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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TBC1D22A-VAPA (FusionGDB2 ID:89316)

Fusion Gene Summary for TBC1D22A-VAPA

Fusion gene summary

Fusion gene information	Fusion gene name: TBC1D22A-VAPA
	Fusion gene ID: 89316
		Hgene	Tgene
	Gene symbol	TBC1D22A	VAPA
	Gene ID	25771	9218
	Gene name	TBC1 domain family member 22A	VAMP associated protein A
	Synonyms	C22orf4\|HSC79E021	VAP-33\|VAP-A\|VAP33\|hVAP-33
	Cytomap	22q13.31	18p11.22
	Type of gene	protein-coding	protein-coding
	Description	TBC1 domain family member 22Aputative GTPase activator	vesicle-associated membrane protein-associated protein A33 kDa VAMP-associated proteinVAMP (vesicle-associated membrane protein)-associated protein A, 33kDaVAMP-Aepididymis secretory sperm binding protein
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000337137, ENST00000355704, ENST00000380995, ENST00000406733, ENST00000407381, ENST00000472791,	ENST00000584796, ENST00000340541, ENST00000400000,
Fusion gene scores	* DoF score	34 X 18 X 14=8568	12 X 11 X 6=792
	# samples	37	14
	** MAII score	log2(37/8568*10)=-4.53336130423394 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/792*10)=-2.50007360313464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TBC1D22A [Title/Abstract] AND VAPA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TBC1D22A(47308084)-VAPA(9931806), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	VAPA	GO:0044791	positive regulation by host of viral release from host cell	19515777
Tgene	VAPA	GO:0044828	negative regulation by host of viral genome replication	19515777
Tgene	VAPA	GO:0044829	positive regulation by host of viral genome replication	19515777

Fusion gene breakpoints across TBC1D22A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VAPA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	2397N	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+

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Fusion Gene ORF analysis for TBC1D22A-VAPA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000337137	ENST00000584796	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
5CDS-3UTR	ENST00000355704	ENST00000584796	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
5CDS-3UTR	ENST00000380995	ENST00000584796	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
5CDS-3UTR	ENST00000406733	ENST00000584796	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
5CDS-3UTR	ENST00000407381	ENST00000584796	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000337137	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000337137	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000355704	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000355704	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000380995	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000380995	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000406733	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000406733	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000407381	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
In-frame	ENST00000407381	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
intron-3CDS	ENST00000472791	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
intron-3CDS	ENST00000472791	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+
intron-3UTR	ENST00000472791	ENST00000584796	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000337137	TBC1D22A	chr22	47308084	+	ENST00000400000	VAPA	chr18	9931806	+	7662	1181	166	1851	561
ENST00000337137	TBC1D22A	chr22	47308084	+	ENST00000340541	VAPA	chr18	9931806	+	2134	1181	166	1986	606
ENST00000380995	TBC1D22A	chr22	47308084	+	ENST00000400000	VAPA	chr18	9931806	+	7651	1170	155	1840	561
ENST00000380995	TBC1D22A	chr22	47308084	+	ENST00000340541	VAPA	chr18	9931806	+	2123	1170	155	1975	606
ENST00000407381	TBC1D22A	chr22	47308084	+	ENST00000400000	VAPA	chr18	9931806	+	7434	953	115	1623	502
ENST00000407381	TBC1D22A	chr22	47308084	+	ENST00000340541	VAPA	chr18	9931806	+	1906	953	115	1758	547
ENST00000355704	TBC1D22A	chr22	47308084	+	ENST00000400000	VAPA	chr18	9931806	+	7368	887	106	1557	483
ENST00000355704	TBC1D22A	chr22	47308084	+	ENST00000340541	VAPA	chr18	9931806	+	1840	887	106	1692	528
ENST00000406733	TBC1D22A	chr22	47308084	+	ENST00000400000	VAPA	chr18	9931806	+	7743	1262	241	1932	563
ENST00000406733	TBC1D22A	chr22	47308084	+	ENST00000340541	VAPA	chr18	9931806	+	2215	1262	241	2067	608

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000337137	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.000122573	0.99987745
ENST00000337137	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.008577607	0.99142236
ENST00000380995	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.000121789	0.99987817
ENST00000380995	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.008217556	0.9917824
ENST00000407381	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	6.83E-05	0.9999317
ENST00000407381	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.002650629	0.9973494
ENST00000355704	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.000119631	0.9998803
ENST00000355704	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.003704668	0.9962953
ENST00000406733	ENST00000400000	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.000174562	0.9998254
ENST00000406733	ENST00000340541	TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	0.006419039	0.99358094

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Fusion Genomic Features for TBC1D22A-VAPA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	1.56E-05	0.9999844
TBC1D22A	chr22	47308084	+	VAPA	chr18	9931806	+	1.56E-05	0.9999844

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBC1D22A-VAPA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:47308084/chr18:9931806)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000340541

169_205

295.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000400000

169_205

250.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000340541

228_248

295.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000400000

228_248

250.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBC1D22A

chr22:47308084

chr18:9931806

ENST00000337137

222_446

338

518.0

Domain

Rab-GAP TBC

Hgene

TBC1D22A

chr22:47308084

chr18:9931806

ENST00000355704

222_446

260

440.0

Domain

Rab-GAP TBC

Hgene

TBC1D22A

chr22:47308084

chr18:9931806

ENST00000380995

222_446

291

325.0

Domain

Rab-GAP TBC

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000340541

14_131

295.0

Domain

MSP

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000400000

14_131

250.0

Domain

MSP

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000340541

2_227

295.0

Topological domain

Cytoplasmic

Tgene

VAPA

chr22:47308084

chr18:9931806

ENST00000400000

2_227

250.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for TBC1D22A-VAPA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89316_89316_1_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000337137_VAPA_chr18_9931806_ENST00000340541_length(transcript)=2134nt_BP=1181nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT
ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG
GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA
CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGAT
CTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTG
TGAATACATAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGAC
TACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTT
TGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTG
GAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCC
ACCAGGGAATGCTCCGACTGTCACTTCAATGAGCAGCATCAACAACACAGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAG
GGGACTCAGTGTGTTGAAACAGGAGAAACAGAAGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACC
TATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAA
GCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGC
ATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCAT
CTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAG

>89316_89316_1_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000337137_VAPA_chr18_9931806_ENST00000340541_length(amino acids)=606AA_BP=338
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTNLKLRNPSDRKVC
FKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDK
LGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQ

--------------------------------------------------------------
>89316_89316_2_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000337137_VAPA_chr18_9931806_ENST00000400000_length(transcript)=7662nt_BP=1181nt
GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA
CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG
GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC
ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA
GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT
GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG
GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG
TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT
CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT
ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG
GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA
CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGAT
CTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTG
TGAATACATAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGAC
TACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTT
TGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTG
GAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGA
ACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAG
GAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCT
CAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGT
TGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTT
CTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAG
GCTTTGCCTTTAATGATCTCTTACGGTTAGAAAACACAATAAAAACAAACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCA
CTAGCAGATGTCAGTTGCACATTGAGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAA
TTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGC
TAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTA
ATATCATGGCAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATA
AAAAAAAATAAAACTGTTAACAGATTCTTGCTCGATAGCTTGTTTGTGTCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACT
TGAAATTATGATGCAAAGGTTTCTCTTGCATTGAAACCCTCTTGGATATTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAA
GGAGTTGATTAAATTTTAAGGTACCACTGGTATTTTGGGAGATTATAATCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAA
TAGAAGTTATGTGATTTCAGTGAGTTGATGTGTACAGCATGGCTGTGCTCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTC
TCAAGGAAGATTTAACTCTCTTTGGTTTTAAATTACTTTTTAACCAGCCTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAATA
GTTAAAAGTAGGTGTTTTTTTCGTGCTCAATTTGGCACTCAAAATAATGTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAA
TTTTCTTTATGAAAAATGATTTTAGCCTTTGCAAATGTTAACCATGTGAAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATAC
TTTCCTGCACTTAGGTTTGTCCTATTCTTCATTTATTCATACTAGGATAGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTAC
ATACAATCTAGTACAAGTGAATTTTTATTCTTAAACATAGGTGTGTTGGCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTG
GATTTTAGAACTGGATGTGGTGCAGTGAAGTATTTTAGGCCCAGGTCTGTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTT
TGGTTGCCTTTTCATTTCAACTGTGTTTTGAATTTGTCAGATCACACATATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCT
CTTGCTTGTGTGCAAAAGTTCCTAAAAGGAAACACAAGTAATGCCTATCCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCT
GTATGCTTTACTGTCTTTGTAAAAATCCCCCTCTCCCCTTTTCTGGTAACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCA
TAAATGCAGAATCAGTAATTCCTTGGCTTAAAGCTCTTATATAATCAATATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTAT
CTTTTTTTAAAGAAATTAAGTTCTTGAAAATTTAGCCAAATCCCGTTTTATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTG
TTCTATGGTTGAGAAATCTGAGGCCTTACGAAGGTTAAGAGAACTTTCCCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGAT
ATCTGGTCTGTTGACTCTAGCTCAGTGTCTTCTGGTAACTGTTGAAAATTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAAT
GCTATTTATAATAACAAGTATATGTGAAATTTCTTATTGTAAGACTACTACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCT
AGAAATGCCTCCCACATTGGTAATAAACATTACAAAATACAATGTATTTTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCT
TTTGAGATAGATTGTAGTCTGGGTAGCATCTTTAAAATGTATGTGGGCTTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGT
GAGACTCTGTTTCTGTTATTTTTAATTGCTGTATGAAATGTGATCAGATTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTA
TTAATTGACTGATAATATGATAATATAGAGATTAAATTGTTTGTCTTCATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTT
ACTTGTATATGTAAGCATGAGGGAAATACACTGTTGCTAATACTGAAATTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACT
GAATGCACTAGCTTCCTTCGTTCTATAACTAATGTACCTTAACTTCCCCCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAG
TGTGTGGTATGTTCCCTTAAAAAAAAATGACACTTGGAAGAAAAATGTATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCT
TTTTTTTTTTGAGACAGAGTCTTGCTTTGTTGCCCAGGCTGGAGGGCAGTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTT
CAAGTGATTCTCATGGCTCAGCCGCCTGAGTAGCTGGGATTACAGGTGTGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGA
CAAGGTTTCACCATGTTGGTCAGGCTGGGCTCAAACTCCTGAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCT
GCCGCACCCAGCCAAGAAAAATAATACTCTTAAATACTTAGATGTTCACCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACT
GTAATCTTTCAGATTACACCACTTTGAAAACAAGTTTTAACAGTAGGGTAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTC
TACCACTTTAGAGACATTCAAGTAATAGTTTTCTTAGAGCTTTGCACATTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAG
GGAAGGATCAATGCTTATTACCATTTGGAAAAACGAAGATCAGAAGGTAAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCAT
TCATGAATAAACTTTAAAAATGTGAAGTGTCCTTTTCCTTTTCACAATACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATA
TCCTGTTAAGCATTAATAGCTAATCACTGGGACTTGAATTCTGATGGCAGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTA
GTAGGAAGTGAGAACAGCTGATTTTCATGCCACGTTTCATAGCCCCACTTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGC
ATCTTGGGAATGAATGCCCAGCCGCTCGTGGGTTGGTGCAAAGAAGTATAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCT
TCTGACACAGTGTGTGCACTTCAGGCAATTTTTGGAAAATATAAAAAATTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACAT
TTCATTCATTTCCCTGTAATATTAATGTTCTTTAAGCATAATCACTAATTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGG
TTTATTGAAAACCAAGTATAAATGTGACTAAAAGCATTTTGCTTTGTTTTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGT
AACATTTGATTGGCCTGGCCTCTTGACAATTCCCTTCTAGTTATGCATATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCT
TGTTTTCCAGTTGTTGCTATGTATAACACCCATCTTGAAAGAGAGTATATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAA
CTATAGCAGTACCTTAACTCATGATGAGCTTAGGAACATAAAAGATAATTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGG
TCTGGGGTGGAGATCTGGCATGGTAGTTTTTTTCAAGCTCCAATCATCGGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGC
AGATATGAAGTAGATTTAATTAAGACTTGACTTCAGCAATACAGGGGAACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGT
TAGGTATTGCTTAAAAAAAATTGCATAAAAGCTTTGCTTGTCAAGTTAGGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAA
ATGAGCTGTCATCGCAAAAAGGCGATTTGAGAAATGTGGGCTTCAGTATTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTG
AGAAATTTATTTTGTCCATCATGTATTTCTCAAAGCAAAAGGTGGTTTTCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTT
ACGTCAGCTCATTTCATCATCATTGATAACTTGTGAAATACTTATCTCCATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATT
AGCTCAAGTCTACACAGCTGAAGTAGCAGAGAAAGTGGGATCTAGATGGTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTG
TCCTGGTCCAAGTCAAATATTGACTCCTCACAAACAGTAAGTATGGCAATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATT
ATTTGTGAAATGTCTTTAAGATTTTTGGTCTTAAATTTTTGAAGACTGCTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACT
CCTGCCCACTAACAATCTCAGTCCGTGAACAAAACCAACATGAACATTCCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGA
ATTTATGGAAATGGCTTATGTAACCTACAAGACTGGAGAACAGAATGTGACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAA
GCAAGAGTTTTTTATAATTGACTTTGTGGTCTAAATTCTTGATACTGTTTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGC
ACTTAAGAACCCTGAGGAAAAATAATACAATGTGTGTGTGTGAGAGAGAGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAA
AAAAAAAATGTGGAGGGTTGAAATGGTAAGGAATTGGAATCTTTTGTATTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGG
TTTGTTAGGAATTACAGTTGTGGGGAGCAAACTTTCTTTTTTGTGCTGTTTTAATTCAAAATGTATATCCTTAATTGTATATAATATGTA
GATAAATATATGAGGGTATTAAGCTACTTTGAATTAAATTTAAGGATATATTTCACATGAAAACAAATACAAACGAGAATCAAAATAAAG

>89316_89316_2_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000337137_VAPA_chr18_9931806_ENST00000400000_length(amino acids)=561AA_BP=338
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTNLKLRNPSDRKVC
FKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDK
LNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPL

--------------------------------------------------------------
>89316_89316_3_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000355704_VAPA_chr18_9931806_ENST00000340541_length(transcript)=1840nt_BP=887nt
CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA
GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC
CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC
TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA
CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC
CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT
CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA
ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA
CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCA
CCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGGCCCCTTCACAGA
TGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGT
GAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAG
TAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATT
AATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCCACCAGGGAATGCTCCGACTGTCAC
TTCAATGAGCAGCATCAACAACACAGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAGGGGACTCAGTGTGTTGAAACAGGA
GAAACAGAAGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTC
ACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCT
GAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAG
TCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGT
GCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTT

>89316_89316_3_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000355704_VAPA_chr18_9931806_ENST00000340541_length(amino acids)=528AA_BP=260
MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ
GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYF
AFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTN
LKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKL
RCVFEMPNENDKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTE

--------------------------------------------------------------
>89316_89316_4_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000355704_VAPA_chr18_9931806_ENST00000400000_length(transcript)=7368nt_BP=887nt
CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA
GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC
CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC
TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA
CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC
CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT
CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA
ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA
CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCA
CCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGGCCCCTTCACAGA
TGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGT
GAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAG
TAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATT
AATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAA
TGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAG
ACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAA
ACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGG
ATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTT
TACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTTAATGATCTCTTAC
GGTTAGAAAACACAATAAAAACAAACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCACTAGCAGATGTCAGTTGCACATTG
AGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTA
TTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGC
CAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTAT
CCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAAAACTGTTAACAGA
TTCTTGCTCGATAGCTTGTTTGTGTCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACTTGAAATTATGATGCAAAGGTTTCT
CTTGCATTGAAACCCTCTTGGATATTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAAGGAGTTGATTAAATTTTAAGGTAC
CACTGGTATTTTGGGAGATTATAATCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAATAGAAGTTATGTGATTTCAGTGAG
TTGATGTGTACAGCATGGCTGTGCTCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTCTCAAGGAAGATTTAACTCTCTTTG
GTTTTAAATTACTTTTTAACCAGCCTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAATAGTTAAAAGTAGGTGTTTTTTTCGT
GCTCAATTTGGCACTCAAAATAATGTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAATTTTCTTTATGAAAAATGATTTTA
GCCTTTGCAAATGTTAACCATGTGAAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATACTTTCCTGCACTTAGGTTTGTCCTA
TTCTTCATTTATTCATACTAGGATAGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTACATACAATCTAGTACAAGTGAATTT
TTATTCTTAAACATAGGTGTGTTGGCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTGGATTTTAGAACTGGATGTGGTGCA
GTGAAGTATTTTAGGCCCAGGTCTGTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTTTGGTTGCCTTTTCATTTCAACTGT
GTTTTGAATTTGTCAGATCACACATATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCTCTTGCTTGTGTGCAAAAGTTCCTA
AAAGGAAACACAAGTAATGCCTATCCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCTGTATGCTTTACTGTCTTTGTAAAA
ATCCCCCTCTCCCCTTTTCTGGTAACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCATAAATGCAGAATCAGTAATTCCTT
GGCTTAAAGCTCTTATATAATCAATATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTATCTTTTTTTAAAGAAATTAAGTTCT
TGAAAATTTAGCCAAATCCCGTTTTATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTGTTCTATGGTTGAGAAATCTGAGGC
CTTACGAAGGTTAAGAGAACTTTCCCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGATATCTGGTCTGTTGACTCTAGCTCA
GTGTCTTCTGGTAACTGTTGAAAATTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAATGCTATTTATAATAACAAGTATATG
TGAAATTTCTTATTGTAAGACTACTACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCTAGAAATGCCTCCCACATTGGTAAT
AAACATTACAAAATACAATGTATTTTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCTTTTGAGATAGATTGTAGTCTGGGT
AGCATCTTTAAAATGTATGTGGGCTTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGTGAGACTCTGTTTCTGTTATTTTTA
ATTGCTGTATGAAATGTGATCAGATTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTATTAATTGACTGATAATATGATAAT
ATAGAGATTAAATTGTTTGTCTTCATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTTACTTGTATATGTAAGCATGAGGGA
AATACACTGTTGCTAATACTGAAATTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACTGAATGCACTAGCTTCCTTCGTTCT
ATAACTAATGTACCTTAACTTCCCCCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAGTGTGTGGTATGTTCCCTTAAAAAA
AAATGACACTTGGAAGAAAAATGTATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCTTTTTTTTTTTGAGACAGAGTCTTG
CTTTGTTGCCCAGGCTGGAGGGCAGTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTTCAAGTGATTCTCATGGCTCAGCCG
CCTGAGTAGCTGGGATTACAGGTGTGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGTCAGG
CTGGGCTCAAACTCCTGAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCGCACCCAGCCAAGAAAAATAA
TACTCTTAAATACTTAGATGTTCACCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACTGTAATCTTTCAGATTACACCACTT
TGAAAACAAGTTTTAACAGTAGGGTAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTCTACCACTTTAGAGACATTCAAGTA
ATAGTTTTCTTAGAGCTTTGCACATTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAGGGAAGGATCAATGCTTATTACCAT
TTGGAAAAACGAAGATCAGAAGGTAAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCATTCATGAATAAACTTTAAAAATGTG
AAGTGTCCTTTTCCTTTTCACAATACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATATCCTGTTAAGCATTAATAGCTAAT
CACTGGGACTTGAATTCTGATGGCAGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTAGTAGGAAGTGAGAACAGCTGATTT
TCATGCCACGTTTCATAGCCCCACTTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGCATCTTGGGAATGAATGCCCAGCCG
CTCGTGGGTTGGTGCAAAGAAGTATAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCTTCTGACACAGTGTGTGCACTTCAG
GCAATTTTTGGAAAATATAAAAAATTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACATTTCATTCATTTCCCTGTAATATTA
ATGTTCTTTAAGCATAATCACTAATTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGGTTTATTGAAAACCAAGTATAAATG
TGACTAAAAGCATTTTGCTTTGTTTTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGTAACATTTGATTGGCCTGGCCTCTT
GACAATTCCCTTCTAGTTATGCATATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCTTGTTTTCCAGTTGTTGCTATGTAT
AACACCCATCTTGAAAGAGAGTATATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAACTATAGCAGTACCTTAACTCATGA
TGAGCTTAGGAACATAAAAGATAATTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGGTCTGGGGTGGAGATCTGGCATGGT
AGTTTTTTTCAAGCTCCAATCATCGGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGCAGATATGAAGTAGATTTAATTAAG
ACTTGACTTCAGCAATACAGGGGAACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGTTAGGTATTGCTTAAAAAAAATTGC
ATAAAAGCTTTGCTTGTCAAGTTAGGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAAATGAGCTGTCATCGCAAAAAGGCG
ATTTGAGAAATGTGGGCTTCAGTATTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTGAGAAATTTATTTTGTCCATCATGT
ATTTCTCAAAGCAAAAGGTGGTTTTCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTTACGTCAGCTCATTTCATCATCATT
GATAACTTGTGAAATACTTATCTCCATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATTAGCTCAAGTCTACACAGCTGAAGT
AGCAGAGAAAGTGGGATCTAGATGGTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTGTCCTGGTCCAAGTCAAATATTGAC
TCCTCACAAACAGTAAGTATGGCAATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATTATTTGTGAAATGTCTTTAAGATTT
TTGGTCTTAAATTTTTGAAGACTGCTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACTCCTGCCCACTAACAATCTCAGTCC
GTGAACAAAACCAACATGAACATTCCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGAATTTATGGAAATGGCTTATGTAAC
CTACAAGACTGGAGAACAGAATGTGACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAAGCAAGAGTTTTTTATAATTGACTT
TGTGGTCTAAATTCTTGATACTGTTTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGCACTTAAGAACCCTGAGGAAAAATA
ATACAATGTGTGTGTGTGAGAGAGAGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAATGTGGAGGGTTGAAAT
GGTAAGGAATTGGAATCTTTTGTATTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGGTTTGTTAGGAATTACAGTTGTGGG
GAGCAAACTTTCTTTTTTGTGCTGTTTTAATTCAAAATGTATATCCTTAATTGTATATAATATGTAGATAAATATATGAGGGTATTAAGC

>89316_89316_4_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000355704_VAPA_chr18_9931806_ENST00000400000_length(amino acids)=483AA_BP=260
MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ
GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYF
AFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTN
LKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKL
RCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTS

--------------------------------------------------------------
>89316_89316_5_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000380995_VAPA_chr18_9931806_ENST00000340541_length(transcript)=2123nt_BP=1170nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGA
GCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCA
CTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGC
AGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATAT
GGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAG
GCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTC
GCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATC
CGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAA
AACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCCACCAGGGAATG
CTCCGACTGTCACTTCAATGAGCAGCATCAACAACACAGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAGGGGACTCAGTG
TGTTGAAACAGGAGAAACAGAAGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAAC
CACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAG
AAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAG
ATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTG
AAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACG

>89316_89316_5_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000380995_VAPA_chr18_9931806_ENST00000340541_length(amino acids)=606AA_BP=338
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTNLKLRNPSDRKVC
FKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDK
LGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQ

--------------------------------------------------------------
>89316_89316_6_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000380995_VAPA_chr18_9931806_ENST00000400000_length(transcript)=7651nt_BP=1170nt
CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC
CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC
AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG
GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA
GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA
ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG
AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG
CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG
CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGA
GCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCA
CTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGC
AGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATAT
GGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAG
GCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTC
GCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATC
CGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAA
AACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGAACCTAGCAAAG
CTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGG
AAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAG
CACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAG
CCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAG
AAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTT
AATGATCTCTTACGGTTAGAAAACACAATAAAAACAAACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCACTAGCAGATGT
CAGTTGCACATTGAGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGT
CTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTC
ATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCA
GAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAA
AACTGTTAACAGATTCTTGCTCGATAGCTTGTTTGTGTCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACTTGAAATTATGA
TGCAAAGGTTTCTCTTGCATTGAAACCCTCTTGGATATTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAAGGAGTTGATTA
AATTTTAAGGTACCACTGGTATTTTGGGAGATTATAATCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAATAGAAGTTATG
TGATTTCAGTGAGTTGATGTGTACAGCATGGCTGTGCTCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTCTCAAGGAAGAT
TTAACTCTCTTTGGTTTTAAATTACTTTTTAACCAGCCTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAATAGTTAAAAGTAG
GTGTTTTTTTCGTGCTCAATTTGGCACTCAAAATAATGTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAATTTTCTTTATG
AAAAATGATTTTAGCCTTTGCAAATGTTAACCATGTGAAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATACTTTCCTGCACT
TAGGTTTGTCCTATTCTTCATTTATTCATACTAGGATAGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTACATACAATCTAG
TACAAGTGAATTTTTATTCTTAAACATAGGTGTGTTGGCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTGGATTTTAGAAC
TGGATGTGGTGCAGTGAAGTATTTTAGGCCCAGGTCTGTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTTTGGTTGCCTTT
TCATTTCAACTGTGTTTTGAATTTGTCAGATCACACATATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCTCTTGCTTGTGT
GCAAAAGTTCCTAAAAGGAAACACAAGTAATGCCTATCCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCTGTATGCTTTAC
TGTCTTTGTAAAAATCCCCCTCTCCCCTTTTCTGGTAACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCATAAATGCAGAA
TCAGTAATTCCTTGGCTTAAAGCTCTTATATAATCAATATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTATCTTTTTTTAAA
GAAATTAAGTTCTTGAAAATTTAGCCAAATCCCGTTTTATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTGTTCTATGGTTG
AGAAATCTGAGGCCTTACGAAGGTTAAGAGAACTTTCCCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGATATCTGGTCTGT
TGACTCTAGCTCAGTGTCTTCTGGTAACTGTTGAAAATTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAATGCTATTTATAA
TAACAAGTATATGTGAAATTTCTTATTGTAAGACTACTACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCTAGAAATGCCTC
CCACATTGGTAATAAACATTACAAAATACAATGTATTTTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCTTTTGAGATAGA
TTGTAGTCTGGGTAGCATCTTTAAAATGTATGTGGGCTTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGTGAGACTCTGTT
TCTGTTATTTTTAATTGCTGTATGAAATGTGATCAGATTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTATTAATTGACTG
ATAATATGATAATATAGAGATTAAATTGTTTGTCTTCATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTTACTTGTATATG
TAAGCATGAGGGAAATACACTGTTGCTAATACTGAAATTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACTGAATGCACTAG
CTTCCTTCGTTCTATAACTAATGTACCTTAACTTCCCCCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAGTGTGTGGTATG
TTCCCTTAAAAAAAAATGACACTTGGAAGAAAAATGTATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCTTTTTTTTTTTG
AGACAGAGTCTTGCTTTGTTGCCCAGGCTGGAGGGCAGTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTTCAAGTGATTCT
CATGGCTCAGCCGCCTGAGTAGCTGGGATTACAGGTGTGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCAC
CATGTTGGTCAGGCTGGGCTCAAACTCCTGAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCGCACCCAG
CCAAGAAAAATAATACTCTTAAATACTTAGATGTTCACCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACTGTAATCTTTCA
GATTACACCACTTTGAAAACAAGTTTTAACAGTAGGGTAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTCTACCACTTTAG
AGACATTCAAGTAATAGTTTTCTTAGAGCTTTGCACATTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAGGGAAGGATCAA
TGCTTATTACCATTTGGAAAAACGAAGATCAGAAGGTAAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCATTCATGAATAAA
CTTTAAAAATGTGAAGTGTCCTTTTCCTTTTCACAATACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATATCCTGTTAAGC
ATTAATAGCTAATCACTGGGACTTGAATTCTGATGGCAGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTAGTAGGAAGTGA
GAACAGCTGATTTTCATGCCACGTTTCATAGCCCCACTTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGCATCTTGGGAAT
GAATGCCCAGCCGCTCGTGGGTTGGTGCAAAGAAGTATAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCTTCTGACACAGT
GTGTGCACTTCAGGCAATTTTTGGAAAATATAAAAAATTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACATTTCATTCATTT
CCCTGTAATATTAATGTTCTTTAAGCATAATCACTAATTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGGTTTATTGAAAA
CCAAGTATAAATGTGACTAAAAGCATTTTGCTTTGTTTTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGTAACATTTGATT
GGCCTGGCCTCTTGACAATTCCCTTCTAGTTATGCATATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCTTGTTTTCCAGT
TGTTGCTATGTATAACACCCATCTTGAAAGAGAGTATATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAACTATAGCAGTA
CCTTAACTCATGATGAGCTTAGGAACATAAAAGATAATTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGGTCTGGGGTGGA
GATCTGGCATGGTAGTTTTTTTCAAGCTCCAATCATCGGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGCAGATATGAAGT
AGATTTAATTAAGACTTGACTTCAGCAATACAGGGGAACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGTTAGGTATTGCT
TAAAAAAAATTGCATAAAAGCTTTGCTTGTCAAGTTAGGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAAATGAGCTGTCA
TCGCAAAAAGGCGATTTGAGAAATGTGGGCTTCAGTATTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTGAGAAATTTATT
TTGTCCATCATGTATTTCTCAAAGCAAAAGGTGGTTTTCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTTACGTCAGCTCA
TTTCATCATCATTGATAACTTGTGAAATACTTATCTCCATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATTAGCTCAAGTCT
ACACAGCTGAAGTAGCAGAGAAAGTGGGATCTAGATGGTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTGTCCTGGTCCAA
GTCAAATATTGACTCCTCACAAACAGTAAGTATGGCAATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATTATTTGTGAAAT
GTCTTTAAGATTTTTGGTCTTAAATTTTTGAAGACTGCTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACTCCTGCCCACTA
ACAATCTCAGTCCGTGAACAAAACCAACATGAACATTCCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGAATTTATGGAAA
TGGCTTATGTAACCTACAAGACTGGAGAACAGAATGTGACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAAGCAAGAGTTTT
TTATAATTGACTTTGTGGTCTAAATTCTTGATACTGTTTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGCACTTAAGAACC
CTGAGGAAAAATAATACAATGTGTGTGTGTGAGAGAGAGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAATGT
GGAGGGTTGAAATGGTAAGGAATTGGAATCTTTTGTATTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGGTTTGTTAGGAA
TTACAGTTGTGGGGAGCAAACTTTCTTTTTTGTGCTGTTTTAATTCAAAATGTATATCCTTAATTGTATATAATATGTAGATAAATATAT
GAGGGTATTAAGCTACTTTGAATTAAATTTAAGGATATATTTCACATGAAAACAAATACAAACGAGAATCAAAATAAAGTTTTGCAAAGT

>89316_89316_6_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000380995_VAPA_chr18_9931806_ENST00000400000_length(amino acids)=561AA_BP=338
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND
EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTNLKLRNPSDRKVC
FKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDK
LNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPL

--------------------------------------------------------------
>89316_89316_7_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000406733_VAPA_chr18_9931806_ENST00000340541_length(transcript)=2215nt_BP=1262nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT
GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC
CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG
GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCAT
ATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACAT
AGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACC
TCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGA
TCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGC
AAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCCACCAGGGAA
TGCTCCGACTGTCACTTCAATGAGCAGCATCAACAACACAGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAGGGGACTCAG
TGTGTTGAAACAGGAGAAACAGAAGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAA
ACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGA
AGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAG
AGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAG
TGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCA

>89316_89316_7_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000406733_VAPA_chr18_9931806_ENST00000340541_length(amino acids)=608AA_BP=340
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR
NDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTNLKLRNPSDRK
VCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNEN
DKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKR

--------------------------------------------------------------
>89316_89316_8_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000406733_VAPA_chr18_9931806_ENST00000400000_length(transcript)=7743nt_BP=1262nt
AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA
GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA
CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG
GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA
TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC
CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC
CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC
AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA
TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC
AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT
GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC
CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG
GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCAT
ATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACAT
AGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACC
TCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGA
TCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGC
AAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGAACCTAGCAA
AGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAAT
GGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGT
AGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGC
AGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACC
AGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCT
TTAATGATCTCTTACGGTTAGAAAACACAATAAAAACAAACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCACTAGCAGAT
GTCAGTTGCACATTGAGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGA
GTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCAC
TCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGG
CAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAAT
AAAACTGTTAACAGATTCTTGCTCGATAGCTTGTTTGTGTCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACTTGAAATTAT
GATGCAAAGGTTTCTCTTGCATTGAAACCCTCTTGGATATTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAAGGAGTTGAT
TAAATTTTAAGGTACCACTGGTATTTTGGGAGATTATAATCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAATAGAAGTTA
TGTGATTTCAGTGAGTTGATGTGTACAGCATGGCTGTGCTCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTCTCAAGGAAG
ATTTAACTCTCTTTGGTTTTAAATTACTTTTTAACCAGCCTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAATAGTTAAAAGT
AGGTGTTTTTTTCGTGCTCAATTTGGCACTCAAAATAATGTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAATTTTCTTTA
TGAAAAATGATTTTAGCCTTTGCAAATGTTAACCATGTGAAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATACTTTCCTGCA
CTTAGGTTTGTCCTATTCTTCATTTATTCATACTAGGATAGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTACATACAATCT
AGTACAAGTGAATTTTTATTCTTAAACATAGGTGTGTTGGCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTGGATTTTAGA
ACTGGATGTGGTGCAGTGAAGTATTTTAGGCCCAGGTCTGTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTTTGGTTGCCT
TTTCATTTCAACTGTGTTTTGAATTTGTCAGATCACACATATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCTCTTGCTTGT
GTGCAAAAGTTCCTAAAAGGAAACACAAGTAATGCCTATCCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCTGTATGCTTT
ACTGTCTTTGTAAAAATCCCCCTCTCCCCTTTTCTGGTAACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCATAAATGCAG
AATCAGTAATTCCTTGGCTTAAAGCTCTTATATAATCAATATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTATCTTTTTTTA
AAGAAATTAAGTTCTTGAAAATTTAGCCAAATCCCGTTTTATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTGTTCTATGGT
TGAGAAATCTGAGGCCTTACGAAGGTTAAGAGAACTTTCCCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGATATCTGGTCT
GTTGACTCTAGCTCAGTGTCTTCTGGTAACTGTTGAAAATTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAATGCTATTTAT
AATAACAAGTATATGTGAAATTTCTTATTGTAAGACTACTACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCTAGAAATGCC
TCCCACATTGGTAATAAACATTACAAAATACAATGTATTTTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCTTTTGAGATA
GATTGTAGTCTGGGTAGCATCTTTAAAATGTATGTGGGCTTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGTGAGACTCTG
TTTCTGTTATTTTTAATTGCTGTATGAAATGTGATCAGATTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTATTAATTGAC
TGATAATATGATAATATAGAGATTAAATTGTTTGTCTTCATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTTACTTGTATA
TGTAAGCATGAGGGAAATACACTGTTGCTAATACTGAAATTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACTGAATGCACT
AGCTTCCTTCGTTCTATAACTAATGTACCTTAACTTCCCCCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAGTGTGTGGTA
TGTTCCCTTAAAAAAAAATGACACTTGGAAGAAAAATGTATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCTTTTTTTTTT
TGAGACAGAGTCTTGCTTTGTTGCCCAGGCTGGAGGGCAGTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTTCAAGTGATT
CTCATGGCTCAGCCGCCTGAGTAGCTGGGATTACAGGTGTGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTC
ACCATGTTGGTCAGGCTGGGCTCAAACTCCTGAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCGCACCC
AGCCAAGAAAAATAATACTCTTAAATACTTAGATGTTCACCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACTGTAATCTTT
CAGATTACACCACTTTGAAAACAAGTTTTAACAGTAGGGTAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTCTACCACTTT
AGAGACATTCAAGTAATAGTTTTCTTAGAGCTTTGCACATTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAGGGAAGGATC
AATGCTTATTACCATTTGGAAAAACGAAGATCAGAAGGTAAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCATTCATGAATA
AACTTTAAAAATGTGAAGTGTCCTTTTCCTTTTCACAATACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATATCCTGTTAA
GCATTAATAGCTAATCACTGGGACTTGAATTCTGATGGCAGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTAGTAGGAAGT
GAGAACAGCTGATTTTCATGCCACGTTTCATAGCCCCACTTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGCATCTTGGGA
ATGAATGCCCAGCCGCTCGTGGGTTGGTGCAAAGAAGTATAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCTTCTGACACA
GTGTGTGCACTTCAGGCAATTTTTGGAAAATATAAAAAATTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACATTTCATTCAT
TTCCCTGTAATATTAATGTTCTTTAAGCATAATCACTAATTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGGTTTATTGAA
AACCAAGTATAAATGTGACTAAAAGCATTTTGCTTTGTTTTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGTAACATTTGA
TTGGCCTGGCCTCTTGACAATTCCCTTCTAGTTATGCATATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCTTGTTTTCCA
GTTGTTGCTATGTATAACACCCATCTTGAAAGAGAGTATATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAACTATAGCAG
TACCTTAACTCATGATGAGCTTAGGAACATAAAAGATAATTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGGTCTGGGGTG
GAGATCTGGCATGGTAGTTTTTTTCAAGCTCCAATCATCGGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGCAGATATGAA
GTAGATTTAATTAAGACTTGACTTCAGCAATACAGGGGAACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGTTAGGTATTG
CTTAAAAAAAATTGCATAAAAGCTTTGCTTGTCAAGTTAGGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAAATGAGCTGT
CATCGCAAAAAGGCGATTTGAGAAATGTGGGCTTCAGTATTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTGAGAAATTTA
TTTTGTCCATCATGTATTTCTCAAAGCAAAAGGTGGTTTTCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTTACGTCAGCT
CATTTCATCATCATTGATAACTTGTGAAATACTTATCTCCATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATTAGCTCAAGT
CTACACAGCTGAAGTAGCAGAGAAAGTGGGATCTAGATGGTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTGTCCTGGTCC
AAGTCAAATATTGACTCCTCACAAACAGTAAGTATGGCAATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATTATTTGTGAA
ATGTCTTTAAGATTTTTGGTCTTAAATTTTTGAAGACTGCTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACTCCTGCCCAC
TAACAATCTCAGTCCGTGAACAAAACCAACATGAACATTCCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGAATTTATGGA
AATGGCTTATGTAACCTACAAGACTGGAGAACAGAATGTGACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAAGCAAGAGTT
TTTTATAATTGACTTTGTGGTCTAAATTCTTGATACTGTTTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGCACTTAAGAA
CCCTGAGGAAAAATAATACAATGTGTGTGTGTGAGAGAGAGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAAT
GTGGAGGGTTGAAATGGTAAGGAATTGGAATCTTTTGTATTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGGTTTGTTAGG
AATTACAGTTGTGGGGAGCAAACTTTCTTTTTTGTGCTGTTTTAATTCAAAATGTATATCCTTAATTGTATATAATATGTAGATAAATAT
ATGAGGGTATTAAGCTACTTTGAATTAAATTTAAGGATATATTTCACATGAAAACAAATACAAACGAGAATCAAAATAAAGTTTTGCAAA

>89316_89316_8_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000406733_VAPA_chr18_9931806_ENST00000400000_length(amino acids)=563AA_BP=340
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR
NDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIGPFTDVVTTNLKLRNPSDRK
VCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNEN
DKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTS

--------------------------------------------------------------
>89316_89316_9_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000407381_VAPA_chr18_9931806_ENST00000340541_length(transcript)=1906nt_BP=953nt
CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG
CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT
CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC
AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT
GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC
CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA
GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATT
GCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGA
CCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGAC
AATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGT
ATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCCACCAGGGAATGCTCCGACTGTCACTTCAATGAGCAGCATCAACAACAC
AGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAGGGGACTCAGTGTGTTGAAACAGGAGAAACAGAAGAATGATATGGAACC
TAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAA
ACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAG
AAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGT
AATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTC
TTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCT

>89316_89316_9_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000407381_VAPA_chr18_9931806_ENST00000340541_length(amino acids)=547AA_BP=279
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL
PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPF
FVVFICEYIGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTS
DMEAVWKEAKPDELMDSKLRCVFEMPNENDKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNA
SKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAIFIGF

--------------------------------------------------------------
>89316_89316_10_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000407381_VAPA_chr18_9931806_ENST00000400000_length(transcript)=7434nt_BP=953nt
CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG
CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT
CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC
AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT
GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC
CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA
GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATT
GCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGA
CCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGAC
AATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGT
ATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTAT
GCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCT
ATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATC
CTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTT
GTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTAT
GGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTTAATGATCTCTTACGGTTAGAAAACACAATAAAAACAA
ACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCACTAGCAGATGTCAGTTGCACATTGAGTCCTTTATGAAATTCATAAATA
AAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTA
TCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATG
GTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTG
AGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAAAACTGTTAACAGATTCTTGCTCGATAGCTTGTTTGTG
TCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACTTGAAATTATGATGCAAAGGTTTCTCTTGCATTGAAACCCTCTTGGATA
TTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAAGGAGTTGATTAAATTTTAAGGTACCACTGGTATTTTGGGAGATTATAA
TCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAATAGAAGTTATGTGATTTCAGTGAGTTGATGTGTACAGCATGGCTGTGC
TCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTCTCAAGGAAGATTTAACTCTCTTTGGTTTTAAATTACTTTTTAACCAGC
CTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAATAGTTAAAAGTAGGTGTTTTTTTCGTGCTCAATTTGGCACTCAAAATAAT
GTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAATTTTCTTTATGAAAAATGATTTTAGCCTTTGCAAATGTTAACCATGTG
AAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATACTTTCCTGCACTTAGGTTTGTCCTATTCTTCATTTATTCATACTAGGAT
AGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTACATACAATCTAGTACAAGTGAATTTTTATTCTTAAACATAGGTGTGTTG
GCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTGGATTTTAGAACTGGATGTGGTGCAGTGAAGTATTTTAGGCCCAGGTCT
GTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTTTGGTTGCCTTTTCATTTCAACTGTGTTTTGAATTTGTCAGATCACACA
TATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCTCTTGCTTGTGTGCAAAAGTTCCTAAAAGGAAACACAAGTAATGCCTAT
CCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCTGTATGCTTTACTGTCTTTGTAAAAATCCCCCTCTCCCCTTTTCTGGTA
ACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCATAAATGCAGAATCAGTAATTCCTTGGCTTAAAGCTCTTATATAATCAA
TATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTATCTTTTTTTAAAGAAATTAAGTTCTTGAAAATTTAGCCAAATCCCGTTT
TATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTGTTCTATGGTTGAGAAATCTGAGGCCTTACGAAGGTTAAGAGAACTTTC
CCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGATATCTGGTCTGTTGACTCTAGCTCAGTGTCTTCTGGTAACTGTTGAAAA
TTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAATGCTATTTATAATAACAAGTATATGTGAAATTTCTTATTGTAAGACTAC
TACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCTAGAAATGCCTCCCACATTGGTAATAAACATTACAAAATACAATGTATT
TTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCTTTTGAGATAGATTGTAGTCTGGGTAGCATCTTTAAAATGTATGTGGGC
TTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGTGAGACTCTGTTTCTGTTATTTTTAATTGCTGTATGAAATGTGATCAGA
TTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTATTAATTGACTGATAATATGATAATATAGAGATTAAATTGTTTGTCTTC
ATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTTACTTGTATATGTAAGCATGAGGGAAATACACTGTTGCTAATACTGAAA
TTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACTGAATGCACTAGCTTCCTTCGTTCTATAACTAATGTACCTTAACTTCCC
CCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAGTGTGTGGTATGTTCCCTTAAAAAAAAATGACACTTGGAAGAAAAATGT
ATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCTTTTTTTTTTTGAGACAGAGTCTTGCTTTGTTGCCCAGGCTGGAGGGCA
GTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTTCAAGTGATTCTCATGGCTCAGCCGCCTGAGTAGCTGGGATTACAGGTG
TGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGTCAGGCTGGGCTCAAACTCCTGAATCCGC
CTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCGCACCCAGCCAAGAAAAATAATACTCTTAAATACTTAGATGTTCA
CCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACTGTAATCTTTCAGATTACACCACTTTGAAAACAAGTTTTAACAGTAGGG
TAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTCTACCACTTTAGAGACATTCAAGTAATAGTTTTCTTAGAGCTTTGCACA
TTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAGGGAAGGATCAATGCTTATTACCATTTGGAAAAACGAAGATCAGAAGGT
AAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCATTCATGAATAAACTTTAAAAATGTGAAGTGTCCTTTTCCTTTTCACAAT
ACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATATCCTGTTAAGCATTAATAGCTAATCACTGGGACTTGAATTCTGATGGC
AGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTAGTAGGAAGTGAGAACAGCTGATTTTCATGCCACGTTTCATAGCCCCAC
TTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGCATCTTGGGAATGAATGCCCAGCCGCTCGTGGGTTGGTGCAAAGAAGTA
TAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCTTCTGACACAGTGTGTGCACTTCAGGCAATTTTTGGAAAATATAAAAAA
TTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACATTTCATTCATTTCCCTGTAATATTAATGTTCTTTAAGCATAATCACTAA
TTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGGTTTATTGAAAACCAAGTATAAATGTGACTAAAAGCATTTTGCTTTGTT
TTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGTAACATTTGATTGGCCTGGCCTCTTGACAATTCCCTTCTAGTTATGCAT
ATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCTTGTTTTCCAGTTGTTGCTATGTATAACACCCATCTTGAAAGAGAGTAT
ATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAACTATAGCAGTACCTTAACTCATGATGAGCTTAGGAACATAAAAGATAA
TTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGGTCTGGGGTGGAGATCTGGCATGGTAGTTTTTTTCAAGCTCCAATCATC
GGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGCAGATATGAAGTAGATTTAATTAAGACTTGACTTCAGCAATACAGGGGA
ACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGTTAGGTATTGCTTAAAAAAAATTGCATAAAAGCTTTGCTTGTCAAGTTA
GGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAAATGAGCTGTCATCGCAAAAAGGCGATTTGAGAAATGTGGGCTTCAGTA
TTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTGAGAAATTTATTTTGTCCATCATGTATTTCTCAAAGCAAAAGGTGGTTT
TCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTTACGTCAGCTCATTTCATCATCATTGATAACTTGTGAAATACTTATCTC
CATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATTAGCTCAAGTCTACACAGCTGAAGTAGCAGAGAAAGTGGGATCTAGATG
GTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTGTCCTGGTCCAAGTCAAATATTGACTCCTCACAAACAGTAAGTATGGCA
ATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATTATTTGTGAAATGTCTTTAAGATTTTTGGTCTTAAATTTTTGAAGACTG
CTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACTCCTGCCCACTAACAATCTCAGTCCGTGAACAAAACCAACATGAACATT
CCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGAATTTATGGAAATGGCTTATGTAACCTACAAGACTGGAGAACAGAATGT
GACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAAGCAAGAGTTTTTTATAATTGACTTTGTGGTCTAAATTCTTGATACTGT
TTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGCACTTAAGAACCCTGAGGAAAAATAATACAATGTGTGTGTGTGAGAGAG
AGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAATGTGGAGGGTTGAAATGGTAAGGAATTGGAATCTTTTGTA
TTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGGTTTGTTAGGAATTACAGTTGTGGGGAGCAAACTTTCTTTTTTGTGCTG
TTTTAATTCAAAATGTATATCCTTAATTGTATATAATATGTAGATAAATATATGAGGGTATTAAGCTACTTTGAATTAAATTTAAGGATA

>89316_89316_10_TBC1D22A-VAPA_TBC1D22A_chr22_47308084_ENST00000407381_VAPA_chr18_9931806_ENST00000400000_length(amino acids)=502AA_BP=279
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL
PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPF
FVVFICEYIGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTS
DMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLR

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Fusion Gene PPI Analysis for TBC1D22A-VAPA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TBC1D22A-VAPA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TBC1D22A-VAPA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source