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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TC2N-FBLN5 (FusionGDB2 ID:89629)

Fusion Gene Summary for TC2N-FBLN5

Fusion gene summary

Fusion gene information	Fusion gene name: TC2N-FBLN5
	Fusion gene ID: 89629
		Hgene	Tgene
	Gene symbol	TC2N	FBLN5
	Gene ID	123036	10516
	Gene name	tandem C2 domains, nuclear	fibulin 5
	Synonyms	C14orf47\|C2CD1\|MTAC2D1\|Tac2-N	ADCL2\|ARCL1A\|ARMD3\|DANCE\|EVEC\|FIBL-5\|HNARMD\|UP50
	Cytomap	14q32.12	14q32.12
	Type of gene	protein-coding	protein-coding
	Description	tandem C2 domains nuclear proteinC2 calcium-dependent domain containing 1membrane targeting (tandem) C2 domain containing 1tandem C2 protein in nucleus	fibulin-5developmental arteries and neural crest EGF-like proteinembryonic vascular EGF-like repeat-containing proteintestis tissue sperm-binding protein Li 75nurine p50 protein
	Modification date	20200315	20200313
	UniProtAcc	.	Q9UBX5
	Ensembl transtripts involved in fusion gene	ENST00000340892, ENST00000360594, ENST00000435962, ENST00000556018, ENST00000555302,	ENST00000556961, ENST00000267620, ENST00000342058, ENST00000556154,
Fusion gene scores	* DoF score	6 X 11 X 7=462	11 X 8 X 7=616
	# samples	15	15
	** MAII score	log2(15/462*10)=-1.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/616*10)=-2.03796785019902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TC2N [Title/Abstract] AND FBLN5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TC2N(92278656)-FBLN5(92361416), # samples:2
Anticipated loss of major functional domain due to fusion event.	TC2N-FBLN5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FBLN5	GO:0046903	secretion	20599547

Fusion gene breakpoints across TC2N (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBLN5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-3C-AALI-01A	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
ChimerDB4	BRCA	TCGA-JL-A3YW-01A	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
ChimerDB4	BRCA	TCGA-LL-A5YO-01A	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
ChimerDB4	STAD	TCGA-VQ-A91N-01A	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-

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Fusion Gene ORF analysis for TC2N-FBLN5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000340892	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
5CDS-intron	ENST00000340892	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
5CDS-intron	ENST00000340892	ENST00000556961	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
5CDS-intron	ENST00000360594	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
5CDS-intron	ENST00000360594	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
5CDS-intron	ENST00000360594	ENST00000556961	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
5CDS-intron	ENST00000435962	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
5CDS-intron	ENST00000435962	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
5CDS-intron	ENST00000435962	ENST00000556961	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
5CDS-intron	ENST00000556018	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
5CDS-intron	ENST00000556018	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
5CDS-intron	ENST00000556018	ENST00000556961	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000340892	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
Frame-shift	ENST00000340892	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000340892	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
Frame-shift	ENST00000340892	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000340892	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
Frame-shift	ENST00000340892	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000360594	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000360594	ENST00000267620	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000360594	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000360594	ENST00000342058	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000360594	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000360594	ENST00000556154	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000435962	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000435962	ENST00000267620	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000435962	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000435962	ENST00000342058	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000435962	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000435962	ENST00000556154	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000556018	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000556018	ENST00000267620	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000556018	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000556018	ENST00000342058	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
Frame-shift	ENST00000556018	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
Frame-shift	ENST00000556018	ENST00000556154	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
In-frame	ENST00000340892	ENST00000267620	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
In-frame	ENST00000340892	ENST00000342058	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
In-frame	ENST00000340892	ENST00000556154	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
In-frame	ENST00000360594	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000360594	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000360594	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000435962	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000435962	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000435962	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000556018	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000556018	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
In-frame	ENST00000556018	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
intron-3CDS	ENST00000555302	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
intron-3CDS	ENST00000555302	ENST00000267620	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
intron-3CDS	ENST00000555302	ENST00000267620	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
intron-3CDS	ENST00000555302	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
intron-3CDS	ENST00000555302	ENST00000342058	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
intron-3CDS	ENST00000555302	ENST00000342058	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
intron-3CDS	ENST00000555302	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
intron-3CDS	ENST00000555302	ENST00000556154	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
intron-3CDS	ENST00000555302	ENST00000556154	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-
intron-intron	ENST00000555302	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92361416	-
intron-intron	ENST00000555302	ENST00000556961	TC2N	chr14	92278656	-	FBLN5	chr14	92409305	-
intron-intron	ENST00000555302	ENST00000556961	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000340892	TC2N	chr14	92280047	-	ENST00000267620	FBLN5	chr14	92406960	-	2562	381	357	1778	473
ENST00000340892	TC2N	chr14	92280047	-	ENST00000342058	FBLN5	chr14	92406960	-	1838	381	357	1655	432
ENST00000340892	TC2N	chr14	92280047	-	ENST00000556154	FBLN5	chr14	92406960	-	1837	381	357	1655	432

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000340892	ENST00000267620	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-	0.00144743	0.9985525
ENST00000340892	ENST00000342058	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-	0.002078215	0.99792176
ENST00000340892	ENST00000556154	TC2N	chr14	92280047	-	FBLN5	chr14	92406960	-	0.002055017	0.997945

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Fusion Genomic Features for TC2N-FBLN5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TC2N-FBLN5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:92278656/chr14:92361416)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FBLN5 Q9UBX5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). {ECO:0000250\|UniProtKB:Q9WVH9, ECO:0000269\|PubMed:10428823, ECO:0000269\|PubMed:17255108, ECO:0000269\|PubMed:18185537}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

127_167

126

449.0

Domain

EGF-like 2%3B calcium-binding

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

168_206

126

449.0

Domain

EGF-like 3%3B calcium-binding

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

207_246

126

449.0

Domain

EGF-like 4%3B calcium-binding

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

247_287

126

449.0

Domain

EGF-like 5%3B calcium-binding

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

288_333

126

449.0

Domain

EGF-like 6%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

127_167

449.0

Domain

EGF-like 2%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

168_206

449.0

Domain

EGF-like 3%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

207_246

449.0

Domain

EGF-like 4%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

247_287

449.0

Domain

EGF-like 5%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

288_333

449.0

Domain

EGF-like 6%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

42_82

449.0

Domain

EGF-like 1%3B calcium-binding

Tgene

FBLN5

chr14:92280047

chr14:92406960

ENST00000342058

54_56

449.0

Motif

Cell attachment site

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000340892

223_342

100

491.0

Domain

C2 1

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000340892

344_471

100

491.0

Domain

C2 2

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000360594

223_342

100

491.0

Domain

C2 1

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000360594

344_471

100

491.0

Domain

C2 2

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000435962

223_342

100

491.0

Domain

C2 1

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000435962

344_471

100

491.0

Domain

C2 2

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000556018

223_342

100

427.0

Domain

C2 1

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000556018

344_471

100

427.0

Domain

C2 2

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000340892

223_342

491.0

Domain

C2 1

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000340892

344_471

491.0

Domain

C2 2

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000360594

223_342

491.0

Domain

C2 1

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000360594

344_471

491.0

Domain

C2 2

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000435962

223_342

491.0

Domain

C2 1

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000435962

344_471

491.0

Domain

C2 2

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000556018

223_342

427.0

Domain

C2 1

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000556018

344_471

427.0

Domain

C2 2

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000340892

447_449

100

491.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000360594

447_449

100

491.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000435962

447_449

100

491.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92278656

chr14:92361416

ENST00000556018

447_449

100

427.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000340892

447_449

491.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000360594

447_449

491.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000435962

447_449

491.0

Motif

Nuclear localization signal

Hgene

TC2N

chr14:92280047

chr14:92406960

ENST00000556018

447_449

427.0

Motif

Nuclear localization signal

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

42_82

126

449.0

Domain

EGF-like 1%3B calcium-binding

Tgene

FBLN5

chr14:92278656

chr14:92361416

ENST00000342058

54_56

126

449.0

Motif

Cell attachment site

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Fusion Gene Sequence for TC2N-FBLN5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89629_89629_1_TC2N-FBLN5_TC2N_chr14_92280047_ENST00000340892_FBLN5_chr14_92406960_ENST00000267620_length(transcript)=2562nt_BP=381nt
GGCCGCGCGAGGTGACCGGAGTCACAGTTCCCGCAGGCGGCGACAGCAGAGCGCCCACTGCCTCCAGCAGGTAACCGGCCGCGGCCGCGC
GGCGCCGGCCCAGCGCGGGCGTGGGACGTGGAGACCCGGAGGAGGGCGGCGGGACCCGGGCGGGGAAAGGCGCGGCGTGGCTTGGCTCAG
GTGCGCTTCTCCCACCTGGCAGCTCGCTCAGGGCTGTGGGGGGTGCCTGTGAGGGCGGCCCCGCCTTGCGGGCTGGAGATTAATATTAAG
ATTGGAAGTTTGTGTCTTTTGCTGGATATTGGAAATTGAATGTAATGGCAACAGAATTTATAAAGAGTTGCTGTGGAGGATGTTTCTATG
GTGAAACAGAAAAACACAACTGCACAGTGCACGAATGGCTTTGACCTGGATCGCCAGTCAGGACAGTGTTTAGATGGAGTTTCCCTCTCG
TCGCCTAGGCTGGAGTGCAATGGCGCAATCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAA
GTAGCTGGAATTACAGATATTGATGAATGCCGAACCATCCCCGAGGCCTGCCGAGGAGACATGATGTGTGTTAACCAAAATGGCGGGTAT
TTATGCATTCCCCGGACAAACCCTGTGTATCGAGGGCCCTACTCGAACCCCTACTCGACCCCCTACTCAGGTCCGTACCCAGCAGCTGCC
CCACCACTCTCAGCTCCAAACTATCCCACGATCTCCAGGCCTCTTATATGCCGCTTTGGATACCAGATGGATGAAAGCAACCAATGTGTG
GATGTGGACGAGTGTGCAACAGATTCCCACCAGTGCAACCCCACCCAGATCTGCATCAATACTGAAGGCGGGTACACCTGCTCCTGCACC
GACGGATATTGGCTTCTGGAAGGCCAGTGCTTAGACATTGATGAATGTCGCTATGGTTACTGCCAGCAGCTCTGTGCGAATGTTCCTGGA
TCCTATTCTTGTACATGCAACCCTGGTTTTACCCTCAATGAGGATGGAAGGTCTTGCCAAGATGTGAACGAGTGTGCCACCGAGAACCCC
TGCGTGCAAACCTGCGTCAACACCTACGGCTCTTTCATCTGCCGCTGTGACCCAGGATATGAACTTGAGGAAGATGGCGTTCATTGCAGT
GATATGGACGAGTGCAGCTTCTCTGAGTTCCTCTGCCAACATGAGTGTGTGAACCAGCCCGGCACATACTTCTGCTCCTGCCCTCCAGGC
TACATCCTGCTGGATGACAACCGAAGCTGCCAAGACATCAACGAATGTGAGCACAGGAACCACACGTGCAACCTGCAGCAGACGTGCTAC
AATTTACAAGGGGGCTTCAAATGCATTGACCCCATCCGCTGTGAGGAGCCTTATCTGAGGATCAGTGATAACCGCTGTATGTGTCCTGCT
GAGAACCCTGGCTGCAGAGACCAGCCCTTTACCATCTTGTACCGGGACATGGACGTGGTGTCAGGACGCTCCGTTCCCGCTGACATCTTC
CAAATGCAAGCCACGACCCGCTACCCTGGGGCCTATTACATTTTCCAGATCAAATCTGGGAATGAGGGCAGAGAATTTTACATGCGGCAA
ACGGGCCCCATCAGTGCCACCCTGGTGATGACACGCCCCATCAAAGGGCCCCGGGAAATCCAGCTGGACTTGGAAATGATCACTGTCAAC
ACTGTCATCAACTTCAGAGGCAGCTCCGTGATCCGACTGCGGATATATGTGTCGCAGTACCCATTCTGAGCCTCGGGCTGGAGCCTCCGA
CGCTGCCTCTCATTGGCACCAAGGGACAGGAGAAGAGAGGAAATAACAGAGAGAATGAGAGCGACACAGACGTTAGGCATTTCCTGCTGA
ACGTTTCCCCGAAGAGTCAGCCCCGACTTCCTGACTCTCACCTGTACTATTGCAGACCTGTCACCCTGCAGGACTTGCCACCCCCAGTTC
CTATGACACAGTTATCAAAAAGTATTATCATTGCTCCCCTGATAGAAGATTGTTGGTGAATTTTCAAGGCCTTCAGTTTATTTCCACTAT
TTTCAAAGAAAATAGATTAGGTTTGCGGGGGTCTGAGTCTATGTTCAAAGACTGTGAACAGCTTGCTGTCACTTCTTCACCTCTTCCACT
CCTTCTCTCACTGTGTTACTGCTTTGCAAAGACCCGGGAGCTGGCGGGGAACCCTGGGAGTAGCTAGTTTGCTTTTTGCGTACACAGAGA
AGGCTATGTAAACAAACCACAGCAGGATCGAAGGGTTTTTAGAGAATGTGTTTCAAAACCATGCCTGGTATTTTCAACCATAAAAGAAGT
TTCAGTTGTCCTTAAATTTGTATAACGGTTTAATTCTGTCTTGTTCATTTTGAGTATTTTTAAAAAATATGTCGTAGAATTCCTTCGAAA
GGCCTTCAGACACATGCTATGTTCTGTCTTCCCAAACCCAGTCTCCTCTCCATTTTAGCCCAGTGTTTTCTTTGAGGACCCCTTAATCTT

>89629_89629_1_TC2N-FBLN5_TC2N_chr14_92280047_ENST00000340892_FBLN5_chr14_92406960_ENST00000267620_length(amino acids)=473AA_BP=8
MVKQKNTTAQCTNGFDLDRQSGQCLDGVSLSSPRLECNGAISAHCNLCLPGSSDSSASASQVAGITDIDECRTIPEACRGDMMCVNQNGG
YLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSC
TDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHC
SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCP
AENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITV

--------------------------------------------------------------
>89629_89629_2_TC2N-FBLN5_TC2N_chr14_92280047_ENST00000340892_FBLN5_chr14_92406960_ENST00000342058_length(transcript)=1838nt_BP=381nt
GGCCGCGCGAGGTGACCGGAGTCACAGTTCCCGCAGGCGGCGACAGCAGAGCGCCCACTGCCTCCAGCAGGTAACCGGCCGCGGCCGCGC
GGCGCCGGCCCAGCGCGGGCGTGGGACGTGGAGACCCGGAGGAGGGCGGCGGGACCCGGGCGGGGAAAGGCGCGGCGTGGCTTGGCTCAG
GTGCGCTTCTCCCACCTGGCAGCTCGCTCAGGGCTGTGGGGGGTGCCTGTGAGGGCGGCCCCGCCTTGCGGGCTGGAGATTAATATTAAG
ATTGGAAGTTTGTGTCTTTTGCTGGATATTGGAAATTGAATGTAATGGCAACAGAATTTATAAAGAGTTGCTGTGGAGGATGTTTCTATG
GTGAAACAGAAAAACACAACTGCACAGTGCACGAATGGCTTTGACCTGGATCGCCAGTCAGGACAGTGTTTAGATATTGATGAATGCCGA
ACCATCCCCGAGGCCTGCCGAGGAGACATGATGTGTGTTAACCAAAATGGCGGGTATTTATGCATTCCCCGGACAAACCCTGTGTATCGA
GGGCCCTACTCGAACCCCTACTCGACCCCCTACTCAGGTCCGTACCCAGCAGCTGCCCCACCACTCTCAGCTCCAAACTATCCCACGATC
TCCAGGCCTCTTATATGCCGCTTTGGATACCAGATGGATGAAAGCAACCAATGTGTGGATGTGGACGAGTGTGCAACAGATTCCCACCAG
TGCAACCCCACCCAGATCTGCATCAATACTGAAGGCGGGTACACCTGCTCCTGCACCGACGGATATTGGCTTCTGGAAGGCCAGTGCTTA
GACATTGATGAATGTCGCTATGGTTACTGCCAGCAGCTCTGTGCGAATGTTCCTGGATCCTATTCTTGTACATGCAACCCTGGTTTTACC
CTCAATGAGGATGGAAGGTCTTGCCAAGATGTGAACGAGTGTGCCACCGAGAACCCCTGCGTGCAAACCTGCGTCAACACCTACGGCTCT
TTCATCTGCCGCTGTGACCCAGGATATGAACTTGAGGAAGATGGCGTTCATTGCAGTGATATGGACGAGTGCAGCTTCTCTGAGTTCCTC
TGCCAACATGAGTGTGTGAACCAGCCCGGCACATACTTCTGCTCCTGCCCTCCAGGCTACATCCTGCTGGATGACAACCGAAGCTGCCAA
GACATCAACGAATGTGAGCACAGGAACCACACGTGCAACCTGCAGCAGACGTGCTACAATTTACAAGGGGGCTTCAAATGCATTGACCCC
ATCCGCTGTGAGGAGCCTTATCTGAGGATCAGTGATAACCGCTGTATGTGTCCTGCTGAGAACCCTGGCTGCAGAGACCAGCCCTTTACC
ATCTTGTACCGGGACATGGACGTGGTGTCAGGACGCTCCGTTCCCGCTGACATCTTCCAAATGCAAGCCACGACCCGCTACCCTGGGGCC
TATTACATTTTCCAGATCAAATCTGGGAATGAGGGCAGAGAATTTTACATGCGGCAAACGGGCCCCATCAGTGCCACCCTGGTGATGACA
CGCCCCATCAAAGGGCCCCGGGAAATCCAGCTGGACTTGGAAATGATCACTGTCAACACTGTCATCAACTTCAGAGGCAGCTCCGTGATC
CGACTGCGGATATATGTGTCGCAGTACCCATTCTGAGCCTCGGGCTGGAGCCTCCGACGCTGCCTCTCATTGGCACCAAGGGACAGGAGA
AGAGAGGAAATAACAGAGAGAATGAGAGCGACACAGACGTTAGGCATTTCCTGCTGAACGTTTCCCCGAAGAGTCAGCCCCGACTTCCTG

>89629_89629_2_TC2N-FBLN5_TC2N_chr14_92280047_ENST00000340892_FBLN5_chr14_92406960_ENST00000342058_length(amino acids)=432AA_BP=8
MVKQKNTTAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPT
ISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGF
TLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSC
QDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPG

--------------------------------------------------------------
>89629_89629_3_TC2N-FBLN5_TC2N_chr14_92280047_ENST00000340892_FBLN5_chr14_92406960_ENST00000556154_length(transcript)=1837nt_BP=381nt
GGCCGCGCGAGGTGACCGGAGTCACAGTTCCCGCAGGCGGCGACAGCAGAGCGCCCACTGCCTCCAGCAGGTAACCGGCCGCGGCCGCGC
GGCGCCGGCCCAGCGCGGGCGTGGGACGTGGAGACCCGGAGGAGGGCGGCGGGACCCGGGCGGGGAAAGGCGCGGCGTGGCTTGGCTCAG
GTGCGCTTCTCCCACCTGGCAGCTCGCTCAGGGCTGTGGGGGGTGCCTGTGAGGGCGGCCCCGCCTTGCGGGCTGGAGATTAATATTAAG
ATTGGAAGTTTGTGTCTTTTGCTGGATATTGGAAATTGAATGTAATGGCAACAGAATTTATAAAGAGTTGCTGTGGAGGATGTTTCTATG
GTGAAACAGAAAAACACAACTGCACAGTGCACGAATGGCTTTGACCTGGATCGCCAGTCAGGACAGTGTTTAGATATTGATGAATGCCGA
ACCATCCCCGAGGCCTGCCGAGGAGACATGATGTGTGTTAACCAAAATGGCGGGTATTTATGCATTCCCCGGACAAACCCTGTGTATCGA
GGGCCCTACTCGAACCCCTACTCGACCCCCTACTCAGGTCCGTACCCAGCAGCTGCCCCACCACTCTCAGCTCCAAACTATCCCACGATC
TCCAGGCCTCTTATATGCCGCTTTGGATACCAGATGGATGAAAGCAACCAATGTGTGGATGTGGACGAGTGTGCAACAGATTCCCACCAG
TGCAACCCCACCCAGATCTGCATCAATACTGAAGGCGGGTACACCTGCTCCTGCACCGACGGATATTGGCTTCTGGAAGGCCAGTGCTTA
GACATTGATGAATGTCGCTATGGTTACTGCCAGCAGCTCTGTGCGAATGTTCCTGGATCCTATTCTTGTACATGCAACCCTGGTTTTACC
CTCAATGAGGATGGAAGGTCTTGCCAAGATGTGAACGAGTGTGCCACCGAGAACCCCTGCGTGCAAACCTGCGTCAACACCTACGGCTCT
TTCATCTGCCGCTGTGACCCAGGATATGAACTTGAGGAAGATGGCGTTCATTGCAGTGATATGGACGAGTGCAGCTTCTCTGAGTTCCTC
TGCCAACATGAGTGTGTGAACCAGCCCGGCACATACTTCTGCTCCTGCCCTCCAGGCTACATCCTGCTGGATGACAACCGAAGCTGCCAA
GACATCAACGAATGTGAGCACAGGAACCACACGTGCAACCTGCAGCAGACGTGCTACAATTTACAAGGGGGCTTCAAATGCATTGACCCC
ATCCGCTGTGAGGAGCCTTATCTGAGGATCAGTGATAACCGCTGTATGTGTCCTGCTGAGAACCCTGGCTGCAGAGACCAGCCCTTTACC
ATCTTGTACCGGGACATGGACGTGGTGTCAGGACGCTCCGTTCCCGCTGACATCTTCCAAATGCAAGCCACGACCCGCTACCCTGGGGCC
TATTACATTTTCCAGATCAAATCTGGGAATGAGGGCAGAGAATTTTACATGCGGCAAACGGGCCCCATCAGTGCCACCCTGGTGATGACA
CGCCCCATCAAAGGGCCCCGGGAAATCCAGCTGGACTTGGAAATGATCACTGTCAACACTGTCATCAACTTCAGAGGCAGCTCCGTGATC
CGACTGCGGATATATGTGTCGCAGTACCCATTCTGAGCCTCGGGCTGGAGCCTCCGACGCTGCCTCTCATTGGCACCAAGGGACAGGAGA
AGAGAGGAAATAACAGAGAGAATGAGAGCGACACAGACGTTAGGCATTTCCTGCTGAACGTTTCCCCGAAGAGTCAGCCCCGACTTCCTG

>89629_89629_3_TC2N-FBLN5_TC2N_chr14_92280047_ENST00000340892_FBLN5_chr14_92406960_ENST00000556154_length(amino acids)=432AA_BP=8
MVKQKNTTAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPT
ISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGF
TLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSC
QDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TC2N-FBLN5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TC2N-FBLN5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TC2N-FBLN5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source