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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TCEAL2-DLG2 (FusionGDB2 ID:89660)

Fusion Gene Summary for TCEAL2-DLG2

Fusion gene summary

Fusion gene information	Fusion gene name: TCEAL2-DLG2
	Fusion gene ID: 89660
		Hgene	Tgene
	Gene symbol	TCEAL2	DLG2
	Gene ID	140597	4355
	Gene name	transcription elongation factor A like 2	membrane palmitoylated protein 2
	Synonyms	MY0876G05\|WEX1\|my048	DLG2
	Cytomap	Xq22.1	17q21.31
	Type of gene	protein-coding	protein-coding
	Description	transcription elongation factor A protein-like 2TCEA-like protein 2transcription elongation factor A (SII)-like 2transcription elongation factor S-II protein-like 2	MAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
	Modification date	20200313	20200313
	UniProtAcc	.	Q15700
	Ensembl transtripts involved in fusion gene	ENST00000329035, ENST00000372780, ENST00000476749,	ENST00000280241, ENST00000330014, ENST00000376104, ENST00000376106, ENST00000398301, ENST00000398304, ENST00000398309, ENST00000404783, ENST00000418306, ENST00000426717, ENST00000472545, ENST00000524982, ENST00000530800, ENST00000531015, ENST00000532653, ENST00000537455, ENST00000543673,
Fusion gene scores	* DoF score	2 X 2 X 1=4	45 X 44 X 9=17820
	# samples	2	48
	** MAII score	log2(2/4*10)=2.32192809488736	log2(48/17820*10)=-5.21431912080077 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TCEAL2 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TCEAL2(101382471)-DLG2(84132425), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TCEAL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DLG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA757827	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+

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Fusion Gene ORF analysis for TCEAL2-DLG2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000329035	ENST00000280241	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000330014	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000376104	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000376106	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000398301	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000398304	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000398309	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000404783	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000418306	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000426717	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000472545	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000524982	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000530800	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000531015	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000532653	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000537455	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000543673	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000280241	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000330014	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000376104	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000376106	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000398301	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000398304	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000398309	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000404783	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000418306	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000426717	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000472545	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000524982	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000530800	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000531015	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000532653	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000537455	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000543673	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000280241	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000330014	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000376104	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000376106	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000398301	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000398304	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000398309	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000404783	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000418306	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000426717	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000472545	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000524982	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000530800	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000531015	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000532653	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000537455	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000543673	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for TCEAL2-DLG2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCEAL2-DLG2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:101382471/:84132425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DLG2 Q15700
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TCEAL2-DLG2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TCEAL2-DLG2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TCEAL2-DLG2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TCEAL2-DLG2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source