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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCEB1-STAU2 (FusionGDB2 ID:89679)

Fusion Gene Summary for TCEB1-STAU2

check button Fusion gene summary
Fusion gene informationFusion gene name: TCEB1-STAU2
Fusion gene ID: 89679
HgeneTgene
Gene symbol

TCEB1

STAU2

Gene ID

6921

27067

Gene nameelongin Cstaufen double-stranded RNA binding protein 2
SynonymsSIII|TCEB139K2|39K3
Cytomap

8q21.11

8q21.11

Type of geneprotein-codingprotein-coding
Descriptionelongin-CRNA polymerase II transcription factor SIII subunit CSIII p15elongin 15 kDa subunittranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)transcription elongation factor B polypeptide 1transcription elongation factor B sudouble-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000284811, ENST00000518127, 
ENST00000519487, ENST00000520242, 
ENST00000522337, ENST00000523815, 
ENST00000602840, ENST00000520210, 
ENST00000355780, ENST00000517542, 
ENST00000519961, ENST00000521210, 
ENST00000521451, ENST00000521727, 
ENST00000522509, ENST00000523558, 
ENST00000521419, ENST00000522962, 
ENST00000524104, ENST00000522695, 
ENST00000524300, 
Fusion gene scores* DoF score2 X 3 X 3=1821 X 18 X 11=4158
# samples 329
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/4158*10)=-3.84176495284344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCEB1 [Title/Abstract] AND STAU2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCEB1(74871999)-STAU2(74529686), # samples:1
TCEB1(74884312)-STAU2(74495065), # samples:1
Anticipated loss of major functional domain due to fusion event.TCEB1-STAU2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TCEB1-STAU2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TCEB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STAU2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA87TCEB1chr8

74871999

-STAU2chr8

74529686

-
ChimerDB4STADTCGA-FP-8211-01ATCEB1chr8

74884312

-STAU2chr8

74495065

-


Top

Fusion Gene ORF analysis for TCEB1-STAU2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000284811ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000284811ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000518127ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000519487ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000520242ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000522337ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000523815ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-5UTRENST00000602840ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000284811ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000284811ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000284811ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000518127ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000518127ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000518127ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000519487ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000519487ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000519487ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000520242ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000520242ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000520242ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000522337ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000522337ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000522337ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000523815ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000523815ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000523815ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000602840ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000602840ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
5CDS-intronENST00000602840ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
5UTR-3CDSENST00000520210ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520210ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000520242ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-3CDSENST00000522337ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000520210ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000520210ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000520210ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000520242ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000520242ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000520242ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000522337ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000522337ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
5UTR-intronENST00000522337ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
Frame-shiftENST00000284811ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000284811ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000518127ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000518127ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000520242ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000520242ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000522337ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000522337ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000523815ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000523815ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000602840ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
Frame-shiftENST00000602840ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
In-frameENST00000519487ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
In-frameENST00000519487ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-3CDSENST00000284811ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000284811ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000518127ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000519487ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000520210ENST00000522695TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-3CDSENST00000520210ENST00000524300TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-3CDSENST00000523815ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000523815ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000355780TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000517542TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000519961TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000521210TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000521451TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000521727TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000522509TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000522695TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000523558TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-3CDSENST00000602840ENST00000524300TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-5UTRENST00000520210ENST00000355780TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000517542TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000519961TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000521210TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000521451TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000521727TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000522509TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-5UTRENST00000520210ENST00000523558TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-intronENST00000284811ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000284811ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000284811ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000518127ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000518127ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000518127ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000519487ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000519487ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000519487ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000520210ENST00000521419TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-intronENST00000520210ENST00000522962TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-intronENST00000520210ENST00000524104TCEB1chr8

74871999

-STAU2chr8

74529686

-
intron-intronENST00000523815ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000523815ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000523815ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000602840ENST00000521419TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000602840ENST00000522962TCEB1chr8

74884312

-STAU2chr8

74495065

-
intron-intronENST00000602840ENST00000524104TCEB1chr8

74884312

-STAU2chr8

74495065

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000519487TCEB1chr874871999-ENST00000522695STAU2chr874529686-24191132191415398
ENST00000519487TCEB1chr874871999-ENST00000524300STAU2chr874529686-24171132191415398

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000519487ENST00000522695TCEB1chr874871999-STAU2chr874529686-0.0005106970.9994893
ENST00000519487ENST00000524300TCEB1chr874871999-STAU2chr874529686-0.0005048970.999495

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Fusion Genomic Features for TCEB1-STAU2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCEB1-STAU2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:74871999/chr8:74529686)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAU2chr8:74871999chr8:74529686ENST0000052410406207_2740106.0DomainDRBM 3
TgeneSTAU2chr8:74871999chr8:74529686ENST0000052410406307_3750106.0DomainDRBM 4
TgeneSTAU2chr8:74871999chr8:74529686ENST00000524104068_750106.0DomainDRBM 1
TgeneSTAU2chr8:74871999chr8:74529686ENST000005241040695_1810106.0DomainDRBM 2
TgeneSTAU2chr8:74871999chr8:74529686ENST0000052410406273_2910106.0MotifNuclear localization signal 1
TgeneSTAU2chr8:74871999chr8:74529686ENST0000052410406373_4120106.0MotifNuclear localization signal 2
TgeneSTAU2chr8:74871999chr8:74529686ENST0000052410406381_5700106.0RegionRequired for dendritic transport

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TCEB1-STAU2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89679_89679_1_TCEB1-STAU2_TCEB1_chr8_74871999_ENST00000519487_STAU2_chr8_74529686_ENST00000522695_length(transcript)=2419nt_BP=113nt
TAGCAGTTTACATGTGGATTTATTCATTCTGGAGATACAATGGCAAGGAAACAGCTGTGGAAACTACTAAAGTTCCTGGGGAAGCAAAGT
AGAATTTCATAAGAACAAAATGGGTATCATTGCCCAGTGCCTAAGATCTTTTATGTTCAGCTCACTGTAGGAAATAATGAATTTTTTGGG
GAAGGAAAGACTCGACAAGCTGCTAGACACAATGCTGCAATGAAAGCCCTCCAAGCACTGCAGAATGAACCTATTCCAGAAAGATCTCCT
CAGAATGGTGAATCAGGAAAGGATGTGGATGATGACAAAGATGCAAATAAGTCTGAGATCAGCTTAGTGTTTGAAATTGCTCTGAAGCGA
AATATGCCTGTCAGTTTTGAGGTTATTAAAGAAAGTGGACCACCACATATGAAAAGCTTTGTTACTCGAGTGTCAGTAGGAGAGTTCTCT
GCAGAAGGAGAAGGAAATAGCAAAAAACTCTCCAAGAAGCGCGCTGCGACCACCGTCTTACAGGAGCTTAAAAAACTTCCACCTCTTCCT
GTGGTGGAAAAGCCAAAACTATTTTTTAAAAAACGCCCTAAAACAATAGTAAAGGCCGGACCAGAATATGGCCAAGGGATGAACCCTATT
AGCCGCCTGGCGCAAATTCAACAGGCCAAAAAGGAAAAGGAGCCGGATTATGTTTTGCTTTCAGAAAGAGGAATGCCTCGACGTCGAGAA
TTTGTGATGCAGGTGAAGGTAGGCAATGAAGTTGCTACAGGAACAGGACCTAATAAAAAGATAGCCAAAAAAAATGCTGCAGAAGCAATG
CTGTTACAACTTGGTTATAAAGCATCCACTAATCTTCAGGATCAACTTGAGAAGACAGGGGAAAACAAAGGATGGAGTGGTCCAAAGCCT
GGGTTTCCTGAACCAACAAATAATACTCCAAAAGGAATTCTTCATTTGTCTCCTGATGTTTATCAAGAGATGGAAGCCAGCCGCCACAAA
GTAATCTCTGGCACTACTCTAGGCTATTTGTCACCCAAAGATATGAACCAACCTTCAAGCTCTTTCTTCAGTATATCTCCCACATCGAAT
AGTTCAGCTACAATTGCCAGGGAACTCCTTATGAATGGAACATCTTCTACAGCTGAAGCCATAGGTTTAAAAGGAAGTTCTCCTACTCCC
CCTTGTTCTCCAGTACAACCTTCAAAACAACTGGAATATTTAGCAAGGATTCAAGGCTTTCAGGCAGCCTTAAGTGCCTTGAAACAATTT
TCTGAACAAGGACTGGATCCAATCGATGGAGCAATGAATATCGAAAAAGGTTCTCTTGAAAAACAAGCCAAGCATCTGAGAGAGAAAGCG
GACAATAACCAGGCACCCCCGGGCTCCATCGCTCAGGACTGCAAGAAATCAAACTCGGCCGTCTAGCAGCTCCCAGAACCCGCGGCTGCC
ACCGCATCCTTATAAACCTGTCAGCACGCATGAGGGTGTCTGTGTTCAGGGAAATGAATGACTAATACCATTATTTGAGTCTTATGTGAA
GACAACACTATTCTAACACGAGAGATAATATACATGGTACTGTTTATTCAACTGGGGAAAAATAAAACTTTGAGCATTTCCCTTGGAACT
CGAGATCAGATCATAACTCATTTGCCTAGAGGCAGCAGAAATCTGATCCTGCTACTGGAGCTTAAAATAACAAGTAAAGAAAAGTGTTAG
AAACAAAGCTAAAATTTTAACATGATTAATAATAGAGAAGTTGGGTTTGGTTCTGTTGTTATGATTGTTTTGTCGTGGTGCTTGTGTTCA
GTTATATTCTCTCTCTCTCTCATTTCAAATACTGCTTGACAATTCGAAAATGAACCAATGATGTGCTGTGGAATGTGATGGTTGTCTTCA
TATAGAGTCACATGGTTTCTCTTTTTATGCAGATATTTATAATCTTCATCCTATATCAGTAGGAATAACTATAAGGTGCACTACAAAAAG
ATGTATGCAAACAAACATGTTTTAAATCAGGTCAGATATCTGATGAAAAATACGAACTAATGTTAAGAGCAAGTAGTTTCAACATACTCC
AGGAACTGAGAAACAAAACAAAGCAATTGTGGGTTTTGAGCTCCATATACTCTTAGCAAGTAAGGGGGCGTCTTGCCCCTATATATCATC
TTCCCGGATTCCACTCCCTGTTGTGGGAATCGCGCCCACCCCCATCCGTGTGTTGTAGCCACTCACGGTTTGCATCAAGAGTGTTTTTTG
TAACTGCCTCTGGACTTGGGACAGTGAGTAGGATCAAAAATAAATAATGTACATGACGGGGAAGGGAAAAACCTGTTGGAGTTGCTTCCA

>89679_89679_1_TCEB1-STAU2_TCEB1_chr8_74871999_ENST00000519487_STAU2_chr8_74529686_ENST00000522695_length(amino acids)=398AA_BP=
MKALQALQNEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKK
RAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVAT
GTGPNKKIAKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPK
DMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAIGLKGSSPTPPCSPVQPSKQLEYLARIQGFQAALSALKQFSEQGLDPIDGAMN

--------------------------------------------------------------
>89679_89679_2_TCEB1-STAU2_TCEB1_chr8_74871999_ENST00000519487_STAU2_chr8_74529686_ENST00000524300_length(transcript)=2417nt_BP=113nt
TAGCAGTTTACATGTGGATTTATTCATTCTGGAGATACAATGGCAAGGAAACAGCTGTGGAAACTACTAAAGTTCCTGGGGAAGCAAAGT
AGAATTTCATAAGAACAAAATGGGTATCATTGCCCAGTGCCTAAGATCTTTTATGTTCAGCTCACTGTAGGAAATAATGAATTTTTTGGG
GAAGGAAAGACTCGACAAGCTGCTAGACACAATGCTGCAATGAAAGCCCTCCAAGCACTGCAGAATGAACCTATTCCAGAAAGATCTCCT
CAGAATGGTGAATCAGGAAAGGATGTGGATGATGACAAAGATGCAAATAAGTCTGAGATCAGCTTAGTGTTTGAAATTGCTCTGAAGCGA
AATATGCCTGTCAGTTTTGAGGTTATTAAAGAAAGTGGACCACCACATATGAAAAGCTTTGTTACTCGAGTGTCAGTAGGAGAGTTCTCT
GCAGAAGGAGAAGGAAATAGCAAAAAACTCTCCAAGAAGCGCGCTGCGACCACCGTCTTACAGGAGCTTAAAAAACTTCCACCTCTTCCT
GTGGTGGAAAAGCCAAAACTATTTTTTAAAAAACGCCCTAAAACAATAGTAAAGGCCGGACCAGAATATGGCCAAGGGATGAACCCTATT
AGCCGCCTGGCGCAAATTCAACAGGCCAAAAAGGAAAAGGAGCCGGATTATGTTTTGCTTTCAGAAAGAGGAATGCCTCGACGTCGAGAA
TTTGTGATGCAGGTGAAGGTAGGCAATGAAGTTGCTACAGGAACAGGACCTAATAAAAAGATAGCCAAAAAAAATGCTGCAGAAGCAATG
CTGTTACAACTTGGTTATAAAGCATCCACTAATCTTCAGGATCAACTTGAGAAGACAGGGGAAAACAAAGGATGGAGTGGTCCAAAGCCT
GGGTTTCCTGAACCAACAAATAATACTCCAAAAGGAATTCTTCATTTGTCTCCTGATGTTTATCAAGAGATGGAAGCCAGCCGCCACAAA
GTAATCTCTGGCACTACTCTAGGCTATTTGTCACCCAAAGATATGAACCAACCTTCAAGCTCTTTCTTCAGTATATCTCCCACATCGAAT
AGTTCAGCTACAATTGCCAGGGAACTCCTTATGAATGGAACATCTTCTACAGCTGAAGCCATAGGTTTAAAAGGAAGTTCTCCTACTCCC
CCTTGTTCTCCAGTACAACCTTCAAAACAACTGGAATATTTAGCAAGGATTCAAGGCTTTCAGGCAGCCTTAAGTGCCTTGAAACAATTT
TCTGAACAAGGACTGGATCCAATCGATGGAGCAATGAATATCGAAAAAGGTTCTCTTGAAAAACAAGCCAAGCATCTGAGAGAGAAAGCG
GACAATAACCAGGCACCCCCGGGCTCCATCGCTCAGGACTGCAAGAAATCAAACTCGGCCGTCTAGCAGCTCCCAGAACCCGCGGCTGCC
ACCGCATCCTTATAAACCTGTCAGCACGCATGAGGGTGTCTGTGTTCAGGGAAATGAATGACTAATACCATTATTTGAGTCTTATGTGAA
GACAACACTATTCTAACACGAGAGATAATATACATGGTACTGTTTATTCAACTGGGGAAAAATAAAACTTTGAGCATTTCCCTTGGAACT
CGAGATCAGATCATAACTCATTTGCCTAGAGGCAGCAGAAATCTGATCCTGCTACTGGAGCTTAAAATAACAAGTAAAGAAAAGTGTTAG
AAACAAAGCTAAAATTTTAACATGATTAATAATAGAGAAGTTGGGTTTGGTTCTGTTGTTATGATTGTTTTGTCGTGGTGCTTGTGTTCA
GTTATATTCTCTCTCTCTCTCATTTCAAATACTGCTTGACAATTCGAAAATGAACCAATGATGTGCTGTGGAATGTGATGGTTGTCTTCA
TATAGAGTCACATGGTTTCTCTTTTTATGCAGATATTTATAATCTTCATCCTATATCAGTAGGAATAACTATAAGGTGCACTACAAAAAG
ATGTATGCAAACAAACATGTTTTAAATCAGGTCAGATATCTGATGAAAAATACGAACTAATGTTAAGAGCAAGTAGTTTCAACATACTCC
AGGAACTGAGAAACAAAACAAAGCAATTGTGGGTTTTGAGCTCCATATACTCTTAGCAAGTAAGGGGGCGTCTTGCCCCTATATATCATC
TTCCCGGATTCCACTCCCTGTTGTGGGAATCGCGCCCACCCCCATCCGTGTGTTGTAGCCACTCACGGTTTGCATCAAGAGTGTTTTTTG
TAACTGCCTCTGGACTTGGGACAGTGAGTAGGATCAAAAATAAATAATGTACATGACGGGGAAGGGAAAAACCTGTTGGAGTTGCTTCCA

>89679_89679_2_TCEB1-STAU2_TCEB1_chr8_74871999_ENST00000519487_STAU2_chr8_74529686_ENST00000524300_length(amino acids)=398AA_BP=
MKALQALQNEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKK
RAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVAT
GTGPNKKIAKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPK
DMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAIGLKGSSPTPPCSPVQPSKQLEYLARIQGFQAALSALKQFSEQGLDPIDGAMN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TCEB1-STAU2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCEB1-STAU2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCEB1-STAU2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource