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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBC1D23-CMSS1 (FusionGDB2 ID:89326)

Fusion Gene Summary for TBC1D23-CMSS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D23-CMSS1
Fusion gene ID: 89326
HgeneTgene
Gene symbol

TBC1D23

CMSS1

Gene ID

55773

84319

Gene nameTBC1 domain family member 23cms1 ribosomal small subunit homolog
SynonymsNS4ATP1|PCH11C3orf26
Cytomap

3q12.1-q12.2

3q12.1

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 23HCV non-structural protein 4A-transactivated protein 1HCV nonstructural protein 4A-transactivated protein 1protein CMSS1
Modification date2020032020200313
UniProtAcc.

Q9BQ75

Ensembl transtripts involved in fusion geneENST00000486274, ENST00000344949, 
ENST00000394144, ENST00000475134, 
ENST00000421999, ENST00000489081, 
ENST00000496116, 
Fusion gene scores* DoF score6 X 7 X 7=29411 X 9 X 9=891
# samples 813
** MAII scorelog2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/891*10)=-2.77691380849347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D23 [Title/Abstract] AND CMSS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBC1D23(100002655)-CMSS1(99890683), # samples:1
TBC1D23(99979915)-CMSS1(99879274), # samples:1
TBC1D23(100002654)-CMSS1(99890682), # samples:1
Anticipated loss of major functional domain due to fusion event.TBC1D23-CMSS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBC1D23

GO:0099041

vesicle tethering to Golgi

29426865


check buttonFusion gene breakpoints across TBC1D23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CMSS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A129-01ATBC1D23chr3

100002654

+CMSS1chr3

99890682

+
ChimerDB4BRCATCGA-AO-A129-01ATBC1D23chr3

100002655

+CMSS1chr3

99890683

+
ChimerDB4ESCATCGA-LN-A7HZTBC1D23chr3

99979915

+CMSS1chr3

99879274

+


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Fusion Gene ORF analysis for TBC1D23-CMSS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486274ENST00000421999TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
3UTR-3CDSENST00000486274ENST00000421999TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
3UTR-3CDSENST00000486274ENST00000421999TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
3UTR-intronENST00000486274ENST00000489081TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
3UTR-intronENST00000486274ENST00000489081TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
3UTR-intronENST00000486274ENST00000489081TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
3UTR-intronENST00000486274ENST00000496116TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
3UTR-intronENST00000486274ENST00000496116TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
3UTR-intronENST00000486274ENST00000496116TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
5CDS-intronENST00000344949ENST00000489081TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
5CDS-intronENST00000344949ENST00000489081TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
5CDS-intronENST00000344949ENST00000489081TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
5CDS-intronENST00000344949ENST00000496116TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
5CDS-intronENST00000344949ENST00000496116TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
5CDS-intronENST00000344949ENST00000496116TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
5CDS-intronENST00000394144ENST00000489081TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
5CDS-intronENST00000394144ENST00000489081TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
5CDS-intronENST00000394144ENST00000489081TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
5CDS-intronENST00000394144ENST00000496116TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
5CDS-intronENST00000394144ENST00000496116TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
5CDS-intronENST00000394144ENST00000496116TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
Frame-shiftENST00000344949ENST00000421999TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
Frame-shiftENST00000394144ENST00000421999TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
In-frameENST00000344949ENST00000421999TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
In-frameENST00000344949ENST00000421999TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
In-frameENST00000394144ENST00000421999TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
In-frameENST00000394144ENST00000421999TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
intron-3CDSENST00000475134ENST00000421999TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
intron-3CDSENST00000475134ENST00000421999TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
intron-3CDSENST00000475134ENST00000421999TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
intron-intronENST00000475134ENST00000489081TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
intron-intronENST00000475134ENST00000489081TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
intron-intronENST00000475134ENST00000489081TBC1D23chr3

99979915

+CMSS1chr3

99879274

+
intron-intronENST00000475134ENST00000496116TBC1D23chr3

100002654

+CMSS1chr3

99890682

+
intron-intronENST00000475134ENST00000496116TBC1D23chr3

100002655

+CMSS1chr3

99890683

+
intron-intronENST00000475134ENST00000496116TBC1D23chr3

99979915

+CMSS1chr3

99879274

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344949TBC1D23chr3100002655+ENST00000421999CMSS1chr399890683+103149418815265
ENST00000394144TBC1D23chr3100002655+ENST00000421999CMSS1chr399890683+10204837804265
ENST00000344949TBC1D23chr3100002654+ENST00000421999CMSS1chr399890682+103149418815265
ENST00000394144TBC1D23chr3100002654+ENST00000421999CMSS1chr399890682+10204837804265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344949ENST00000421999TBC1D23chr3100002655+CMSS1chr399890683+0.0025577910.99744225
ENST00000394144ENST00000421999TBC1D23chr3100002655+CMSS1chr399890683+0.0025870960.997413
ENST00000344949ENST00000421999TBC1D23chr3100002654+CMSS1chr399890682+0.0025577910.99744225
ENST00000394144ENST00000421999TBC1D23chr3100002654+CMSS1chr399890682+0.0025870960.997413

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Fusion Genomic Features for TBC1D23-CMSS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBC1D23chr3100002655+CMSS1chr399890682+0.0174861530.98251384
TBC1D23chr399979915+CMSS1chr399879273+0.0007415390.99925846
TBC1D23chr3100002655+CMSS1chr399890682+0.0174861530.98251384
TBC1D23chr399979915+CMSS1chr399879273+0.0007415390.99925846

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TBC1D23-CMSS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:100002655/chr3:99890683)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CMSS1

Q9BQ75

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D23chr3:100002654chr3:99890682ENST00000344949+418334_446158685.0DomainRhodanese
HgeneTBC1D23chr3:100002654chr3:99890682ENST00000344949+41844_225158685.0DomainRab-GAP TBC
HgeneTBC1D23chr3:100002654chr3:99890682ENST00000394144+419334_446158700.0DomainRhodanese
HgeneTBC1D23chr3:100002654chr3:99890682ENST00000394144+41944_225158700.0DomainRab-GAP TBC
HgeneTBC1D23chr3:100002655chr3:99890683ENST00000344949+418334_446158685.0DomainRhodanese
HgeneTBC1D23chr3:100002655chr3:99890683ENST00000344949+41844_225158685.0DomainRab-GAP TBC
HgeneTBC1D23chr3:100002655chr3:99890683ENST00000394144+419334_446158700.0DomainRhodanese
HgeneTBC1D23chr3:100002655chr3:99890683ENST00000394144+41944_225158700.0DomainRab-GAP TBC


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Fusion Gene Sequence for TBC1D23-CMSS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89326_89326_1_TBC1D23-CMSS1_TBC1D23_chr3_100002654_ENST00000344949_CMSS1_chr3_99890682_ENST00000421999_length(transcript)=1031nt_BP=494nt
ACGTGGACGTCAACAGCAATGGCGGAAGGAGAAGATGTGCCGCCGCTGCCAACGTCGAGCGGCGACGGCTGGGAAAAAGATCTTGAAGAA
GCTCTGGAAGCAGGAGGTTGTGATCTTGAAACGTTGAGAAATATAATTCAAGGAAGACCGCTGCCTGCTGATCTGAGGGCCAAAGTTTGG
AAGATTGCTCTGAATGTTGCAGGAAAAGGTGATAGTTTGGCATCATGGGATGGTATTTTAGACTTGCCAGAACAGAACACTATTCACAAA
GATTGCCTGCAGTTTATTGACCAGCTTTCAGTGCCAGAGGAGAAGGCAGCAGAATTACTTTTGGATATTGAATCTGTAATTACCTTTTAT
TGTAAATCACGTAACATTAAATATAGCACATCCCTTAGCTGGATACATCTACTGAAACCATTGGTGCATCTTCAACTGCCACGCAGCGAT
TTATACAACTGCTTTTATGCCATAATGAATAAGTACATTCCCAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTT
GCAAAGCACATAAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAA
CTTGTTAAACAAGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATG
GACATTCCCGAGATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTT
TTCTAAGTCTGTGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTA
AATATCAGCAAATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGA

>89326_89326_1_TBC1D23-CMSS1_TBC1D23_chr3_100002654_ENST00000344949_CMSS1_chr3_99890682_ENST00000421999_length(amino acids)=265AA_BP=158
MAEGEDVPPLPTSSGDGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLQFI
DQLSVPEEKAAELLLDIESVITFYCKSRNIKYSTSLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRSMTAFRGDGKVIKLFAKHIKV

--------------------------------------------------------------
>89326_89326_2_TBC1D23-CMSS1_TBC1D23_chr3_100002654_ENST00000394144_CMSS1_chr3_99890682_ENST00000421999_length(transcript)=1020nt_BP=483nt
AACAGCAATGGCGGAAGGAGAAGATGTGCCGCCGCTGCCAACGTCGAGCGGCGACGGCTGGGAAAAAGATCTTGAAGAAGCTCTGGAAGC
AGGAGGTTGTGATCTTGAAACGTTGAGAAATATAATTCAAGGAAGACCGCTGCCTGCTGATCTGAGGGCCAAAGTTTGGAAGATTGCTCT
GAATGTTGCAGGAAAAGGTGATAGTTTGGCATCATGGGATGGTATTTTAGACTTGCCAGAACAGAACACTATTCACAAAGATTGCCTGCA
GTTTATTGACCAGCTTTCAGTGCCAGAGGAGAAGGCAGCAGAATTACTTTTGGATATTGAATCTGTAATTACCTTTTATTGTAAATCACG
TAACATTAAATATAGCACATCCCTTAGCTGGATACATCTACTGAAACCATTGGTGCATCTTCAACTGCCACGCAGCGATTTATACAACTG
CTTTTATGCCATAATGAATAAGTACATTCCCAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTTGCAAAGCACAT
AAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAACTTGTTAAACA
AGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATGGACATTCCCGA
GATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTTTTCTAAGTCTG
TGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTAAATATCAGCAA
ATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGACAACTCTCTTA

>89326_89326_2_TBC1D23-CMSS1_TBC1D23_chr3_100002654_ENST00000394144_CMSS1_chr3_99890682_ENST00000421999_length(amino acids)=265AA_BP=158
MAEGEDVPPLPTSSGDGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLQFI
DQLSVPEEKAAELLLDIESVITFYCKSRNIKYSTSLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRSMTAFRGDGKVIKLFAKHIKV

--------------------------------------------------------------
>89326_89326_3_TBC1D23-CMSS1_TBC1D23_chr3_100002655_ENST00000344949_CMSS1_chr3_99890683_ENST00000421999_length(transcript)=1031nt_BP=494nt
ACGTGGACGTCAACAGCAATGGCGGAAGGAGAAGATGTGCCGCCGCTGCCAACGTCGAGCGGCGACGGCTGGGAAAAAGATCTTGAAGAA
GCTCTGGAAGCAGGAGGTTGTGATCTTGAAACGTTGAGAAATATAATTCAAGGAAGACCGCTGCCTGCTGATCTGAGGGCCAAAGTTTGG
AAGATTGCTCTGAATGTTGCAGGAAAAGGTGATAGTTTGGCATCATGGGATGGTATTTTAGACTTGCCAGAACAGAACACTATTCACAAA
GATTGCCTGCAGTTTATTGACCAGCTTTCAGTGCCAGAGGAGAAGGCAGCAGAATTACTTTTGGATATTGAATCTGTAATTACCTTTTAT
TGTAAATCACGTAACATTAAATATAGCACATCCCTTAGCTGGATACATCTACTGAAACCATTGGTGCATCTTCAACTGCCACGCAGCGAT
TTATACAACTGCTTTTATGCCATAATGAATAAGTACATTCCCAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTT
GCAAAGCACATAAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAA
CTTGTTAAACAAGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATG
GACATTCCCGAGATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTT
TTCTAAGTCTGTGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTA
AATATCAGCAAATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGA

>89326_89326_3_TBC1D23-CMSS1_TBC1D23_chr3_100002655_ENST00000344949_CMSS1_chr3_99890683_ENST00000421999_length(amino acids)=265AA_BP=158
MAEGEDVPPLPTSSGDGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLQFI
DQLSVPEEKAAELLLDIESVITFYCKSRNIKYSTSLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRSMTAFRGDGKVIKLFAKHIKV

--------------------------------------------------------------
>89326_89326_4_TBC1D23-CMSS1_TBC1D23_chr3_100002655_ENST00000394144_CMSS1_chr3_99890683_ENST00000421999_length(transcript)=1020nt_BP=483nt
AACAGCAATGGCGGAAGGAGAAGATGTGCCGCCGCTGCCAACGTCGAGCGGCGACGGCTGGGAAAAAGATCTTGAAGAAGCTCTGGAAGC
AGGAGGTTGTGATCTTGAAACGTTGAGAAATATAATTCAAGGAAGACCGCTGCCTGCTGATCTGAGGGCCAAAGTTTGGAAGATTGCTCT
GAATGTTGCAGGAAAAGGTGATAGTTTGGCATCATGGGATGGTATTTTAGACTTGCCAGAACAGAACACTATTCACAAAGATTGCCTGCA
GTTTATTGACCAGCTTTCAGTGCCAGAGGAGAAGGCAGCAGAATTACTTTTGGATATTGAATCTGTAATTACCTTTTATTGTAAATCACG
TAACATTAAATATAGCACATCCCTTAGCTGGATACATCTACTGAAACCATTGGTGCATCTTCAACTGCCACGCAGCGATTTATACAACTG
CTTTTATGCCATAATGAATAAGTACATTCCCAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTTGCAAAGCACAT
AAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAACTTGTTAAACA
AGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATGGACATTCCCGA
GATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTTTTCTAAGTCTG
TGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTAAATATCAGCAA
ATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGACAACTCTCTTA

>89326_89326_4_TBC1D23-CMSS1_TBC1D23_chr3_100002655_ENST00000394144_CMSS1_chr3_99890683_ENST00000421999_length(amino acids)=265AA_BP=158
MAEGEDVPPLPTSSGDGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLQFI
DQLSVPEEKAAELLLDIESVITFYCKSRNIKYSTSLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRSMTAFRGDGKVIKLFAKHIKV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBC1D23-CMSS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBC1D23-CMSS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBC1D23-CMSS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource