGTGCAACCTTCACATGAATGGGAATGTTATCACCTCAGACCAGCCCATCCTGCTGCGGCTGAGTGACAGCCCATCAATGAAAAA
GGAGAGCGAGCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCTGAAGGCACTCTT
CAAGTCCTCAGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCAGAAGTGGGGGCA
GAGGAGGGTGGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAAGGGTTGCCAGGG
ATAAAGAGCTTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGTTTCCTGTAGTAT
GTTTCTTCATCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTCTTATCTGGAAAT
GGTACACTGAATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTTTTCCAGGGGCCG
AGGGGCTGCCTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAGCCAGGTCGGCCT
GAGAGCTGTGCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCCCAGTGGCTCCAG
GCCTCACTAGTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTGTCGTCTCCACCC
AGAGGAAGTTCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTCTGGGTGTCTTTG
CTGGGAGGGGGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCCGCCAGCTCTCTT
CTGGTTGGGCCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAGTTTGTTCCTGGC
TCTCCATTTCTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGGGCACTGTTTGTT
CCCACTTATGTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGGGAGCAGGGCAGC
TCTACCAGGCAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATGACCAGGCCAGTG
TTGTCACTGAGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACGGTTCTGGGAGCT
CTGCAAAATCAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAGCCCAGTGAAAAA
AACCAGAGACTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAGGCTCTGAGGCTG
CCCAGGACGGGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCTCCTAACCCTTTC
AAGTGGGTGCAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCCAGAAGGCAGTAG
GACCTGGTTTTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCCCTGCATGGCTTT
ATCCTCCCTCTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCATCTGGAGCTGGT
GCTATAGGTGACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGGGAGGAGAAGGTG
GTGGGCTAGTCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGAAGGGGCATTAAG

>89303_89303_2_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000337137_POLDIP3_chr22_42983578_ENST00000252115_length(amino acids)=293AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTI

--------------------------------------------------------------
>89303_89303_3_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000337137_POLDIP3_chr22_42983578_ENST00000348657_length(transcript)=3118nt_BP=803nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGGCAGCC
GATGAAGTGCAACCTTCACATGAATGGGAATGTTATCACCTCAGACCAGCCCATCCTGCTGCGGCTGAGTGACAGCCCATCAATGAAAAA
GGAGAGCGAGCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCTGAAGGCACTCTT
CAAGTCCTCAGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCAGAAGTGGGGGCA
GAGGAGGGTGGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAAGGGTTGCCAGGG
ATAAAGAGCTTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGTTTCCTGTAGTAT
GTTTCTTCATCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTCTTATCTGGAAAT
GGTACACTGAATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTTTTCCAGGGGCCG
AGGGGCTGCCTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAGCCAGGTCGGCCT
GAGAGCTGTGCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCCCAGTGGCTCCAG
GCCTCACTAGTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTGTCGTCTCCACCC
AGAGGAAGTTCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTCTGGGTGTCTTTG
CTGGGAGGGGGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCCGCCAGCTCTCTT
CTGGTTGGGCCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAGTTTGTTCCTGGC
TCTCCATTTCTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGGGCACTGTTTGTT
CCCACTTATGTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGGGAGCAGGGCAGC
TCTACCAGGCAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATGACCAGGCCAGTG
TTGTCACTGAGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACGGTTCTGGGAGCT
CTGCAAAATCAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAGCCCAGTGAAAAA
AACCAGAGACTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAGGCTCTGAGGCTG
CCCAGGACGGGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCTCCTAACCCTTTC
AAGTGGGTGCAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCCAGAAGGCAGTAG
GACCTGGTTTTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCCCTGCATGGCTTT
ATCCTCCCTCTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCATCTGGAGCTGGT
GCTATAGGTGACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGGGAGGAGAAGGTG
GTGGGCTAGTCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGAAGGGGCATTAAG

>89303_89303_3_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000337137_POLDIP3_chr22_42983578_ENST00000348657_length(amino acids)=293AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTI

--------------------------------------------------------------
>89303_89303_4_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000380995_POLDIP3_chr22_42981974_ENST00000348657_length(transcript)=3040nt_BP=792nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGCGGCTGAGTGACAGCCC
ATCAATGAAAAAGGAGAGCGAGCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCT
GAAGGCACTCTTCAAGTCCTCAGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCA
GAAGTGGGGGCAGAGGAGGGTGGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAA
GGGTTGCCAGGGATAAAGAGCTTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGT
TTCCTGTAGTATGTTTCTTCATCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTC
TTATCTGGAAATGGTACACTGAATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTT
TTCCAGGGGCCGAGGGGCTGCCTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAG
CCAGGTCGGCCTGAGAGCTGTGCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCC
CAGTGGCTCCAGGCCTCACTAGTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTG
TCGTCTCCACCCAGAGGAAGTTCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTC
TGGGTGTCTTTGCTGGGAGGGGGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCC
GCCAGCTCTCTTCTGGTTGGGCCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAG
TTTGTTCCTGGCTCTCCATTTCTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGG
GCACTGTTTGTTCCCACTTATGTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGG
GAGCAGGGCAGCTCTACCAGGCAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATG
ACCAGGCCAGTGTTGTCACTGAGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACG
GTTCTGGGAGCTCTGCAAAATCAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAG
CCCAGTGAAAAAAACCAGAGACTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAG
GCTCTGAGGCTGCCCAGGACGGGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCT
CCTAACCCTTTCAAGTGGGTGCAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCC
AGAAGGCAGTAGGACCTGGTTTTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCC
CTGCATGGCTTTATCCTCCCTCTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCA
TCTGGAGCTGGTGCTATAGGTGACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGG
GAGGAGAAGGTGGTGGGCTAGTCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGA

>89303_89303_4_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000380995_POLDIP3_chr22_42981974_ENST00000348657_length(amino acids)=214AA_BP=
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS

--------------------------------------------------------------
>89303_89303_5_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000380995_POLDIP3_chr22_42983578_ENST00000252115_length(transcript)=3107nt_BP=792nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGGCAGCCGATGAAGTGCA
ACCTTCACATGAATGGGAATGTTATCACCTCAGACCAGCCCATCCTGCTGCGGCTGAGTGACAGCCCATCAATGAAAAAGGAGAGCGAGC
TGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCTGAAGGCACTCTTCAAGTCCTCAG
GGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCAGAAGTGGGGGCAGAGGAGGGTGG
CTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAAGGGTTGCCAGGGATAAAGAGCTT
CCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGTTTCCTGTAGTATGTTTCTTCATC
TCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTCTTATCTGGAAATGGTACACTGAA
TTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTTTTCCAGGGGCCGAGGGGCTGCCT
TTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAGCCAGGTCGGCCTGAGAGCTGTGC
CGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCCCAGTGGCTCCAGGCCTCACTAGT
GGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTGTCGTCTCCACCCAGAGGAAGTTC
TCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTCTGGGTGTCTTTGCTGGGAGGGGG
CTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCCGCCAGCTCTCTTCTGGTTGGGCC
TTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAGTTTGTTCCTGGCTCTCCATTTCT
GGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGGGCACTGTTTGTTCCCACTTATGT
GAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGGGAGCAGGGCAGCTCTACCAGGCA
AGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATGACCAGGCCAGTGTTGTCACTGAG
TGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACGGTTCTGGGAGCTCTGCAAAATCA
GTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAGCCCAGTGAAAAAAACCAGAGACT
CATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAGGCTCTGAGGCTGCCCAGGACGGG
AAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCTCCTAACCCTTTCAAGTGGGTGCA
GACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCCAGAAGGCAGTAGGACCTGGTTTT
TCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCCCTGCATGGCTTTATCCTCCCTCT
CATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCATCTGGAGCTGGTGCTATAGGTGA
CCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGGGAGGAGAAGGTGGTGGGCTAGTC
CTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGAAGGGGCATTAAGAGATGAAGGGT

>89303_89303_5_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000380995_POLDIP3_chr22_42983578_ENST00000252115_length(amino acids)=293AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTI

--------------------------------------------------------------
>89303_89303_6_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000380995_POLDIP3_chr22_42983578_ENST00000348657_length(transcript)=3107nt_BP=792nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGGCAGCCGATGAAGTGCA
ACCTTCACATGAATGGGAATGTTATCACCTCAGACCAGCCCATCCTGCTGCGGCTGAGTGACAGCCCATCAATGAAAAAGGAGAGCGAGC
TGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCTGAAGGCACTCTTCAAGTCCTCAG
GGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCAGAAGTGGGGGCAGAGGAGGGTGG
CTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAAGGGTTGCCAGGGATAAAGAGCTT
CCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGTTTCCTGTAGTATGTTTCTTCATC
TCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTCTTATCTGGAAATGGTACACTGAA
TTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTTTTCCAGGGGCCGAGGGGCTGCCT
TTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAGCCAGGTCGGCCTGAGAGCTGTGC
CGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCCCAGTGGCTCCAGGCCTCACTAGT
GGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTGTCGTCTCCACCCAGAGGAAGTTC
TCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTCTGGGTGTCTTTGCTGGGAGGGGG
CTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCCGCCAGCTCTCTTCTGGTTGGGCC
TTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAGTTTGTTCCTGGCTCTCCATTTCT
GGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGGGCACTGTTTGTTCCCACTTATGT
GAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGGGAGCAGGGCAGCTCTACCAGGCA
AGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATGACCAGGCCAGTGTTGTCACTGAG
TGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACGGTTCTGGGAGCTCTGCAAAATCA
GTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAGCCCAGTGAAAAAAACCAGAGACT
CATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAGGCTCTGAGGCTGCCCAGGACGGG
AAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCTCCTAACCCTTTCAAGTGGGTGCA
GACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCCAGAAGGCAGTAGGACCTGGTTTT
TCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCCCTGCATGGCTTTATCCTCCCTCT
CATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCATCTGGAGCTGGTGCTATAGGTGA
CCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGGGAGGAGAAGGTGGTGGGCTAGTC
CTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGAAGGGGCATTAAGAGATGAAGGGT

>89303_89303_6_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000380995_POLDIP3_chr22_42983578_ENST00000348657_length(amino acids)=293AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTI

--------------------------------------------------------------
>89303_89303_7_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000406733_POLDIP3_chr22_42981974_ENST00000348657_length(transcript)=3132nt_BP=884nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGCGGCTGAGTGACAGC
CCATCAATGAAAAAGGAGAGCGAGCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATC
CTGAAGGCACTCTTCAAGTCCTCAGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGC
CAGAAGTGGGGGCAGAGGAGGGTGGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGG
AAGGGTTGCCAGGGATAAAGAGCTTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAAC
GTTTCCTGTAGTATGTTTCTTCATCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATT
TCTTATCTGGAAATGGTACACTGAATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCT
TTTTCCAGGGGCCGAGGGGCTGCCTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGG
AGCCAGGTCGGCCTGAGAGCTGTGCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTC
CCCAGTGGCTCCAGGCCTCACTAGTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCG
TGTCGTCTCCACCCAGAGGAAGTTCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCT
TCTGGGTGTCTTTGCTGGGAGGGGGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAG
CCGCCAGCTCTCTTCTGGTTGGGCCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTC
AGTTTGTTCCTGGCTCTCCATTTCTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAG
GGGCACTGTTTGTTCCCACTTATGTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAA
GGGAGCAGGGCAGCTCTACCAGGCAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAA
TGACCAGGCCAGTGTTGTCACTGAGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCA
CGGTTCTGGGAGCTCTGCAAAATCAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCT
AGCCCAGTGAAAAAAACCAGAGACTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGC
AGGCTCTGAGGCTGCCCAGGACGGGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATT
CTCCTAACCCTTTCAAGTGGGTGCAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCAT
CCAGAAGGCAGTAGGACCTGGTTTTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCT
CCCTGCATGGCTTTATCCTCCCTCTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGC
CATCTGGAGCTGGTGCTATAGGTGACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACC
GGGAGGAGAAGGTGGTGGGCTAGTCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAG

>89303_89303_7_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000406733_POLDIP3_chr22_42981974_ENST00000348657_length(amino acids)=216AA_BP=
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG

--------------------------------------------------------------
>89303_89303_8_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000406733_POLDIP3_chr22_42983578_ENST00000252115_length(transcript)=3199nt_BP=884nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGGCAGCCGATGAAGTG
CAACCTTCACATGAATGGGAATGTTATCACCTCAGACCAGCCCATCCTGCTGCGGCTGAGTGACAGCCCATCAATGAAAAAGGAGAGCGA
GCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCTGAAGGCACTCTTCAAGTCCTC
AGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCAGAAGTGGGGGCAGAGGAGGGT
GGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAAGGGTTGCCAGGGATAAAGAGC
TTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGTTTCCTGTAGTATGTTTCTTCA
TCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTCTTATCTGGAAATGGTACACTG
AATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTTTTCCAGGGGCCGAGGGGCTGC
CTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAGCCAGGTCGGCCTGAGAGCTGT
GCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCCCAGTGGCTCCAGGCCTCACTA
GTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTGTCGTCTCCACCCAGAGGAAGT
TCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTCTGGGTGTCTTTGCTGGGAGGG
GGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCCGCCAGCTCTCTTCTGGTTGGG
CCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAGTTTGTTCCTGGCTCTCCATTT
CTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGGGCACTGTTTGTTCCCACTTAT
GTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGGGAGCAGGGCAGCTCTACCAGG
CAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATGACCAGGCCAGTGTTGTCACTG
AGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACGGTTCTGGGAGCTCTGCAAAAT
CAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAGCCCAGTGAAAAAAACCAGAGA
CTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAGGCTCTGAGGCTGCCCAGGACG
GGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCTCCTAACCCTTTCAAGTGGGTG
CAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCCAGAAGGCAGTAGGACCTGGTT
TTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCCCTGCATGGCTTTATCCTCCCT
CTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCATCTGGAGCTGGTGCTATAGGT
GACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGGGAGGAGAAGGTGGTGGGCTAG
TCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGAAGGGGCATTAAGAGATGAAGG

>89303_89303_8_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000406733_POLDIP3_chr22_42983578_ENST00000252115_length(amino acids)=295AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPD

--------------------------------------------------------------
>89303_89303_9_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000406733_POLDIP3_chr22_42983578_ENST00000348657_length(transcript)=3199nt_BP=884nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGGGCAGCCGATGAAGTG
CAACCTTCACATGAATGGGAATGTTATCACCTCAGACCAGCCCATCCTGCTGCGGCTGAGTGACAGCCCATCAATGAAAAAGGAGAGCGA
GCTGCCTCGCAGGGTGAACTCTGCCTCCTCCTCCAACCCCCCTGCCGAAGTGGACCCTGACACCATCCTGAAGGCACTCTTCAAGTCCTC
AGGGGCCTCTGTGACCACGCAGCCCACAGAATTCAAAATCAAGCTTTGAGCAGGGGAGTGAGGCAGCCAGAAGTGGGGGCAGAGGAGGGT
GGCTCTGTTTCCCCAAGGCAAAGCTTATGACCAATGGGCCATCGGACTGGAGACCCCTGATTGTGGGAAGGGTTGCCAGGGATAAAGAGC
TTCCTCACTGGATGGGACCCGCCTTTCTGTGTTGTGTTCTGCCCTGTGCTCTTCTCTCTACGTTAACGTTTCCTGTAGTATGTTTCTTCA
TCTCATCGCCAAGGTAGGCTTGTGTTTTTCAGTGTGTGCCTCCCCGAGCCTCAGCCCCAAGCTGATTTCTTATCTGGAAATGGTACACTG
AATTCTCTGGGTGGCTTTCTTGTGGCCCCATGGGATGCAGCGTGGGGGCTGTCTGAAGGACCCTGCTTTTTCCAGGGGCCGAGGGGCTGC
CTTTCCTTTGTGTGTATTAAGCTTTTCAAACAATGGAGGGGATGGAGAGCCCTGGTGTCCTGACGGGAGCCAGGTCGGCCTGAGAGCTGT
GCCGCTCCTCTGTCTTGTCAGTGGAGGTGCCTGGGTGGGGAGCAGGTCTCAGGCCTCTTGTCCTCTCCCCAGTGGCTCCAGGCCTCACTA
GTGGCAAGGGCAGGATGAGGCTGCACCGCTGGGAAGAGTCTATCTAAGCTCTTGGCTTGGAGTCCCGTGTCGTCTCCACCCAGAGGAAGT
TCTCCAGAGTTCACCTTTCCCTTTTCCTTGAGTTGTGCTGAATGCCCCACCCCAGCTCTCTTTCCCTTCTGGGTGTCTTTGCTGGGAGGG
GGCTGTGTTGTGAGCCCTCCCGGTTCTCACCTCGCCTGGCACTTAACCACACCCTGGTTTTGTGTAGCCGCCAGCTCTCTTCTGGTTGGG
CCTTTGAAAGGCTCAGCCTCCCATTGTGCAGTGCTTGGGTTTGGAGCTTATTTGAATGGAAGAGGTCAGTTTGTTCCTGGCTCTCCATTT
CTGGCCTCAGTTGTCTACAGGACAGTGGTCAGGGATGCCTGGAGGCATATATCCAGCTGCCACCAAGGGGCACTGTTTGTTCCCACTTAT
GTGAGTGACCCCATCCATCCATGACCAGAGGATTATTTTCCTGCCTTGGCAGAGGAGGAGGAGTCAAGGGAGCAGGGCAGCTCTACCAGG
CAAGGTGTTTCCCCAGCATAGGCGCAGACAGTTGGGACGAAACTTCAGAGCCCAGGCAGTCCCTGAATGACCAGGCCAGTGTTGTCACTG
AGTGGTCCCCTGCTGGTTGGGAGTGAAGAGAATCCAGGCTGGCAGAGCTGGAGCCAGTTGGGGAGCACGGTTCTGGGAGCTCTGCAAAAT
CAGTAGCAAGTGCTGGAAAAGGCACATGCCGAAGATACTCAAGAGCTCCCAAGATTTGCTTGAGGCTAGCCCAGTGAAAAAAACCAGAGA
CTCATGTTTCCAGGGGTCAGTCTGTCAGGCAGGAAGGACCCAGGATTTGAACCCAGCTTCAGTGTGCAGGCTCTGAGGCTGCCCAGGACG
GGAAAGTCCAAGGAAGGGGCCTGGTGGTGCTCCACTTGCAGTTCTTTAAAGAATGCTGCTTTTTATTCTCCTAACCCTTTCAAGTGGGTG
CAGACTTCTCGTTAGCAGCTGGAAGACATTCCTCCCACACTTTTCCCTTCCTGGCCCAAGAGAGCATCCAGAAGGCAGTAGGACCTGGTT
TTTCAGGTACTGGGAGCCGGGGGCTCACTGCTTGCACTGTGCTTAGGGTAGGGATGGTAAATATCCTCCCTGCATGGCTTTATCCTCCCT
CTCATCCCAAAGCAGGTATCTTCTGGTTGTCACAGAGTTTCATTGAGTCCAGCTGCAGCCACGTGGCCATCTGGAGCTGGTGCTATAGGT
GACCATCTGGTACATTGAGGGGACCTGTTTGCCTCCTCCACTCTATAAGCAGTCATCTTGGGAGACCGGGAGGAGAAGGTGGTGGGCTAG
TCCTGTGTCCTCCTCCACTTCCCATGCCTCTATGTTACCCATCTGTGTCTCCTGTGCAGAAGGAGAGGAAGGGGCATTAAGAGATGAAGG

>89303_89303_9_TBC1D22A-POLDIP3_TBC1D22A_chr22_47193517_ENST00000406733_POLDIP3_chr22_42983578_ENST00000348657_length(amino acids)=295AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TBC1D22A-POLDIP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TBC1D22A-POLDIP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TBC1D22A-POLDIP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource