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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBC1D22A-SREBF2 (FusionGDB2 ID:89311)

Fusion Gene Summary for TBC1D22A-SREBF2

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D22A-SREBF2
Fusion gene ID: 89311
HgeneTgene
Gene symbol

TBC1D22A

SREBF2

Gene ID

25771

6721

Gene nameTBC1 domain family member 22Asterol regulatory element binding transcription factor 2
SynonymsC22orf4|HSC79E021SREBP-2|SREBP2|bHLHd2
Cytomap

22q13.31

22q13.2

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 22Aputative GTPase activatorsterol regulatory element-binding protein 2class D basic helix-loop-helix protein 2
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337137, ENST00000355704, 
ENST00000380995, ENST00000406733, 
ENST00000407381, ENST00000472791, 
ENST00000491541, ENST00000361204, 
Fusion gene scores* DoF score34 X 18 X 14=856813 X 14 X 6=1092
# samples 3715
** MAII scorelog2(37/8568*10)=-4.53336130423394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D22A [Title/Abstract] AND SREBF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBC1D22A(47308084)-SREBF2(42262835), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSREBF2

GO:0000122

negative regulation of transcription by RNA polymerase II

15358760|19098903

TgeneSREBF2

GO:0010886

positive regulation of cholesterol storage

15358760

TgeneSREBF2

GO:0032933

SREBP signaling pathway

27614840

TgeneSREBF2

GO:0045944

positive regulation of transcription by RNA polymerase II

12242332|12446768

TgeneSREBF2

GO:0090370

negative regulation of cholesterol efflux

15358760


check buttonFusion gene breakpoints across TBC1D22A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SREBF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A4F4-06ATBC1D22Achr22

47308084

-SREBF2chr22

42262835

+
ChimerDB4SKCMTCGA-FS-A4F4-06ATBC1D22Achr22

47308084

+SREBF2chr22

42262835

+


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Fusion Gene ORF analysis for TBC1D22A-SREBF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337137ENST00000491541TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
5CDS-intronENST00000355704ENST00000491541TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
5CDS-intronENST00000380995ENST00000491541TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
5CDS-intronENST00000406733ENST00000491541TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
5CDS-intronENST00000407381ENST00000491541TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
In-frameENST00000337137ENST00000361204TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
In-frameENST00000355704ENST00000361204TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
In-frameENST00000380995ENST00000361204TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
In-frameENST00000406733ENST00000361204TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
In-frameENST00000407381ENST00000361204TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
intron-3CDSENST00000472791ENST00000361204TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+
intron-intronENST00000472791ENST00000491541TBC1D22Achr22

47308084

+SREBF2chr22

42262835

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337137TBC1D22Achr2247308084+ENST00000361204SREBF2chr2242262835+6167118116645181450
ENST00000380995TBC1D22Achr2247308084+ENST00000361204SREBF2chr2242262835+6156117015545071450
ENST00000407381TBC1D22Achr2247308084+ENST00000361204SREBF2chr2242262835+593995311542901391
ENST00000355704TBC1D22Achr2247308084+ENST00000361204SREBF2chr2242262835+587388710642241372
ENST00000406733TBC1D22Achr2247308084+ENST00000361204SREBF2chr2242262835+6248126224145991452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337137ENST00000361204TBC1D22Achr2247308084+SREBF2chr2242262835+0.0046070920.9953929
ENST00000380995ENST00000361204TBC1D22Achr2247308084+SREBF2chr2242262835+0.0045440410.995456
ENST00000407381ENST00000361204TBC1D22Achr2247308084+SREBF2chr2242262835+0.0039124180.99608755
ENST00000355704ENST00000361204TBC1D22Achr2247308084+SREBF2chr2242262835+0.0037974540.9962025
ENST00000406733ENST00000361204TBC1D22Achr2247308084+SREBF2chr2242262835+0.0054877050.9945123

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Fusion Genomic Features for TBC1D22A-SREBF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBC1D22Achr2247308084+SREBF2chr2242262834+3.60E-060.9999964
TBC1D22Achr2247308084+SREBF2chr2242262834+3.60E-060.9999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TBC1D22A-SREBF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:47308084/chr22:42262835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019125_244291142.0Compositional biasNote=Gln-rich
TgeneSREBF2chr22:47308084chr22:42262835ENST0000036120401952_124291142.0Compositional biasNote=Gly/Pro/Ser-rich
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019330_380291142.0DomainbHLH
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019380_401291142.0RegionNote=Leucine-zipper
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019501_533291142.0Topological domainLumenal
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019555_1139291142.0Topological domainCytoplasmic
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019480_500291142.0TransmembraneHelical
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019534_554291142.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D22Achr22:47308084chr22:42262835ENST00000337137+813222_446338518.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47308084chr22:42262835ENST00000355704+611222_446260440.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47308084chr22:42262835ENST00000380995+89222_446291325.0DomainRab-GAP TBC
TgeneSREBF2chr22:47308084chr22:42262835ENST000003612040191_50291142.0RegionTranscriptional activation (acidic)
TgeneSREBF2chr22:47308084chr22:42262835ENST000003612040191_479291142.0Topological domainCytoplasmic


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Fusion Gene Sequence for TBC1D22A-SREBF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89311_89311_1_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000337137_SREBF2_chr22_42262835_ENST00000361204_length(transcript)=6167nt_BP=1181nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT
ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG
GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA
CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGAT
CTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTG
TGAATACATAGAGATGCTGCAATTTGTCAGTAATCAAGTGGGAGAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGG
CAGTGGTGGTAGTGGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGCAGCGGAGCTGTGGACCC
TTCAGTGCAACGGTCATTCACCCAGGTCACATTACCTTCCTTCTCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGT
TTCTCCCACCTCAGTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAACCTCAAACTCAGCTGCA
ACAACAGACGGTAATGATCACGCCAACATTCAGCACCACTCCGCAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTAC
TAGCTTTCAAGTCCTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAGCAGCAGGTGCAGACAGT
ACAGGCCCAGCGGGTGCTGACACAAACGGCCAATGGCACGCTGCAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGT
GCAGCAGGTCCCGGTCCTGGTCCAGCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACAGATGGCAGCCCTGTTAT
GGCTGCGGTCCAGAACCCGGCCCTCACCGCCCTCACCACCCCTATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGG
GACCATTCTGACCACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTCAAGCAGCTTGAGCCCCC
CAAAGAAGGAGAAAGGCGGACAACCCATAATATCATTGAGAAACGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCT
GGTCATGGGGACAGACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTGCAGCAGGTCAATCATAA
ACTGCGCCAGGAGAACATGGTGCTGAAGCTGGCAAATCAAAAGAACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGA
GGTGGACCTGAAGATCGAGGACTTTAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCCCAGGCTGGCTTCTCTCC
CTACTCCATTGACTCTGAGCCAGGAAGCCCTCTATTGGATGATGCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCAT
GGTAGACCGCTCACGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTGCTGCAGTGGGGAGGGGC
CCACGACTCTGACCAGCACCCACACTCAGGCTCTGGCCGCAGTGTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGAT
GCCTACTCTTCTCTTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGGGAGCCAGTGATCCGGCC
ACACTCGCGCTCCTCGGTCACCTTCTGGAGGCACCGGAAACAGGCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAA
CCTACAAACCTGCCTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCCTGGAACGTGATCCGCTA
CAGCCTGCAGAAGCTACGCCTGGTGCGCTGGCTGCTCAAGAAAGTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGA
AGACGAAGCTAAGACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGGAAGCTTCCTGCAGGATC
CGCCTGTTCCGATGTACACATGGCGTTGTGTGCCGTGAACCTGGCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGAT
CCATCTGACTGCTGCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTCAGCCGAGCCCAGAGCCT
GTGTGGCCCCGAGCACAGTGCTGTTCCTGACTCCCTGCGCTGGCTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTC
TGTGAAGTCAGCTGCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCACCAGGCCTTCTGCAAGAA
CCTGCTGGAGCGAGCTATAGAGTCCTTGGTGAAACCTCAGGCCAAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAG
TGCTCTGGAGTACTTGAAATTACTTCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGGAGCTCCGTGCTCAAGTC
CGCCCTGGGTCCAGACATCATCTGTCGGTGGTGGACGTCTGCAATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCG
CTCTCATTTTACCAAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATCTTCCATGCCTGCAGAGC
CATGCATGCCTCACTCCCTGGGAAAGCAGATGGGCAGCAGAGTTCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCT
CAACGTCAGTGGGGCCACCTCTGACCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTGTCGCTACGGACAGCGCT
CTGGCAAAAACAGGCCAGTGCCAGCCAGGCTGTGGGGGAGACCTACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGG
CAGCCTGCGCAGGCTGGCACACAGCTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGCCTGATGGCAGGAGCCAG
CCCCACCCGCACCCACCAGCTGCTGGAACACAGCCTGCGGCGGCGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGG
CCAGCGAGAGCGGGCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGCCAGCGGGCAGTGCTGCT
GGCCGAAGCTGCCCGCACCCTGGAGAAGGTGGGCGACCGGCGCTCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCAC
TGCCATTGCCGCCTCCTGACCACCAGGCTCAGCCCACCCCTCCACCTCTCTCTCGATTTCTCTCTCTCCCCCTCAGCATCTTCCCGCTGA
GAGTGGTGGGGAAGAGCCTTGTCTTCTTAGCTGTCACCTGCCGAGGCTTCTGGGCCACTCAGGCCAGTGCACCCCTGGGCAGAGCCCCTT
AAAGCTGCTGTCACTAGATGCCCATGGTCCAGGGCCTGGTGGGCGTGAGAGGATAGGTGGCAGGGCAGAAACTGGGCAGCCCTGACTTGA
TAGCAGCAGGGGGAGCTCCCAAGCTGCCAAGCCCCTGCCTCCAGCCTTCCTGAGTTTCTCTCTCCTGAACCCTACTCTCTCCTTTTTGCT
TCCTCAGTTTTTATCAGGCTTTCTCTGGGGGACAGCAGTCTCTGAGCACCAGGGAGCAGTTGCCCTCAGGCCTGTGCCCAGCATGCCCTC
CCCTTTTTATACGAATGTTTTCTACCAGTGTGCTTGGGTTTGCCATGATGCGAGGCTGAGTTGCTGTAGCGTCTTGATTCTCTCCCTGGG
TCTGCGTTCCCTCCCCTGGGCCTGACTGAGCCTGCTCATTGTTTTTCCCTTTATTACACAGGACAGCCAGGGGAGGAGGGGGGCCCAGCC
CTGGGAGGCTGGTGGGAGGCAGGGGGCAGGCCTGCGGATGCATGAAATAATGTTGGCATTATTTTTTAATTTTTTAAAAAATAAATGGTA
TCTTATTTAATTGTCCTGTTCCTTCCCACTCCCCGCCTCCTAGGATGTTAGCCCAAGCTCAGGGTAGGCCCAGGGGGCTGGGAGAAATGA
AGCCACCCATGGGGACTGGGGACCAGGGGCCTTCAGCATGGCTTCTAGGTTCCCTCCTCCCCCTACCCCATCTCCTACCTCCACAGTACA
GACTGTCCCCAACTTAACAGTGGTTCAACTTAAACCATGTTTCAACTTTACAATTGGTCTGTTGGGGTATTAAATGAATTTGTGACTTAG
GATATTTTCATTTATGATGGGTTTATCAGGAAGTAACCCCATGGTAAGTTGAGGCATATCTGTATATATTTAAACCTAATTAATTCTTGA
GCTGAAAATAAATAAACCAGGATGGCAGGGACCAACCCCTAATCCCTCCCCAGCGGCAAGCCCCTCTTTTCAGAGTGGGCAGAGGGTTGC
CTATGGTGGGCACTAGGAATGAGGTCCCCTGCCTCGATGCGGGTCCTAGGAGAAAAAGTCCTACTTTTCTGGGTCCCCAGGTGCAGCACC
TCCCGGAGACTGTTTCTCCCATGGCCTCCTGAGTGATGGGCCCTGCCTCCCTGTGCCTCATCCTCAGGCTGGTTGGAGCAGAGGGTGGGC
AGGAGCCCCAGCACAGACTGGGGGGTGCTCACAGCAGGGCCACCTTGATGCAGGCTGGAATGTTATCCCTGGGGTGTGCTTGGACCCCAC
CTGCTTTCTTTCTCTCCTGCCCCTCCCCTACTCTCACTGTAATTTATGGACCCTGCCCGCCTGCGTGTTGTGTGTATGTCCTGTGCCTTT
TCTCACTATTGTTTGGGTGTGGGAGGGGGTGGTTTTTCACTGAAAAGGGGGGTACACCTATAGCTTTCTTGATGTTCAATCAATCAGTCA

>89311_89311_1_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000337137_SREBF2_chr22_42262835_ENST00000361204_length(amino acids)=1450AA_BP=338
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEMLQFVSNQVGEFPDLFSEQLC
SSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQP
QTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTV
AAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVK
QLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGS
LVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLL
QWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFA
AAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGK
LPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFM
ERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRS
SVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGH
LWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRL
MAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVK

--------------------------------------------------------------
>89311_89311_2_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000355704_SREBF2_chr22_42262835_ENST00000361204_length(transcript)=5873nt_BP=887nt
CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA
GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC
CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC
TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA
CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC
CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT
CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA
ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA
CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCA
CCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGATGCTGCAATT
TGTCAGTAATCAAGTGGGAGAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGGTAGTGGTAGCAGCAG
CGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGCAGCGGAGCTGTGGACCCTTCAGTGCAACGGTCATTCACCCA
GGTCACATTACCTTCCTTCTCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCACCTCAGTTCCCACCAC
ACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAACCTCAAACTCAGCTGCAACAACAGACGGTAATGATCACGCC
AACATTCAGCACCACTCCGCAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCAAGTCCTTCAGCCTCA
AGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAGCAGCAGGTGCAGACAGTACAGGCCCAGCGGGTGCTGACACA
AACGGCCAATGGCACGCTGCAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGTCCCGGTCCTGGTCCA
GCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACAGATGGCAGCCCTGTTATGGCTGCGGTCCAGAACCCGGCCCT
CACCGCCCTCACCACCCCTATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCTGACCACAATGCCTGT
AATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTCAAGCAGCTTGAGCCCCCCAAAGAAGGAGAAAGGCGGACAAC
CCATAATATCATTGAGAAACGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGGGACAGACGCCAAGAT
GCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTGCAGCAGGTCAATCATAAACTGCGCCAGGAGAACATGGTGCT
GAAGCTGGCAAATCAAAAGAACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCTGAAGATCGAGGACTT
TAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCCCAGGCTGGCTTCTCTCCCTACTCCATTGACTCTGAGCCAGG
AAGCCCTCTATTGGATGATGCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCGCTCACGGATTCTTCT
GTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTGCTGCAGTGGGGAGGGGCCCACGACTCTGACCAGCACCCACA
CTCAGGCTCTGGCCGCAGTGTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCTTCTCTTATGGCTGGT
AAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGGGAGCCAGTGATCCGGCCACACTCGCGCTCCTCGGTCACCTT
CTGGAGGCACCGGAAACAGGCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAACCTACAAACCTGCCTGGCAGTTTT
GGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCCTGGAACGTGATCCGCTACAGCCTGCAGAAGCTACGCCTGGT
GCGCTGGCTGCTCAAGAAAGTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGCTAAGACCAGCGCCCG
GGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGGAAGCTTCCTGCAGGATCCGCCTGTTCCGATGTACACATGGC
GTTGTGTGCCGTGAACCTGGCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGACTGCTGCCATGGGGCT
CAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTCAGCCGAGCCCAGAGCCTGTGTGGCCCCGAGCACAGTGCTGT
TCCTGACTCCCTGCGCTGGCTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTCAGCTGCCAAGGAGAG
TCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCACCAGGCCTTCTGCAAGAACCTGCTGGAGCGAGCTATAGAGTC
CTTGGTGAAACCTCAGGCCAAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGAGTACTTGAAATTACT
TCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGGAGCTCCGTGCTCAAGTCCGCCCTGGGTCCAGACATCATCTG
TCGGTGGTGGACGTCTGCAATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTTTACCAAAGTGGAACG
CATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATCTTCCATGCCTGCAGAGCCATGCATGCCTCACTCCCTGGGAA
AGCAGATGGGCAGCAGAGTTCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAGTGGGGCCACCTCTGA
CCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTGTCGCTACGGACAGCGCTCTGGCAAAAACAGGCCAGTGCCAG
CCAGGCTGTGGGGGAGACCTACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCGCAGGCTGGCACACAG
CTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGCCTGATGGCAGGAGCCAGCCCCACCCGCACCCACCAGCTGCT
GGAACACAGCCTGCGGCGGCGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGAGCGGGCCACCGCCAT
CCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGCCAGCGGGCAGTGCTGCTGGCCGAAGCTGCCCGCACCCTGGA
GAAGGTGGGCGACCGGCGCTCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGCCGCCTCCTGACCACC
AGGCTCAGCCCACCCCTCCACCTCTCTCTCGATTTCTCTCTCTCCCCCTCAGCATCTTCCCGCTGAGAGTGGTGGGGAAGAGCCTTGTCT
TCTTAGCTGTCACCTGCCGAGGCTTCTGGGCCACTCAGGCCAGTGCACCCCTGGGCAGAGCCCCTTAAAGCTGCTGTCACTAGATGCCCA
TGGTCCAGGGCCTGGTGGGCGTGAGAGGATAGGTGGCAGGGCAGAAACTGGGCAGCCCTGACTTGATAGCAGCAGGGGGAGCTCCCAAGC
TGCCAAGCCCCTGCCTCCAGCCTTCCTGAGTTTCTCTCTCCTGAACCCTACTCTCTCCTTTTTGCTTCCTCAGTTTTTATCAGGCTTTCT
CTGGGGGACAGCAGTCTCTGAGCACCAGGGAGCAGTTGCCCTCAGGCCTGTGCCCAGCATGCCCTCCCCTTTTTATACGAATGTTTTCTA
CCAGTGTGCTTGGGTTTGCCATGATGCGAGGCTGAGTTGCTGTAGCGTCTTGATTCTCTCCCTGGGTCTGCGTTCCCTCCCCTGGGCCTG
ACTGAGCCTGCTCATTGTTTTTCCCTTTATTACACAGGACAGCCAGGGGAGGAGGGGGGCCCAGCCCTGGGAGGCTGGTGGGAGGCAGGG
GGCAGGCCTGCGGATGCATGAAATAATGTTGGCATTATTTTTTAATTTTTTAAAAAATAAATGGTATCTTATTTAATTGTCCTGTTCCTT
CCCACTCCCCGCCTCCTAGGATGTTAGCCCAAGCTCAGGGTAGGCCCAGGGGGCTGGGAGAAATGAAGCCACCCATGGGGACTGGGGACC
AGGGGCCTTCAGCATGGCTTCTAGGTTCCCTCCTCCCCCTACCCCATCTCCTACCTCCACAGTACAGACTGTCCCCAACTTAACAGTGGT
TCAACTTAAACCATGTTTCAACTTTACAATTGGTCTGTTGGGGTATTAAATGAATTTGTGACTTAGGATATTTTCATTTATGATGGGTTT
ATCAGGAAGTAACCCCATGGTAAGTTGAGGCATATCTGTATATATTTAAACCTAATTAATTCTTGAGCTGAAAATAAATAAACCAGGATG
GCAGGGACCAACCCCTAATCCCTCCCCAGCGGCAAGCCCCTCTTTTCAGAGTGGGCAGAGGGTTGCCTATGGTGGGCACTAGGAATGAGG
TCCCCTGCCTCGATGCGGGTCCTAGGAGAAAAAGTCCTACTTTTCTGGGTCCCCAGGTGCAGCACCTCCCGGAGACTGTTTCTCCCATGG
CCTCCTGAGTGATGGGCCCTGCCTCCCTGTGCCTCATCCTCAGGCTGGTTGGAGCAGAGGGTGGGCAGGAGCCCCAGCACAGACTGGGGG
GTGCTCACAGCAGGGCCACCTTGATGCAGGCTGGAATGTTATCCCTGGGGTGTGCTTGGACCCCACCTGCTTTCTTTCTCTCCTGCCCCT
CCCCTACTCTCACTGTAATTTATGGACCCTGCCCGCCTGCGTGTTGTGTGTATGTCCTGTGCCTTTTCTCACTATTGTTTGGGTGTGGGA
GGGGGTGGTTTTTCACTGAAAAGGGGGGTACACCTATAGCTTTCTTGATGTTCAATCAATCAGTCACTGTGTCCCAGACATATTCAATAA

>89311_89311_2_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000355704_SREBF2_chr22_42262835_ENST00000361204_length(amino acids)=1372AA_BP=260
MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ
GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYF
AFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEMLQFVSNQV
GEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATP
ILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGT
LQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQE
KVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQ
KNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTF
LCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRK
QADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALA
YHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLR
WLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVD
SVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQ
SSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAY
RKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDR

--------------------------------------------------------------
>89311_89311_3_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000380995_SREBF2_chr22_42262835_ENST00000361204_length(transcript)=6156nt_BP=1170nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGA
GCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCA
CTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGC
AGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATAT
GGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAG
AGATGCTGCAATTTGTCAGTAATCAAGTGGGAGAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGGTA
GTGGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGCAGCGGAGCTGTGGACCCTTCAGTGCAAC
GGTCATTCACCCAGGTCACATTACCTTCCTTCTCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCACCT
CAGTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAACCTCAAACTCAGCTGCAACAACAGACGG
TAATGATCACGCCAACATTCAGCACCACTCCGCAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCAAG
TCCTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAGCAGCAGGTGCAGACAGTACAGGCCCAGC
GGGTGCTGACACAAACGGCCAATGGCACGCTGCAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGTCC
CGGTCCTGGTCCAGCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACAGATGGCAGCCCTGTTATGGCTGCGGTCC
AGAACCCGGCCCTCACCGCCCTCACCACCCCTATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCTGA
CCACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTCAAGCAGCTTGAGCCCCCCAAAGAAGGAG
AAAGGCGGACAACCCATAATATCATTGAGAAACGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGGGA
CAGACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTGCAGCAGGTCAATCATAAACTGCGCCAGG
AGAACATGGTGCTGAAGCTGGCAAATCAAAAGAACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCTGA
AGATCGAGGACTTTAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCCCAGGCTGGCTTCTCTCCCTACTCCATTG
ACTCTGAGCCAGGAAGCCCTCTATTGGATGATGCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCGCT
CACGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTGCTGCAGTGGGGAGGGGCCCACGACTCTG
ACCAGCACCCACACTCAGGCTCTGGCCGCAGTGTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCTTC
TCTTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGGGAGCCAGTGATCCGGCCACACTCGCGCT
CCTCGGTCACCTTCTGGAGGCACCGGAAACAGGCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAACCTACAAACCT
GCCTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCCTGGAACGTGATCCGCTACAGCCTGCAGA
AGCTACGCCTGGTGCGCTGGCTGCTCAAGAAAGTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGCTA
AGACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGGAAGCTTCCTGCAGGATCCGCCTGTTCCG
ATGTACACATGGCGTTGTGTGCCGTGAACCTGGCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGACTG
CTGCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTCAGCCGAGCCCAGAGCCTGTGTGGCCCCG
AGCACAGTGCTGTTCCTGACTCCCTGCGCTGGCTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTCAG
CTGCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCACCAGGCCTTCTGCAAGAACCTGCTGGAGC
GAGCTATAGAGTCCTTGGTGAAACCTCAGGCCAAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGAGT
ACTTGAAATTACTTCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGGAGCTCCGTGCTCAAGTCCGCCCTGGGTC
CAGACATCATCTGTCGGTGGTGGACGTCTGCAATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTTTA
CCAAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATCTTCCATGCCTGCAGAGCCATGCATGCCT
CACTCCCTGGGAAAGCAGATGGGCAGCAGAGTTCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAGTG
GGGCCACCTCTGACCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTGTCGCTACGGACAGCGCTCTGGCAAAAAC
AGGCCAGTGCCAGCCAGGCTGTGGGGGAGACCTACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCGCA
GGCTGGCACACAGCTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGCCTGATGGCAGGAGCCAGCCCCACCCGCA
CCCACCAGCTGCTGGAACACAGCCTGCGGCGGCGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGAGC
GGGCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGCCAGCGGGCAGTGCTGCTGGCCGAAGCTG
CCCGCACCCTGGAGAAGGTGGGCGACCGGCGCTCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGCCG
CCTCCTGACCACCAGGCTCAGCCCACCCCTCCACCTCTCTCTCGATTTCTCTCTCTCCCCCTCAGCATCTTCCCGCTGAGAGTGGTGGGG
AAGAGCCTTGTCTTCTTAGCTGTCACCTGCCGAGGCTTCTGGGCCACTCAGGCCAGTGCACCCCTGGGCAGAGCCCCTTAAAGCTGCTGT
CACTAGATGCCCATGGTCCAGGGCCTGGTGGGCGTGAGAGGATAGGTGGCAGGGCAGAAACTGGGCAGCCCTGACTTGATAGCAGCAGGG
GGAGCTCCCAAGCTGCCAAGCCCCTGCCTCCAGCCTTCCTGAGTTTCTCTCTCCTGAACCCTACTCTCTCCTTTTTGCTTCCTCAGTTTT
TATCAGGCTTTCTCTGGGGGACAGCAGTCTCTGAGCACCAGGGAGCAGTTGCCCTCAGGCCTGTGCCCAGCATGCCCTCCCCTTTTTATA
CGAATGTTTTCTACCAGTGTGCTTGGGTTTGCCATGATGCGAGGCTGAGTTGCTGTAGCGTCTTGATTCTCTCCCTGGGTCTGCGTTCCC
TCCCCTGGGCCTGACTGAGCCTGCTCATTGTTTTTCCCTTTATTACACAGGACAGCCAGGGGAGGAGGGGGGCCCAGCCCTGGGAGGCTG
GTGGGAGGCAGGGGGCAGGCCTGCGGATGCATGAAATAATGTTGGCATTATTTTTTAATTTTTTAAAAAATAAATGGTATCTTATTTAAT
TGTCCTGTTCCTTCCCACTCCCCGCCTCCTAGGATGTTAGCCCAAGCTCAGGGTAGGCCCAGGGGGCTGGGAGAAATGAAGCCACCCATG
GGGACTGGGGACCAGGGGCCTTCAGCATGGCTTCTAGGTTCCCTCCTCCCCCTACCCCATCTCCTACCTCCACAGTACAGACTGTCCCCA
ACTTAACAGTGGTTCAACTTAAACCATGTTTCAACTTTACAATTGGTCTGTTGGGGTATTAAATGAATTTGTGACTTAGGATATTTTCAT
TTATGATGGGTTTATCAGGAAGTAACCCCATGGTAAGTTGAGGCATATCTGTATATATTTAAACCTAATTAATTCTTGAGCTGAAAATAA
ATAAACCAGGATGGCAGGGACCAACCCCTAATCCCTCCCCAGCGGCAAGCCCCTCTTTTCAGAGTGGGCAGAGGGTTGCCTATGGTGGGC
ACTAGGAATGAGGTCCCCTGCCTCGATGCGGGTCCTAGGAGAAAAAGTCCTACTTTTCTGGGTCCCCAGGTGCAGCACCTCCCGGAGACT
GTTTCTCCCATGGCCTCCTGAGTGATGGGCCCTGCCTCCCTGTGCCTCATCCTCAGGCTGGTTGGAGCAGAGGGTGGGCAGGAGCCCCAG
CACAGACTGGGGGGTGCTCACAGCAGGGCCACCTTGATGCAGGCTGGAATGTTATCCCTGGGGTGTGCTTGGACCCCACCTGCTTTCTTT
CTCTCCTGCCCCTCCCCTACTCTCACTGTAATTTATGGACCCTGCCCGCCTGCGTGTTGTGTGTATGTCCTGTGCCTTTTCTCACTATTG
TTTGGGTGTGGGAGGGGGTGGTTTTTCACTGAAAAGGGGGGTACACCTATAGCTTTCTTGATGTTCAATCAATCAGTCACTGTGTCCCAG

>89311_89311_3_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000380995_SREBF2_chr22_42262835_ENST00000361204_length(amino acids)=1450AA_BP=338
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEMLQFVSNQVGEFPDLFSEQLC
SSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQP
QTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTV
AAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVK
QLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGS
LVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLL
QWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFA
AAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGK
LPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFM
ERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRS
SVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGH
LWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRL
MAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVK

--------------------------------------------------------------
>89311_89311_4_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000406733_SREBF2_chr22_42262835_ENST00000361204_length(transcript)=6248nt_BP=1262nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT
GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC
CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG
GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCAT
ATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACAT
AGAGATGCTGCAATTTGTCAGTAATCAAGTGGGAGAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGG
TAGTGGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGCAGCGGAGCTGTGGACCCTTCAGTGCA
ACGGTCATTCACCCAGGTCACATTACCTTCCTTCTCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCAC
CTCAGTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAACCTCAAACTCAGCTGCAACAACAGAC
GGTAATGATCACGCCAACATTCAGCACCACTCCGCAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCA
AGTCCTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAGCAGCAGGTGCAGACAGTACAGGCCCA
GCGGGTGCTGACACAAACGGCCAATGGCACGCTGCAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGT
CCCGGTCCTGGTCCAGCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACAGATGGCAGCCCTGTTATGGCTGCGGT
CCAGAACCCGGCCCTCACCGCCCTCACCACCCCTATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCT
GACCACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTCAAGCAGCTTGAGCCCCCCAAAGAAGG
AGAAAGGCGGACAACCCATAATATCATTGAGAAACGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGG
GACAGACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTGCAGCAGGTCAATCATAAACTGCGCCA
GGAGAACATGGTGCTGAAGCTGGCAAATCAAAAGAACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCT
GAAGATCGAGGACTTTAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCCCAGGCTGGCTTCTCTCCCTACTCCAT
TGACTCTGAGCCAGGAAGCCCTCTATTGGATGATGCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCG
CTCACGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTGCTGCAGTGGGGAGGGGCCCACGACTC
TGACCAGCACCCACACTCAGGCTCTGGCCGCAGTGTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCT
TCTCTTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGGGAGCCAGTGATCCGGCCACACTCGCG
CTCCTCGGTCACCTTCTGGAGGCACCGGAAACAGGCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAACCTACAAAC
CTGCCTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCCTGGAACGTGATCCGCTACAGCCTGCA
GAAGCTACGCCTGGTGCGCTGGCTGCTCAAGAAAGTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGC
TAAGACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGGAAGCTTCCTGCAGGATCCGCCTGTTC
CGATGTACACATGGCGTTGTGTGCCGTGAACCTGGCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGAC
TGCTGCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTCAGCCGAGCCCAGAGCCTGTGTGGCCC
CGAGCACAGTGCTGTTCCTGACTCCCTGCGCTGGCTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTC
AGCTGCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCACCAGGCCTTCTGCAAGAACCTGCTGGA
GCGAGCTATAGAGTCCTTGGTGAAACCTCAGGCCAAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGA
GTACTTGAAATTACTTCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGGAGCTCCGTGCTCAAGTCCGCCCTGGG
TCCAGACATCATCTGTCGGTGGTGGACGTCTGCAATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTT
TACCAAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATCTTCCATGCCTGCAGAGCCATGCATGC
CTCACTCCCTGGGAAAGCAGATGGGCAGCAGAGTTCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAG
TGGGGCCACCTCTGACCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTGTCGCTACGGACAGCGCTCTGGCAAAA
ACAGGCCAGTGCCAGCCAGGCTGTGGGGGAGACCTACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCG
CAGGCTGGCACACAGCTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGCCTGATGGCAGGAGCCAGCCCCACCCG
CACCCACCAGCTGCTGGAACACAGCCTGCGGCGGCGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGA
GCGGGCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGCCAGCGGGCAGTGCTGCTGGCCGAAGC
TGCCCGCACCCTGGAGAAGGTGGGCGACCGGCGCTCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGC
CGCCTCCTGACCACCAGGCTCAGCCCACCCCTCCACCTCTCTCTCGATTTCTCTCTCTCCCCCTCAGCATCTTCCCGCTGAGAGTGGTGG
GGAAGAGCCTTGTCTTCTTAGCTGTCACCTGCCGAGGCTTCTGGGCCACTCAGGCCAGTGCACCCCTGGGCAGAGCCCCTTAAAGCTGCT
GTCACTAGATGCCCATGGTCCAGGGCCTGGTGGGCGTGAGAGGATAGGTGGCAGGGCAGAAACTGGGCAGCCCTGACTTGATAGCAGCAG
GGGGAGCTCCCAAGCTGCCAAGCCCCTGCCTCCAGCCTTCCTGAGTTTCTCTCTCCTGAACCCTACTCTCTCCTTTTTGCTTCCTCAGTT
TTTATCAGGCTTTCTCTGGGGGACAGCAGTCTCTGAGCACCAGGGAGCAGTTGCCCTCAGGCCTGTGCCCAGCATGCCCTCCCCTTTTTA
TACGAATGTTTTCTACCAGTGTGCTTGGGTTTGCCATGATGCGAGGCTGAGTTGCTGTAGCGTCTTGATTCTCTCCCTGGGTCTGCGTTC
CCTCCCCTGGGCCTGACTGAGCCTGCTCATTGTTTTTCCCTTTATTACACAGGACAGCCAGGGGAGGAGGGGGGCCCAGCCCTGGGAGGC
TGGTGGGAGGCAGGGGGCAGGCCTGCGGATGCATGAAATAATGTTGGCATTATTTTTTAATTTTTTAAAAAATAAATGGTATCTTATTTA
ATTGTCCTGTTCCTTCCCACTCCCCGCCTCCTAGGATGTTAGCCCAAGCTCAGGGTAGGCCCAGGGGGCTGGGAGAAATGAAGCCACCCA
TGGGGACTGGGGACCAGGGGCCTTCAGCATGGCTTCTAGGTTCCCTCCTCCCCCTACCCCATCTCCTACCTCCACAGTACAGACTGTCCC
CAACTTAACAGTGGTTCAACTTAAACCATGTTTCAACTTTACAATTGGTCTGTTGGGGTATTAAATGAATTTGTGACTTAGGATATTTTC
ATTTATGATGGGTTTATCAGGAAGTAACCCCATGGTAAGTTGAGGCATATCTGTATATATTTAAACCTAATTAATTCTTGAGCTGAAAAT
AAATAAACCAGGATGGCAGGGACCAACCCCTAATCCCTCCCCAGCGGCAAGCCCCTCTTTTCAGAGTGGGCAGAGGGTTGCCTATGGTGG
GCACTAGGAATGAGGTCCCCTGCCTCGATGCGGGTCCTAGGAGAAAAAGTCCTACTTTTCTGGGTCCCCAGGTGCAGCACCTCCCGGAGA
CTGTTTCTCCCATGGCCTCCTGAGTGATGGGCCCTGCCTCCCTGTGCCTCATCCTCAGGCTGGTTGGAGCAGAGGGTGGGCAGGAGCCCC
AGCACAGACTGGGGGGTGCTCACAGCAGGGCCACCTTGATGCAGGCTGGAATGTTATCCCTGGGGTGTGCTTGGACCCCACCTGCTTTCT
TTCTCTCCTGCCCCTCCCCTACTCTCACTGTAATTTATGGACCCTGCCCGCCTGCGTGTTGTGTGTATGTCCTGTGCCTTTTCTCACTAT
TGTTTGGGTGTGGGAGGGGGTGGTTTTTCACTGAAAAGGGGGGTACACCTATAGCTTTCTTGATGTTCAATCAATCAGTCACTGTGTCCC

>89311_89311_4_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000406733_SREBF2_chr22_42262835_ENST00000361204_length(amino acids)=1452AA_BP=340
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR
NDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEMLQFVSNQVGEFPDLFSEQ
LCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQP
QPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQ
TVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGG
VKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDL
GSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTS
LLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGD
FAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHIT
GKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKF
FMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLS
RSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERAS
GHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATV
RLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMI

--------------------------------------------------------------
>89311_89311_5_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000407381_SREBF2_chr22_42262835_ENST00000361204_length(transcript)=5939nt_BP=953nt
CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG
CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT
CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC
AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT
GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC
CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA
GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGATGCTGCAATTTGTCAGTAATCAAGTGGGAGAGTT
CCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGGTAGTGGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAG
CAGCAGCAATGGCAGGGGCAGCAGCAGCGGAGCTGTGGACCCTTCAGTGCAACGGTCATTCACCCAGGTCACATTACCTTCCTTCTCTCC
CTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCACCTCAGTTCCCACCACACCCAGGGCAACTCCTATTCTTCA
GCCCCGCCCCCAGCCCCAGCCTCAACCTCAAACTCAGCTGCAACAACAGACGGTAATGATCACGCCAACATTCAGCACCACTCCGCAGAC
GAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCAAGTCCTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTC
CCAGGTACAGCCGGTCACCATTCAGCAGCAGGTGCAGACAGTACAGGCCCAGCGGGTGCTGACACAAACGGCCAATGGCACGCTGCAGAC
CCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGTCCCGGTCCTGGTCCAGCCTCAGATCATCAAGACAGATTC
CCTTGTTTTGACCACACTGAAGACAGATGGCAGCCCTGTTATGGCTGCGGTCCAGAACCCGGCCCTCACCGCCCTCACCACCCCTATCCA
GACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCTGACCACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCC
CATTAAGCAGGTACCTGGGGGAGTCAAGCAGCTTGAGCCCCCCAAAGAAGGAGAAAGGCGGACAACCCATAATATCATTGAGAAACGATA
TCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGGGACAGACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAA
GGCCATTGATTACATCAAATACTTGCAGCAGGTCAATCATAAACTGCGCCAGGAGAACATGGTGCTGAAGCTGGCAAATCAAAAGAACAA
GCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCTGAAGATCGAGGACTTTAATCAGAATGTCCTTCTGATGTC
CCCCCCAGCCTCTGACTCAGGGTCCCAGGCTGGCTTCTCTCCCTACTCCATTGACTCTGAGCCAGGAAGCCCTCTATTGGATGATGCAAA
GGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCGCTCACGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCT
CTCCTTTAACCCCCTGACTTCCCTGCTGCAGTGGGGAGGGGCCCACGACTCTGACCAGCACCCACACTCAGGCTCTGGCCGCAGTGTCCT
GTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCTTCTCTTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGT
CTTTGTGAAGCTGCTGGTTCATGGGGAGCCAGTGATCCGGCCACACTCGCGCTCCTCGGTCACCTTCTGGAGGCACCGGAAACAGGCAGA
TCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAACCTACAAACCTGCCTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCG
CCTGGACCTGGCCTGCAGCCTCTCCTGGAACGTGATCCGCTACAGCCTGCAGAAGCTACGCCTGGTGCGCTGGCTGCTCAAGAAAGTCTT
CCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGCTAAGACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCG
GCTGCACCAGCTGCACATCACAGGGAAGCTTCCTGCAGGATCCGCCTGTTCCGATGTACACATGGCGTTGTGTGCCGTGAACCTGGCTGA
ATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGACTGCTGCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCT
GGGCTTCCTGGCCAGCTACTTCCTCAGCCGAGCCCAGAGCCTGTGTGGCCCCGAGCACAGTGCTGTTCCTGACTCCCTGCGCTGGCTCTG
CCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTCAGCTGCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCC
AGCTGACCCCATTGCGCAGGTCCACCAGGCCTTCTGCAAGAACCTGCTGGAGCGAGCTATAGAGTCCTTGGTGAAACCTCAGGCCAAGAA
GAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGAGTACTTGAAATTACTTCATTCTTTTGTGGACTCTGTGGG
GGTTATGAGCCCCCCACTCTCCAGGAGCTCCGTGCTCAAGTCCGCCCTGGGTCCAGACATCATCTGTCGGTGGTGGACGTCTGCAATCAC
TGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTTTACCAAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGAC
AGAGAGCCCCCTGGTGAAGGCCATCTTCCATGCCTGCAGAGCCATGCATGCCTCACTCCCTGGGAAAGCAGATGGGCAGCAGAGTTCCTT
CTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAGTGGGGCCACCTCTGACCCTGCCCTCAACCACGTGGTCCA
GCTGCTCACCTGTGACCTGCTACTGTCGCTACGGACAGCGCTCTGGCAAAAACAGGCCAGTGCCAGCCAGGCTGTGGGGGAGACCTACCA
CGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCGCAGGCTGGCACACAGCTTCCGCCCAGCATACCGCAAGGT
GTTCCTGCATGAAGCCACCGTGCGCCTGATGGCAGGAGCCAGCCCCACCCGCACCCACCAGCTGCTGGAACACAGCCTGCGGCGGCGCAC
CACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGAGCGGGCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCC
CCTCTCCTTCCTCTCCTCCCCGGGCCAGCGGGCAGTGCTGCTGGCCGAAGCTGCCCGCACCCTGGAGAAGGTGGGCGACCGGCGCTCCTG
CAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGCCGCCTCCTGACCACCAGGCTCAGCCCACCCCTCCACCTC
TCTCTCGATTTCTCTCTCTCCCCCTCAGCATCTTCCCGCTGAGAGTGGTGGGGAAGAGCCTTGTCTTCTTAGCTGTCACCTGCCGAGGCT
TCTGGGCCACTCAGGCCAGTGCACCCCTGGGCAGAGCCCCTTAAAGCTGCTGTCACTAGATGCCCATGGTCCAGGGCCTGGTGGGCGTGA
GAGGATAGGTGGCAGGGCAGAAACTGGGCAGCCCTGACTTGATAGCAGCAGGGGGAGCTCCCAAGCTGCCAAGCCCCTGCCTCCAGCCTT
CCTGAGTTTCTCTCTCCTGAACCCTACTCTCTCCTTTTTGCTTCCTCAGTTTTTATCAGGCTTTCTCTGGGGGACAGCAGTCTCTGAGCA
CCAGGGAGCAGTTGCCCTCAGGCCTGTGCCCAGCATGCCCTCCCCTTTTTATACGAATGTTTTCTACCAGTGTGCTTGGGTTTGCCATGA
TGCGAGGCTGAGTTGCTGTAGCGTCTTGATTCTCTCCCTGGGTCTGCGTTCCCTCCCCTGGGCCTGACTGAGCCTGCTCATTGTTTTTCC
CTTTATTACACAGGACAGCCAGGGGAGGAGGGGGGCCCAGCCCTGGGAGGCTGGTGGGAGGCAGGGGGCAGGCCTGCGGATGCATGAAAT
AATGTTGGCATTATTTTTTAATTTTTTAAAAAATAAATGGTATCTTATTTAATTGTCCTGTTCCTTCCCACTCCCCGCCTCCTAGGATGT
TAGCCCAAGCTCAGGGTAGGCCCAGGGGGCTGGGAGAAATGAAGCCACCCATGGGGACTGGGGACCAGGGGCCTTCAGCATGGCTTCTAG
GTTCCCTCCTCCCCCTACCCCATCTCCTACCTCCACAGTACAGACTGTCCCCAACTTAACAGTGGTTCAACTTAAACCATGTTTCAACTT
TACAATTGGTCTGTTGGGGTATTAAATGAATTTGTGACTTAGGATATTTTCATTTATGATGGGTTTATCAGGAAGTAACCCCATGGTAAG
TTGAGGCATATCTGTATATATTTAAACCTAATTAATTCTTGAGCTGAAAATAAATAAACCAGGATGGCAGGGACCAACCCCTAATCCCTC
CCCAGCGGCAAGCCCCTCTTTTCAGAGTGGGCAGAGGGTTGCCTATGGTGGGCACTAGGAATGAGGTCCCCTGCCTCGATGCGGGTCCTA
GGAGAAAAAGTCCTACTTTTCTGGGTCCCCAGGTGCAGCACCTCCCGGAGACTGTTTCTCCCATGGCCTCCTGAGTGATGGGCCCTGCCT
CCCTGTGCCTCATCCTCAGGCTGGTTGGAGCAGAGGGTGGGCAGGAGCCCCAGCACAGACTGGGGGGTGCTCACAGCAGGGCCACCTTGA
TGCAGGCTGGAATGTTATCCCTGGGGTGTGCTTGGACCCCACCTGCTTTCTTTCTCTCCTGCCCCTCCCCTACTCTCACTGTAATTTATG
GACCCTGCCCGCCTGCGTGTTGTGTGTATGTCCTGTGCCTTTTCTCACTATTGTTTGGGTGTGGGAGGGGGTGGTTTTTCACTGAAAAGG

>89311_89311_5_TBC1D22A-SREBF2_TBC1D22A_chr22_47308084_ENST00000407381_SREBF2_chr22_42262835_ENST00000361204_length(amino acids)=1391AA_BP=279
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL
PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPF
FVVFICEYIEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAP
TLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQ
QQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPT
LVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYL
QQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSP
PVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHG
EPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPA
TEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFL
SRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEE
SCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAI
FHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAG
FQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBC1D22A-SREBF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSREBF2chr22:47308084chr22:42262835ENST00000361204019237_49129.3333333333333321142.0LMNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBC1D22A-SREBF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBC1D22A-SREBF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource