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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCF20-CENPM (FusionGDB2 ID:89735)

Fusion Gene Summary for TCF20-CENPM

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF20-CENPM
Fusion gene ID: 89735
HgeneTgene
Gene symbol

TCF20

CENPM

Gene ID

6942

79019

Gene nametranscription factor 20centromere protein M
SynonymsAR1|DDVIBA|SPBP|TCF-20C22orf18|CENP-M|PANE1
Cytomap

22q13.2|22q13.3

22q13.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 20SPRE-binding proteinnuclear factor SPBPstromelysin-1 PDGF-responsive element-binding proteinstromelysin-1 platelet-derived growth factor-responsive element binding proteincentromere protein Minterphase centromere complex protein 39proliferation-associated nuclear element protein 1
Modification date2020031320200329
UniProtAcc.

Q9NSP4

Ensembl transtripts involved in fusion geneENST00000335626, ENST00000359486, 
ENST00000404876, 		ENST00000402338, 
ENST00000402420, ENST00000404067, 
ENST00000407253, ENST00000472374, 
ENST00000215980, 
Fusion gene scores* DoF score14 X 8 X 8=8964 X 3 X 2=24
# samples 154
** MAII scorelog2(15/896*10)=-2.57853623156172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TCF20 [Title/Abstract] AND CENPM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCF20(42605657)-CENPM(42342500), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TCF20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CENPM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A828-06ATCF20chr22

42605657

-CENPMchr22

42342500

-


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Fusion Gene ORF analysis for TCF20-CENPM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000335626ENST00000402338TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000335626ENST00000402420TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000335626ENST00000404067TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000335626ENST00000407253TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000359486ENST00000402338TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000359486ENST00000402420TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000359486ENST00000404067TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000359486ENST00000407253TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000404876ENST00000402338TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000404876ENST00000402420TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000404876ENST00000404067TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-5UTRENST00000404876ENST00000407253TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-intronENST00000335626ENST00000472374TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-intronENST00000359486ENST00000472374TCF20chr22

42605657

-CENPMchr22

42342500

-
5CDS-intronENST00000404876ENST00000472374TCF20chr22

42605657

-CENPMchr22

42342500

-
In-frameENST00000335626ENST00000215980TCF20chr22

42605657

-CENPMchr22

42342500

-
In-frameENST00000359486ENST00000215980TCF20chr22

42605657

-CENPMchr22

42342500

-
In-frameENST00000404876ENST00000215980TCF20chr22

42605657

-CENPMchr22

42342500

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359486TCF20chr2242605657-ENST00000215980CENPMchr2242342500-6613579212562772050
ENST00000335626TCF20chr2242605657-ENST00000215980CENPMchr2242342500-6611579012362752050
ENST00000404876TCF20chr2242605657-ENST00000215980CENPMchr2242342500-137955801043347

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359486ENST00000215980TCF20chr2242605657-CENPMchr2242342500-0.0024130190.99758697
ENST00000335626ENST00000215980TCF20chr2242605657-CENPMchr2242342500-0.0024147650.9975852
ENST00000404876ENST00000215980TCF20chr2242605657-CENPMchr2242342500-0.0204335360.9795665

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Fusion Genomic Features for TCF20-CENPM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCF20-CENPM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:42605657/chr22:42342500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CENPM

Q9NSP4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. {ECO:0000269|PubMed:16716197}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141556_156418851939.0Compositional biasNote=Poly-Pro
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-14174_18218851939.0Compositional biasNote=Poly-Gln
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-14203_26218851939.0Compositional biasNote=Ser-rich
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-14310_32218851939.0Compositional biasNote=Poly-Gln
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-1462_7018851939.0Compositional biasNote=Poly-Ala
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151556_15641885490.3333333333333Compositional biasNote=Poly-Pro
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-15174_1821885490.3333333333333Compositional biasNote=Poly-Gln
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-15203_2621885490.3333333333333Compositional biasNote=Ser-rich
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-15310_3221885490.3333333333333Compositional biasNote=Poly-Gln
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-1562_701885490.3333333333333Compositional biasNote=Poly-Ala
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141537_155118851939.0DNA bindingNote=A.T hook
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151537_15511885490.3333333333333DNA bindingNote=A.T hook
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141254_126818851939.0MotifNuclear localization signal
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141576_160018851939.0MotifNuclear localization signal
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141785_179218851939.0MotifNuclear localization signal
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151254_12681885490.3333333333333MotifNuclear localization signal
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151576_16001885490.3333333333333MotifNuclear localization signal
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151785_17921885490.3333333333333MotifNuclear localization signal
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141170_119118851939.0RegionNote=Leucine-zipper
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151170_11911885490.3333333333333RegionNote=Leucine-zipper
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141829_186518851939.0Zinc fingerC2HC pre-PHD-type%3B degenerate
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151829_18651885490.3333333333333Zinc fingerC2HC pre-PHD-type%3B degenerate
HgeneTCF20chr22:42605657chr22:42342500ENST00000359486-151885_19331885490.3333333333333Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF20chr22:42605657chr22:42342500ENST00000335626-141885_193318851939.0Zinc fingerPHD-type


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Fusion Gene Sequence for TCF20-CENPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89735_89735_1_TCF20-CENPM_TCF20_chr22_42605657_ENST00000335626_CENPM_chr22_42342500_ENST00000215980_length(transcript)=6611nt_BP=5790nt
TGGGCCTCTGATTCATCTTTATTCCCTCCATCATCTAGACTTGATTTTATTTGTACCAAGGAGATGCGTGTCTAATGTTTTTCTTTCTTC
TATTTCTAGGAGGGCTGTTGGCCTGCTGCTGTGCTGCTGAACAGTATGCAGTCCTTTCGGGAGCAAAGCAGTTACCACGGAAACCAGCAA
AGCTACCCACAGGAGGTACACGGCTCATCCCGGCTAGAAGAGTTCAGCCCTCGTCAGGCCCAGATGTTCCAGAATTTTGGAGGTACAGGT
GGCAGTAGTGGCAGCAGTGGCAGTGGCAGTGGTGGTGGACGACGAGGAGCAGCAGCTGCTGCGGCAGCGATGGCTAGCGAGACCTCTGGC
CATCAAGGTTACCAGGGTTTCAGGAAAGAGGCTGGAGATTTTTACTACATGGCAGGCAACAAAGACCCCGTGACTACAGGAACCCCACAG
CCTCCTCAGCGAAGGCCTTCTGGGCCTGTGCAGAGCTATGGACCCCCCCAGGGGAGCAGCTTTGGCAATCAGTATGGGAGTGAGGGTCAT
GTGGGCCAGTTTCAAGCACAGCACTCTGGCCTTGGCGGTGTGTCACATTATCAGCAGGATTACACTGGGCCTTTCTCTCCAGGGAGTGCT
CAGTACCAACAGCAGGCTTCCAGCCAGCAGCAGCAGCAGCAAGTCCAGCAGTTGAGACAACAGCTTTACCAGTCCCATCAGCCCCTGCCA
CAGGCCACTGGCCAACCAGCATCCAGCTCATCCCATCTACAGCCAATGCAGCGGCCCTCAACTCTGCCATCCTCTGCTGCTGGTTACCAG
TTAAGAGTGGGTCAGTTTGGCCAACACTATCAGTCTTCTGCTTCCTCCTCCTCCTCCTCCTCCTTCCCTTCACCACAGCGTTTTAGCCAG
TCTGGACAGAGCTATGATGGCAGTTACAATGTGAATGCTGGATCTCAGTATGAAGGACACAATGTGGGTTCTAATGCACAGGCTTATGGA
ACACAATCCAATTACAGCTATCAGCCTCAATCTATGAAGAATTTTGAACAGGCAAAGATTCCACAAGGGACCCAACAGGGGCAGCAGCAG
CAGCAACCGCAGCAACAACAACACCCTTCTCAGCATGTGATGCAGTATACTAACGCTGCCACCAAGCTGCCCCTGCAAAGCCAAGTGGGG
CAGTACAACCAGCCTGAGGTTCCTGTGAGGTCCCCCATGCAGTTTCACCAGAACTTCAGCCCCATTTCTAACCCTTCTCCAGCTGCCTCT
GTGGTTCAGTCTCCAAGCTGTAGTTCTACCCCATCTCCTCTCATGCAGACTGGGGAGAATCTCCAGTGTGGGCAAGGCAGTGTGCCTATG
GGTTCCAGAAACAGAATTTTACAGTTAATGCCTCAACTCAGTCCAACCCCATCAATGATGCCCAGTCCTAATTCTCATGCTGCAGGCTTC
AAAGGGTTTGGACTAGAAGGGGTACCAGAAAAGCGACTGACAGATCCTGGGTTGAGTAGTTTGAGTGCTCTGAGTACTCAAGTGGCCAAT
CTTCCTAACACTGTCCAGCACATGTTACTTTCTGATGCCCTGACTCCTCAGAAGAAGACCTCCAAGAGGCCCTCATCTTCCAAGAAAGCA
GATAGCTGCACAAATTCTGAAGGCTCCTCACAACCTGAAGAACAGCTGAAGTCCCCTATGGCAGAGTCATTAGATGGAGGCTGCTCCAGC
AGTTCAGAGGATCAAGGCGAGAGAGTGCGGCAACTAAGTGGCCAGAGCACCAGCTCTGACACCACCTACAAGGGTGGAGCCTCTGAGAAA
GCTGGCTCCTCACCGGCACAAGGTGCTCAGAATGAACCCCCCAGACTCAATGCTAGTCCTGCCGCAAGAGAAGAGGCCACCTCACCAGGC
GCTAAGGACATGCCATTGTCATCCGACGGGAACCCAAAGGTTAATGAGAAGACTGTTGGGGTGATTGTCTCCCGGGAAGCCATGACAGGT
CGGGTAGAAAAGCCTGGTGGACAAGATAAAGGCTCCCAAGAGGATGATCCTGCAGCCACTCAAAGGCCACCTAGCAATGGTGGGGCAAAG
GAAACCAGTCATGCATCACTTCCCCAGCCAGAGCCTCCAGGAGGAGGAGGGAGCAAAGGAAACAAGAATGGCGATAACAACTCCAACCAT
AATGGAGAAGGAAATGGCCAGAGTGGCCACTCTGCAGCGGGCCCTGGTTTTACGAGCAGAACTGAGCCTAGCAAATCTCCTGGAAGTCTG
CGCTATAGTTACAAAGATAGTTTCGGGTCAGCCGTGCCACGAAATGTCAGTGGCTTTCCTCAGTATCCTACAGGGCAAGAAAAGGGAGAT
TTCACTGGCCATGGGGAACGAAAGGGTAGAAATGAAAAATTCCCAAGCCTCCTGCAGGAAGTGCTTCAGGGTTACCACCACCACCCTGAC
AGGAGATATTCTAGGAGTACTCAAGAGCATCAGGGGATGGCTGGTAGCCTAGAAGGAACCACAAGGCCCAATGTCTTGGTTAGTCAAACC
AATGAATTAGCTAGCAGGGGCCTTCTGAACAAAAGCATTGGGTCTCTATTAGAAAATCCCCACTGGGGCCCCTGGGAAAGGAAATCAAGC
AGCACAGCTCCTGAAATGAAACAGATCAATTTGACTGACTATCCAATTCCCAGAAAGTTTGAAATAGAGCCTCAGTCATCAGCACATGAG
CCTGGGGGTTCCCTCTCTGAAAGAAGATCAGTGATCTGTGATATTTCTCCACTAAGACAGATTGTCAGGGACCCAGGGGCTCACTCACTG
GGACACATGAGTGCCGACACCAGAATTGGGAGGAATGACCGTCTCAATCCAACTTTAAGTCAGTCGGTCATTCTTCCTGGTGGTTTGGTG
TCCATGGAAACCAAGCTGAAATCCCAGAGCGGGCAGATAAAAGAGGAAGACTTTGAACAGTCTAAATCTCAAGCTAGTTTCAACAACAAG
AAATCTGGAGACCACTGCCATCCTCCTAGCATCAAGCATGAGTCTTACCGCGGCAATGCCAGCCCTGGAGCAGCAACCCATGATTCCCTT
TCAGACTATGGCCCGCAAGACAGCAGACCCACGCCAATGCGGCGGGTCCCTGGCAGAGTTGGTGGTCGGGAGGGCATGAGGGGTCGGTCC
CCTTCTCAATATCATGACTTTGCAGAAAAATTGAAAATGTCTCCTGGGCGGAGCAGAGGCCCAGGGGGAGACCCTCATCACATGAATCCA
CACATGACCTTTTCAGAGAGGGCTAACCGGAGTTCTTTACACACTCCCTTTTCTCCCAACTCAGAAACCCTGGCCTCTGCTTATCATGCA
AATACTCGGGCTCATGCTTATGGGGACCCTAACGCAGGTTTGAATTCTCAGCTGCATTATAAGAGACAGATGTACCAACAGCAACCAGAG
GAGTATAAAGACTGGAGCAGCGGTTCTGCTCAGGGAGTAATTGCTGCAGCACAGCACAGGCAGGAGGGGCCACGGAAGAGTCCAAGGCAG
CAGCAGTTTCTTGACAGAGTACGGAGCCCTCTGAAAAATGACAAAGATGGTATGATGTATGGCCCACCAGTGGGGACTTACCATGACCCC
AGTGCCCAGGAGGCTGGGCGCTGCCTAATGTCTAGTGATGGTCTGCCTAACAAGGGCATGGAATTAAAGCATGGCTCCCAGAAGTTACAA
GAATCCTGTTGGGATCTTTCTCGGCAAACTTCTCCAGCCAAAAGCAGCGGTCCTCCAGGAATGTCCAGTCAAAAAAGGTATGGGCCGCCC
CATGAGACTGATGGACATGGACTAGCTGAGGCTACACAGTCATCCAAACCTGGTAGTGTTATGCTGAGACTTCCAGGCCAGGAGGATCAT
TCTTCTCAAAACCCCTTAATCATGAGGAGGCGTGTTCGTTCTTTTATCTCTCCCATTCCCAGTAAGAGACAGTCACAAGATGTAAAGAAC
AGTAGCACTGAAGATAAAGGTCGCCTCCTTCACTCATCAAAAGAAGGCGCTGATAAAGCATTCAATTCCTATGCCCATCTTTCTCACAGT
CAGGATATCAAGTCTATCCCTAAGAGAGATTCCTCCAAGGACCTTCCAAGTCCAGATAGTAGAAACTGCCCTGCTGTTACCCTCACAAGC
CCTGCTAAGACCAAAATACTGCCCCCACGGAAAGGACGGGGATTGAAATTGGAAGCTATAGTTCAGAAGATTACATCCCCAAATATTAGG
AGGAGCGCATCTTCGAACAGTGCGGAGGCTGGGGGAGACACGGTTACGCTTGATGATATACTGTCTTTGAAGAGTGGTCCTCCTGAAGGT
GGGAGTGTTGCTGTTCAGGATGCTGACATAGAGAAGAGAAAAGGTGAGGTGGCTTCGGACCTAGTCAGTCCAGCAAACCAGGAGTTGCAC
GTAGAGAAACCTCTTCCAAGGTCTTCAGAAGAGTGGCGTGGCAGCGTGGATGACAAAGTGAAGACAGAGACACATGCAGAAACAGTTACT
GCCGGAAAGGAACCCCCTGGTGCCATGACATCCACAACCTCACAGAAGCCTGGTAGTAACCAAGGGAGACCAGATGGTTCCCTGGGTGGA
ACAGCACCTTTAATCTTTCCAGACTCAAAGAATGTACCTCCAGTGGGCATATTGGCCCCTGAGGCAAACCCCAAGGCTGAAGAGAAGGAG
AACGATACAGTGACGATTTCACCGAAGCAAGAGGGTTTCCCTCCAAAGGGATATTTCCCATCAGGAAAGAAGAAGGGGAGACCCATTGGT
AGTGTGAATAAGCAAAAGAAACAGCAGCAGCCACCGCCTCCACCCCCTCAGCCCCCACAGATACCAGAAGGTTCTGCAGATGGAGAGCCA
AAGCCAAAAAAACAGAGGCAAAGGAGGGAGAGAAGGAAGCCTGGGGCCCAGCCGAGGAAGCGAAAAACCAAACAAGCAGTTCCCATTGTG
GAACCCCAAGAACCTGAGATCAAACTAAAATATGCCACCCAGCCACTGGATAAAACTGATGCCAAGAACAAGTCTTTTTACCCTTACATC
CATGTAGTAAATAAGTGTGAACTTGGAGCCGTTTGTACAATCATCAATGCTGAGGAAGAAGAACAGACCAAATTAGTGAGGGGCAGGAAG
GGTCAGAGGTCACTGACCCCTCCACCTAGCAGCACTGAAAGCAAGGCGCTCCCGGCCTCGTCCTTTATGCTGCAGGGACCTGTTGTGACA
GAGTCTTCGGTTATGGGGCACCTGGTTTGCTGTCTGTGTGGCAAGTGGGCCAGTTACCGGAACATGGGTGACCTCTTTGGACCTTTTTAT
CCCCAAGATTATGCAGCCACTCTCCCGAAGAATCCACCTCCTAAGAGGGCCACAGAAATGCAGAGCAAAGTTAAGGTACGGCACAAAAGT
GCTTCTAATGGCTCCAAGACGGACACTGAGGAGGAGGAAGAGCAGCAGCAGCAGCAGAAGGAGCAGAGAAGCCTGGCCGCACACCCCAGG
TTTAAGCGGCGCCACCGCTCGGAAGACTGTGGTGGAGGCCCTCGGTCCCTGTCCAGGGGGCTCCCTTGTAAAAAAGCAGCCACTGAGGGC
AGCAGTGAAAAGACTGTTTTGGACTCGAAGCCCTCCGTGCCCACCACTTCAGAAGGTGGCCCTGAGCTGGAGTTACAAATCCCTGAACTA
CCTCTTGACAGCAATGAATTTTGGGTCCATGAGGGTTGTATTCTCTGGGCCAATGGAATCTACCTGGTTTGTGGCAGGCTCTATGGCCTG
CAGGAAGCGCTGGAAATAGCCAGAGAGATGCTGGTGGGCACGGAGGATGCTCTTCTGCAGCAGCTGGCGGACTCGATGCTCAAAGAGGAC
TGCGCCTCCGAGCTGAAGGTCCACTTGGCAAAGTCCCTCCCTTTGCCCTCCAGTGTGAATCGGCCCCGAATTGACCTGATCGTGTTTGTG
GTTAATCTTCACAGCAAATACAGTCTCCAGAACACAGAGGAGTCCCTGCGCCATGTGGATGCCAGCTTCTTCTTGGGGAAGGTGTGTTTC
CTCGCCACAGGTGCTGGGCGGGAGAGCCACTGCAGCATTCACCGGCACACCGTGGTGAAGCTGGCCCACACCTATCAAAGCCCCCTGCTC
TACTGTGACCTGGAGGTGGAAGGCTTTAGGGCCACCATGGCGCAGCGCCTGGTGCGCGTGCTGCAGATCTGTGCTGGCCACGTGCCCGGT
GTCTCAGCTCTGAACCTGCTGTCCCTGCTGAGAAGCTCTGAGGGCCCCTCCCTGGAGGACCTGTGAGGGTGGCTGGCCCCTGGGCTGCCC
CTTCTCATGGCTTCGTGCTGACTCCATAAACATTCTCTGTTGAGGATGTCCAGTCAGGGCTTGACAGGCCCAGGCTCAGCCCGCCGTGGC
TGGGAAGGTTCCCTGCAGTGCCAGTGCTGCAGCAGGGAGAGCTGGGCAGAAGCAGCGAGGGGGCCCAGCTGGCGAGACTGTAGCCCCCTC
CCACTCCCACACTCACTCTTGCAGAGCCTGTGTCTTTAAGCAGCTGGCGTGTTACATCTCCATTTAAGGTTTCCTTTGAACAAAAGGTCT

>89735_89735_1_TCF20-CENPM_TCF20_chr22_42605657_ENST00000335626_CENPM_chr22_42342500_ENST00000215980_length(amino acids)=2050AA_BP=1
MLNSMQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMASETSGHQGYQGFRKEA
GDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQ
QQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQPMQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNV
NAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVRS
PMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEK
RLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQ
LSGQSTSSDTTYKGGASEKAGSSPAQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKG
SQEDDPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSKSPGSLRYSYKDSFGSA
VPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNK
SIGSLLENPHWGPWERKSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGR
NDRLNPTLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGPQDSRPT
PMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHTPFSPNSETLASAYHANTRAHAYGDPN
AGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMS
SDGLPNKGMELKHGSQKLQESCWDLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRR
VRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPAVTLTSPAKTKILPPRK
GRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAVQDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEE
WRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQE
GFPPKGYFPSGKKKGRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKY
ATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESKALPASSFMLQGPVVTESSVMGHLVCC
LCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCG
GGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREML
VGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHC

--------------------------------------------------------------
>89735_89735_2_TCF20-CENPM_TCF20_chr22_42605657_ENST00000359486_CENPM_chr22_42342500_ENST00000215980_length(transcript)=6613nt_BP=5792nt
TCTGGGCCTCTGATTCATCTTTATTCCCTCCATCATCTAGACTTGATTTTATTTGTACCAAGGAGATGCGTGTCTAATGTTTTTCTTTCT
TCTATTTCTAGGAGGGCTGTTGGCCTGCTGCTGTGCTGCTGAACAGTATGCAGTCCTTTCGGGAGCAAAGCAGTTACCACGGAAACCAGC
AAAGCTACCCACAGGAGGTACACGGCTCATCCCGGCTAGAAGAGTTCAGCCCTCGTCAGGCCCAGATGTTCCAGAATTTTGGAGGTACAG
GTGGCAGTAGTGGCAGCAGTGGCAGTGGCAGTGGTGGTGGACGACGAGGAGCAGCAGCTGCTGCGGCAGCGATGGCTAGCGAGACCTCTG
GCCATCAAGGTTACCAGGGTTTCAGGAAAGAGGCTGGAGATTTTTACTACATGGCAGGCAACAAAGACCCCGTGACTACAGGAACCCCAC
AGCCTCCTCAGCGAAGGCCTTCTGGGCCTGTGCAGAGCTATGGACCCCCCCAGGGGAGCAGCTTTGGCAATCAGTATGGGAGTGAGGGTC
ATGTGGGCCAGTTTCAAGCACAGCACTCTGGCCTTGGCGGTGTGTCACATTATCAGCAGGATTACACTGGGCCTTTCTCTCCAGGGAGTG
CTCAGTACCAACAGCAGGCTTCCAGCCAGCAGCAGCAGCAGCAAGTCCAGCAGTTGAGACAACAGCTTTACCAGTCCCATCAGCCCCTGC
CACAGGCCACTGGCCAACCAGCATCCAGCTCATCCCATCTACAGCCAATGCAGCGGCCCTCAACTCTGCCATCCTCTGCTGCTGGTTACC
AGTTAAGAGTGGGTCAGTTTGGCCAACACTATCAGTCTTCTGCTTCCTCCTCCTCCTCCTCCTCCTTCCCTTCACCACAGCGTTTTAGCC
AGTCTGGACAGAGCTATGATGGCAGTTACAATGTGAATGCTGGATCTCAGTATGAAGGACACAATGTGGGTTCTAATGCACAGGCTTATG
GAACACAATCCAATTACAGCTATCAGCCTCAATCTATGAAGAATTTTGAACAGGCAAAGATTCCACAAGGGACCCAACAGGGGCAGCAGC
AGCAGCAACCGCAGCAACAACAACACCCTTCTCAGCATGTGATGCAGTATACTAACGCTGCCACCAAGCTGCCCCTGCAAAGCCAAGTGG
GGCAGTACAACCAGCCTGAGGTTCCTGTGAGGTCCCCCATGCAGTTTCACCAGAACTTCAGCCCCATTTCTAACCCTTCTCCAGCTGCCT
CTGTGGTTCAGTCTCCAAGCTGTAGTTCTACCCCATCTCCTCTCATGCAGACTGGGGAGAATCTCCAGTGTGGGCAAGGCAGTGTGCCTA
TGGGTTCCAGAAACAGAATTTTACAGTTAATGCCTCAACTCAGTCCAACCCCATCAATGATGCCCAGTCCTAATTCTCATGCTGCAGGCT
TCAAAGGGTTTGGACTAGAAGGGGTACCAGAAAAGCGACTGACAGATCCTGGGTTGAGTAGTTTGAGTGCTCTGAGTACTCAAGTGGCCA
ATCTTCCTAACACTGTCCAGCACATGTTACTTTCTGATGCCCTGACTCCTCAGAAGAAGACCTCCAAGAGGCCCTCATCTTCCAAGAAAG
CAGATAGCTGCACAAATTCTGAAGGCTCCTCACAACCTGAAGAACAGCTGAAGTCCCCTATGGCAGAGTCATTAGATGGAGGCTGCTCCA
GCAGTTCAGAGGATCAAGGCGAGAGAGTGCGGCAACTAAGTGGCCAGAGCACCAGCTCTGACACCACCTACAAGGGTGGAGCCTCTGAGA
AAGCTGGCTCCTCACCGGCACAAGGTGCTCAGAATGAACCCCCCAGACTCAATGCTAGTCCTGCCGCAAGAGAAGAGGCCACCTCACCAG
GCGCTAAGGACATGCCATTGTCATCCGACGGGAACCCAAAGGTTAATGAGAAGACTGTTGGGGTGATTGTCTCCCGGGAAGCCATGACAG
GTCGGGTAGAAAAGCCTGGTGGACAAGATAAAGGCTCCCAAGAGGATGATCCTGCAGCCACTCAAAGGCCACCTAGCAATGGTGGGGCAA
AGGAAACCAGTCATGCATCACTTCCCCAGCCAGAGCCTCCAGGAGGAGGAGGGAGCAAAGGAAACAAGAATGGCGATAACAACTCCAACC
ATAATGGAGAAGGAAATGGCCAGAGTGGCCACTCTGCAGCGGGCCCTGGTTTTACGAGCAGAACTGAGCCTAGCAAATCTCCTGGAAGTC
TGCGCTATAGTTACAAAGATAGTTTCGGGTCAGCCGTGCCACGAAATGTCAGTGGCTTTCCTCAGTATCCTACAGGGCAAGAAAAGGGAG
ATTTCACTGGCCATGGGGAACGAAAGGGTAGAAATGAAAAATTCCCAAGCCTCCTGCAGGAAGTGCTTCAGGGTTACCACCACCACCCTG
ACAGGAGATATTCTAGGAGTACTCAAGAGCATCAGGGGATGGCTGGTAGCCTAGAAGGAACCACAAGGCCCAATGTCTTGGTTAGTCAAA
CCAATGAATTAGCTAGCAGGGGCCTTCTGAACAAAAGCATTGGGTCTCTATTAGAAAATCCCCACTGGGGCCCCTGGGAAAGGAAATCAA
GCAGCACAGCTCCTGAAATGAAACAGATCAATTTGACTGACTATCCAATTCCCAGAAAGTTTGAAATAGAGCCTCAGTCATCAGCACATG
AGCCTGGGGGTTCCCTCTCTGAAAGAAGATCAGTGATCTGTGATATTTCTCCACTAAGACAGATTGTCAGGGACCCAGGGGCTCACTCAC
TGGGACACATGAGTGCCGACACCAGAATTGGGAGGAATGACCGTCTCAATCCAACTTTAAGTCAGTCGGTCATTCTTCCTGGTGGTTTGG
TGTCCATGGAAACCAAGCTGAAATCCCAGAGCGGGCAGATAAAAGAGGAAGACTTTGAACAGTCTAAATCTCAAGCTAGTTTCAACAACA
AGAAATCTGGAGACCACTGCCATCCTCCTAGCATCAAGCATGAGTCTTACCGCGGCAATGCCAGCCCTGGAGCAGCAACCCATGATTCCC
TTTCAGACTATGGCCCGCAAGACAGCAGACCCACGCCAATGCGGCGGGTCCCTGGCAGAGTTGGTGGTCGGGAGGGCATGAGGGGTCGGT
CCCCTTCTCAATATCATGACTTTGCAGAAAAATTGAAAATGTCTCCTGGGCGGAGCAGAGGCCCAGGGGGAGACCCTCATCACATGAATC
CACACATGACCTTTTCAGAGAGGGCTAACCGGAGTTCTTTACACACTCCCTTTTCTCCCAACTCAGAAACCCTGGCCTCTGCTTATCATG
CAAATACTCGGGCTCATGCTTATGGGGACCCTAACGCAGGTTTGAATTCTCAGCTGCATTATAAGAGACAGATGTACCAACAGCAACCAG
AGGAGTATAAAGACTGGAGCAGCGGTTCTGCTCAGGGAGTAATTGCTGCAGCACAGCACAGGCAGGAGGGGCCACGGAAGAGTCCAAGGC
AGCAGCAGTTTCTTGACAGAGTACGGAGCCCTCTGAAAAATGACAAAGATGGTATGATGTATGGCCCACCAGTGGGGACTTACCATGACC
CCAGTGCCCAGGAGGCTGGGCGCTGCCTAATGTCTAGTGATGGTCTGCCTAACAAGGGCATGGAATTAAAGCATGGCTCCCAGAAGTTAC
AAGAATCCTGTTGGGATCTTTCTCGGCAAACTTCTCCAGCCAAAAGCAGCGGTCCTCCAGGAATGTCCAGTCAAAAAAGGTATGGGCCGC
CCCATGAGACTGATGGACATGGACTAGCTGAGGCTACACAGTCATCCAAACCTGGTAGTGTTATGCTGAGACTTCCAGGCCAGGAGGATC
ATTCTTCTCAAAACCCCTTAATCATGAGGAGGCGTGTTCGTTCTTTTATCTCTCCCATTCCCAGTAAGAGACAGTCACAAGATGTAAAGA
ACAGTAGCACTGAAGATAAAGGTCGCCTCCTTCACTCATCAAAAGAAGGCGCTGATAAAGCATTCAATTCCTATGCCCATCTTTCTCACA
GTCAGGATATCAAGTCTATCCCTAAGAGAGATTCCTCCAAGGACCTTCCAAGTCCAGATAGTAGAAACTGCCCTGCTGTTACCCTCACAA
GCCCTGCTAAGACCAAAATACTGCCCCCACGGAAAGGACGGGGATTGAAATTGGAAGCTATAGTTCAGAAGATTACATCCCCAAATATTA
GGAGGAGCGCATCTTCGAACAGTGCGGAGGCTGGGGGAGACACGGTTACGCTTGATGATATACTGTCTTTGAAGAGTGGTCCTCCTGAAG
GTGGGAGTGTTGCTGTTCAGGATGCTGACATAGAGAAGAGAAAAGGTGAGGTGGCTTCGGACCTAGTCAGTCCAGCAAACCAGGAGTTGC
ACGTAGAGAAACCTCTTCCAAGGTCTTCAGAAGAGTGGCGTGGCAGCGTGGATGACAAAGTGAAGACAGAGACACATGCAGAAACAGTTA
CTGCCGGAAAGGAACCCCCTGGTGCCATGACATCCACAACCTCACAGAAGCCTGGTAGTAACCAAGGGAGACCAGATGGTTCCCTGGGTG
GAACAGCACCTTTAATCTTTCCAGACTCAAAGAATGTACCTCCAGTGGGCATATTGGCCCCTGAGGCAAACCCCAAGGCTGAAGAGAAGG
AGAACGATACAGTGACGATTTCACCGAAGCAAGAGGGTTTCCCTCCAAAGGGATATTTCCCATCAGGAAAGAAGAAGGGGAGACCCATTG
GTAGTGTGAATAAGCAAAAGAAACAGCAGCAGCCACCGCCTCCACCCCCTCAGCCCCCACAGATACCAGAAGGTTCTGCAGATGGAGAGC
CAAAGCCAAAAAAACAGAGGCAAAGGAGGGAGAGAAGGAAGCCTGGGGCCCAGCCGAGGAAGCGAAAAACCAAACAAGCAGTTCCCATTG
TGGAACCCCAAGAACCTGAGATCAAACTAAAATATGCCACCCAGCCACTGGATAAAACTGATGCCAAGAACAAGTCTTTTTACCCTTACA
TCCATGTAGTAAATAAGTGTGAACTTGGAGCCGTTTGTACAATCATCAATGCTGAGGAAGAAGAACAGACCAAATTAGTGAGGGGCAGGA
AGGGTCAGAGGTCACTGACCCCTCCACCTAGCAGCACTGAAAGCAAGGCGCTCCCGGCCTCGTCCTTTATGCTGCAGGGACCTGTTGTGA
CAGAGTCTTCGGTTATGGGGCACCTGGTTTGCTGTCTGTGTGGCAAGTGGGCCAGTTACCGGAACATGGGTGACCTCTTTGGACCTTTTT
ATCCCCAAGATTATGCAGCCACTCTCCCGAAGAATCCACCTCCTAAGAGGGCCACAGAAATGCAGAGCAAAGTTAAGGTACGGCACAAAA
GTGCTTCTAATGGCTCCAAGACGGACACTGAGGAGGAGGAAGAGCAGCAGCAGCAGCAGAAGGAGCAGAGAAGCCTGGCCGCACACCCCA
GGTTTAAGCGGCGCCACCGCTCGGAAGACTGTGGTGGAGGCCCTCGGTCCCTGTCCAGGGGGCTCCCTTGTAAAAAAGCAGCCACTGAGG
GCAGCAGTGAAAAGACTGTTTTGGACTCGAAGCCCTCCGTGCCCACCACTTCAGAAGGTGGCCCTGAGCTGGAGTTACAAATCCCTGAAC
TACCTCTTGACAGCAATGAATTTTGGGTCCATGAGGGTTGTATTCTCTGGGCCAATGGAATCTACCTGGTTTGTGGCAGGCTCTATGGCC
TGCAGGAAGCGCTGGAAATAGCCAGAGAGATGCTGGTGGGCACGGAGGATGCTCTTCTGCAGCAGCTGGCGGACTCGATGCTCAAAGAGG
ACTGCGCCTCCGAGCTGAAGGTCCACTTGGCAAAGTCCCTCCCTTTGCCCTCCAGTGTGAATCGGCCCCGAATTGACCTGATCGTGTTTG
TGGTTAATCTTCACAGCAAATACAGTCTCCAGAACACAGAGGAGTCCCTGCGCCATGTGGATGCCAGCTTCTTCTTGGGGAAGGTGTGTT
TCCTCGCCACAGGTGCTGGGCGGGAGAGCCACTGCAGCATTCACCGGCACACCGTGGTGAAGCTGGCCCACACCTATCAAAGCCCCCTGC
TCTACTGTGACCTGGAGGTGGAAGGCTTTAGGGCCACCATGGCGCAGCGCCTGGTGCGCGTGCTGCAGATCTGTGCTGGCCACGTGCCCG
GTGTCTCAGCTCTGAACCTGCTGTCCCTGCTGAGAAGCTCTGAGGGCCCCTCCCTGGAGGACCTGTGAGGGTGGCTGGCCCCTGGGCTGC
CCCTTCTCATGGCTTCGTGCTGACTCCATAAACATTCTCTGTTGAGGATGTCCAGTCAGGGCTTGACAGGCCCAGGCTCAGCCCGCCGTG
GCTGGGAAGGTTCCCTGCAGTGCCAGTGCTGCAGCAGGGAGAGCTGGGCAGAAGCAGCGAGGGGGCCCAGCTGGCGAGACTGTAGCCCCC
TCCCACTCCCACACTCACTCTTGCAGAGCCTGTGTCTTTAAGCAGCTGGCGTGTTACATCTCCATTTAAGGTTTCCTTTGAACAAAAGGT

>89735_89735_2_TCF20-CENPM_TCF20_chr22_42605657_ENST00000359486_CENPM_chr22_42342500_ENST00000215980_length(amino acids)=2050AA_BP=1
MLNSMQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMASETSGHQGYQGFRKEA
GDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQ
QQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQPMQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNV
NAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVRS
PMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEK
RLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQ
LSGQSTSSDTTYKGGASEKAGSSPAQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKG
SQEDDPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSKSPGSLRYSYKDSFGSA
VPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNK
SIGSLLENPHWGPWERKSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGR
NDRLNPTLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGPQDSRPT
PMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHTPFSPNSETLASAYHANTRAHAYGDPN
AGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMS
SDGLPNKGMELKHGSQKLQESCWDLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRR
VRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPAVTLTSPAKTKILPPRK
GRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAVQDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEE
WRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQE
GFPPKGYFPSGKKKGRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKY
ATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESKALPASSFMLQGPVVTESSVMGHLVCC
LCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCG
GGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREML
VGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHC

--------------------------------------------------------------
>89735_89735_3_TCF20-CENPM_TCF20_chr22_42605657_ENST00000404876_CENPM_chr22_42342500_ENST00000215980_length(transcript)=1379nt_BP=558nt
ATGGGGCACCTGGTTTGCTGTCTGTGTGGCAAGTGGGCCAGTTACCGGAACATGGGTGACCTCTTTGGACCTTTTTATCCCCAAGATTAT
GCAGCCACTCTCCCGAAGAATCCACCTCCTAAGAGGGCCACAGAAATGCAGAGCAAAGTTAAGGTACGGCACAAAAGTGCTTCTAATGGC
TCCAAGACGGACACTGAGGAGGAGGAAGAGCAGCAGCAGCAGCAGAAGGAGCAGAGAAGCCTGGCCGCACACCCCAGGTTTAAGCGGCGC
CACCGCTCGGAAGACTGTGGTGGAGGCCCTCGGTCCCTGTCCAGGGGGCTCCCTTGTAAAAAAGCAGCCACTGAGGGCAGCAGTGAAAAG
ACTGTTTTGGACTCGAAGCCCTCCGTGCCCACCACTTCAGAAGGTGGCCCTGAGCTGGAGTTACAAATCCCTGAACTACCTCTTGACAGC
AATGAATTTTGGGTCCATGAGGGTTGTATTCTCTGGGCCAATGGAATCTACCTGGTTTGTGGCAGGCTCTATGGCCTGCAGGAAGCGCTG
GAAATAGCCAGAGAGATGCTGGTGGGCACGGAGGATGCTCTTCTGCAGCAGCTGGCGGACTCGATGCTCAAAGAGGACTGCGCCTCCGAG
CTGAAGGTCCACTTGGCAAAGTCCCTCCCTTTGCCCTCCAGTGTGAATCGGCCCCGAATTGACCTGATCGTGTTTGTGGTTAATCTTCAC
AGCAAATACAGTCTCCAGAACACAGAGGAGTCCCTGCGCCATGTGGATGCCAGCTTCTTCTTGGGGAAGGTGTGTTTCCTCGCCACAGGT
GCTGGGCGGGAGAGCCACTGCAGCATTCACCGGCACACCGTGGTGAAGCTGGCCCACACCTATCAAAGCCCCCTGCTCTACTGTGACCTG
GAGGTGGAAGGCTTTAGGGCCACCATGGCGCAGCGCCTGGTGCGCGTGCTGCAGATCTGTGCTGGCCACGTGCCCGGTGTCTCAGCTCTG
AACCTGCTGTCCCTGCTGAGAAGCTCTGAGGGCCCCTCCCTGGAGGACCTGTGAGGGTGGCTGGCCCCTGGGCTGCCCCTTCTCATGGCT
TCGTGCTGACTCCATAAACATTCTCTGTTGAGGATGTCCAGTCAGGGCTTGACAGGCCCAGGCTCAGCCCGCCGTGGCTGGGAAGGTTCC
CTGCAGTGCCAGTGCTGCAGCAGGGAGAGCTGGGCAGAAGCAGCGAGGGGGCCCAGCTGGCGAGACTGTAGCCCCCTCCCACTCCCACAC
TCACTCTTGCAGAGCCTGTGTCTTTAAGCAGCTGGCGTGTTACATCTCCATTTAAGGTTTCCTTTGAACAAAAGGTCTGTGGCTAAAAAA

>89735_89735_3_TCF20-CENPM_TCF20_chr22_42605657_ENST00000404876_CENPM_chr22_42342500_ENST00000215980_length(amino acids)=347AA_BP=0
MGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRR
HRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEAL
EIAREMLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TCF20-CENPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCF20-CENPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCF20-CENPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource