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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBL1X-SHROOM2 (FusionGDB2 ID:89573)

Fusion Gene Summary for TBL1X-SHROOM2

check button Fusion gene summary
Fusion gene informationFusion gene name: TBL1X-SHROOM2
Fusion gene ID: 89573
HgeneTgene
Gene symbol

TBL1X

SHROOM2

Gene ID

6907

357

Gene nametransducin beta like 1 X-linkedshroom family member 2
SynonymsCHNG8|EBI|SMAP55|TBL1APXL|HSAPXL
Cytomap

Xp22.31-p22.2

Xp22.2

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1Xtransducin beta like 1X-linkedtransducin beta-like protein 1Xtransducin-beta-like protein 1, X-linkedprotein Shroom2APX homolog of Xenopusapical-like protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000217964, ENST00000380961, 
ENST00000407597, ENST00000424279, 
ENST00000536365, ENST00000497555, 
ENST00000418909, ENST00000493668, 
ENST00000380913, 
Fusion gene scores* DoF score12 X 10 X 7=8406 X 5 X 5=150
# samples 188
** MAII scorelog2(18/840*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBL1X [Title/Abstract] AND SHROOM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBL1X(9622362)-SHROOM2(9841691), # samples:1
TBL1X(9469889)-SHROOM2(9841691), # samples:1
TBL1X(9622362)-SHROOM2(9841692), # samples:1
TBL1X(9469889)-SHROOM2(9841692), # samples:1
Anticipated loss of major functional domain due to fusion event.TBL1X-SHROOM2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TBL1X-SHROOM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBL1X

GO:0000122

negative regulation of transcription by RNA polymerase II

12628926

HgeneTBL1X

GO:0045893

positive regulation of transcription, DNA-templated

18193033

HgeneTBL1X

GO:0045944

positive regulation of transcription by RNA polymerase II

18193033

TgeneSHROOM2

GO:0000902

cell morphogenesis

16684770


check buttonFusion gene breakpoints across TBL1X (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SHROOM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A43HTBL1XchrX

9622362

+SHROOM2chrX

9841691

+
ChimerDB4ESCATCGA-L5-A43HTBL1XchrX

9622362

+SHROOM2chrX

9841692

+
ChimerDB4LUADTCGA-55-6712-01ATBL1XchrX

9469889

+SHROOM2chrX

9841692

+
ChimerDB4LUADTCGA-55-6712TBL1XchrX

9469889

+SHROOM2chrX

9841691

+


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Fusion Gene ORF analysis for TBL1X-SHROOM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000217964ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000217964ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000217964ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000217964ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000380961ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000380961ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000380961ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000380961ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000407597ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000407597ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000407597ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000407597ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000424279ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000424279ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000424279ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000424279ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000536365ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000536365ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5CDS-intronENST00000536365ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
5CDS-intronENST00000536365ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
5UTR-3CDSENST00000217964ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-3CDSENST00000217964ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-3CDSENST00000380961ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-3CDSENST00000380961ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-3CDSENST00000407597ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-3CDSENST00000407597ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-3CDSENST00000424279ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-3CDSENST00000424279ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-3CDSENST00000536365ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-3CDSENST00000536365ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000217964ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000217964ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000217964ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000217964ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000380961ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000380961ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000380961ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000380961ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000407597ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000407597ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000407597ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000407597ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000424279ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000424279ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000424279ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000424279ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000536365ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000536365ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
5UTR-intronENST00000536365ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
5UTR-intronENST00000536365ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
Frame-shiftENST00000217964ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
Frame-shiftENST00000217964ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
Frame-shiftENST00000380961ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
Frame-shiftENST00000380961ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
Frame-shiftENST00000407597ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
Frame-shiftENST00000407597ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
Frame-shiftENST00000424279ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
Frame-shiftENST00000424279ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
Frame-shiftENST00000536365ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
Frame-shiftENST00000536365ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
intron-3CDSENST00000497555ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
intron-3CDSENST00000497555ENST00000380913TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
intron-3CDSENST00000497555ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
intron-3CDSENST00000497555ENST00000380913TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
intron-intronENST00000497555ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
intron-intronENST00000497555ENST00000418909TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
intron-intronENST00000497555ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
intron-intronENST00000497555ENST00000418909TBL1XchrX

9469889

+SHROOM2chrX

9841691

+
intron-intronENST00000497555ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841691

+
intron-intronENST00000497555ENST00000493668TBL1XchrX

9622362

+SHROOM2chrX

9841692

+
intron-intronENST00000497555ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841692

+
intron-intronENST00000497555ENST00000493668TBL1XchrX

9469889

+SHROOM2chrX

9841691

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TBL1X-SHROOM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBL1XchrX9469889+SHROOM2chrX9841691+0.0026962060.9973037
TBL1XchrX9469889+SHROOM2chrX9841691+0.0026962060.9973037
TBL1XchrX9622362+SHROOM2chrX9841691+5.94E-050.9999405
TBL1XchrX9469889+SHROOM2chrX9841691+0.0026962060.9973037
TBL1XchrX9469889+SHROOM2chrX9841691+0.0026962060.9973037
TBL1XchrX9622362+SHROOM2chrX9841691+5.94E-050.9999405

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TBL1X-SHROOM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:9622362/:9841691)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TBL1X-SHROOM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TBL1X-SHROOM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBL1X-SHROOM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBL1X-SHROOM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource