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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBCB-TBC1D9B (FusionGDB2 ID:89457)

Fusion Gene Summary for TBCB-TBC1D9B

check button Fusion gene summary
Fusion gene informationFusion gene name: TBCB-TBC1D9B
Fusion gene ID: 89457
HgeneTgene
Gene symbol

TBCB

TBC1D9B

Gene ID

1155

23061

Gene nametubulin folding cofactor BTBC1 domain family member 9B
SynonymsCG22|CKAP1|CKAPIGRAMD9B
Cytomap

19q13.12

5q35.3

Type of geneprotein-codingprotein-coding
Descriptiontubulin-folding cofactor Bcytoskeleton associated protein 1cytoskeleton-associated protein CKAPItubulin-specific chaperone BTBC1 domain family member 9BTBC1 domain family, member 9B (with GRAM domain)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000392178, ENST00000221855, 
ENST00000589996, ENST00000585746, 
ENST00000586868, 		ENST00000355235, 
ENST00000356834, ENST00000444477, 
ENST00000518085, ENST00000519746, 
Fusion gene scores* DoF score7 X 6 X 4=1684 X 4 X 4=64
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBCB [Title/Abstract] AND TBC1D9B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBCB(36606576)-TBC1D9B(179306197), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TBCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBC1D9B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer173NTBCBchr19

36606576

+TBC1D9Bchr5

179306197

-


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Fusion Gene ORF analysis for TBCB-TBC1D9B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000392178ENST00000355235TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
3UTR-3CDSENST00000392178ENST00000356834TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
3UTR-intronENST00000392178ENST00000444477TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
3UTR-intronENST00000392178ENST00000518085TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
3UTR-intronENST00000392178ENST00000519746TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
5CDS-intronENST00000221855ENST00000444477TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
5CDS-intronENST00000221855ENST00000518085TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
5CDS-intronENST00000221855ENST00000519746TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
5CDS-intronENST00000589996ENST00000444477TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
5CDS-intronENST00000589996ENST00000518085TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
5CDS-intronENST00000589996ENST00000519746TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
In-frameENST00000221855ENST00000355235TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
In-frameENST00000221855ENST00000356834TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
In-frameENST00000589996ENST00000355235TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
In-frameENST00000589996ENST00000356834TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-3CDSENST00000585746ENST00000355235TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-3CDSENST00000585746ENST00000356834TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-3CDSENST00000586868ENST00000355235TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-3CDSENST00000586868ENST00000356834TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-intronENST00000585746ENST00000444477TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-intronENST00000585746ENST00000518085TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-intronENST00000585746ENST00000519746TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-intronENST00000586868ENST00000444477TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-intronENST00000586868ENST00000518085TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-
intron-intronENST00000586868ENST00000519746TBCBchr19

36606576

+TBC1D9Bchr5

179306197

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000221855TBCBchr1936606576+ENST00000355235TBC1D9Bchr5179306197-43576895482974808
ENST00000221855TBCBchr1936606576+ENST00000356834TBC1D9Bchr5179306197-44086895483025825
ENST00000589996TBCBchr1936606576+ENST00000355235TBC1D9Bchr5179306197-3824156152441808
ENST00000589996TBCBchr1936606576+ENST00000356834TBC1D9Bchr5179306197-3875156152492825

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221855ENST00000355235TBCBchr1936606576+TBC1D9Bchr5179306197-0.0054999630.99450004
ENST00000221855ENST00000356834TBCBchr1936606576+TBC1D9Bchr5179306197-0.0052512040.9947488
ENST00000589996ENST00000355235TBCBchr1936606576+TBC1D9Bchr5179306197-0.0050494010.99495065
ENST00000589996ENST00000356834TBCBchr1936606576+TBC1D9Bchr5179306197-0.0048787370.9951213

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Fusion Genomic Features for TBCB-TBC1D9B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBCB-TBC1D9B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:36606576/chr5:179306197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000355235721508_6954721234.0DomainRab-GAP TBC
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000355235721879_9144721234.0DomainEF-hand
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000356834722508_6954721251.0DomainRab-GAP TBC
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000356834722879_9144721251.0DomainEF-hand
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000355235721668_6884721234.0TransmembraneHelical
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000356834722668_6884721251.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCBchr19:36606576chr5:179306197ENST00000221855+16183_22538245.0DomainCAP-Gly
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000355235721142_2094721234.0DomainNote=GRAM 1
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000355235721288_3564721234.0DomainNote=GRAM 2
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000356834722142_2094721251.0DomainNote=GRAM 1
TgeneTBC1D9Bchr19:36606576chr5:179306197ENST00000356834722288_3564721251.0DomainNote=GRAM 2


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Fusion Gene Sequence for TBCB-TBC1D9B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89457_89457_1_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000221855_TBC1D9B_chr5_179306197_ENST00000355235_length(transcript)=4357nt_BP=689nt
GCCGCCTCGGGCTCGGCTCTCTCCGCGCAGAGGTTTCATGGCTTGCTTCAATCTTTTGATATCTTAGAGTAATTGCTTCCAATTTTTGGG
CATCGCCGCCTCAGTTTACAGAATAGTATGGATCTGGTGCCAGAGCCGGGAAAACGATGCGCATCGTAAACCGCAAAACACTGAGCATCC
AGGACAGAAGCCAAGGCGCTTGGCTTGGTTGAAGGCCAGTGCGCATGCGCGAGTTTACCCTTCGCGGACTGGGCGAGCTCTTGCCACTCC
TACCTCCGGGCTTCAGTCTTCGCCGCCTGTTCTGGTCCTTTCCCGGGCCGCTATTGGAAGAACCGTGAACTATGGAAGGCCCCTCTGGAT
TGGCTGGGCTGGCCCAAGAGTAAGGAGAGCCCTCTTCCTGGCGGTGGGGAAGGGACGGCGGCGATTGGCGGACGCTCCTGGCAGGAGAGC
GCGGATTGGTCAGGCACGGAGCAGGAGGCGGGGCTGATAGCCCAGCAGCAGCAGCGGCGGCGGCGGCTGCGGAGCGGGTGTGAGGCGGCT
GGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGCAGCTCCC
TCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGGCCAAGGAGAAGATGAAAGAGGAGTCATGGC
ACATCCACTTCTTCGAGTACGGGCGTGGCGTGTGCATGTACCGCACAGCCAAGACGCGGGCACTGGTCCTGAAGGGTATCCCTGAGAGCC
TCCGGGGAGAGCTGTGGCTCCTCTTCTCCGGGGCCTGGAATGAGATGGTGACTCACCCCGGGTACTATGCTGAGCTGGTGGAGAAGTCCA
CCGGGAAGTACAGCCTGGCCACAGAGGAGATCGAGCGAGACCTGCACCGCTCCATGCCCGAGCACCCTGCCTTCCAGAACGAGCTGGGGA
TTGCTGCCCTCCGGCGGGTGCTGACTGCCTATGCCTTCCGAAACCCCACCATCGGCTACTGCCAGGCAATGAACATCGTGACCTCGGTGC
TCCTGCTCTATGGCAGTGAGGAGGAGGCCTTCTGGCTCCTGGTGGCCCTGTGCGAGCGCATGCTGCCCGACTACTACAACACCAGGGTGG
TGGGAGCCCTGGTGGACCAAGGCATCTTCGAAGAGCTCACGAGAGACTTCCTGCCGCAGCTCTCGGAGAAGATGCAGGACCTGGGGGTGA
TCTCCAGCATCTCGCTGTCCTGGTTCCTGACCCTCTTCCTCAGCGTCATGCCCTTCGAGAGCGCCGTGGTCATCGTCGACTGCTTTTTCT
ATGAGGGCATCAAGGTGATCCTGCAGGTGGCCCTGGCCGTCCTGGACGCCAACATGGAGCAGCTGCTGGGCTGCAGCGACGAGGGCGAGG
CCATGACCATGCTGGGCAGATACCTGGATAATGTGGTCAACAAGCAGAGTGTCTCTCCTCCTATCCCGCACCTCCGTGCCTTGCTGAGCA
GCAGCGATGACCCCCCTGCAGAGGTGGACATCTTTGAGCTCCTGAAAGTGTCCTATGAGAAATTCAGCAGCCTGAGGGCCGAAGACATTG
AGCAGATGCGGTTTAAACAGAGGCTGAAAGTGATCCAGTCCTTGGAGGACACGGCCAAGAGGAGTGTGGTCCGAGCTATACCTGTGGACA
TTGGTTTCTCCATTGAAGAGCTGGAGGACCTTTACATGGTGTTTAAGGCCAAGCACCTGGCTAGCCAGTACTGGGGGTGCAGCCGCACAA
TGGCCGGCCGTCGGGACCCCAGCCTGCCCTACCTGGAGCAGTACCGGATTGATGCCAGCCAGTTCCGGGAACTCTTTGCCAGCCTGACAC
CCTGGGCCTGTGGCTCCCACACACCTCTGCTGGCAGGGCGCATGTTCAGGCTCCTGGACGAAAACAAGGACTCGCTGATCAACTTCAAGG
AGTTCGTGACAGGGATGAGCGGGATGTACCACGGGGACCTGACAGAGAAGCTCAAGGTGCTCTACAAGCTACACCTTCCCCCAGCTCTGA
GCCCAGAGGAAGCCGAGTCAGCCCTGGAGGCGGCCCATTATTTCACAGAGGACAGCTCCTCAGAAGAAGCACTACCACAGGAAGAGCAAG
AAGGAAGTGGAAGTGAGGAGAGAGGAGAGGAGAAGGGGACCAGCTCTCCGGACTATCGGCACTACCTTCGAATGTGGGCCAAGGAGAAAG
AGGCTCAGAAGGAGACGATTAAGGATCTTCCCAAGATGAACCAGGAGCAGTTCATTGAGCTGTGCAAGACGCTTTACAACATGTTCAGTG
AAGACCCCATGGAGCAGGACCTGTACCACGCCATCGCCACCGTGGCCAGCCTCCTGCTCCGCATCGGAGAGGTGGGGAAGAAGTTCTCAG
CCCGCACAGGCAGGAAGCCCAGGGACTGTGCCACTGAGGAGGACGAGCCACCAGCACCCGAACTGCATCAGGACGCAGCCAGGGAGCTTC
AGCCCCCAGCTGCAGGAGACCCCCAAGCCAAAGCAGGCGGAGACACACACCTCGGAAAAGCCCCACAGGAGAGCCAGGTGGTGGTGGAGG
GGGGCAGCGGCGAGGGACAGGGCTCACCCTCCCAGCTGCTGTCTGACGATGAAACCAAAGACGACATGTCCATGTCCTCCTACTCGGTGG
TCAGCACGGGCTCCCTGCAATGTGAAGACCTTGCAGACGACACGGTGCTGGTGGGCGGGGAGGCCTGCAGCCCCACAGCGCGCATCGGCG
GCACCGTCGACACCGACTGGTGCATCTCCTTTGAGCAGATCCTGGCCTCCATCCTGACGGAGTCCGTGCTGGTGAACTTCTTTGAGAAGA
GAGTGGACATTGGACTCAAGATCAAGGACCAAAAGAAAGTGGAGAGACAGTTCAGCACCGCCAGTGACCATGAGCAGCCTGGAGTTTCCG
GCTGATGCCTGCAGCTGTGAGGCCTGGCCCAAGGTGTCATCAGTGGGGCTGGCCTCATCTCCTCCTGCCTTTCCTCCCTTATCAGTTTCT
CTTTAAAGGTGTGCCCCTCCTGCTCTCCCAGGAGCAGTGAGTTGTGAGTGGAAAGAAGGCTGGTGCAGACCCAGCTGCCTTAGACAGATT
CCCTGGGCCTGCATCTCCTGGCGCCGGCTGCTTCTGGGCCCAGGAAGAGGCTGTGGCTCCCACCTTCCTTACACCTGGTGGGAGCCCGCC
TCGCACCAGCTGCACCTGCCTAGCATTACAGGCTCTCAGATCTGCCCTTGCTTGCCTCATACCTCTGTGCTCCACACTGCGGCCAGGCCA
GCTGAGTCCCTCCATCCGTGGATGCTTTCCTGCAGCTATGTGGTATGGGGGTCATTCCTGCCTCTTGGCACCAGGTTGGGGGGCATGTGC
TTGTTGGGCACCAAAGTGATGGAACCCTCAGGTGCTCTCCGGGAGCCTGAACCTCCTGACTGAGGAACATGGGCAGAACATGTTTATTGC
ACAGAGTGGGCGCTGCGCACAGGCGTGGCTGTACACGTGCTCTCAGCTCATCATCCTTTCCAGTAACTTTAAAAAAACATCCCTCAGGTC
CTGATATATTTCCTTGGATTCATTTCACTTGGCTAGAAATTACACTGTGCTCAATGCCTTAATAAATCCCTGAAAGAAATAAAAACCACT
GTGTGCAATGCCTTGCTGTGGCCCCCAACCACTGCTTAGGCCTCCCAACTTCTCCCCAGGCCAAGTATGGGGCCCTGGCTGTGTTCTGGA
AGTTCAAGACACTTAGTCCTCCACAGTGGGTGGAAGAGTGCAAGGTCTGCCAGGTCAGATGGAGACGCAGAACCTGCTGGTGCAAGCTGG
GCAGGTCCTGACCAACCTGCATCAGGGGATGCCCTGAGCTCCACAGGTCTTCATGGGCAGGGGTTGTGGGTCCTGGTGAAGGAAGTGCAT
CCTCAGGCCTGGGCTGTAGCAAGCTGTCTGCCCTTGGGTTCAAGAACCAGACTGTGGAGCCAAAGGTGACCGCAGGGGGCCCCAGGGCTG
GAGCCACAAGGATACCCTCACTTTGCATGAGGAGCTGAAACTGACCAGTGTCCAGTGTTAGCCCCCACATGGGGCTGCTCTTGCTTCTAC
TAAAAGATACAGCAGTTACCCCCTTATCCACAGGGGATACAGTGGATATCTAAAACCAGACCCCCAGTGGATGTCTAAAACCACAGATAA
TAACAAACCTTATACATACTGTTTTTTCCTATGCATACATACCTGTGATTAAGTTTATGAATTAGGCACCTTAAGAGATTGACAACAATA

>89457_89457_1_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000221855_TBC1D9B_chr5_179306197_ENST00000355235_length(amino acids)=808AA_BP=47
MQASAGRGKMEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRG
ELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL
YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEG
IKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQM
RFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWA
CGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEEALPQEEQEGS
GSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSART
GRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDDETKDDMSMSSYSVVST

--------------------------------------------------------------
>89457_89457_2_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000221855_TBC1D9B_chr5_179306197_ENST00000356834_length(transcript)=4408nt_BP=689nt
GCCGCCTCGGGCTCGGCTCTCTCCGCGCAGAGGTTTCATGGCTTGCTTCAATCTTTTGATATCTTAGAGTAATTGCTTCCAATTTTTGGG
CATCGCCGCCTCAGTTTACAGAATAGTATGGATCTGGTGCCAGAGCCGGGAAAACGATGCGCATCGTAAACCGCAAAACACTGAGCATCC
AGGACAGAAGCCAAGGCGCTTGGCTTGGTTGAAGGCCAGTGCGCATGCGCGAGTTTACCCTTCGCGGACTGGGCGAGCTCTTGCCACTCC
TACCTCCGGGCTTCAGTCTTCGCCGCCTGTTCTGGTCCTTTCCCGGGCCGCTATTGGAAGAACCGTGAACTATGGAAGGCCCCTCTGGAT
TGGCTGGGCTGGCCCAAGAGTAAGGAGAGCCCTCTTCCTGGCGGTGGGGAAGGGACGGCGGCGATTGGCGGACGCTCCTGGCAGGAGAGC
GCGGATTGGTCAGGCACGGAGCAGGAGGCGGGGCTGATAGCCCAGCAGCAGCAGCGGCGGCGGCGGCTGCGGAGCGGGTGTGAGGCGGCT
GGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGCAGCTCCC
TCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGGCCAAGGAGAAGATGAAAGAGGAGTCATGGC
ACATCCACTTCTTCGAGTACGGGCGTGGCGTGTGCATGTACCGCACAGCCAAGACGCGGGCACTGGTCCTGAAGGGTATCCCTGAGAGCC
TCCGGGGAGAGCTGTGGCTCCTCTTCTCCGGGGCCTGGAATGAGATGGTGACTCACCCCGGGTACTATGCTGAGCTGGTGGAGAAGTCCA
CCGGGAAGTACAGCCTGGCCACAGAGGAGATCGAGCGAGACCTGCACCGCTCCATGCCCGAGCACCCTGCCTTCCAGAACGAGCTGGGGA
TTGCTGCCCTCCGGCGGGTGCTGACTGCCTATGCCTTCCGAAACCCCACCATCGGCTACTGCCAGGCAATGAACATCGTGACCTCGGTGC
TCCTGCTCTATGGCAGTGAGGAGGAGGCCTTCTGGCTCCTGGTGGCCCTGTGCGAGCGCATGCTGCCCGACTACTACAACACCAGGGTGG
TGGGAGCCCTGGTGGACCAAGGCATCTTCGAAGAGCTCACGAGAGACTTCCTGCCGCAGCTCTCGGAGAAGATGCAGGACCTGGGGGTGA
TCTCCAGCATCTCGCTGTCCTGGTTCCTGACCCTCTTCCTCAGCGTCATGCCCTTCGAGAGCGCCGTGGTCATCGTCGACTGCTTTTTCT
ATGAGGGCATCAAGGTGATCCTGCAGGTGGCCCTGGCCGTCCTGGACGCCAACATGGAGCAGCTGCTGGGCTGCAGCGACGAGGGCGAGG
CCATGACCATGCTGGGCAGATACCTGGATAATGTGGTCAACAAGCAGAGTGTCTCTCCTCCTATCCCGCACCTCCGTGCCTTGCTGAGCA
GCAGCGATGACCCCCCTGCAGAGGTGGACATCTTTGAGCTCCTGAAAGTGTCCTATGAGAAATTCAGCAGCCTGAGGGCCGAAGACATTG
AGCAGATGCGGTTTAAACAGAGGCTGAAAGTGATCCAGTCCTTGGAGGACACGGCCAAGAGGAGTGTGGTCCGAGCTATACCTGTGGACA
TTGGTTTCTCCATTGAAGAGCTGGAGGACCTTTACATGGTGTTTAAGGCCAAGCACCTGGCTAGCCAGTACTGGGGGTGCAGCCGCACAA
TGGCCGGCCGTCGGGACCCCAGCCTGCCCTACCTGGAGCAGTACCGGATTGATGCCAGCCAGTTCCGGGAACTCTTTGCCAGCCTGACAC
CCTGGGCCTGTGGCTCCCACACACCTCTGCTGGCAGGGCGCATGTTCAGGCTCCTGGACGAAAACAAGGACTCGCTGATCAACTTCAAGG
AGTTCGTGACAGGGATGAGCGGGATGTACCACGGGGACCTGACAGAGAAGCTCAAGGTGCTCTACAAGCTACACCTTCCCCCAGCTCTGA
GCCCAGAGGAAGCCGAGTCAGCCCTGGAGGCGGCCCATTATTTCACAGAGGACAGCTCCTCAGAAGCATCTCCTCTGGCCTCAGATCTGG
ATCTTTTCCTGCCCTGGGAGGCTCAAGAAGCACTACCACAGGAAGAGCAAGAAGGAAGTGGAAGTGAGGAGAGAGGAGAGGAGAAGGGGA
CCAGCTCTCCGGACTATCGGCACTACCTTCGAATGTGGGCCAAGGAGAAAGAGGCTCAGAAGGAGACGATTAAGGATCTTCCCAAGATGA
ACCAGGAGCAGTTCATTGAGCTGTGCAAGACGCTTTACAACATGTTCAGTGAAGACCCCATGGAGCAGGACCTGTACCACGCCATCGCCA
CCGTGGCCAGCCTCCTGCTCCGCATCGGAGAGGTGGGGAAGAAGTTCTCAGCCCGCACAGGCAGGAAGCCCAGGGACTGTGCCACTGAGG
AGGACGAGCCACCAGCACCCGAACTGCATCAGGACGCAGCCAGGGAGCTTCAGCCCCCAGCTGCAGGAGACCCCCAAGCCAAAGCAGGCG
GAGACACACACCTCGGAAAAGCCCCACAGGAGAGCCAGGTGGTGGTGGAGGGGGGCAGCGGCGAGGGACAGGGCTCACCCTCCCAGCTGC
TGTCTGACGATGAAACCAAAGACGACATGTCCATGTCCTCCTACTCGGTGGTCAGCACGGGCTCCCTGCAATGTGAAGACCTTGCAGACG
ACACGGTGCTGGTGGGCGGGGAGGCCTGCAGCCCCACAGCGCGCATCGGCGGCACCGTCGACACCGACTGGTGCATCTCCTTTGAGCAGA
TCCTGGCCTCCATCCTGACGGAGTCCGTGCTGGTGAACTTCTTTGAGAAGAGAGTGGACATTGGACTCAAGATCAAGGACCAAAAGAAAG
TGGAGAGACAGTTCAGCACCGCCAGTGACCATGAGCAGCCTGGAGTTTCCGGCTGATGCCTGCAGCTGTGAGGCCTGGCCCAAGGTGTCA
TCAGTGGGGCTGGCCTCATCTCCTCCTGCCTTTCCTCCCTTATCAGTTTCTCTTTAAAGGTGTGCCCCTCCTGCTCTCCCAGGAGCAGTG
AGTTGTGAGTGGAAAGAAGGCTGGTGCAGACCCAGCTGCCTTAGACAGATTCCCTGGGCCTGCATCTCCTGGCGCCGGCTGCTTCTGGGC
CCAGGAAGAGGCTGTGGCTCCCACCTTCCTTACACCTGGTGGGAGCCCGCCTCGCACCAGCTGCACCTGCCTAGCATTACAGGCTCTCAG
ATCTGCCCTTGCTTGCCTCATACCTCTGTGCTCCACACTGCGGCCAGGCCAGCTGAGTCCCTCCATCCGTGGATGCTTTCCTGCAGCTAT
GTGGTATGGGGGTCATTCCTGCCTCTTGGCACCAGGTTGGGGGGCATGTGCTTGTTGGGCACCAAAGTGATGGAACCCTCAGGTGCTCTC
CGGGAGCCTGAACCTCCTGACTGAGGAACATGGGCAGAACATGTTTATTGCACAGAGTGGGCGCTGCGCACAGGCGTGGCTGTACACGTG
CTCTCAGCTCATCATCCTTTCCAGTAACTTTAAAAAAACATCCCTCAGGTCCTGATATATTTCCTTGGATTCATTTCACTTGGCTAGAAA
TTACACTGTGCTCAATGCCTTAATAAATCCCTGAAAGAAATAAAAACCACTGTGTGCAATGCCTTGCTGTGGCCCCCAACCACTGCTTAG
GCCTCCCAACTTCTCCCCAGGCCAAGTATGGGGCCCTGGCTGTGTTCTGGAAGTTCAAGACACTTAGTCCTCCACAGTGGGTGGAAGAGT
GCAAGGTCTGCCAGGTCAGATGGAGACGCAGAACCTGCTGGTGCAAGCTGGGCAGGTCCTGACCAACCTGCATCAGGGGATGCCCTGAGC
TCCACAGGTCTTCATGGGCAGGGGTTGTGGGTCCTGGTGAAGGAAGTGCATCCTCAGGCCTGGGCTGTAGCAAGCTGTCTGCCCTTGGGT
TCAAGAACCAGACTGTGGAGCCAAAGGTGACCGCAGGGGGCCCCAGGGCTGGAGCCACAAGGATACCCTCACTTTGCATGAGGAGCTGAA
ACTGACCAGTGTCCAGTGTTAGCCCCCACATGGGGCTGCTCTTGCTTCTACTAAAAGATACAGCAGTTACCCCCTTATCCACAGGGGATA
CAGTGGATATCTAAAACCAGACCCCCAGTGGATGTCTAAAACCACAGATAATAACAAACCTTATACATACTGTTTTTTCCTATGCATACA

>89457_89457_2_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000221855_TBC1D9B_chr5_179306197_ENST00000356834_length(amino acids)=825AA_BP=47
MQASAGRGKMEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRG
ELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL
YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEG
IKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQM
RFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWA
CGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLASDLDLF
LPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVA
SLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSD
DETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVER

--------------------------------------------------------------
>89457_89457_3_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000589996_TBC1D9B_chr5_179306197_ENST00000355235_length(transcript)=3824nt_BP=156nt
GGCGGCTGGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGC
AGCTCCCTCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGGCCAAGGAGAAGATGAAAGAGGAG
TCATGGCACATCCACTTCTTCGAGTACGGGCGTGGCGTGTGCATGTACCGCACAGCCAAGACGCGGGCACTGGTCCTGAAGGGTATCCCT
GAGAGCCTCCGGGGAGAGCTGTGGCTCCTCTTCTCCGGGGCCTGGAATGAGATGGTGACTCACCCCGGGTACTATGCTGAGCTGGTGGAG
AAGTCCACCGGGAAGTACAGCCTGGCCACAGAGGAGATCGAGCGAGACCTGCACCGCTCCATGCCCGAGCACCCTGCCTTCCAGAACGAG
CTGGGGATTGCTGCCCTCCGGCGGGTGCTGACTGCCTATGCCTTCCGAAACCCCACCATCGGCTACTGCCAGGCAATGAACATCGTGACC
TCGGTGCTCCTGCTCTATGGCAGTGAGGAGGAGGCCTTCTGGCTCCTGGTGGCCCTGTGCGAGCGCATGCTGCCCGACTACTACAACACC
AGGGTGGTGGGAGCCCTGGTGGACCAAGGCATCTTCGAAGAGCTCACGAGAGACTTCCTGCCGCAGCTCTCGGAGAAGATGCAGGACCTG
GGGGTGATCTCCAGCATCTCGCTGTCCTGGTTCCTGACCCTCTTCCTCAGCGTCATGCCCTTCGAGAGCGCCGTGGTCATCGTCGACTGC
TTTTTCTATGAGGGCATCAAGGTGATCCTGCAGGTGGCCCTGGCCGTCCTGGACGCCAACATGGAGCAGCTGCTGGGCTGCAGCGACGAG
GGCGAGGCCATGACCATGCTGGGCAGATACCTGGATAATGTGGTCAACAAGCAGAGTGTCTCTCCTCCTATCCCGCACCTCCGTGCCTTG
CTGAGCAGCAGCGATGACCCCCCTGCAGAGGTGGACATCTTTGAGCTCCTGAAAGTGTCCTATGAGAAATTCAGCAGCCTGAGGGCCGAA
GACATTGAGCAGATGCGGTTTAAACAGAGGCTGAAAGTGATCCAGTCCTTGGAGGACACGGCCAAGAGGAGTGTGGTCCGAGCTATACCT
GTGGACATTGGTTTCTCCATTGAAGAGCTGGAGGACCTTTACATGGTGTTTAAGGCCAAGCACCTGGCTAGCCAGTACTGGGGGTGCAGC
CGCACAATGGCCGGCCGTCGGGACCCCAGCCTGCCCTACCTGGAGCAGTACCGGATTGATGCCAGCCAGTTCCGGGAACTCTTTGCCAGC
CTGACACCCTGGGCCTGTGGCTCCCACACACCTCTGCTGGCAGGGCGCATGTTCAGGCTCCTGGACGAAAACAAGGACTCGCTGATCAAC
TTCAAGGAGTTCGTGACAGGGATGAGCGGGATGTACCACGGGGACCTGACAGAGAAGCTCAAGGTGCTCTACAAGCTACACCTTCCCCCA
GCTCTGAGCCCAGAGGAAGCCGAGTCAGCCCTGGAGGCGGCCCATTATTTCACAGAGGACAGCTCCTCAGAAGAAGCACTACCACAGGAA
GAGCAAGAAGGAAGTGGAAGTGAGGAGAGAGGAGAGGAGAAGGGGACCAGCTCTCCGGACTATCGGCACTACCTTCGAATGTGGGCCAAG
GAGAAAGAGGCTCAGAAGGAGACGATTAAGGATCTTCCCAAGATGAACCAGGAGCAGTTCATTGAGCTGTGCAAGACGCTTTACAACATG
TTCAGTGAAGACCCCATGGAGCAGGACCTGTACCACGCCATCGCCACCGTGGCCAGCCTCCTGCTCCGCATCGGAGAGGTGGGGAAGAAG
TTCTCAGCCCGCACAGGCAGGAAGCCCAGGGACTGTGCCACTGAGGAGGACGAGCCACCAGCACCCGAACTGCATCAGGACGCAGCCAGG
GAGCTTCAGCCCCCAGCTGCAGGAGACCCCCAAGCCAAAGCAGGCGGAGACACACACCTCGGAAAAGCCCCACAGGAGAGCCAGGTGGTG
GTGGAGGGGGGCAGCGGCGAGGGACAGGGCTCACCCTCCCAGCTGCTGTCTGACGATGAAACCAAAGACGACATGTCCATGTCCTCCTAC
TCGGTGGTCAGCACGGGCTCCCTGCAATGTGAAGACCTTGCAGACGACACGGTGCTGGTGGGCGGGGAGGCCTGCAGCCCCACAGCGCGC
ATCGGCGGCACCGTCGACACCGACTGGTGCATCTCCTTTGAGCAGATCCTGGCCTCCATCCTGACGGAGTCCGTGCTGGTGAACTTCTTT
GAGAAGAGAGTGGACATTGGACTCAAGATCAAGGACCAAAAGAAAGTGGAGAGACAGTTCAGCACCGCCAGTGACCATGAGCAGCCTGGA
GTTTCCGGCTGATGCCTGCAGCTGTGAGGCCTGGCCCAAGGTGTCATCAGTGGGGCTGGCCTCATCTCCTCCTGCCTTTCCTCCCTTATC
AGTTTCTCTTTAAAGGTGTGCCCCTCCTGCTCTCCCAGGAGCAGTGAGTTGTGAGTGGAAAGAAGGCTGGTGCAGACCCAGCTGCCTTAG
ACAGATTCCCTGGGCCTGCATCTCCTGGCGCCGGCTGCTTCTGGGCCCAGGAAGAGGCTGTGGCTCCCACCTTCCTTACACCTGGTGGGA
GCCCGCCTCGCACCAGCTGCACCTGCCTAGCATTACAGGCTCTCAGATCTGCCCTTGCTTGCCTCATACCTCTGTGCTCCACACTGCGGC
CAGGCCAGCTGAGTCCCTCCATCCGTGGATGCTTTCCTGCAGCTATGTGGTATGGGGGTCATTCCTGCCTCTTGGCACCAGGTTGGGGGG
CATGTGCTTGTTGGGCACCAAAGTGATGGAACCCTCAGGTGCTCTCCGGGAGCCTGAACCTCCTGACTGAGGAACATGGGCAGAACATGT
TTATTGCACAGAGTGGGCGCTGCGCACAGGCGTGGCTGTACACGTGCTCTCAGCTCATCATCCTTTCCAGTAACTTTAAAAAAACATCCC
TCAGGTCCTGATATATTTCCTTGGATTCATTTCACTTGGCTAGAAATTACACTGTGCTCAATGCCTTAATAAATCCCTGAAAGAAATAAA
AACCACTGTGTGCAATGCCTTGCTGTGGCCCCCAACCACTGCTTAGGCCTCCCAACTTCTCCCCAGGCCAAGTATGGGGCCCTGGCTGTG
TTCTGGAAGTTCAAGACACTTAGTCCTCCACAGTGGGTGGAAGAGTGCAAGGTCTGCCAGGTCAGATGGAGACGCAGAACCTGCTGGTGC
AAGCTGGGCAGGTCCTGACCAACCTGCATCAGGGGATGCCCTGAGCTCCACAGGTCTTCATGGGCAGGGGTTGTGGGTCCTGGTGAAGGA
AGTGCATCCTCAGGCCTGGGCTGTAGCAAGCTGTCTGCCCTTGGGTTCAAGAACCAGACTGTGGAGCCAAAGGTGACCGCAGGGGGCCCC
AGGGCTGGAGCCACAAGGATACCCTCACTTTGCATGAGGAGCTGAAACTGACCAGTGTCCAGTGTTAGCCCCCACATGGGGCTGCTCTTG
CTTCTACTAAAAGATACAGCAGTTACCCCCTTATCCACAGGGGATACAGTGGATATCTAAAACCAGACCCCCAGTGGATGTCTAAAACCA
CAGATAATAACAAACCTTATACATACTGTTTTTTCCTATGCATACATACCTGTGATTAAGTTTATGAATTAGGCACCTTAAGAGATTGAC

>89457_89457_3_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000589996_TBC1D9B_chr5_179306197_ENST00000355235_length(amino acids)=808AA_BP=47
MQASAGRGKMEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRG
ELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL
YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEG
IKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQM
RFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWA
CGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEEALPQEEQEGS
GSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSART
GRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDDETKDDMSMSSYSVVST

--------------------------------------------------------------
>89457_89457_4_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000589996_TBC1D9B_chr5_179306197_ENST00000356834_length(transcript)=3875nt_BP=156nt
GGCGGCTGGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGC
AGCTCCCTCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGGCCAAGGAGAAGATGAAAGAGGAG
TCATGGCACATCCACTTCTTCGAGTACGGGCGTGGCGTGTGCATGTACCGCACAGCCAAGACGCGGGCACTGGTCCTGAAGGGTATCCCT
GAGAGCCTCCGGGGAGAGCTGTGGCTCCTCTTCTCCGGGGCCTGGAATGAGATGGTGACTCACCCCGGGTACTATGCTGAGCTGGTGGAG
AAGTCCACCGGGAAGTACAGCCTGGCCACAGAGGAGATCGAGCGAGACCTGCACCGCTCCATGCCCGAGCACCCTGCCTTCCAGAACGAG
CTGGGGATTGCTGCCCTCCGGCGGGTGCTGACTGCCTATGCCTTCCGAAACCCCACCATCGGCTACTGCCAGGCAATGAACATCGTGACC
TCGGTGCTCCTGCTCTATGGCAGTGAGGAGGAGGCCTTCTGGCTCCTGGTGGCCCTGTGCGAGCGCATGCTGCCCGACTACTACAACACC
AGGGTGGTGGGAGCCCTGGTGGACCAAGGCATCTTCGAAGAGCTCACGAGAGACTTCCTGCCGCAGCTCTCGGAGAAGATGCAGGACCTG
GGGGTGATCTCCAGCATCTCGCTGTCCTGGTTCCTGACCCTCTTCCTCAGCGTCATGCCCTTCGAGAGCGCCGTGGTCATCGTCGACTGC
TTTTTCTATGAGGGCATCAAGGTGATCCTGCAGGTGGCCCTGGCCGTCCTGGACGCCAACATGGAGCAGCTGCTGGGCTGCAGCGACGAG
GGCGAGGCCATGACCATGCTGGGCAGATACCTGGATAATGTGGTCAACAAGCAGAGTGTCTCTCCTCCTATCCCGCACCTCCGTGCCTTG
CTGAGCAGCAGCGATGACCCCCCTGCAGAGGTGGACATCTTTGAGCTCCTGAAAGTGTCCTATGAGAAATTCAGCAGCCTGAGGGCCGAA
GACATTGAGCAGATGCGGTTTAAACAGAGGCTGAAAGTGATCCAGTCCTTGGAGGACACGGCCAAGAGGAGTGTGGTCCGAGCTATACCT
GTGGACATTGGTTTCTCCATTGAAGAGCTGGAGGACCTTTACATGGTGTTTAAGGCCAAGCACCTGGCTAGCCAGTACTGGGGGTGCAGC
CGCACAATGGCCGGCCGTCGGGACCCCAGCCTGCCCTACCTGGAGCAGTACCGGATTGATGCCAGCCAGTTCCGGGAACTCTTTGCCAGC
CTGACACCCTGGGCCTGTGGCTCCCACACACCTCTGCTGGCAGGGCGCATGTTCAGGCTCCTGGACGAAAACAAGGACTCGCTGATCAAC
TTCAAGGAGTTCGTGACAGGGATGAGCGGGATGTACCACGGGGACCTGACAGAGAAGCTCAAGGTGCTCTACAAGCTACACCTTCCCCCA
GCTCTGAGCCCAGAGGAAGCCGAGTCAGCCCTGGAGGCGGCCCATTATTTCACAGAGGACAGCTCCTCAGAAGCATCTCCTCTGGCCTCA
GATCTGGATCTTTTCCTGCCCTGGGAGGCTCAAGAAGCACTACCACAGGAAGAGCAAGAAGGAAGTGGAAGTGAGGAGAGAGGAGAGGAG
AAGGGGACCAGCTCTCCGGACTATCGGCACTACCTTCGAATGTGGGCCAAGGAGAAAGAGGCTCAGAAGGAGACGATTAAGGATCTTCCC
AAGATGAACCAGGAGCAGTTCATTGAGCTGTGCAAGACGCTTTACAACATGTTCAGTGAAGACCCCATGGAGCAGGACCTGTACCACGCC
ATCGCCACCGTGGCCAGCCTCCTGCTCCGCATCGGAGAGGTGGGGAAGAAGTTCTCAGCCCGCACAGGCAGGAAGCCCAGGGACTGTGCC
ACTGAGGAGGACGAGCCACCAGCACCCGAACTGCATCAGGACGCAGCCAGGGAGCTTCAGCCCCCAGCTGCAGGAGACCCCCAAGCCAAA
GCAGGCGGAGACACACACCTCGGAAAAGCCCCACAGGAGAGCCAGGTGGTGGTGGAGGGGGGCAGCGGCGAGGGACAGGGCTCACCCTCC
CAGCTGCTGTCTGACGATGAAACCAAAGACGACATGTCCATGTCCTCCTACTCGGTGGTCAGCACGGGCTCCCTGCAATGTGAAGACCTT
GCAGACGACACGGTGCTGGTGGGCGGGGAGGCCTGCAGCCCCACAGCGCGCATCGGCGGCACCGTCGACACCGACTGGTGCATCTCCTTT
GAGCAGATCCTGGCCTCCATCCTGACGGAGTCCGTGCTGGTGAACTTCTTTGAGAAGAGAGTGGACATTGGACTCAAGATCAAGGACCAA
AAGAAAGTGGAGAGACAGTTCAGCACCGCCAGTGACCATGAGCAGCCTGGAGTTTCCGGCTGATGCCTGCAGCTGTGAGGCCTGGCCCAA
GGTGTCATCAGTGGGGCTGGCCTCATCTCCTCCTGCCTTTCCTCCCTTATCAGTTTCTCTTTAAAGGTGTGCCCCTCCTGCTCTCCCAGG
AGCAGTGAGTTGTGAGTGGAAAGAAGGCTGGTGCAGACCCAGCTGCCTTAGACAGATTCCCTGGGCCTGCATCTCCTGGCGCCGGCTGCT
TCTGGGCCCAGGAAGAGGCTGTGGCTCCCACCTTCCTTACACCTGGTGGGAGCCCGCCTCGCACCAGCTGCACCTGCCTAGCATTACAGG
CTCTCAGATCTGCCCTTGCTTGCCTCATACCTCTGTGCTCCACACTGCGGCCAGGCCAGCTGAGTCCCTCCATCCGTGGATGCTTTCCTG
CAGCTATGTGGTATGGGGGTCATTCCTGCCTCTTGGCACCAGGTTGGGGGGCATGTGCTTGTTGGGCACCAAAGTGATGGAACCCTCAGG
TGCTCTCCGGGAGCCTGAACCTCCTGACTGAGGAACATGGGCAGAACATGTTTATTGCACAGAGTGGGCGCTGCGCACAGGCGTGGCTGT
ACACGTGCTCTCAGCTCATCATCCTTTCCAGTAACTTTAAAAAAACATCCCTCAGGTCCTGATATATTTCCTTGGATTCATTTCACTTGG
CTAGAAATTACACTGTGCTCAATGCCTTAATAAATCCCTGAAAGAAATAAAAACCACTGTGTGCAATGCCTTGCTGTGGCCCCCAACCAC
TGCTTAGGCCTCCCAACTTCTCCCCAGGCCAAGTATGGGGCCCTGGCTGTGTTCTGGAAGTTCAAGACACTTAGTCCTCCACAGTGGGTG
GAAGAGTGCAAGGTCTGCCAGGTCAGATGGAGACGCAGAACCTGCTGGTGCAAGCTGGGCAGGTCCTGACCAACCTGCATCAGGGGATGC
CCTGAGCTCCACAGGTCTTCATGGGCAGGGGTTGTGGGTCCTGGTGAAGGAAGTGCATCCTCAGGCCTGGGCTGTAGCAAGCTGTCTGCC
CTTGGGTTCAAGAACCAGACTGTGGAGCCAAAGGTGACCGCAGGGGGCCCCAGGGCTGGAGCCACAAGGATACCCTCACTTTGCATGAGG
AGCTGAAACTGACCAGTGTCCAGTGTTAGCCCCCACATGGGGCTGCTCTTGCTTCTACTAAAAGATACAGCAGTTACCCCCTTATCCACA
GGGGATACAGTGGATATCTAAAACCAGACCCCCAGTGGATGTCTAAAACCACAGATAATAACAAACCTTATACATACTGTTTTTTCCTAT
GCATACATACCTGTGATTAAGTTTATGAATTAGGCACCTTAAGAGATTGACAACAATAACTAATAATAAAATGTAACGGTTATACTGTAA

>89457_89457_4_TBCB-TBC1D9B_TBCB_chr19_36606576_ENST00000589996_TBC1D9B_chr5_179306197_ENST00000356834_length(amino acids)=825AA_BP=47
MQASAGRGKMEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRG
ELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL
YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEG
IKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQM
RFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWA
CGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLASDLDLF
LPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVA
SLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSD
DETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBCB-TBC1D9B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBCB-TBC1D9B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBCB-TBC1D9B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource