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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBC1D22A-RIBC2 (FusionGDB2 ID:89307)

Fusion Gene Summary for TBC1D22A-RIBC2

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D22A-RIBC2
Fusion gene ID: 89307
HgeneTgene
Gene symbol

TBC1D22A

RIBC2

Gene ID

25771

26150

Gene nameTBC1 domain family member 22ARIB43A domain with coiled-coils 2
SynonymsC22orf4|HSC79E021C22orf11|TRIB
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 22Aputative GTPase activatorRIB43A-like with coiled-coils protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337137, ENST00000355704, 
ENST00000380995, ENST00000406733, 
ENST00000407381, ENST00000472791, 
ENST00000466226, ENST00000342894, 
ENST00000538017, 
Fusion gene scores* DoF score34 X 18 X 14=85682 X 1 X 2=4
# samples 372
** MAII scorelog2(37/8568*10)=-4.53336130423394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TBC1D22A [Title/Abstract] AND RIBC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBC1D22A(47290742)-RIBC2(45826780), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TBC1D22A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RIBC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-7660-01ATBC1D22Achr22

47290742

-RIBC2chr22

45826780

+
ChimerDB4LUADTCGA-44-7660-01ATBC1D22Achr22

47290742

+RIBC2chr22

45826780

+


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Fusion Gene ORF analysis for TBC1D22A-RIBC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337137ENST00000466226TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
5CDS-3UTRENST00000355704ENST00000466226TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
5CDS-3UTRENST00000380995ENST00000466226TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
5CDS-3UTRENST00000406733ENST00000466226TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
5CDS-3UTRENST00000407381ENST00000466226TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000337137ENST00000342894TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000337137ENST00000538017TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000355704ENST00000342894TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000355704ENST00000538017TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000380995ENST00000342894TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000380995ENST00000538017TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000406733ENST00000342894TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000406733ENST00000538017TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000407381ENST00000342894TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
In-frameENST00000407381ENST00000538017TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
intron-3CDSENST00000472791ENST00000342894TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
intron-3CDSENST00000472791ENST00000538017TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+
intron-3UTRENST00000472791ENST00000466226TBC1D22Achr22

47290742

+RIBC2chr22

45826780

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337137TBC1D22Achr2247290742+ENST00000342894RIBC2chr2245826780+144610661661311381
ENST00000337137TBC1D22Achr2247290742+ENST00000538017RIBC2chr2245826780+136310661661311381
ENST00000380995TBC1D22Achr2247290742+ENST00000342894RIBC2chr2245826780+143510551551300381
ENST00000380995TBC1D22Achr2247290742+ENST00000538017RIBC2chr2245826780+135210551551300381
ENST00000407381TBC1D22Achr2247290742+ENST00000342894RIBC2chr2245826780+12188381151083322
ENST00000407381TBC1D22Achr2247290742+ENST00000538017RIBC2chr2245826780+11358381151083322
ENST00000355704TBC1D22Achr2247290742+ENST00000342894RIBC2chr2245826780+11527721061017303
ENST00000355704TBC1D22Achr2247290742+ENST00000538017RIBC2chr2245826780+10697721061017303
ENST00000406733TBC1D22Achr2247290742+ENST00000342894RIBC2chr2245826780+152711472411392383
ENST00000406733TBC1D22Achr2247290742+ENST00000538017RIBC2chr2245826780+144411472411392383

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337137ENST00000342894TBC1D22Achr2247290742+RIBC2chr2245826780+0.015323540.9846764
ENST00000337137ENST00000538017TBC1D22Achr2247290742+RIBC2chr2245826780+0.008938390.9910616
ENST00000380995ENST00000342894TBC1D22Achr2247290742+RIBC2chr2245826780+0.0167551170.9832449
ENST00000380995ENST00000538017TBC1D22Achr2247290742+RIBC2chr2245826780+0.0100734590.9899266
ENST00000407381ENST00000342894TBC1D22Achr2247290742+RIBC2chr2245826780+0.0146343550.9853656
ENST00000407381ENST00000538017TBC1D22Achr2247290742+RIBC2chr2245826780+0.0097993640.9902006
ENST00000355704ENST00000342894TBC1D22Achr2247290742+RIBC2chr2245826780+0.0155512530.9844488
ENST00000355704ENST00000538017TBC1D22Achr2247290742+RIBC2chr2245826780+0.0109168220.9890832
ENST00000406733ENST00000342894TBC1D22Achr2247290742+RIBC2chr2245826780+0.024063160.9759369
ENST00000406733ENST00000538017TBC1D22Achr2247290742+RIBC2chr2245826780+0.019027970.98097205

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Fusion Genomic Features for TBC1D22A-RIBC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBC1D22Achr2247290742+RIBC2chr2245826779+0.0002702480.9997297
TBC1D22Achr2247290742+RIBC2chr2245826779+0.0002702480.9997297

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TBC1D22A-RIBC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:47290742/chr22:45826780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D22Achr22:47290742chr22:45826780ENST00000337137+713222_446300518.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47290742chr22:45826780ENST00000355704+511222_446222440.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47290742chr22:45826780ENST00000380995+79222_446253325.0DomainRab-GAP TBC
TgeneRIBC2chr22:47290742chr22:45826780ENST0000034289447222_255228310.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for TBC1D22A-RIBC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89307_89307_1_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000337137_RIBC2_chr22_45826780_ENST00000342894_length(transcript)=1446nt_BP=1066nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT
ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG
GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA
CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGA
AAAGCGCCAGCGAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCA
GCGCGACCTGCGCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATAC
AAATCAACCCACGGGAGACTATTTCACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAA
GAGTGGCTACCTTAAAGAGTCACGTTTCTTTTTTAAAGATACACTCCTTGGGCCACAAGTACCCTTCAGCTGTAATCGTCCACTGTGGAC

>89307_89307_1_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000337137_RIBC2_chr22_45826780_ENST00000342894_length(amino acids)=381AA_BP=300
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKKYM

--------------------------------------------------------------
>89307_89307_2_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000337137_RIBC2_chr22_45826780_ENST00000538017_length(transcript)=1363nt_BP=1066nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT
ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG
GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA
CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGA
AAAGCGCCAGCGAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCA
GCGCGACCTGCGCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATAC
AAATCAACCCACGGGAGACTATTTCACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAA

>89307_89307_2_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000337137_RIBC2_chr22_45826780_ENST00000538017_length(amino acids)=381AA_BP=300
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKKYM

--------------------------------------------------------------
>89307_89307_3_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000355704_RIBC2_chr22_45826780_ENST00000342894_length(transcript)=1152nt_BP=772nt
CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA
GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC
CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC
TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA
CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC
CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT
CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA
ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA
CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCAGCGAGACCTGGACTG
GGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCTGCGCAGAGCTCTGGA
CAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACCCACGGGAGACTATTT
CACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAAGAGTGGCTACCTTAAAGAGTCACG

>89307_89307_3_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000355704_RIBC2_chr22_45826780_ENST00000342894_length(amino acids)=303AA_BP=222
MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ
GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYF
AFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLS

--------------------------------------------------------------
>89307_89307_4_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000355704_RIBC2_chr22_45826780_ENST00000538017_length(transcript)=1069nt_BP=772nt
CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA
GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC
CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC
TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA
CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC
CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT
CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA
ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA
CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCAGCGAGACCTGGACTG
GGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCTGCGCAGAGCTCTGGA
CAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACCCACGGGAGACTATTT

>89307_89307_4_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000355704_RIBC2_chr22_45826780_ENST00000538017_length(amino acids)=303AA_BP=222
MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ
GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYF
AFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLS

--------------------------------------------------------------
>89307_89307_5_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000380995_RIBC2_chr22_45826780_ENST00000342894_length(transcript)=1435nt_BP=1055nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGA
GCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCA
CTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGC
AGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCAGC
GAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCTGC
GCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACCCA
CGGGAGACTATTTCACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAAGAGTGGCTACC

>89307_89307_5_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000380995_RIBC2_chr22_45826780_ENST00000342894_length(amino acids)=381AA_BP=300
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKKYM

--------------------------------------------------------------
>89307_89307_6_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000380995_RIBC2_chr22_45826780_ENST00000538017_length(transcript)=1352nt_BP=1055nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGA
GCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCA
CTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGC
AGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCAGC
GAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCTGC
GCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACCCA
CGGGAGACTATTTCACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAAGAGTGGCTACC

>89307_89307_6_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000380995_RIBC2_chr22_45826780_ENST00000538017_length(amino acids)=381AA_BP=300
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKKYM

--------------------------------------------------------------
>89307_89307_7_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000406733_RIBC2_chr22_45826780_ENST00000342894_length(transcript)=1527nt_BP=1147nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT
GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC
CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG
GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCA
GCGAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCT
GCGCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACC
CACGGGAGACTATTTCACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAAGAGTGGCTA

>89307_89307_7_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000406733_RIBC2_chr22_45826780_ENST00000342894_length(amino acids)=383AA_BP=302
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR
NDEVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKK

--------------------------------------------------------------
>89307_89307_8_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000406733_RIBC2_chr22_45826780_ENST00000538017_length(transcript)=1444nt_BP=1147nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT
GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC
CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG
GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCA
GCGAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGCTCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCT
GCGCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAAGGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACC
CACGGGAGACTATTTCACACAATTTAATACAGGAAGTCGATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAAGAGTGGCTA

>89307_89307_8_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000406733_RIBC2_chr22_45826780_ENST00000538017_length(amino acids)=383AA_BP=302
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR
NDEVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKK

--------------------------------------------------------------
>89307_89307_9_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000407381_RIBC2_chr22_45826780_ENST00000342894_length(transcript)=1218nt_BP=838nt
CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG
CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT
CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC
AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT
GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC
CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA
GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCAGCGAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGC
TCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCTGCGCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAA
GGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACCCACGGGAGACTATTTCACACAATTTAATACAGGAAGTCG
ATAATGAGGAACACACCCTTGTTCCCGTCATTCACGTATAAAGAGTGGCTACCTTAAAGAGTCACGTTTCTTTTTTAAAGATACACTCCT

>89307_89307_9_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000407381_RIBC2_chr22_45826780_ENST00000342894_length(amino acids)=322AA_BP=241
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL
PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFER

--------------------------------------------------------------
>89307_89307_10_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000407381_RIBC2_chr22_45826780_ENST00000538017_length(transcript)=1135nt_BP=838nt
CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG
CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT
CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC
AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT
GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC
CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA
GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGAGGCTCCAGGAAGAAAAGCGCCAGCGAGACCTGGACTGGGACCGGCGGAGGATTCAGGGGGC
TCGCGCCACCCTGCTGTTTGAGCGGCAGCAGTGGCGGCGGCAGCGCGACCTGCGCAGAGCTCTGGACAGCAGCAACCTCAGCCTGGCCAA
GGAGCAGCATTTGCAGAAAAAATATATGAATGAAGTCTATACAAATCAACCCACGGGAGACTATTTCACACAATTTAATACAGGAAGTCG

>89307_89307_10_TBC1D22A-RIBC2_TBC1D22A_chr22_47290742_ENST00000407381_RIBC2_chr22_45826780_ENST00000538017_length(amino acids)=322AA_BP=241
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL
PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTERLQEEKRQRDLDWDRRRIQGARATLLFER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBC1D22A-RIBC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBC1D22A-RIBC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBC1D22A-RIBC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource