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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TBC1D30-PPM1H (FusionGDB2 ID:89358) |
Fusion Gene Summary for TBC1D30-PPM1H |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D30-PPM1H | Fusion gene ID: 89358 | Hgene | Tgene | Gene symbol | TBC1D30 | PPM1H | Gene ID | 23329 | 57460 |
| Gene name | TBC1 domain family member 30 | protein phosphatase, Mg2+/Mn2+ dependent 1H | |
| Synonyms | - | ARHCL1|NERPP-2C|URCC2 | |
| Cytomap | 12q14.3 | 12q14.1-q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 30 | protein phosphatase 1Hneurite extension-related protein phosphatase related to PP2Cprotein phosphatase 1H (PP2C domain containing)ras homolog gene family, member C like 1 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000229088, ENST00000539867, ENST00000542120, ENST00000456757, | ENST00000551214, ENST00000228705, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 12 X 10 X 6=720 |
| # samples | 7 | 11 | |
| ** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TBC1D30 [Title/Abstract] AND PPM1H [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TBC1D30(65232631)-PPM1H(63226059), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TBC1D30 | GO:0043547 | positive regulation of GTPase activity | 17646400 |
| Fusion gene breakpoints across TBC1D30 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PPM1H (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-19-2624-01A | TBC1D30 | chr12 | 65232631 | - | PPM1H | chr12 | 63226059 | - |
| ChimerDB4 | GBM | TCGA-19-2624 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
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Fusion Gene ORF analysis for TBC1D30-PPM1H |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000229088 | ENST00000551214 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| 5CDS-intron | ENST00000539867 | ENST00000551214 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| 5CDS-intron | ENST00000542120 | ENST00000551214 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| In-frame | ENST00000229088 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| In-frame | ENST00000539867 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| In-frame | ENST00000542120 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| intron-3CDS | ENST00000456757 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| intron-intron | ENST00000456757 | ENST00000551214 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000542120 | TBC1D30 | chr12 | 65232631 | + | ENST00000228705 | PPM1H | chr12 | 63226059 | - | 6642 | 835 | 2 | 2134 | 710 |
| ENST00000229088 | TBC1D30 | chr12 | 65232631 | + | ENST00000228705 | PPM1H | chr12 | 63226059 | - | 7228 | 1421 | 0 | 2720 | 906 |
| ENST00000539867 | TBC1D30 | chr12 | 65232631 | + | ENST00000228705 | PPM1H | chr12 | 63226059 | - | 7047 | 1240 | 308 | 2539 | 743 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000542120 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - | 0.000860988 | 0.99913895 |
| ENST00000229088 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - | 0.000226415 | 0.99977356 |
| ENST00000539867 | ENST00000228705 | TBC1D30 | chr12 | 65232631 | + | PPM1H | chr12 | 63226059 | - | 0.001218077 | 0.998782 |
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Fusion Genomic Features for TBC1D30-PPM1H |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TBC1D30-PPM1H |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65232631/chr12:63226059) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TBC1D30 | chr12:65232631 | chr12:63226059 | ENST00000229088 | + | 8 | 13 | 249_457 | 473 | 925.0 | Domain | Rab-GAP TBC |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TBC1D30 | chr12:65232631 | chr12:63226059 | ENST00000539867 | + | 7 | 12 | 249_457 | 310 | 762.0 | Domain | Rab-GAP TBC |
| Tgene | PPM1H | chr12:65232631 | chr12:63226059 | ENST00000228705 | 0 | 10 | 77_507 | 81 | 515.0 | Domain | PPM-type phosphatase |
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Fusion Gene Sequence for TBC1D30-PPM1H |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >89358_89358_1_TBC1D30-PPM1H_TBC1D30_chr12_65232631_ENST00000229088_PPM1H_chr12_63226059_ENST00000228705_length(transcript)=7228nt_BP=1421nt ATGGACGTCCTTCCCACCGGCGGGGGCCGCCCGGGGCTCCGGACGGAGCTGGAATTCCGCGGCGGCGGTGGCGAGGCGAGGCTGGAGAGT CAGGAGGAAGAAACGATTCCTGCAGCTCCCCCAGCCCCGCGCCTCCGGGGAGCGGCGGAGCGGCCGCGGCGCTCCCGGGACACGTGGGAC GGCGATGAGGACACGGAGCCCGGCGAGGCGTGCGGCGGCCGCACAAGCCGCACGGCGTCCCTGGTGAGCGGGCTGCTCAACGAGCTGTAC AGCTGCACAGAGGAGGAGGAGGCGGCGGGCGGGGGCCGCGGGGCCGAGGGCCGCCGGCGGCGCCGCGACAGCCTCGACAGCTCCACCGAG GCCTCGGGCTCCGACGTGGTCCTGGGCGGCCGCAGCGGTGCCGGCGACTCCCGCGTGCTGCAGGAGCTGCAGGAGCGACCGAGCCAGCGG CATCAGATGCTGTACCTGCGGCAGAAAGACGCTAATGAACTGAAGACGATCCTTCGAGAGCTAAAGTACAGAATTGGCATCCAGTCGGCC AAGTTACTTCGGCATCTGAAGCAGAAAGATAGGCTTCTGCATAAAGTGCAGAGGAACTGTGATATTGTGACTGCCTGCTTGCAGGCTGTG TCACAGAAGAGAAGAGTTGATACCAAGTTGAAATTCACTCTTGAGCCATCTTTAGGTCAAAATGGTTTTCAGCAGTGGTACGATGCTCTC AAGGCAGTTGCCAGGCTATCCACAGGAATACCAAAGGAATGGAGGAGAAAGGTTTGGTTGACCTTGGCAGATCATTATTTGCACAGTATA GCCATTGACTGGGACAAAACCATGCGCTTCACTTTCAATGAAAGGAGTAATCCTGATGATGACTCCATGGGAATTCAGATAGTCAAGGAC CTTCACCGCACAGGCTGTAGTTCTTACTGTGGCCAGGAGGCTGAGCAGGACAGGGTTGTGTTGAAGCGGGTGCTGCTGGCCTATGCCCGA TGGAACAAAACTGTTGGGTACTGCCAAGGCTTTAACATCCTGGCTGCACTAATTCTGGAAGTGATGGAAGGCAATGAAGGGGATGCCCTG AAAATTATGATTTACCTTATTGATAAGGTACTTCCCGAAAGCTATTTCGTCAATAATCTCCGGGCATTGTCTGTGGATATGGCTGTCTTC AGAGACCTTTTAAGAATGAAGCTGCCGGAATTATCTCAGCACCTGGATACTCTTCAGAGAACTGCAAACAAAGAAAGTGGAGGTGGATAT GAGCCCCCACTTACAAATGTCTTCACGATGCAGTGGTTTCTGACTCTCTTTGCCACATGCCTCCCTAATCAGACCGTTTTAAAGATCTGG GATTCAGTCTTCTTTGAAGGTTCAGAAATCATCCTAAGGGTGTCGCTGGCTATCTGGGCAAAATTAGGAGAGGTTATCAATGCCGGGAAG AGCACACACAATGAAGACCAAGCCAGCTGTGAGGTGCTCACTGTGAAGAAGAAGGCAGGGGCCGTGACCTCAACCCCAAACAGGAACTCA TCCAAGAGACGGTCCTCCCTTCCCAATGGGGAAGGGCTGCAGCTGAAGGAGAACTCGGAATCCGAGGGTGTTTCCTGCCACTATTGGTCG CTGTTTGACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTG GACATCCTGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGG GCAGCCTCCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAG TGCCTGGTCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGC TGCACGGCCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAA ATTATCCCCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAAT GAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGG GCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTG ACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATC TACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTA GCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCC CGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATA CATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGG GAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCC TTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCT TTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGT GTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTC AAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTT CTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTT TTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCC CCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAG TTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTG TGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATAT AAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTC ATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATC TTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTC TTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAG TGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTAC GGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGA CCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAG AGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCT CCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGT GCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTA GCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATG TGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCC TGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCT TCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTA TGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGG CATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAG ACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAAT TGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGC CCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTG ACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTT GTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAA CTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAG CAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCC AGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTG GGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCA GTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGA TCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGAT TCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCT CAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCT TCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGG TAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGC ACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACG CGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAG TGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAG GCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGT TTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGG TGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTT CAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATT TTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATAT >89358_89358_1_TBC1D30-PPM1H_TBC1D30_chr12_65232631_ENST00000229088_PPM1H_chr12_63226059_ENST00000228705_length(amino acids)=906AA_BP=474 MDVLPTGGGRPGLRTELEFRGGGGEARLESQEEETIPAAPPAPRLRGAAERPRRSRDTWDGDEDTEPGEACGGRTSRTASLVSGLLNELY SCTEEEEAAGGGRGAEGRRRRRDSLDSSTEASGSDVVLGGRSGAGDSRVLQELQERPSQRHQMLYLRQKDANELKTILRELKYRIGIQSA KLLRHLKQKDRLLHKVQRNCDIVTACLQAVSQKRRVDTKLKFTLEPSLGQNGFQQWYDALKAVARLSTGIPKEWRRKVWLTLADHYLHSI AIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDAL KIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIW DSVFFEGSEIILRVSLAIWAKLGEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWS LFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHE CLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGN EFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRI YDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLI -------------------------------------------------------------- >89358_89358_2_TBC1D30-PPM1H_TBC1D30_chr12_65232631_ENST00000539867_PPM1H_chr12_63226059_ENST00000228705_length(transcript)=7047nt_BP=1240nt ACGCCGCCTCCGTCTCCCACGCGCTCGCTCGCTCGCTCGCTCCCGCCCTCCCCGCCTCGAGCGATCTCCTGCCTCAGCCTTGCAGGCTCC GCACTGCAGATGCCTGCTGGCTTCCCTGCGCTCGGCGGCTCCCGCGGTGCCCCGTAAGTCCCCGTGACCCTCCAGCACCAGCCGGCTGTG CGCTCCCTGCTCCCACGGGCCGGTCAGCCGCAGACACTCACCCAGCTCCGCGAGCTCAGCCGCTCAGCGAGTGGGGTAGCGGGGACCGAG ACGGACGGTAGCCGTGCCAGAGCCCGGGGCGCTCTCGGATGCGGCAGGACAAGCTGACCGGGTCTCTGAGGCGCGGGGGGAGATGCCTGA AGCGGCAGGGCGGCGGCGTGGGCACCATCCTGAGCAATGTGCTCAAGAAGCGCAGCTGCATTTCCCGGACCGCGCCCCGGCTGCTGTGCA CCCTGGAGCCGGGAGTTGATACCAAGTTGAAATTCACTCTTGAGCCATCTTTAGGTCAAAATGGTTTTCAGCAGTGGTACGATGCTCTCA AGGCAGTTGCCAGGCTATCCACAGGAATACCAAAGGAATGGAGGAGAAAGGTTTGGTTGACCTTGGCAGATCATTATTTGCACAGTATAG CCATTGACTGGGACAAAACCATGCGCTTCACTTTCAATGAAAGGAGTAATCCTGATGATGACTCCATGGGAATTCAGATAGTCAAGGACC TTCACCGCACAGGCTGTAGTTCTTACTGTGGCCAGGAGGCTGAGCAGGACAGGGTTGTGTTGAAGCGGGTGCTGCTGGCCTATGCCCGAT GGAACAAAACTGTTGGGTACTGCCAAGGCTTTAACATCCTGGCTGCACTAATTCTGGAAGTGATGGAAGGCAATGAAGGGGATGCCCTGA AAATTATGATTTACCTTATTGATAAGGTACTTCCCGAAAGCTATTTCGTCAATAATCTCCGGGCATTGTCTGTGGATATGGCTGTCTTCA GAGACCTTTTAAGAATGAAGCTGCCGGAATTATCTCAGCACCTGGATACTCTTCAGAGAACTGCAAACAAAGAAAGTGGAGGTGGATATG AGCCCCCACTTACAAATGTCTTCACGATGCAGTGGTTTCTGACTCTCTTTGCCACATGCCTCCCTAATCAGACCGTTTTAAAGATCTGGG ATTCAGTCTTCTTTGAAGGTTCAGAAATCATCCTAAGGGTGTCGCTGGCTATCTGGGCAAAATTAGGAGAGGTTATCAATGCCGGGAAGA GCACACACAATGAAGACCAAGCCAGCTGTGAGGTGCTCACTGTGAAGAAGAAGGCAGGGGCCGTGACCTCAACCCCAAACAGGAACTCAT CCAAGAGACGGTCCTCCCTTCCCAATGGGGAAGGGCTGCAGCTGAAGGAGAACTCGGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGC TGTTTGACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGG ACATCCTGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGG CAGCCTCCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGT GCCTGGTCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCT GCACGGCCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAA TTATCCCCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATG AGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGG CATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGA CCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCT ACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAG CAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCC GGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATAC ATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGG AAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCT TTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTT TCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTG TAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCA AAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTC TCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTT TTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCC CACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGT TGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGT GTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATA AAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCA TGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCT TTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCT TCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGT GCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACG GCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGAC CCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGA GGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTC CTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTG CAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAG CTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGT GACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCT GAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTT CTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTAT GGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGC ATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGA CTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATT GAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCC CCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGA CTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTG TCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAAC TCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGC AGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCA GGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGG GGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAG TATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGAT CTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATT CTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTC AGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTT CTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGT AAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCA CACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGC GAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGT GTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGG CTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTT TGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGT GGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTC AGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTT TGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATA >89358_89358_2_TBC1D30-PPM1H_TBC1D30_chr12_65232631_ENST00000539867_PPM1H_chr12_63226059_ENST00000228705_length(amino acids)=743AA_BP=311 MRQDKLTGSLRRGGRCLKRQGGGVGTILSNVLKKRSCISRTAPRLLCTLEPGVDTKLKFTLEPSLGQNGFQQWYDALKAVARLSTGIPKE WRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNI LAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWF LTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGL QLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGS PSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETE RQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHD SNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISN -------------------------------------------------------------- >89358_89358_3_TBC1D30-PPM1H_TBC1D30_chr12_65232631_ENST00000542120_PPM1H_chr12_63226059_ENST00000228705_length(transcript)=6642nt_BP=835nt GACTGCCTGCTTGCAGGCTGTGTCACAGAAGAGAACATGGCAGAACAGTATGCTCAGGAGTTGATACCAAGTTGAAATTCACTCTTGAGC CATCTTTAGGTCAAAATGGTTTTCAGCAGTGGTACGATGCTCTCAAGGCAGTTGCCAGGCTATCCACAGGAATACCAAAGGAATGGAGGA GAAAGGTTTGGTTGACCTTGGCAGATCATTATTTGCACAGTATAGCCATTGACTGGGACAAAACCATGCGCTTCACTTTCAATGAAAGGA GTAATCCTGATGATGACTCCATGGGAATTCAGATAGTCAAGGACCTTCACCGCACAGGCTGTAGTTCTTACTGTGGCCAGGAGGCTGAGC AGGACAGGGTTGTGTTGAAGCGGGTGCTGCTGGCCTATGCCCGATGGAACAAAACTGTTGGGTACTGCCAAGGCTTTAACATCCTGGCTG CACTAATTCTGGAAGTGATGGAAGGCAATGAAGGGGATGCCCTGAAAATTATGATTTACCTTATTGATAAGGTACTTCCCGAAAGCTATT TCGTCAATAATCTCCGGGCATTGTCTGTGGATATGGCTGTCTTCAGAGACCTTTTAAGAATGAAGCTGCCGGAATTATCTCAGCACCTGG ATACTCTTCAGAGAACTGCAAACAAAGAAAGTGGAGGTGGATATGAGCCCCCACTTACAAATGTCTTCACGATGCAGTGGTTTCTGACTC TCTTTGCCACATGCCTCCCTAATCAGACCGTTTTAAAGATCTGGGATTCAGTCTTCTTTGAAGGTTCAGAAATCATCCTAAGGGTGTCGC TGGCTATCTGGGCAAAATTAGGAGAGGTTATCAATGCCGGGAAGAGCACACACAATGAAGACCAAGCCAGCTGTGAGGTGCTCACTGTGA AGAAGAAGGCAGGGGCCGTGACCTCAACCCCAAACAGGAACTCATCCAAGAGACGGTCCTCCCTTCCCAATGGGGAAGGGCTGCAGCTGA AGGAGAACTCGGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTGACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCAC GCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCCTGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGG AGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCTCCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCA CGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGGTCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACC TACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGGCCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTG CAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCCCCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGC GACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGC TTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATAT ATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACA TCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCT TGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATC CTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGAC TGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGAC AGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCC AAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGC AAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGT CATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCT ACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTT CAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATT TTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTG CTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGC CCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTT TCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGA ATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTT GGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGA TCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAA TGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTT CCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCA AGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTAT TGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTA GAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCAT TTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTC TGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGT TGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTT GCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGT CATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCA TTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGAT GTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATT ATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTA GTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAA CGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGT CACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATT CTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTT GTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCT AAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATT TTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCT ATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTG GAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGC TTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGT GGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTA TGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAG GCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAA TATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAG AACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCA GATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGA CGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCA GATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTG AAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGA ACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCC CAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAAC TACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTT TTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAA >89358_89358_3_TBC1D30-PPM1H_TBC1D30_chr12_65232631_ENST00000542120_PPM1H_chr12_63226059_ENST00000228705_length(amino acids)=710AA_BP=278 LPACRLCHRREHGRTVCSGVDTKLKFTLEPSLGQNGFQQWYDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERS NPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYF VNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSL AIWAKLGEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASR LLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDL QIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKEL GKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLIL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TBC1D30-PPM1H |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TBC1D30-PPM1H |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TBC1D30-PPM1H |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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