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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TBL1Y-USP13 (FusionGDB2 ID:89581)

Fusion Gene Summary for TBL1Y-USP13

Fusion gene summary

Fusion gene information	Fusion gene name: TBL1Y-USP13
	Fusion gene ID: 89581
		Hgene	Tgene
	Gene symbol	TBL1Y	USP13
	Gene ID	90665	8975
	Gene name	transducin beta like 1 Y-linked	ubiquitin specific peptidase 13
	Synonyms	DFNY2\|TBL1	ISOT3\|IsoT-3
	Cytomap	Yp11.2	3q26.33
	Type of gene	protein-coding	protein-coding
	Description	F-box-like/WD repeat-containing protein TBL1Ytransducin beta-like 1transducin beta-like protein 1Ytransducin-beta-like protein 1, Y-linked	ubiquitin carboxyl-terminal hydrolase 13deubiquitinating enzyme 13ubiquitin specific peptidase 13 (isopeptidase T-3)ubiquitin specific protease 13 (isopeptidase T-3)ubiquitin thioesterase 13ubiquitin thiolesterase 13ubiquitin-specific-processing pro
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000346432, ENST00000355162, ENST00000383032,	ENST00000482333, ENST00000496897, ENST00000263966,
Fusion gene scores	* DoF score	3 X 2 X 3=18	4 X 4 X 3=48
	# samples	3	4
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TBL1Y [Title/Abstract] AND USP13 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TBL1Y(6942661)-USP13(179478899), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	USP13	GO:0010506	regulation of autophagy	21962518
Tgene	USP13	GO:0035523	protein K29-linked deubiquitination	26280536
Tgene	USP13	GO:0044313	protein K6-linked deubiquitination	26280536
Tgene	USP13	GO:0050821	protein stabilization	21659512\|26280536
Tgene	USP13	GO:0070536	protein K63-linked deubiquitination	22216260\|26280536

Fusion gene breakpoints across TBL1Y (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A07G	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+

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Fusion Gene ORF analysis for TBL1Y-USP13

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000346432	ENST00000482333	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
5CDS-intron	ENST00000346432	ENST00000496897	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
5CDS-intron	ENST00000355162	ENST00000482333	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
5CDS-intron	ENST00000355162	ENST00000496897	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
5CDS-intron	ENST00000383032	ENST00000482333	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
5CDS-intron	ENST00000383032	ENST00000496897	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
In-frame	ENST00000346432	ENST00000263966	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
In-frame	ENST00000355162	ENST00000263966	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+
In-frame	ENST00000383032	ENST00000263966	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000355162

TBL1Y

chrY

6942661

ENST00000263966

USP13

chr3

179478899

7475

1571

616

2214

532

ENST00000346432

TBL1Y

chrY

6942661

ENST00000263966

USP13

chr3

179478899

7411

1507

552

2150

532

ENST00000383032

TBL1Y

chrY

6942661

ENST00000263966

USP13

chr3

179478899

7506

1602

647

2245

532

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355162	ENST00000263966	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+	0.001418421	0.99858165
ENST00000346432	ENST00000263966	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+	0.001420533	0.9985795
ENST00000383032	ENST00000263966	TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+	0.001409345	0.99859065

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Fusion Genomic Features for TBL1Y-USP13

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+	1.37E-06	0.9999987
TBL1Y	chrY	6942661	+	USP13	chr3	179478899	+	1.37E-06	0.9999987

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBL1Y-USP13

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrY:6942661/chr3:179478899)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

41_86

318

523.0

Domain

Note=F-box-like

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

4_36

318

523.0

Domain

LisH

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

41_86

318

523.0

Domain

Note=F-box-like

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

4_36

318

523.0

Domain

LisH

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

41_86

318

523.0

Domain

Note=F-box-like

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

4_36

318

523.0

Domain

LisH

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

177_216

318

523.0

Repeat

Note=WD 1

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

233_272

318

523.0

Repeat

Note=WD 2

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

274_313

318

523.0

Repeat

Note=WD 3

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

177_216

318

523.0

Repeat

Note=WD 1

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

233_272

318

523.0

Repeat

Note=WD 2

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

274_313

318

523.0

Repeat

Note=WD 3

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

177_216

318

523.0

Repeat

Note=WD 1

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

233_272

318

523.0

Repeat

Note=WD 2

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

274_313

318

523.0

Repeat

Note=WD 3

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000263966

652_693

649

864.0

Domain

UBA 1

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000263966

727_767

649

864.0

Domain

UBA 2

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000496897

652_693

584

799.0

Domain

UBA 1

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000496897

727_767

584

799.0

Domain

UBA 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

316_354

318

523.0

Repeat

Note=WD 4

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

357_396

318

523.0

Repeat

Note=WD 5

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

399_447

318

523.0

Repeat

Note=WD 6

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

450_489

318

523.0

Repeat

Note=WD 7

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000346432

491_521

318

523.0

Repeat

Note=WD 8

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

316_354

318

523.0

Repeat

Note=WD 4

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

357_396

318

523.0

Repeat

Note=WD 5

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

399_447

318

523.0

Repeat

Note=WD 6

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

450_489

318

523.0

Repeat

Note=WD 7

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000355162

491_521

318

523.0

Repeat

Note=WD 8

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

316_354

318

523.0

Repeat

Note=WD 4

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

357_396

318

523.0

Repeat

Note=WD 5

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

399_447

318

523.0

Repeat

Note=WD 6

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

450_489

318

523.0

Repeat

Note=WD 7

Hgene

TBL1Y

chrY:6942661

chr3:179478899

ENST00000383032

491_521

318

523.0

Repeat

Note=WD 8

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000263966

336_861

649

864.0

Domain

Note=USP

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000496897

336_861

584

799.0

Domain

Note=USP

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000263966

209_281

649

864.0

Zinc finger

UBP-type

Tgene

USP13

chrY:6942661

chr3:179478899

ENST00000496897

209_281

584

799.0

Zinc finger

UBP-type

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Fusion Gene Sequence for TBL1Y-USP13

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89581_89581_1_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000346432_USP13_chr3_179478899_ENST00000263966_length(transcript)=7411nt_BP=1507nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTTGTAAGGTGCTAAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTG
GATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGA
GGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGGCTTTC
ACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGAAGGGA
CTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAGTTGCT
GTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCA
GCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAG
AATGGAGCACATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGG
GGCCACGAGTCTGAGGTGTTCATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGG
AACCTGAATGAGAATAGCAACGGGGGCTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAA
GATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGT
AACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTA
GACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGCATCAGACATCGATGAGTCATCA
GTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGGCGCCGAGGTGGCCTTC
AACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGCTTCTGCTGGAGCCTCT
GTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCAGCGAAATCAGGCTATT
CAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGAAGACAGTGATTTTGTG
ATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGGATCTGGAACATATGAG
CTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGGAAGATGGGTGATTTAC
AATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACCAAGCTAAACCTCAAAT
ATAAAAATTGGCGAAAAGAAGCCATACGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAACAACTAGACATGAAGGA
ATATATGGGGTATTTATCGTTTATTTAAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAATTTCTATTAGTGATGAT
ACACTATTATATTGTAGATAGTTTTTATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCATATTGCTGGTGGAGGA
TCTGCCATCAGCACATCAAAAATGGGGATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGCCTCTGGAGAAACCAAA
TAATGTGGCCAGTGGTGTGGCCTTACCCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAGTTGGGTGGGGCTTTAT
TTGTGACATAATTTTTTTCATGACATACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAATAGAGCCTCTGCAATGA
AAGATATTTTTAATTTGTCACATTAAAATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGTGAGACTTTTACTAGAA
AAGTGAGTCCACTAGAAAATCTGTGACAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAAAAAGCAAGTAAATATT
TTAACAAAACTATGACTCAGGAACCTTCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCTGAGTTATGCCTTTAAG
TGCTGTCAAGAATTCACTTGGGTTTGGGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGTACTTTGTCAAAGGTAG
GTAAATTCTCTGTTTCTCAGCAGCCCTTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTCTTTTTACCATCTCACA
TGATAACTCTTTGGAGTCATGTCAAGTGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGCCTCCGTTTCCTTGTTT
TTCTGGGGCCAGAGTCTCATCTCTGCCTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGATGTGACCAACAGTGTGA
TCTTGGACACACTAAGGATTTTAGATGCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTGGTTATTTCAGCATTTT
AGTTGCAACCTGGGATTAGATTAGAGTTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATAATTTTCCTACTGGTCC
GTACCAAATTCTAGAGTCTCTGGAGTTGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCTGTTTAACATGTATTTG
TTTGGTTGAAAGGATCTTTTTAGAAACTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACATTGGGTTAGGATGTAGT
GAGTTGTGAACAATCAGGATTCTGGGTGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGACCGAGAGACATGGTGTC
TAAGGCCCATGGCCTGGAGACCTGGGTGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCCTGTGCCTCACTGTCCT
CATCTGAACAATGGTATGATGACACCTGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACAGTGAACCTTCAATGAG
TAGAATGTGGTATGCCATGGTGGGTTGTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTGGGAACAAATGAGATTG
GCAGAAGGAGGGAGCTCACGGTGCAGTACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAACTTGGATTTCCTAAAGC
AGTCCCACTCTGTTATGAGAGTCACTGACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCCCCTTAGGGCAGAGTGA
GTGTCATAGAATAATGACTCCAAACCCACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTGTTTTTTGGAATTGGGG
GTGACTGGGTGGTTTGGATTGAAATGTGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAATAAAACTTTTAAAAATC
AGTGATGTAAAATCAATATTTAAGACTATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCTAGACATGTTGTAAAAA
AATTGTGCTATGGCTGCCTTTTCTTCTGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATATGTGCTATTCTTTACTT
CAGATTGAGAGTTGGGAAAAACTGGAGTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTATCTCAATATATACAAGG
CAGGTTCCCCTATAAAAGTCTGGAATGTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAAAAGTGGAATAACGTGT
GGATTTTGTCAACTCATTATCAGTCTGTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTCCCTGTATATGGGTGTC
TGTGTGAAAGACAGCACTTTCTTCCTGTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTCTTTGGAAAAGGTAATG
TATCAAAGTTTTTATTTTGCCAATTGATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTGGGATTTTCTTTTAAAG
AAAAAAAAAGTATGCAGAAAAGACTATTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAATATTTTGGAATTGACCA
GGCTGCTTTCTCCTACCTGCAAGAGAATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAGCGGGGATAGCTCGAGC
CTCTTGCTCCCTGAGTCATTTATTCCCTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGGGTCTGTATCCTGACTC
CACTCTAAGTGAGGTGGGACTGAATCACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAGATTAGCTCCAAAGTCC
TCTCTTGCCCTAACATTTTATTTTTATTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATCACTTAGAGGTTTGGAT
GTTATATTTTTGCATTGTTACAGCTTATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCCCTCTGTTTGTATTCCT
GCTCCACTTATCTATACTTTTTTGGGTAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTGCCAAGGCTGGAGTACA
GTGGTGCAATCTCAGCTCACTGCAGCCTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGATTACTGGCGCAC
GCCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCAACCT
GCCTCAGCCTCCCAAAGTGCTGGGATTACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGAAAAAAACAACTTTCTA
GTCCATGAGGTACTTTGGCTCCATCCCCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAAGCCTCAGAACTGCCTT
CAACTACATCTGTCACCTTTATAGAATATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCTAGAGCTGTGATCCCCA
AATAAGTGCTGACAAAATTGTCTACCACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATCACATCAGTACATGCCT
TCTGTGGGGAGATGGCAGGGGGCAGGGGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAGATAAAAGAAATCCTAC
GCTATAGAACAAGGTTCTGTACTCTTGAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACTCCATAAATCACTCTAA
AAGAGTTTGCATAAGACTCGGTAGACCTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTACTCAAAGTTTGGCTTGT
TCAAATCGAGACTGTGTTGTACACATACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAAATATTTCACCAATATT
TCATATTGATAACATGCTGAAATGACACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTATATAATTGAAATTAAAA
TTCTTTTCACCCATTTTTATTTTTTTAAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTTATACTTCTATTGGACA
GCCCCACTCTAGACTTACATGGTGTGGGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTATCTAAATAGACAGAAAC
AACACAAATATTTTTGCTGGAGTCAGGAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTTCTGCCGAAAAACCAAT
ATATATATGTATGATCCCAATTAAAAGACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGGAGCTGCTACCTTTGCT
CTTCTAGCATCTTCTAGGTACCAAGGATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAAAATCCTCTTGTGGTTT
CCCCTCCCCAGGTATTGTTGAGTCTGTTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGATGTGCCGCTTGTCTCA
GCCTTGGCAGAGGCTGAGTCTGTTCCTGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTTGTATTTATTTTATTTT
GCACTAGTCACAGTTGTTGTTAAACTGTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATGGATGATTTATTGCTTC

>89581_89581_1_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000346432_USP13_chr3_179478899_ENST00000263966_length(amino acids)=532AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSASDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWII
VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEME

--------------------------------------------------------------
>89581_89581_2_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000355162_USP13_chr3_179478899_ENST00000263966_length(transcript)=7475nt_BP=1571nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTTTTGAAGAAATGAAGCAGGACTTGATGTGGAT
TGTCATAAACTGTTTCTCCCTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTGGATGCTGAGAAGCCTGCTGGTTCAGA
GGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGAGGTGAGGCTAAGATGAGCATAACCAG
TGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGGCTTTCACGTTTGGGATCGAGAGCCACATCAG
CCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGAAGGGACTGCAGTATGTAGAGGCTGAGATAAG
CATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAGTTGCTGTGATTCCTGATGTGGTGCAGATGCG
GCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCAGCAATGGCAAAGGCGGCAACCATGAC
CCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAGAATGGAGCACATGAAATCAATAATCA
CTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGGGGCCACGAGTCTGAGGTGTTCATTTG
TGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGGAACCTGAATGAGAATAGCAACGGGGG
CTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAAGATGTCACCTCACTGGACTGGAACAG
TGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGTAACCTGGCCAGCACCTTAGGCCAACA
TAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTAGACAAAACAACAATAATTTGGGATGC
TCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGCATCAGACATCGATGAGTCATCAGTGATGCAGCTGGCCGAGATGGGTTT
CCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGGCGCCGAGGTGGCCTTCAACTGGATCATTGTTCACATGGAAGA
GCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGCTTCTGCTGGAGCCTCTGTTTTTGGTGCTTCTGGACTGGATAA
CCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCAGCGAAATCAGGCTATTCAGGCACTACGAGCAACGAATAATAA
CCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGAAGACAGTGATTTTGTGATTGAGATGGAGAATAATGCCAATGC
AAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGGATCTGGAACATATGAGCTATTTGCATTCATCAGTCACATGGG
AACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGGAAGATGGGTGATTTACAATGACCACAAAGTTTGTGCCTCAGA
AAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACCAAGCTAAACCTCAAATATAAAAATTGGCGAAAAGAAGCCATA
CGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAACAACTAGACATGAAGGAATATATGGGGTATTTATCGTTTATTT
AAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAATTTCTATTAGTGATGATACACTATTATATTGTAGATAGTTTTT
ATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCATATTGCTGGTGGAGGATCTGCCATCAGCACATCAAAAATGGG
GATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGCCTCTGGAGAAACCAAATAATGTGGCCAGTGGTGTGGCCTTAC
CCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAGTTGGGTGGGGCTTTATTTGTGACATAATTTTTTTCATGACAT
ACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAATAGAGCCTCTGCAATGAAAGATATTTTTAATTTGTCACATTAA
AATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGTGAGACTTTTACTAGAAAAGTGAGTCCACTAGAAAATCTGTGA
CAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAAAAAGCAAGTAAATATTTTAACAAAACTATGACTCAGGAACCT
TCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCTGAGTTATGCCTTTAAGTGCTGTCAAGAATTCACTTGGGTTTG
GGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGTACTTTGTCAAAGGTAGGTAAATTCTCTGTTTCTCAGCAGCCC
TTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTCTTTTTACCATCTCACATGATAACTCTTTGGAGTCATGTCAAG
TGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGCCTCCGTTTCCTTGTTTTTCTGGGGCCAGAGTCTCATCTCTGC
CTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGATGTGACCAACAGTGTGATCTTGGACACACTAAGGATTTTAGAT
GCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTGGTTATTTCAGCATTTTAGTTGCAACCTGGGATTAGATTAGAG
TTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATAATTTTCCTACTGGTCCGTACCAAATTCTAGAGTCTCTGGAGT
TGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCTGTTTAACATGTATTTGTTTGGTTGAAAGGATCTTTTTAGAAA
CTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACATTGGGTTAGGATGTAGTGAGTTGTGAACAATCAGGATTCTGGG
TGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGACCGAGAGACATGGTGTCTAAGGCCCATGGCCTGGAGACCTGGG
TGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCCTGTGCCTCACTGTCCTCATCTGAACAATGGTATGATGACACC
TGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACAGTGAACCTTCAATGAGTAGAATGTGGTATGCCATGGTGGGTT
GTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTGGGAACAAATGAGATTGGCAGAAGGAGGGAGCTCACGGTGCAG
TACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAACTTGGATTTCCTAAAGCAGTCCCACTCTGTTATGAGAGTCACT
GACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCCCCTTAGGGCAGAGTGAGTGTCATAGAATAATGACTCCAAACC
CACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTGTTTTTTGGAATTGGGGGTGACTGGGTGGTTTGGATTGAAATG
TGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAATAAAACTTTTAAAAATCAGTGATGTAAAATCAATATTTAAGAC
TATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCTAGACATGTTGTAAAAAAATTGTGCTATGGCTGCCTTTTCTTC
TGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATATGTGCTATTCTTTACTTCAGATTGAGAGTTGGGAAAAACTGGA
GTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTATCTCAATATATACAAGGCAGGTTCCCCTATAAAAGTCTGGAAT
GTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAAAAGTGGAATAACGTGTGGATTTTGTCAACTCATTATCAGTCT
GTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTCCCTGTATATGGGTGTCTGTGTGAAAGACAGCACTTTCTTCCT
GTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTCTTTGGAAAAGGTAATGTATCAAAGTTTTTATTTTGCCAATTG
ATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTGGGATTTTCTTTTAAAGAAAAAAAAAGTATGCAGAAAAGACTA
TTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAATATTTTGGAATTGACCAGGCTGCTTTCTCCTACCTGCAAGAGA
ATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAGCGGGGATAGCTCGAGCCTCTTGCTCCCTGAGTCATTTATTCC
CTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGGGTCTGTATCCTGACTCCACTCTAAGTGAGGTGGGACTGAATC
ACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAGATTAGCTCCAAAGTCCTCTCTTGCCCTAACATTTTATTTTTA
TTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATCACTTAGAGGTTTGGATGTTATATTTTTGCATTGTTACAGCTT
ATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCCCTCTGTTTGTATTCCTGCTCCACTTATCTATACTTTTTTGGG
TAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTGCCAAGGCTGGAGTACAGTGGTGCAATCTCAGCTCACTGCAGC
CTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGATTACTGGCGCACGCCACTACGCCCAGCTAATTTTTGTA
TTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCAACCTGCCTCAGCCTCCCAAAGTGCTGGGAT
TACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGAAAAAAACAACTTTCTAGTCCATGAGGTACTTTGGCTCCATCC
CCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAAGCCTCAGAACTGCCTTCAACTACATCTGTCACCTTTATAGAA
TATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCTAGAGCTGTGATCCCCAAATAAGTGCTGACAAAATTGTCTACC
ACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATCACATCAGTACATGCCTTCTGTGGGGAGATGGCAGGGGGCAGG
GGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAGATAAAAGAAATCCTACGCTATAGAACAAGGTTCTGTACTCTT
GAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACTCCATAAATCACTCTAAAAGAGTTTGCATAAGACTCGGTAGAC
CTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTACTCAAAGTTTGGCTTGTTCAAATCGAGACTGTGTTGTACACAT
ACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAAATATTTCACCAATATTTCATATTGATAACATGCTGAAATGAC
ACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTATATAATTGAAATTAAAATTCTTTTCACCCATTTTTATTTTTTT
AAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTTATACTTCTATTGGACAGCCCCACTCTAGACTTACATGGTGTG
GGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTATCTAAATAGACAGAAACAACACAAATATTTTTGCTGGAGTCAG
GAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTTCTGCCGAAAAACCAATATATATATGTATGATCCCAATTAAAA
GACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGGAGCTGCTACCTTTGCTCTTCTAGCATCTTCTAGGTACCAAGG
ATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAAAATCCTCTTGTGGTTTCCCCTCCCCAGGTATTGTTGAGTCTG
TTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGATGTGCCGCTTGTCTCAGCCTTGGCAGAGGCTGAGTCTGTTCC
TGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTTGTATTTATTTTATTTTGCACTAGTCACAGTTGTTGTTAAACT
GTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATGGATGATTTATTGCTTCAATTGTTTTAAATTAAAAGCTATTCT

>89581_89581_2_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000355162_USP13_chr3_179478899_ENST00000263966_length(amino acids)=532AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSASDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWII
VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEME

--------------------------------------------------------------
>89581_89581_3_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000383032_USP13_chr3_179478899_ENST00000263966_length(transcript)=7506nt_BP=1602nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTTGTAAGGTGCTAAGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTT
TTGAAGAAATGAAGCAGGACTTGATGTGGATTGTCATAAACTGTTTCTCCCTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTAT
GACTGGATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGC
CATGAGGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGG
CTTTCACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGA
AGGGACTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAG
TTGCTGTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGG
CATCAGCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGG
AAGAGAATGGAGCACATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCC
TTCGGGGCCACGAGTCTGAGGTGTTCATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGA
TATGGAACCTGAATGAGAATAGCAACGGGGGCTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTA
ATAAAGATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAA
ATGGTAACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTG
GTGTAGACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGCATCAGACATCGATGAGT
CATCAGTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGGCGCCGAGGTGG
CCTTCAACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGCTTCTGCTGGAG
CCTCTGTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCAGCGAAATCAGG
CTATTCAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGAAGACAGTGATT
TTGTGATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGGATCTGGAACAT
ATGAGCTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGGAAGATGGGTGA
TTTACAATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACCAAGCTAAACCT
CAAATATAAAAATTGGCGAAAAGAAGCCATACGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAACAACTAGACATG
AAGGAATATATGGGGTATTTATCGTTTATTTAAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAATTTCTATTAGTG
ATGATACACTATTATATTGTAGATAGTTTTTATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCATATTGCTGGTG
GAGGATCTGCCATCAGCACATCAAAAATGGGGATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGCCTCTGGAGAAA
CCAAATAATGTGGCCAGTGGTGTGGCCTTACCCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAGTTGGGTGGGGC
TTTATTTGTGACATAATTTTTTTCATGACATACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAATAGAGCCTCTGC
AATGAAAGATATTTTTAATTTGTCACATTAAAATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGTGAGACTTTTAC
TAGAAAAGTGAGTCCACTAGAAAATCTGTGACAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAAAAAGCAAGTAA
ATATTTTAACAAAACTATGACTCAGGAACCTTCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCTGAGTTATGCCT
TTAAGTGCTGTCAAGAATTCACTTGGGTTTGGGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGTACTTTGTCAAA
GGTAGGTAAATTCTCTGTTTCTCAGCAGCCCTTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTCTTTTTACCATC
TCACATGATAACTCTTTGGAGTCATGTCAAGTGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGCCTCCGTTTCCT
TGTTTTTCTGGGGCCAGAGTCTCATCTCTGCCTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGATGTGACCAACAG
TGTGATCTTGGACACACTAAGGATTTTAGATGCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTGGTTATTTCAGC
ATTTTAGTTGCAACCTGGGATTAGATTAGAGTTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATAATTTTCCTACT
GGTCCGTACCAAATTCTAGAGTCTCTGGAGTTGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCTGTTTAACATGT
ATTTGTTTGGTTGAAAGGATCTTTTTAGAAACTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACATTGGGTTAGGAT
GTAGTGAGTTGTGAACAATCAGGATTCTGGGTGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGACCGAGAGACATG
GTGTCTAAGGCCCATGGCCTGGAGACCTGGGTGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCCTGTGCCTCACT
GTCCTCATCTGAACAATGGTATGATGACACCTGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACAGTGAACCTTCA
ATGAGTAGAATGTGGTATGCCATGGTGGGTTGTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTGGGAACAAATGA
GATTGGCAGAAGGAGGGAGCTCACGGTGCAGTACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAACTTGGATTTCCT
AAAGCAGTCCCACTCTGTTATGAGAGTCACTGACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCCCCTTAGGGCAG
AGTGAGTGTCATAGAATAATGACTCCAAACCCACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTGTTTTTTGGAAT
TGGGGGTGACTGGGTGGTTTGGATTGAAATGTGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAATAAAACTTTTAA
AAATCAGTGATGTAAAATCAATATTTAAGACTATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCTAGACATGTTGT
AAAAAAATTGTGCTATGGCTGCCTTTTCTTCTGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATATGTGCTATTCTT
TACTTCAGATTGAGAGTTGGGAAAAACTGGAGTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTATCTCAATATATA
CAAGGCAGGTTCCCCTATAAAAGTCTGGAATGTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAAAAGTGGAATAA
CGTGTGGATTTTGTCAACTCATTATCAGTCTGTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTCCCTGTATATGG
GTGTCTGTGTGAAAGACAGCACTTTCTTCCTGTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTCTTTGGAAAAGG
TAATGTATCAAAGTTTTTATTTTGCCAATTGATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTGGGATTTTCTTT
TAAAGAAAAAAAAAGTATGCAGAAAAGACTATTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAATATTTTGGAATT
GACCAGGCTGCTTTCTCCTACCTGCAAGAGAATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAGCGGGGATAGCT
CGAGCCTCTTGCTCCCTGAGTCATTTATTCCCTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGGGTCTGTATCCT
GACTCCACTCTAAGTGAGGTGGGACTGAATCACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAGATTAGCTCCAA
AGTCCTCTCTTGCCCTAACATTTTATTTTTATTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATCACTTAGAGGTT
TGGATGTTATATTTTTGCATTGTTACAGCTTATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCCCTCTGTTTGTA
TTCCTGCTCCACTTATCTATACTTTTTTGGGTAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTGCCAAGGCTGGA
GTACAGTGGTGCAATCTCAGCTCACTGCAGCCTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGATTACTGG
CGCACGCCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTC
AACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGAAAAAAACAACT
TTCTAGTCCATGAGGTACTTTGGCTCCATCCCCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAAGCCTCAGAACT
GCCTTCAACTACATCTGTCACCTTTATAGAATATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCTAGAGCTGTGAT
CCCCAAATAAGTGCTGACAAAATTGTCTACCACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATCACATCAGTACA
TGCCTTCTGTGGGGAGATGGCAGGGGGCAGGGGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAGATAAAAGAAAT
CCTACGCTATAGAACAAGGTTCTGTACTCTTGAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACTCCATAAATCAC
TCTAAAAGAGTTTGCATAAGACTCGGTAGACCTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTACTCAAAGTTTGG
CTTGTTCAAATCGAGACTGTGTTGTACACATACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAAATATTTCACCA
ATATTTCATATTGATAACATGCTGAAATGACACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTATATAATTGAAAT
TAAAATTCTTTTCACCCATTTTTATTTTTTTAAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTTATACTTCTATT
GGACAGCCCCACTCTAGACTTACATGGTGTGGGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTATCTAAATAGACA
GAAACAACACAAATATTTTTGCTGGAGTCAGGAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTTCTGCCGAAAAA
CCAATATATATATGTATGATCCCAATTAAAAGACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGGAGCTGCTACCT
TTGCTCTTCTAGCATCTTCTAGGTACCAAGGATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAAAATCCTCTTGT
GGTTTCCCCTCCCCAGGTATTGTTGAGTCTGTTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGATGTGCCGCTTG
TCTCAGCCTTGGCAGAGGCTGAGTCTGTTCCTGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTTGTATTTATTTT
ATTTTGCACTAGTCACAGTTGTTGTTAAACTGTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATGGATGATTTATT

>89581_89581_3_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000383032_USP13_chr3_179478899_ENST00000263966_length(amino acids)=532AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSASDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWII
VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEME

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Fusion Gene PPI Analysis for TBL1Y-USP13

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TBL1Y-USP13

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TBL1Y-USP13

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source