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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCEB2-DIP2A (FusionGDB2 ID:89682)

Fusion Gene Summary for TCEB2-DIP2A

check button Fusion gene summary
Fusion gene informationFusion gene name: TCEB2-DIP2A
Fusion gene ID: 89682
HgeneTgene
Gene symbol

TCEB2

DIP2A

Gene ID

6923

23181

Gene nameelongin Bdisco interacting protein 2 homolog A
SynonymsSIII|TCEB2C21orf106|DIP2
Cytomap

16p13.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionelongin-BRNA polymerase II transcription factor SIII p18 subunitRNA polymerase II transcription factor SIII subunit BSIII p18elongin 18 kDa subunitelongin, 18-kD subunitepididymis secretory sperm binding proteintranscription elongation factor B (SIdisco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2A
Modification date2020031320200313
UniProtAcc.

Q14689

Ensembl transtripts involved in fusion geneENST00000262306, ENST00000409477, 
ENST00000409906, ENST00000572954, 
ENST00000479654, ENST00000318711, 
ENST00000417564, ENST00000427143, 
ENST00000435722, ENST00000457905, 
ENST00000466639, ENST00000400274, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 7 X 4=168
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCEB2 [Title/Abstract] AND DIP2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCEB2(2826994)-DIP2A(47983771), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDIP2A

GO:0010629

negative regulation of gene expression

20860622


check buttonFusion gene breakpoints across TCEB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DIP2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01ATCEB2chr16

2826994

-DIP2Achr21

47983771

+


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Fusion Gene ORF analysis for TCEB2-DIP2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262306ENST00000479654TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-3UTRENST00000409477ENST00000479654TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-3UTRENST00000409906ENST00000479654TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-3UTRENST00000572954ENST00000479654TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000262306ENST00000318711TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000262306ENST00000417564TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000262306ENST00000427143TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000262306ENST00000435722TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000262306ENST00000457905TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000262306ENST00000466639TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409477ENST00000318711TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409477ENST00000417564TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409477ENST00000427143TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409477ENST00000435722TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409477ENST00000457905TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409477ENST00000466639TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409906ENST00000318711TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409906ENST00000417564TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409906ENST00000427143TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409906ENST00000435722TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409906ENST00000457905TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000409906ENST00000466639TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000572954ENST00000318711TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000572954ENST00000417564TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000572954ENST00000427143TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000572954ENST00000435722TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000572954ENST00000457905TCEB2chr16

2826994

-DIP2Achr21

47983771

+
5CDS-intronENST00000572954ENST00000466639TCEB2chr16

2826994

-DIP2Achr21

47983771

+
In-frameENST00000262306ENST00000400274TCEB2chr16

2826994

-DIP2Achr21

47983771

+
In-frameENST00000409477ENST00000400274TCEB2chr16

2826994

-DIP2Achr21

47983771

+
In-frameENST00000409906ENST00000400274TCEB2chr16

2826994

-DIP2Achr21

47983771

+
In-frameENST00000572954ENST00000400274TCEB2chr16

2826994

-DIP2Achr21

47983771

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262306TCEB2chr162826994-ENST00000400274DIP2Achr2147983771+288917638802254
ENST00000409906TCEB2chr162826994-ENST00000400274DIP2Achr2147983771+290919658822254
ENST00000409477TCEB2chr162826994-ENST00000400274DIP2Achr2147983771+291620314829271
ENST00000572954TCEB2chr162826994-ENST00000400274DIP2Achr2147983771+288417133797254

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262306ENST00000400274TCEB2chr162826994-DIP2Achr2147983771+0.0008474330.99915254
ENST00000409906ENST00000400274TCEB2chr162826994-DIP2Achr2147983771+0.0008959330.9991041
ENST00000409477ENST00000400274TCEB2chr162826994-DIP2Achr2147983771+0.0031142370.9968857
ENST00000572954ENST00000400274TCEB2chr162826994-DIP2Achr2147983771+0.0009531870.99904674

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Fusion Genomic Features for TCEB2-DIP2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TCEB2chr162826993-DIP2Achr2147983770+0.0001446830.9998553
TCEB2chr162826993-DIP2Achr2147983770+0.0001446830.9998553

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TCEB2-DIP2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:2826994/chr21:47983771)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DIP2A

Q14689

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDIP2Achr16:2826994chr21:47983771ENST0000040027433381498_150113591568.0Compositional biasNote=Poly-Val
TgeneDIP2Achr16:2826994chr21:47983771ENST0000041756433381498_150113631572.0Compositional biasNote=Poly-Val
TgeneDIP2Achr16:2826994chr21:47983771ENST000004271430281114_111701111.0Compositional biasNote=Poly-Ala
TgeneDIP2Achr16:2826994chr21:47983771ENST000004271430281498_150101111.0Compositional biasNote=Poly-Val
TgeneDIP2Achr16:2826994chr21:47983771ENST000004357220211114_11170842.0Compositional biasNote=Poly-Ala
TgeneDIP2Achr16:2826994chr21:47983771ENST000004357220211498_15010842.0Compositional biasNote=Poly-Val
TgeneDIP2Achr16:2826994chr21:47983771ENST000004579050221114_11170890.0Compositional biasNote=Poly-Ala
TgeneDIP2Achr16:2826994chr21:47983771ENST000004579050221498_15010890.0Compositional biasNote=Poly-Val
TgeneDIP2Achr16:2826994chr21:47983771ENST000004666390201114_11170799.0Compositional biasNote=Poly-Ala
TgeneDIP2Achr16:2826994chr21:47983771ENST000004666390201498_15010799.0Compositional biasNote=Poly-Val
TgeneDIP2Achr16:2826994chr21:47983771ENST000004271430289_12701111.0DomainDMAP1-binding
TgeneDIP2Achr16:2826994chr21:47983771ENST000004357220219_1270842.0DomainDMAP1-binding
TgeneDIP2Achr16:2826994chr21:47983771ENST000004579050229_1270890.0DomainDMAP1-binding
TgeneDIP2Achr16:2826994chr21:47983771ENST000004666390209_1270799.0DomainDMAP1-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCEB2chr16:2826994chr21:47983771ENST00000262306-251_6646162.0DomainUbiquitin-like
HgeneTCEB2chr16:2826994chr21:47983771ENST00000409906-241_6646119.0DomainUbiquitin-like
TgeneDIP2Achr16:2826994chr21:47983771ENST0000040027433381114_111713591568.0Compositional biasNote=Poly-Ala
TgeneDIP2Achr16:2826994chr21:47983771ENST0000041756433381114_111713631572.0Compositional biasNote=Poly-Ala
TgeneDIP2Achr16:2826994chr21:47983771ENST0000040027433389_12713591568.0DomainDMAP1-binding
TgeneDIP2Achr16:2826994chr21:47983771ENST0000041756433389_12713631572.0DomainDMAP1-binding


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Fusion Gene Sequence for TCEB2-DIP2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89682_89682_1_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000262306_DIP2A_chr21_47983771_ENST00000400274_length(transcript)=2889nt_BP=176nt
GCTGCGCCGGCGCGTCGAGGGGAGAGGCAGCAGCCGCGATGGACGTGTTCCTCATGATCCGGCGCCACAAGACCACCATCTTCACGGACG
CCAAGGAGTCCAGCACGGTGTTCGAACTGAAGCGCATCGTCGAGGGCATCCTCAAGCGGCCTCCTGACGAGCAGCGGCTGTACAAGATCC
TCCCCGGCGTGAAGGTCATCATCGCACACACCGAGACCAAAGGACCCTTGGGAGACTCACACCTGGGAGAGATCTGGGTAAGCAGCCCCC
ACAATGCCACCGGGTACTACACCGTTTACGGGGAGGAGGCGCTTCATGCCGACCACTTCAGTGCCCGGCTGAGTTTTGGAGACACACAGA
CCATCTGGGCAAGGACCGGCTACCTTGGCTTCCTTCGGCGAACAGAGCTCACTGATGCCAGTGGAGGGCGGCACGATGCACTGTATGTGG
TTGGGTCTCTGGATGAAACTCTGGAGCTCAGAGGCATGCGGTACCACCCCATCGACATTGAGACCTCTGTCATCCGAGCACACAGGAGCA
TCGCTGAGTGTGCCGTATTCACCTGGACCAACCTGCTGGTGGTGGTGGTGGAGCTGGATGGGCTAGAGCAGGATGCCCTGGACCTGGTGG
CCCTGGTGACCAACGTGGTGCTGGAGGAGCACTACCTGGTCGTGGGAGTGGTGGTCATCGTGGACCCAGGGGTGATCCCTATCAACTCTC
GGGGTGAGAAGCAGCGCATGCACCTGCGGGACGGCTTCCTGGCTGACCAGCTGGACCCCATCTATGTCGCCTACAACATGTGAGCGCAGC
ACACCGGCCCAGGTGCCGGAGATGAATGAGCCCCAGCAGTCCAAGGTGTGATGTGGGAAGACACCGCAGAGCTCACTCACCGGGACTCGC
CCTTCCTGTGCTCTTACAGATCCCTCTCAACAATCCCCGCATCTCCTTTTAGAAAGCACTTCCTGAATTATTTAAAGAAATATTTTGAAT
CTGCCAAGTACATTTACAAAAACACGGATGCTGGTATTTTAACAGATGGAGAGACAAGGAAAGGAAAGGAAAGGCCTGGCATGGGCATTG
TGAGGAATCACAGGCACCGAGGTTGTTCTCTGCTGTACTGCAAGTTTGCACTTTCTTTAGGCTAAAAATATAGTTCCTGATTTTTAAAAT
TCAGTTATTTATTCCCACTTCAAATGACAAGTTCATATATAGAATTTACGGGAGAAACTTGAGACCATTTACGGGGAGAAACTTGATTCT
GGGAAGATAGCAGAGTACAAACCAGCTGCCTCACTTCTGTTTCACAGGGAGGCTGATGGAAAAAGGAAGCAAGCTGGACCCATCCTCCCT
GCTCACAGAGGGCACTGTGGTCACACACAGTGCCTCCTCTGCCAGTTCCTTTATTGAAAGAGGTGTGCTGGCTGGCCACGGTGGCTTACA
CCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGCAGATCACGAGGTCAGGAGACCGAGACCATCCTGGCTAACATGGTGAAACCCTGT
CTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTATG
AACCAGGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCTACTGCACTCCAGCCTGGGTGACAGCACGAGATGCCGTCTTAAAAAAACAA
AAAAGAGGTGTGCTGCTTGTCAGCATGTATTGTCACGGACACTCAATAAGTGCCATTTTGGACTGTCAAATTTAGATGCTTTGTTTCAGA
AAGATAAGCCAGCATTTAGTTTTAAATCACTTTCCTGGTTTGTAACTTGATGCTGTTTAGTTAAATTGCTAGTTTTCCTAACACTACAAT
ATTAATTCTTCTCGTGGAAGTGTACTGATTTATTATTTTTATTCCAAGTCAGCAGATTTGGAAGCATTGTGGTAAAGTCTAAGGTTTTCA
TATCCATAGTGCTGTTTGGTGAGTACCGGCAGTACAGTTGAGGGGAGCAGGGAACAGCATTGCCCCGTATTGAAGGTGGAGATGGTTACA
TTCTTCACTGCTTTTTGCATTTTGAGTTGTGTGCCTATAAAATTTGGCCAAACCATTTTATTATTTTGTTCAAACTTGACTAAGCTGAGT
GATCTAAAATTATACAGAACCTAAATCAAAGAAGAGAATGTAAAGTCCTTTAGTTACTTCTAAGAATTTGAAGTCAAGCACGAATCTAAG
ACATAGATTATTTTTATATAGCTAATGAAGAGTATGTTACGAAATTGTTGGGTTTTTGGGGTATTGAGGGTGGCAAATTTTGTGAATCAT
GCATGCTTCACAGAAACAACCAGGTTTTTCCAGAATTAGTCTGGATCAGTGCCTAACAAAGCTGTTATTAATTCTCCACACATGAGTCTG
GCTAACTGGGCCAGCTCTCATGTTTTACTCCTGTCTGGCTACAAATAGCACTGTGCATAGTAGCCCTGTTTCCCCATGGTGTTGGACTGT
GGTAAAGTATGTTGTGACATACTGGAATTCTAATAATCCTGTTGTAAGTATGTACAGAATCTATGTAACTTATTGTTGACATACAGAGGT
TTGGGAAGTAGTCTAATGGACATTCCTTACAATAGAATGGCTGGGAAGGGAAAGAAAAAAAAAAAAAAACTACCTAACTCCAATCTTAAT
GTTGTAGTTTTATAGCAAACAAAAATTGTCAGCTTTTTGTATTGAAAGGTCAGTGGTGGTAAGACAAGGTGTCTTGTAAATTAAGATTTT
AAGAAGTGCATTAAAATGTTTTAGAATTACTCTGGGAATTCTGTATATCACACTAAAATTTTTATATCATTATGTTAATAAAAGTTATTG

>89682_89682_1_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000262306_DIP2A_chr21_47983771_ENST00000400274_length(amino acids)=254AA_BP=46
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEE
ALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLL

--------------------------------------------------------------
>89682_89682_2_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000409477_DIP2A_chr21_47983771_ENST00000400274_length(transcript)=2916nt_BP=203nt
GCGGCGGGGGGCGGCTGGGCCGCGCGGGGGGCCCGGGCTTCGTGCTCACGCCGGCCCGCCGCCCCCAGGACGTGTTCCTCATGATCCGGC
GCCACAAGACCACCATCTTCACGGACGCCAAGGAGTCCAGCACGGTGTTCGAACTGAAGCGCATCGTCGAGGGCATCCTCAAGCGGCCTC
CTGACGAGCAGCGGCTGTACAAGATCCTCCCCGGCGTGAAGGTCATCATCGCACACACCGAGACCAAAGGACCCTTGGGAGACTCACACC
TGGGAGAGATCTGGGTAAGCAGCCCCCACAATGCCACCGGGTACTACACCGTTTACGGGGAGGAGGCGCTTCATGCCGACCACTTCAGTG
CCCGGCTGAGTTTTGGAGACACACAGACCATCTGGGCAAGGACCGGCTACCTTGGCTTCCTTCGGCGAACAGAGCTCACTGATGCCAGTG
GAGGGCGGCACGATGCACTGTATGTGGTTGGGTCTCTGGATGAAACTCTGGAGCTCAGAGGCATGCGGTACCACCCCATCGACATTGAGA
CCTCTGTCATCCGAGCACACAGGAGCATCGCTGAGTGTGCCGTATTCACCTGGACCAACCTGCTGGTGGTGGTGGTGGAGCTGGATGGGC
TAGAGCAGGATGCCCTGGACCTGGTGGCCCTGGTGACCAACGTGGTGCTGGAGGAGCACTACCTGGTCGTGGGAGTGGTGGTCATCGTGG
ACCCAGGGGTGATCCCTATCAACTCTCGGGGTGAGAAGCAGCGCATGCACCTGCGGGACGGCTTCCTGGCTGACCAGCTGGACCCCATCT
ATGTCGCCTACAACATGTGAGCGCAGCACACCGGCCCAGGTGCCGGAGATGAATGAGCCCCAGCAGTCCAAGGTGTGATGTGGGAAGACA
CCGCAGAGCTCACTCACCGGGACTCGCCCTTCCTGTGCTCTTACAGATCCCTCTCAACAATCCCCGCATCTCCTTTTAGAAAGCACTTCC
TGAATTATTTAAAGAAATATTTTGAATCTGCCAAGTACATTTACAAAAACACGGATGCTGGTATTTTAACAGATGGAGAGACAAGGAAAG
GAAAGGAAAGGCCTGGCATGGGCATTGTGAGGAATCACAGGCACCGAGGTTGTTCTCTGCTGTACTGCAAGTTTGCACTTTCTTTAGGCT
AAAAATATAGTTCCTGATTTTTAAAATTCAGTTATTTATTCCCACTTCAAATGACAAGTTCATATATAGAATTTACGGGAGAAACTTGAG
ACCATTTACGGGGAGAAACTTGATTCTGGGAAGATAGCAGAGTACAAACCAGCTGCCTCACTTCTGTTTCACAGGGAGGCTGATGGAAAA
AGGAAGCAAGCTGGACCCATCCTCCCTGCTCACAGAGGGCACTGTGGTCACACACAGTGCCTCCTCTGCCAGTTCCTTTATTGAAAGAGG
TGTGCTGGCTGGCCACGGTGGCTTACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGCAGATCACGAGGTCAGGAGACCGAGACC
ATCCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATGGTATGAACCAGGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCTACTGCACTCCAGCCTGGGTGACA
GCACGAGATGCCGTCTTAAAAAAACAAAAAAGAGGTGTGCTGCTTGTCAGCATGTATTGTCACGGACACTCAATAAGTGCCATTTTGGAC
TGTCAAATTTAGATGCTTTGTTTCAGAAAGATAAGCCAGCATTTAGTTTTAAATCACTTTCCTGGTTTGTAACTTGATGCTGTTTAGTTA
AATTGCTAGTTTTCCTAACACTACAATATTAATTCTTCTCGTGGAAGTGTACTGATTTATTATTTTTATTCCAAGTCAGCAGATTTGGAA
GCATTGTGGTAAAGTCTAAGGTTTTCATATCCATAGTGCTGTTTGGTGAGTACCGGCAGTACAGTTGAGGGGAGCAGGGAACAGCATTGC
CCCGTATTGAAGGTGGAGATGGTTACATTCTTCACTGCTTTTTGCATTTTGAGTTGTGTGCCTATAAAATTTGGCCAAACCATTTTATTA
TTTTGTTCAAACTTGACTAAGCTGAGTGATCTAAAATTATACAGAACCTAAATCAAAGAAGAGAATGTAAAGTCCTTTAGTTACTTCTAA
GAATTTGAAGTCAAGCACGAATCTAAGACATAGATTATTTTTATATAGCTAATGAAGAGTATGTTACGAAATTGTTGGGTTTTTGGGGTA
TTGAGGGTGGCAAATTTTGTGAATCATGCATGCTTCACAGAAACAACCAGGTTTTTCCAGAATTAGTCTGGATCAGTGCCTAACAAAGCT
GTTATTAATTCTCCACACATGAGTCTGGCTAACTGGGCCAGCTCTCATGTTTTACTCCTGTCTGGCTACAAATAGCACTGTGCATAGTAG
CCCTGTTTCCCCATGGTGTTGGACTGTGGTAAAGTATGTTGTGACATACTGGAATTCTAATAATCCTGTTGTAAGTATGTACAGAATCTA
TGTAACTTATTGTTGACATACAGAGGTTTGGGAAGTAGTCTAATGGACATTCCTTACAATAGAATGGCTGGGAAGGGAAAGAAAAAAAAA
AAAAAACTACCTAACTCCAATCTTAATGTTGTAGTTTTATAGCAAACAAAAATTGTCAGCTTTTTGTATTGAAAGGTCAGTGGTGGTAAG
ACAAGGTGTCTTGTAAATTAAGATTTTAAGAAGTGCATTAAAATGTTTTAGAATTACTCTGGGAATTCTGTATATCACACTAAAATTTTT

>89682_89682_2_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000409477_DIP2A_chr21_47983771_ENST00000400274_length(amino acids)=271AA_BP=63
MGRAGGPGFVLTPARRPQDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKILPGVKVIIAHTETKGPLGDSHLGEIW
VSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIR
AHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYN

--------------------------------------------------------------
>89682_89682_3_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000409906_DIP2A_chr21_47983771_ENST00000400274_length(transcript)=2909nt_BP=196nt
CGGGAACGGGGCGGAGCGCGGCTGCGCCGGCGCGTCGAGGGGAGAGGCAGCAGCCGCGATGGACGTGTTCCTCATGATCCGGCGCCACAA
GACCACCATCTTCACGGACGCCAAGGAGTCCAGCACGGTGTTCGAACTGAAGCGCATCGTCGAGGGCATCCTCAAGCGGCCTCCTGACGA
GCAGCGGCTGTACAAGATCCTCCCCGGCGTGAAGGTCATCATCGCACACACCGAGACCAAAGGACCCTTGGGAGACTCACACCTGGGAGA
GATCTGGGTAAGCAGCCCCCACAATGCCACCGGGTACTACACCGTTTACGGGGAGGAGGCGCTTCATGCCGACCACTTCAGTGCCCGGCT
GAGTTTTGGAGACACACAGACCATCTGGGCAAGGACCGGCTACCTTGGCTTCCTTCGGCGAACAGAGCTCACTGATGCCAGTGGAGGGCG
GCACGATGCACTGTATGTGGTTGGGTCTCTGGATGAAACTCTGGAGCTCAGAGGCATGCGGTACCACCCCATCGACATTGAGACCTCTGT
CATCCGAGCACACAGGAGCATCGCTGAGTGTGCCGTATTCACCTGGACCAACCTGCTGGTGGTGGTGGTGGAGCTGGATGGGCTAGAGCA
GGATGCCCTGGACCTGGTGGCCCTGGTGACCAACGTGGTGCTGGAGGAGCACTACCTGGTCGTGGGAGTGGTGGTCATCGTGGACCCAGG
GGTGATCCCTATCAACTCTCGGGGTGAGAAGCAGCGCATGCACCTGCGGGACGGCTTCCTGGCTGACCAGCTGGACCCCATCTATGTCGC
CTACAACATGTGAGCGCAGCACACCGGCCCAGGTGCCGGAGATGAATGAGCCCCAGCAGTCCAAGGTGTGATGTGGGAAGACACCGCAGA
GCTCACTCACCGGGACTCGCCCTTCCTGTGCTCTTACAGATCCCTCTCAACAATCCCCGCATCTCCTTTTAGAAAGCACTTCCTGAATTA
TTTAAAGAAATATTTTGAATCTGCCAAGTACATTTACAAAAACACGGATGCTGGTATTTTAACAGATGGAGAGACAAGGAAAGGAAAGGA
AAGGCCTGGCATGGGCATTGTGAGGAATCACAGGCACCGAGGTTGTTCTCTGCTGTACTGCAAGTTTGCACTTTCTTTAGGCTAAAAATA
TAGTTCCTGATTTTTAAAATTCAGTTATTTATTCCCACTTCAAATGACAAGTTCATATATAGAATTTACGGGAGAAACTTGAGACCATTT
ACGGGGAGAAACTTGATTCTGGGAAGATAGCAGAGTACAAACCAGCTGCCTCACTTCTGTTTCACAGGGAGGCTGATGGAAAAAGGAAGC
AAGCTGGACCCATCCTCCCTGCTCACAGAGGGCACTGTGGTCACACACAGTGCCTCCTCTGCCAGTTCCTTTATTGAAAGAGGTGTGCTG
GCTGGCCACGGTGGCTTACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGCAGATCACGAGGTCAGGAGACCGAGACCATCCTGG
CTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGC
TGAGGCAGGAGAATGGTATGAACCAGGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCTACTGCACTCCAGCCTGGGTGACAGCACGAG
ATGCCGTCTTAAAAAAACAAAAAAGAGGTGTGCTGCTTGTCAGCATGTATTGTCACGGACACTCAATAAGTGCCATTTTGGACTGTCAAA
TTTAGATGCTTTGTTTCAGAAAGATAAGCCAGCATTTAGTTTTAAATCACTTTCCTGGTTTGTAACTTGATGCTGTTTAGTTAAATTGCT
AGTTTTCCTAACACTACAATATTAATTCTTCTCGTGGAAGTGTACTGATTTATTATTTTTATTCCAAGTCAGCAGATTTGGAAGCATTGT
GGTAAAGTCTAAGGTTTTCATATCCATAGTGCTGTTTGGTGAGTACCGGCAGTACAGTTGAGGGGAGCAGGGAACAGCATTGCCCCGTAT
TGAAGGTGGAGATGGTTACATTCTTCACTGCTTTTTGCATTTTGAGTTGTGTGCCTATAAAATTTGGCCAAACCATTTTATTATTTTGTT
CAAACTTGACTAAGCTGAGTGATCTAAAATTATACAGAACCTAAATCAAAGAAGAGAATGTAAAGTCCTTTAGTTACTTCTAAGAATTTG
AAGTCAAGCACGAATCTAAGACATAGATTATTTTTATATAGCTAATGAAGAGTATGTTACGAAATTGTTGGGTTTTTGGGGTATTGAGGG
TGGCAAATTTTGTGAATCATGCATGCTTCACAGAAACAACCAGGTTTTTCCAGAATTAGTCTGGATCAGTGCCTAACAAAGCTGTTATTA
ATTCTCCACACATGAGTCTGGCTAACTGGGCCAGCTCTCATGTTTTACTCCTGTCTGGCTACAAATAGCACTGTGCATAGTAGCCCTGTT
TCCCCATGGTGTTGGACTGTGGTAAAGTATGTTGTGACATACTGGAATTCTAATAATCCTGTTGTAAGTATGTACAGAATCTATGTAACT
TATTGTTGACATACAGAGGTTTGGGAAGTAGTCTAATGGACATTCCTTACAATAGAATGGCTGGGAAGGGAAAGAAAAAAAAAAAAAAAC
TACCTAACTCCAATCTTAATGTTGTAGTTTTATAGCAAACAAAAATTGTCAGCTTTTTGTATTGAAAGGTCAGTGGTGGTAAGACAAGGT
GTCTTGTAAATTAAGATTTTAAGAAGTGCATTAAAATGTTTTAGAATTACTCTGGGAATTCTGTATATCACACTAAAATTTTTATATCAT

>89682_89682_3_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000409906_DIP2A_chr21_47983771_ENST00000400274_length(amino acids)=254AA_BP=46
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEE
ALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLL

--------------------------------------------------------------
>89682_89682_4_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000572954_DIP2A_chr21_47983771_ENST00000400274_length(transcript)=2884nt_BP=171nt
GCCGGCGCGTCGAGGGGAGAGGCAGCAGCCGCGATGGACGTGTTCCTCATGATCCGGCGCCACAAGACCACCATCTTCACGGACGCCAAG
GAGTCCAGCACGGTGTTCGAACTGAAGCGCATCGTCGAGGGCATCCTCAAGCGGCCTCCTGACGAGCAGCGGCTGTACAAGATCCTCCCC
GGCGTGAAGGTCATCATCGCACACACCGAGACCAAAGGACCCTTGGGAGACTCACACCTGGGAGAGATCTGGGTAAGCAGCCCCCACAAT
GCCACCGGGTACTACACCGTTTACGGGGAGGAGGCGCTTCATGCCGACCACTTCAGTGCCCGGCTGAGTTTTGGAGACACACAGACCATC
TGGGCAAGGACCGGCTACCTTGGCTTCCTTCGGCGAACAGAGCTCACTGATGCCAGTGGAGGGCGGCACGATGCACTGTATGTGGTTGGG
TCTCTGGATGAAACTCTGGAGCTCAGAGGCATGCGGTACCACCCCATCGACATTGAGACCTCTGTCATCCGAGCACACAGGAGCATCGCT
GAGTGTGCCGTATTCACCTGGACCAACCTGCTGGTGGTGGTGGTGGAGCTGGATGGGCTAGAGCAGGATGCCCTGGACCTGGTGGCCCTG
GTGACCAACGTGGTGCTGGAGGAGCACTACCTGGTCGTGGGAGTGGTGGTCATCGTGGACCCAGGGGTGATCCCTATCAACTCTCGGGGT
GAGAAGCAGCGCATGCACCTGCGGGACGGCTTCCTGGCTGACCAGCTGGACCCCATCTATGTCGCCTACAACATGTGAGCGCAGCACACC
GGCCCAGGTGCCGGAGATGAATGAGCCCCAGCAGTCCAAGGTGTGATGTGGGAAGACACCGCAGAGCTCACTCACCGGGACTCGCCCTTC
CTGTGCTCTTACAGATCCCTCTCAACAATCCCCGCATCTCCTTTTAGAAAGCACTTCCTGAATTATTTAAAGAAATATTTTGAATCTGCC
AAGTACATTTACAAAAACACGGATGCTGGTATTTTAACAGATGGAGAGACAAGGAAAGGAAAGGAAAGGCCTGGCATGGGCATTGTGAGG
AATCACAGGCACCGAGGTTGTTCTCTGCTGTACTGCAAGTTTGCACTTTCTTTAGGCTAAAAATATAGTTCCTGATTTTTAAAATTCAGT
TATTTATTCCCACTTCAAATGACAAGTTCATATATAGAATTTACGGGAGAAACTTGAGACCATTTACGGGGAGAAACTTGATTCTGGGAA
GATAGCAGAGTACAAACCAGCTGCCTCACTTCTGTTTCACAGGGAGGCTGATGGAAAAAGGAAGCAAGCTGGACCCATCCTCCCTGCTCA
CAGAGGGCACTGTGGTCACACACAGTGCCTCCTCTGCCAGTTCCTTTATTGAAAGAGGTGTGCTGGCTGGCCACGGTGGCTTACACCTGT
AATCCCAGCACTTTGGGAGGCCGAGGCGAGCAGATCACGAGGTCAGGAGACCGAGACCATCCTGGCTAACATGGTGAAACCCTGTCTCTA
CTAAAAATACAAAAAATTAGCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTATGAACCA
GGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCTACTGCACTCCAGCCTGGGTGACAGCACGAGATGCCGTCTTAAAAAAACAAAAAAG
AGGTGTGCTGCTTGTCAGCATGTATTGTCACGGACACTCAATAAGTGCCATTTTGGACTGTCAAATTTAGATGCTTTGTTTCAGAAAGAT
AAGCCAGCATTTAGTTTTAAATCACTTTCCTGGTTTGTAACTTGATGCTGTTTAGTTAAATTGCTAGTTTTCCTAACACTACAATATTAA
TTCTTCTCGTGGAAGTGTACTGATTTATTATTTTTATTCCAAGTCAGCAGATTTGGAAGCATTGTGGTAAAGTCTAAGGTTTTCATATCC
ATAGTGCTGTTTGGTGAGTACCGGCAGTACAGTTGAGGGGAGCAGGGAACAGCATTGCCCCGTATTGAAGGTGGAGATGGTTACATTCTT
CACTGCTTTTTGCATTTTGAGTTGTGTGCCTATAAAATTTGGCCAAACCATTTTATTATTTTGTTCAAACTTGACTAAGCTGAGTGATCT
AAAATTATACAGAACCTAAATCAAAGAAGAGAATGTAAAGTCCTTTAGTTACTTCTAAGAATTTGAAGTCAAGCACGAATCTAAGACATA
GATTATTTTTATATAGCTAATGAAGAGTATGTTACGAAATTGTTGGGTTTTTGGGGTATTGAGGGTGGCAAATTTTGTGAATCATGCATG
CTTCACAGAAACAACCAGGTTTTTCCAGAATTAGTCTGGATCAGTGCCTAACAAAGCTGTTATTAATTCTCCACACATGAGTCTGGCTAA
CTGGGCCAGCTCTCATGTTTTACTCCTGTCTGGCTACAAATAGCACTGTGCATAGTAGCCCTGTTTCCCCATGGTGTTGGACTGTGGTAA
AGTATGTTGTGACATACTGGAATTCTAATAATCCTGTTGTAAGTATGTACAGAATCTATGTAACTTATTGTTGACATACAGAGGTTTGGG
AAGTAGTCTAATGGACATTCCTTACAATAGAATGGCTGGGAAGGGAAAGAAAAAAAAAAAAAAACTACCTAACTCCAATCTTAATGTTGT
AGTTTTATAGCAAACAAAAATTGTCAGCTTTTTGTATTGAAAGGTCAGTGGTGGTAAGACAAGGTGTCTTGTAAATTAAGATTTTAAGAA
GTGCATTAAAATGTTTTAGAATTACTCTGGGAATTCTGTATATCACACTAAAATTTTTATATCATTATGTTAATAAAAGTTATTGACTTT

>89682_89682_4_TCEB2-DIP2A_TCEB2_chr16_2826994_ENST00000572954_DIP2A_chr21_47983771_ENST00000400274_length(amino acids)=254AA_BP=46
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEE
ALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TCEB2-DIP2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCEB2-DIP2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCEB2-DIP2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource