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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TBC1D2-GABBR2 (FusionGDB2 ID:89350)

Fusion Gene Summary for TBC1D2-GABBR2

Fusion gene summary

Fusion gene information	Fusion gene name: TBC1D2-GABBR2
	Fusion gene ID: 89350
		Hgene	Tgene
	Gene symbol	TBC1D2	GABBR2
	Gene ID	55357	9568
	Gene name	TBC1 domain family member 2	gamma-aminobutyric acid type B receptor subunit 2
	Synonyms	PARIS-1\|PARIS1\|TBC1D2A	EIEE59\|GABABR2\|GPR51\|GPRC3B\|HG20\|HRIHFB2099\|NDPLHS
	Cytomap	9q22.33	9q22.33
	Type of gene	protein-coding	protein-coding
	Description	TBC1 domain family member 2ATBC1 domain family, member 2Aarmusprostate antigen recognized and identified by SEREX 1	gamma-aminobutyric acid type B receptor subunit 2G-protein coupled receptor 51GABA-B receptor 2GABA-B receptor, R2 subunitGABA-B-R2GABA-BR2gamma-aminobutyric acid (GABA) B receptor, 2gamma-aminobutyric acid B receptor 2gb2
	Modification date	20200313	20200313
	UniProtAcc	.	O75899
	Ensembl transtripts involved in fusion gene	ENST00000342112, ENST00000375064, ENST00000375066, ENST00000493589, ENST00000375063,	ENST00000477471, ENST00000259455,
Fusion gene scores	* DoF score	3 X 3 X 2=18	8 X 8 X 5=320
	# samples	3	8
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TBC1D2 [Title/Abstract] AND GABBR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TBC1D2(100991234)-GABBR2(101258796), # samples:2
Anticipated loss of major functional domain due to fusion event.	TBC1D2-GABBR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TBC1D2	GO:0043547	positive regulation of GTPase activity	20116244
Tgene	GABBR2	GO:0007214	gamma-aminobutyric acid signaling pathway	9872316

Fusion gene breakpoints across TBC1D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GABBR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CN-4739-01A	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
ChimerDB4	HNSC	TCGA-CN-4739	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-

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Fusion Gene ORF analysis for TBC1D2-GABBR2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000342112	ENST00000477471	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
5CDS-5UTR	ENST00000375064	ENST00000477471	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
5CDS-5UTR	ENST00000375066	ENST00000477471	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
5UTR-3CDS	ENST00000493589	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
5UTR-5UTR	ENST00000493589	ENST00000477471	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
Frame-shift	ENST00000342112	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
In-frame	ENST00000375064	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
In-frame	ENST00000375066	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
intron-3CDS	ENST00000375063	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
intron-5UTR	ENST00000375063	ENST00000477471	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375064	TBC1D2	chr9	100991234	-	ENST00000259455	GABBR2	chr9	101258796	-	5688	1017	30	3212	1060
ENST00000375066	TBC1D2	chr9	100991234	-	ENST00000259455	GABBR2	chr9	101258796	-	5741	1070	14	3265	1083

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375064	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-	0.001445734	0.9985543
ENST00000375066	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-	0.001458124	0.99854195

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Fusion Genomic Features for TBC1D2-GABBR2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBC1D2-GABBR2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:100991234/chr9:101258796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GABBR2 O75899
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269\|PubMed:10075644, ECO:0000269\|PubMed:10328880, ECO:0000269\|PubMed:15617512, ECO:0000269\|PubMed:18165688, ECO:0000269\|PubMed:22660477, ECO:0000269\|PubMed:24305054, ECO:0000269\|PubMed:9872316, ECO:0000269\|PubMed:9872744, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

11_14

108

711.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

11_14

326

861.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

11_14

326

918.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

45_142

326

861.0

Domain

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

45_142

326

918.0

Domain

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

781_819

210

942.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

505_522

210

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

544_551

210

942.0

Topological domain

Extracellular

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

573_597

210

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

619_654

210

942.0

Topological domain

Extracellular

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

676_691

210

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

713_720

210

942.0

Topological domain

Extracellular

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

742_941

210

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

484_504

210

942.0

Transmembrane

Helical%3B Name%3D1

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

523_543

210

942.0

Transmembrane

Helical%3B Name%3D2

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

552_572

210

942.0

Transmembrane

Helical%3B Name%3D3

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

598_618

210

942.0

Transmembrane

Helical%3B Name%3D4

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

655_675

210

942.0

Transmembrane

Helical%3B Name%3D5

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

692_712

210

942.0

Transmembrane

Helical%3B Name%3D6

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

721_741

210

942.0

Transmembrane

Helical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

298_416

108

711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

875_913

108

711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

298_416

469.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

875_913

469.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

298_416

326

861.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

875_913

326

861.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

298_416

326

918.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

875_913

326

918.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

11_14

469.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

45_142

108

711.0

Domain

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

625_817

108

711.0

Domain

Rab-GAP TBC

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

45_142

469.0

Domain

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

625_817

469.0

Domain

Rab-GAP TBC

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

625_817

326

861.0

Domain

Rab-GAP TBC

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

625_817

326

918.0

Domain

Rab-GAP TBC

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

42_483

210

942.0

Topological domain

Extracellular

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Fusion Gene Sequence for TBC1D2-GABBR2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89350_89350_1_TBC1D2-GABBR2_TBC1D2_chr9_100991234_ENST00000375064_GABBR2_chr9_101258796_ENST00000259455_length(transcript)=5688nt_BP=1017nt
GCGGACCCCTCGTCCCTCCGCAGTCTCCGGCTGGCAGCGATGGAGGGCGCTGGGGAGAACGCCCCGGAGTCCAGCTCCTCTGCCCCTGGG
TCCGAAGAGTCTGCCAGGGATCCACAGGTGCCGCCTCCGGAGGAAGAATCGGGGGACTGCGCCCGGTCCCTGGAGGCGGTCCCCAAGAAA
CTCTGTGGGTATTTAAGTAAGTTCGGCGGCAAAGGGCCCATCCGGGGCTGGAAATCCCGCTGGTTCTTCTACGACGAAAGGAAATGTCAG
CTGTATTACTCGCGGACCGCTCAGGATGCCAATCCCTTGGACAGCATCGACCTCTCCAGTGCAGTGTTTGACTGTAAGGCGGACGCTGAG
GAGGGGATCTTCGAAATCAAGACTCCCAGCCGGGTTATTACCCTGAAGGCCGCCACCAAGCAAGCGATGCTGTACTGGCTGCAGCAGCTG
CAGATGAAGCGCTGGGAATTCCACAACAGCCCGCCGGCACCTCCTGCCACCCCTGATGCCGCCCTGGCTGGGAATGGGCCCGTCCTGCAC
CTCGAGCTAGGGCAAGAAGAGGCAGAGCTGGAGGAGTTCCTGTGCCCTGTGAAAACACCCCCTGGGCTAGTGGGCGTGGCAGCTGCCTTG
CAGCCCTTCCCTGCCCTTCAGAATATTTCCCTCAAGCACCTGGGGACTGAAATACAGAACACAATGCACAACATCCGTGGCAACAAGCAG
GCCCAGGGAACAGGCCATGAACCTCCAGGGGAAGATTCTCCACAGAGTGGGGAGCCTCAGAGGGAGGAGCAGCCCTTGGCCTCTGACGCC
AGCACCCCAGGGAGAGAGCCAGAGGATTCTCCAAAGCCTGCACCCAAGCCTTCTCTGACCATCAGTTTCGCTCAGAAAGCCAAGCGCCAG
AACAACACCTTCCCATTCTTTTCTGAAGGAATCACACGGAACCGAACTGCCCAGGAGAAAGTGGCAGCCTTGGAGCAACAGGTTCTGATG
CTCACCAAGGAGTTAAAGTCTCAGAAGGTGCGGAATGACCTGACTGGAGTTCTGTATGGCGAGGACATTGAGATTTCAGACACCGAGAGC
TTCTCCAACGATCCCTGTACCAGTGTCAAAAAGCTGAAGGGGAATGATGTGCGGATCATCCTTGGCCAGTTTGACCAGAATATGGCAGCA
AAAGTGTTCTGTTGTGCATACGAGGAGAACATGTATGGTAGTAAATATCAGTGGATCATTCCGGGCTGGTACGAGCCTTCTTGGTGGGAG
CAGGTGCACACGGAAGCCAACTCATCCCGCTGCCTCCGGAAGAATCTGCTTGCTGCCATGGAGGGCTACATTGGCGTGGATTTCGAGCCC
CTGAGCTCCAAGCAGATCAAGACCATCTCAGGAAAGACTCCACAGCAGTATGAGAGAGAGTACAACAACAAGCGGTCAGGCGTGGGGCCC
AGCAAGTTCCACGGGTACGCCTACGATGGCATCTGGGTCATCGCCAAGACACTGCAGAGGGCCATGGAGACACTGCATGCCAGCAGCCGG
CACCAGCGGATCCAGGACTTCAACTACACGGACCACACGCTGGGCAGGATCATCCTCAATGCCATGAACGAGACCAACTTCTTCGGGGTC
ACGGGTCAAGTTGTATTCCGGAATGGGGAGAGAATGGGGACCATTAAATTTACTCAATTTCAAGACAGCAGGGAGGTGAAGGTGGGAGAG
TACAACGCTGTGGCCGACACACTGGAGATCATCAATGACACCATCAGGTTCCAAGGATCCGAACCACCAAAAGACAAGACCATCATCCTG
GAGCAGCTGCGGAAGATCTCCCTACCTCTCTACAGCATCCTCTCTGCCCTCACCATCCTCGGGATGATCATGGCCAGTGCTTTTCTCTTC
TTCAACATCAAGAACCGGAATCAGAAGCTCATAAAGATGTCGAGTCCATACATGAACAACCTTATCATCCTTGGAGGGATGCTCTCCTAT
GCTTCCATATTTCTCTTTGGCCTTGATGGATCCTTTGTCTCTGAAAAGACCTTTGAAACACTTTGCACCGTCAGGACCTGGATTCTCACC
GTGGGCTACACGACCGCTTTTGGGGCCATGTTTGCAAAGACCTGGAGAGTCCACGCCATCTTCAAAAATGTGAAAATGAAGAAGAAGATC
ATCAAGGACCAGAAACTGCTTGTGATCGTGGGGGGCATGCTGCTGATCGACCTGTGTATCCTGATCTGCTGGCAGGCTGTGGACCCCCTG
CGAAGGACAGTGGAGAAGTACAGCATGGAGCCGGACCCAGCAGGACGGGATATCTCCATCCGCCCTCTCCTGGAGCACTGTGAGAACACC
CATATGACCATCTGGCTTGGCATCGTCTATGCCTACAAGGGACTTCTCATGTTGTTCGGTTGTTTCTTAGCTTGGGAGACCCGCAACGTC
AGCATCCCCGCACTCAACGACAGCAAGTACATCGGGATGAGTGTCTACAACGTGGGGATCATGTGCATCATCGGGGCCGCTGTCTCCTTC
CTGACCCGGGACCAGCCCAATGTGCAGTTCTGCATCGTGGCTCTGGTCATCATCTTCTGCAGCACCATCACCCTCTGCCTGGTATTCGTG
CCGAAGCTCATCACCCTGAGAACAAACCCAGATGCAGCAACGCAGAACAGGCGATTCCAGTTCACTCAGAATCAGAAGAAAGAAGATTCT
AAAACGTCCACCTCGGTCACCAGTGTGAACCAAGCCAGCACATCCCGCCTGGAGGGCCTACAGTCAGAAAACCATCGCCTGCGAATGAAG
ATCACAGAGCTGGATAAAGACTTGGAAGAGGTCACCATGCAGCTGCAGGACACACCAGAAAAGACCACCTACATTAAACAGAACCACTAC
CAAGAGCTCAATGACATCCTCAACCTGGGAAACTTCACTGAGAGCACAGATGGAGGAAAGGCCATTTTAAAAAATCACCTCGATCAAAAT
CCCCAGCTACAGTGGAACACAACAGAGCCCTCTCGAACATGCAAAGATCCTATAGAAGATATAAACTCTCCAGAACACATCCAGCGTCGG
CTGTCCCTCCAGCTCCCCATCCTCCACCACGCCTACCTCCCATCCATCGGAGGCGTGGACGCCAGCTGTGTCAGCCCCTGCGTCAGCCCC
ACCGCCAGCCCCCGCCACAGACATGTGCCACCCTCCTTCCGAGTCATGGTCTCGGGCCTGTAAGGGTGGGAGGCCTGGGCCCGGGGCCTC
CCCCGTGACAGAACCACACTGGGCAGAGGGGTCTGCTGCAGAAACACTGTCGGCTCTGGCTGCGGAGAAGCTGGGCACCATGGCTGGCCT
CTCAGGACCACTCGGATGGCACTCAGGTGGACAGGACGGGGCAGGGGGAGACTTGGCACCTGACCTCGAGCCTTATTTGTGAAGTCCTTA
TTTCTTCACAAAGAAGAGGAACGGAAATGGGACGTCTTCCTTAACATCTGCAAACAAGGAGGCGCTGGGATATCAAACTTGCAAAAAAAA
AAAAAAAAAAAAAAAAACAAAAAAACTAGACAAGGAGAGAGGCACTAGAACTCCAGCTGGAAGTCACGGAGTGGCTCGAGCAGCCTTGGG
AAGAGGCAAGGAGCTTCTGAAGAAACTGCCTCTGCACACACATCACTGGCTGTGACCCCTCAGGCTAGCCCTTCTCCACTCTGGGGGAGG
AGGTGGGAAGGGCCACCAGGCCCCCAGCTGCCAGGCCAGCTGACCCCAGCCTTCCTGGAACAGGGAGTCTGCAGGAGCGCAGACAGGCAC
AGCCCTGGAGCAGGCAGGCCGAGGGCTGCGGCACTGGAGCAGGCTGACTTACATGCTCCACATGGGACCTGTGTCACCCAATGAGATGTT
TGTTACTCTGGTAAATGCCACACGTTAACACAATAACACCCATTCCTGGGACCGTGGGGATTTAGGGCACGTCACTGCAGACACGCTCTG
CAGCATTCACCGACAGTCTGTCATGCACCCACCACGTTGGCCATGTCCTTGTGTTCCTATCGGATGCTCCCAGTAACCAGGGGGACCACC
CGAGCTAATCATGGAATGTCTGTTCCCAGCAAACACGATAAAGAAAGATTGTGCACTTTAACCTCTCTCATCAGGGCCCAAGGGCTGGCT
GGGATTTTTTTTTTTTTTTTCCCACTAACTTTGTTTCTGACCAAAGTGAATTGGAGGCACTCTGCTAAAAGACATCCCCGTAGACATAGG
GGAGAGAGTTGCTGGCTGAGGGCTTCCCTTGGCTTCCAGAAGGCAGCCTTCCATCCAGACAAGCCAGTGAGCTCTCCCCTTGGGATCACT
GGGGTGATCAGTCAGCAGATTGATTCTCATTCATAAGATCATTCCTCCCTTTAAATTGAGCCCCTAAGAGCACTGGCCTGGGAGTCAGAC
AGACCTGGGTTCAAGTCCTCAGTCCCCTGCCCACTCCCTACGTGACTTTGATCAGGTCACTAGTGTCTCTCTGAGCCTCAGTTTCCCCTC
TGTAACTTGGGGTTGAACTAAAACACCTGTCCTGCCTACCTCACAAGGTCACTCTGAGGATTGAAACTTGATCTTGTCCAGGAAAGCTTT
GTACCAAACAGTGAAGCCGCCCTGATCCGTGAGGTATGAGTATGACTCTGACCTTCAGCCCTCCCTACAGCCGGGGGTGTGGCCCAGAGA
AGCTTCCAGCACAGCCCTCTACCCAGAACATCCGGGCTGGAGGGAGGCTCCCAGTGACTTTTCTGACATTCCTAGACAGGTTCATTCTTT
GCTCAAGAAAGGCCTGAATGACAATGTCCAGGATGTCTGCACAACTGAGCAGCTCGCTCACTCCCTAAAGAAACCTATTGGCAGCTTCAA
CAGGCAGGCAATAATCTCTTCCCAGAACCACTGCAGTCAGGAATAAACTGTTTTCTCCACCAGGCTTTGACAAAAGGGCCCACAGGAATC
TTACCAATGCCAACATTTCAAAGCACCCTATTTCACGTAGCATAGCTTTCTGCTCCCCTTCCCCAAAGAGAGGTTATGGAGGTACTGTAG
CTTTTAGGGAAAAAAAAATGTTAACACATCACAGGTCAAGTTGAAGTCATTCTCTGTTTAGGCACTAAAAATCGGTGTTGTCACTCACTG
TGTATTACCAGTATTTACTTGCTTTCTTGATTTCACCAAAACCAAATTTAATTTAAAGGACCACATTAATTTTTCAAAGGGAAAGAGACA
ATTAATTGTACATAATGTATACACACACACAAAAAAAAATACCTGTAGAAATATTATTCCAGCATAGCAGGAAAACAAACAAAAGTATTG
GACTGTCGGAGGTGAGCCTGTGCGTCTGTAACCCTTTGTGACTCCTGAGCGTGCGCTGTCTTCTAGGTTAACTCACGAAGTACATTCTCT
GTCTTACTGATACTGTAGGTTCACCCATTTTTTTTTAATTTCCTCGCAAATAACAAGACCCACAGAAGTGACTCTAGCTACTTAATGGTT
CTGTTCTTTTATATGCAGCAAACACACCGTCCATTTCTGAAGAGGCTTCGGCCTGAAGGCATTTTCCAATGATGTTAGTGCACAAAACGC
TTTAAATTAGACTGGAACTGCCAGAATCAAATGTAAATGAGGAATTTCTCGTACCCCTACTGCATGGTATCGATTTTTAATAAATTGTTG

>89350_89350_1_TBC1D2-GABBR2_TBC1D2_chr9_100991234_ENST00000375064_GABBR2_chr9_101258796_ENST00000259455_length(amino acids)=1060AA_BP=329
MAAMEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDA
NPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAEL
EEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDS
PKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKVRNDLTGVLYGEDIEISDTESFSNDPCTSVK
KLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTIS
GKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGE
RMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKL
IKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIV
GGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKY
IGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVN
QASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEP

--------------------------------------------------------------
>89350_89350_2_TBC1D2-GABBR2_TBC1D2_chr9_100991234_ENST00000375066_GABBR2_chr9_101258796_ENST00000259455_length(transcript)=5741nt_BP=1070nt
CTCCCTTTGGGAAGCTGCCCGCCGAGTCTCCGAGATTTGTCCCTGGTGGTCCCGCGGACCCCTCGTCCCTCCGCAGTCTCCGGCTGGCAG
CGATGGAGGGCGCTGGGGAGAACGCCCCGGAGTCCAGCTCCTCTGCCCCTGGGTCCGAAGAGTCTGCCAGGGATCCACAGGTGCCGCCTC
CGGAGGAAGAATCGGGGGACTGCGCCCGGTCCCTGGAGGCGGTCCCCAAGAAACTCTGTGGGTATTTAAGTAAGTTCGGCGGCAAAGGGC
CCATCCGGGGCTGGAAATCCCGCTGGTTCTTCTACGACGAAAGGAAATGTCAGCTGTATTACTCGCGGACCGCTCAGGATGCCAATCCCT
TGGACAGCATCGACCTCTCCAGTGCAGTGTTTGACTGTAAGGCGGACGCTGAGGAGGGGATCTTCGAAATCAAGACTCCCAGCCGGGTTA
TTACCCTGAAGGCCGCCACCAAGCAAGCGATGCTGTACTGGCTGCAGCAGCTGCAGATGAAGCGCTGGGAATTCCACAACAGCCCGCCGG
CACCTCCTGCCACCCCTGATGCCGCCCTGGCTGGGAATGGGCCCGTCCTGCACCTCGAGCTAGGGCAAGAAGAGGCAGAGCTGGAGGAGT
TCCTGTGCCCTGTGAAAACACCCCCTGGGCTAGTGGGCGTGGCAGCTGCCTTGCAGCCCTTCCCTGCCCTTCAGAATATTTCCCTCAAGC
ACCTGGGGACTGAAATACAGAACACAATGCACAACATCCGTGGCAACAAGCAGGCCCAGGGAACAGGCCATGAACCTCCAGGGGAAGATT
CTCCACAGAGTGGGGAGCCTCAGAGGGAGGAGCAGCCCTTGGCCTCTGACGCCAGCACCCCAGGGAGAGAGCCAGAGGATTCTCCAAAGC
CTGCACCCAAGCCTTCTCTGACCATCAGTTTCGCTCAGAAAGCCAAGCGCCAGAACAACACCTTCCCATTCTTTTCTGAAGGAATCACAC
GGAACCGAACTGCCCAGGAGAAAGTGGCAGCCTTGGAGCAACAGGTTCTGATGCTCACCAAGGAGTTAAAGTCTCAGAAGGTGCGGAATG
ACCTGACTGGAGTTCTGTATGGCGAGGACATTGAGATTTCAGACACCGAGAGCTTCTCCAACGATCCCTGTACCAGTGTCAAAAAGCTGA
AGGGGAATGATGTGCGGATCATCCTTGGCCAGTTTGACCAGAATATGGCAGCAAAAGTGTTCTGTTGTGCATACGAGGAGAACATGTATG
GTAGTAAATATCAGTGGATCATTCCGGGCTGGTACGAGCCTTCTTGGTGGGAGCAGGTGCACACGGAAGCCAACTCATCCCGCTGCCTCC
GGAAGAATCTGCTTGCTGCCATGGAGGGCTACATTGGCGTGGATTTCGAGCCCCTGAGCTCCAAGCAGATCAAGACCATCTCAGGAAAGA
CTCCACAGCAGTATGAGAGAGAGTACAACAACAAGCGGTCAGGCGTGGGGCCCAGCAAGTTCCACGGGTACGCCTACGATGGCATCTGGG
TCATCGCCAAGACACTGCAGAGGGCCATGGAGACACTGCATGCCAGCAGCCGGCACCAGCGGATCCAGGACTTCAACTACACGGACCACA
CGCTGGGCAGGATCATCCTCAATGCCATGAACGAGACCAACTTCTTCGGGGTCACGGGTCAAGTTGTATTCCGGAATGGGGAGAGAATGG
GGACCATTAAATTTACTCAATTTCAAGACAGCAGGGAGGTGAAGGTGGGAGAGTACAACGCTGTGGCCGACACACTGGAGATCATCAATG
ACACCATCAGGTTCCAAGGATCCGAACCACCAAAAGACAAGACCATCATCCTGGAGCAGCTGCGGAAGATCTCCCTACCTCTCTACAGCA
TCCTCTCTGCCCTCACCATCCTCGGGATGATCATGGCCAGTGCTTTTCTCTTCTTCAACATCAAGAACCGGAATCAGAAGCTCATAAAGA
TGTCGAGTCCATACATGAACAACCTTATCATCCTTGGAGGGATGCTCTCCTATGCTTCCATATTTCTCTTTGGCCTTGATGGATCCTTTG
TCTCTGAAAAGACCTTTGAAACACTTTGCACCGTCAGGACCTGGATTCTCACCGTGGGCTACACGACCGCTTTTGGGGCCATGTTTGCAA
AGACCTGGAGAGTCCACGCCATCTTCAAAAATGTGAAAATGAAGAAGAAGATCATCAAGGACCAGAAACTGCTTGTGATCGTGGGGGGCA
TGCTGCTGATCGACCTGTGTATCCTGATCTGCTGGCAGGCTGTGGACCCCCTGCGAAGGACAGTGGAGAAGTACAGCATGGAGCCGGACC
CAGCAGGACGGGATATCTCCATCCGCCCTCTCCTGGAGCACTGTGAGAACACCCATATGACCATCTGGCTTGGCATCGTCTATGCCTACA
AGGGACTTCTCATGTTGTTCGGTTGTTTCTTAGCTTGGGAGACCCGCAACGTCAGCATCCCCGCACTCAACGACAGCAAGTACATCGGGA
TGAGTGTCTACAACGTGGGGATCATGTGCATCATCGGGGCCGCTGTCTCCTTCCTGACCCGGGACCAGCCCAATGTGCAGTTCTGCATCG
TGGCTCTGGTCATCATCTTCTGCAGCACCATCACCCTCTGCCTGGTATTCGTGCCGAAGCTCATCACCCTGAGAACAAACCCAGATGCAG
CAACGCAGAACAGGCGATTCCAGTTCACTCAGAATCAGAAGAAAGAAGATTCTAAAACGTCCACCTCGGTCACCAGTGTGAACCAAGCCA
GCACATCCCGCCTGGAGGGCCTACAGTCAGAAAACCATCGCCTGCGAATGAAGATCACAGAGCTGGATAAAGACTTGGAAGAGGTCACCA
TGCAGCTGCAGGACACACCAGAAAAGACCACCTACATTAAACAGAACCACTACCAAGAGCTCAATGACATCCTCAACCTGGGAAACTTCA
CTGAGAGCACAGATGGAGGAAAGGCCATTTTAAAAAATCACCTCGATCAAAATCCCCAGCTACAGTGGAACACAACAGAGCCCTCTCGAA
CATGCAAAGATCCTATAGAAGATATAAACTCTCCAGAACACATCCAGCGTCGGCTGTCCCTCCAGCTCCCCATCCTCCACCACGCCTACC
TCCCATCCATCGGAGGCGTGGACGCCAGCTGTGTCAGCCCCTGCGTCAGCCCCACCGCCAGCCCCCGCCACAGACATGTGCCACCCTCCT
TCCGAGTCATGGTCTCGGGCCTGTAAGGGTGGGAGGCCTGGGCCCGGGGCCTCCCCCGTGACAGAACCACACTGGGCAGAGGGGTCTGCT
GCAGAAACACTGTCGGCTCTGGCTGCGGAGAAGCTGGGCACCATGGCTGGCCTCTCAGGACCACTCGGATGGCACTCAGGTGGACAGGAC
GGGGCAGGGGGAGACTTGGCACCTGACCTCGAGCCTTATTTGTGAAGTCCTTATTTCTTCACAAAGAAGAGGAACGGAAATGGGACGTCT
TCCTTAACATCTGCAAACAAGGAGGCGCTGGGATATCAAACTTGCAAAAAAAAAAAAAAAAAAAAAAAAACAAAAAAACTAGACAAGGAG
AGAGGCACTAGAACTCCAGCTGGAAGTCACGGAGTGGCTCGAGCAGCCTTGGGAAGAGGCAAGGAGCTTCTGAAGAAACTGCCTCTGCAC
ACACATCACTGGCTGTGACCCCTCAGGCTAGCCCTTCTCCACTCTGGGGGAGGAGGTGGGAAGGGCCACCAGGCCCCCAGCTGCCAGGCC
AGCTGACCCCAGCCTTCCTGGAACAGGGAGTCTGCAGGAGCGCAGACAGGCACAGCCCTGGAGCAGGCAGGCCGAGGGCTGCGGCACTGG
AGCAGGCTGACTTACATGCTCCACATGGGACCTGTGTCACCCAATGAGATGTTTGTTACTCTGGTAAATGCCACACGTTAACACAATAAC
ACCCATTCCTGGGACCGTGGGGATTTAGGGCACGTCACTGCAGACACGCTCTGCAGCATTCACCGACAGTCTGTCATGCACCCACCACGT
TGGCCATGTCCTTGTGTTCCTATCGGATGCTCCCAGTAACCAGGGGGACCACCCGAGCTAATCATGGAATGTCTGTTCCCAGCAAACACG
ATAAAGAAAGATTGTGCACTTTAACCTCTCTCATCAGGGCCCAAGGGCTGGCTGGGATTTTTTTTTTTTTTTTCCCACTAACTTTGTTTC
TGACCAAAGTGAATTGGAGGCACTCTGCTAAAAGACATCCCCGTAGACATAGGGGAGAGAGTTGCTGGCTGAGGGCTTCCCTTGGCTTCC
AGAAGGCAGCCTTCCATCCAGACAAGCCAGTGAGCTCTCCCCTTGGGATCACTGGGGTGATCAGTCAGCAGATTGATTCTCATTCATAAG
ATCATTCCTCCCTTTAAATTGAGCCCCTAAGAGCACTGGCCTGGGAGTCAGACAGACCTGGGTTCAAGTCCTCAGTCCCCTGCCCACTCC
CTACGTGACTTTGATCAGGTCACTAGTGTCTCTCTGAGCCTCAGTTTCCCCTCTGTAACTTGGGGTTGAACTAAAACACCTGTCCTGCCT
ACCTCACAAGGTCACTCTGAGGATTGAAACTTGATCTTGTCCAGGAAAGCTTTGTACCAAACAGTGAAGCCGCCCTGATCCGTGAGGTAT
GAGTATGACTCTGACCTTCAGCCCTCCCTACAGCCGGGGGTGTGGCCCAGAGAAGCTTCCAGCACAGCCCTCTACCCAGAACATCCGGGC
TGGAGGGAGGCTCCCAGTGACTTTTCTGACATTCCTAGACAGGTTCATTCTTTGCTCAAGAAAGGCCTGAATGACAATGTCCAGGATGTC
TGCACAACTGAGCAGCTCGCTCACTCCCTAAAGAAACCTATTGGCAGCTTCAACAGGCAGGCAATAATCTCTTCCCAGAACCACTGCAGT
CAGGAATAAACTGTTTTCTCCACCAGGCTTTGACAAAAGGGCCCACAGGAATCTTACCAATGCCAACATTTCAAAGCACCCTATTTCACG
TAGCATAGCTTTCTGCTCCCCTTCCCCAAAGAGAGGTTATGGAGGTACTGTAGCTTTTAGGGAAAAAAAAATGTTAACACATCACAGGTC
AAGTTGAAGTCATTCTCTGTTTAGGCACTAAAAATCGGTGTTGTCACTCACTGTGTATTACCAGTATTTACTTGCTTTCTTGATTTCACC
AAAACCAAATTTAATTTAAAGGACCACATTAATTTTTCAAAGGGAAAGAGACAATTAATTGTACATAATGTATACACACACACAAAAAAA
AATACCTGTAGAAATATTATTCCAGCATAGCAGGAAAACAAACAAAAGTATTGGACTGTCGGAGGTGAGCCTGTGCGTCTGTAACCCTTT
GTGACTCCTGAGCGTGCGCTGTCTTCTAGGTTAACTCACGAAGTACATTCTCTGTCTTACTGATACTGTAGGTTCACCCATTTTTTTTTA
ATTTCCTCGCAAATAACAAGACCCACAGAAGTGACTCTAGCTACTTAATGGTTCTGTTCTTTTATATGCAGCAAACACACCGTCCATTTC
TGAAGAGGCTTCGGCCTGAAGGCATTTTCCAATGATGTTAGTGCACAAAACGCTTTAAATTAGACTGGAACTGCCAGAATCAAATGTAAA

>89350_89350_2_TBC1D2-GABBR2_TBC1D2_chr9_100991234_ENST00000375066_GABBR2_chr9_101258796_ENST00000259455_length(amino acids)=1083AA_BP=352
MPAESPRFVPGGPADPSSLRSLRLAAMEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGW
KSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPAT
PDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSG
EPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKVRNDLTGV
LYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLL
AAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRI
ILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSAL
TILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRV
HAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLM
LFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR
RFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTD
GGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBC1D2-GABBR2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375064	-	5	13	1_169	326.0	861.0	CADH1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375066	-	5	13	1_169	326.0	918.0	CADH1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000342112	-	4	12	1_169	108.0	711.0	CADH1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375063	-	1	7	1_169	0	469.0	CADH1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000342112	-	4	12	295_433	108.0	711.0	RAC1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375063	-	1	7	295_433	0	469.0	RAC1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375064	-	5	13	295_433	326.0	861.0	RAC1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375066	-	5	13	295_433	326.0	918.0	RAC1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TBC1D2-GABBR2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TBC1D2-GABBR2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source