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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCF3-C19orf25 (FusionGDB2 ID:89763)

Fusion Gene Summary for TCF3-C19orf25

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3-C19orf25
Fusion gene ID: 89763
HgeneTgene
Gene symbol

TCF3

C19orf25

Gene ID

83439

148223

Gene nametranscription factor 7 like 1chromosome 19 open reading frame 25
SynonymsTCF-3|TCF3-
Cytomap

2p11.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)UPF0449 protein C19orf25
Modification date2020031320200313
UniProtAcc

TFPT

Q9UFG5

Ensembl transtripts involved in fusion geneENST00000262965, ENST00000344749, 
ENST00000395423, ENST00000453954, 
ENST00000588136, 		ENST00000427685, 
ENST00000436106, ENST00000585675, 
ENST00000586564, ENST00000588849, 
ENST00000588871, ENST00000591027, 
ENST00000592872, ENST00000588427, 
Fusion gene scores* DoF score21 X 26 X 9=49142 X 2 X 2=8
# samples 272
** MAII scorelog2(27/4914*10)=-4.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TCF3 [Title/Abstract] AND C19orf25 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCF3(1619110)-C19orf25(1461823), # samples:2
C19orf25(1478773)-TCF3(1632404), # samples:1
Anticipated loss of major functional domain due to fusion event.C19orf25-TCF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TCF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C19orf25 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080-01ATCF3chr19

1619110

-C19orf25chr19

1461823

-


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Fusion Gene ORF analysis for TCF3-C19orf25

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262965ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
Frame-shiftENST00000262965ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
Frame-shiftENST00000344749ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
Frame-shiftENST00000395423ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
In-frameENST00000453954ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
In-frameENST00000588136ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000453954TCF3chr191619110-ENST00000588427C19orf25chr191461823-19241242171327436
ENST00000588136TCF3chr191619110-ENST00000588427C19orf25chr191461823-262919474972032511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000453954ENST00000588427TCF3chr191619110-C19orf25chr191461823-0.1047987040.89520127
ENST00000588136ENST00000588427TCF3chr191619110-C19orf25chr191461823-0.084962710.9150373

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Fusion Genomic Features for TCF3-C19orf25


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCF3-C19orf25


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1619110/chr19:1461823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

TFPT

C19orf25

Q9UFG5

253

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF3chr19:1619110chr19:1461823ENST00000262965-1619170_176483655.0MotifNuclear localization signal
HgeneTCF3chr19:1619110chr19:1461823ENST00000262965-161919_27483655.0MotifNote=9aaTAD
HgeneTCF3chr19:1619110chr19:1461823ENST00000344749-1619170_176483652.0MotifNuclear localization signal
HgeneTCF3chr19:1619110chr19:1461823ENST00000344749-161919_27483652.0MotifNote=9aaTAD
HgeneTCF3chr19:1619110chr19:1461823ENST00000588136-1519170_176483527.0MotifNuclear localization signal
HgeneTCF3chr19:1619110chr19:1461823ENST00000588136-151919_27483527.0MotifNote=9aaTAD
HgeneTCF3chr19:1619110chr19:1461823ENST00000262965-1619389_425483655.0RegionNote=Leucine-zipper
HgeneTCF3chr19:1619110chr19:1461823ENST00000344749-1619389_425483652.0RegionNote=Leucine-zipper
HgeneTCF3chr19:1619110chr19:1461823ENST00000588136-1519389_425483527.0RegionNote=Leucine-zipper
TgeneC19orf25chr19:1619110chr19:1461823ENST000004361060381_1090119.0Coiled coilOntology_term=ECO:0000255
TgeneC19orf25chr19:1619110chr19:1461823ENST000005856750381_1090119.0Coiled coilOntology_term=ECO:0000255
TgeneC19orf25chr19:1619110chr19:1461823ENST000005865640281_1090119.0Coiled coilOntology_term=ECO:0000255
TgeneC19orf25chr19:1619110chr19:1461823ENST000005928720381_1090119.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF3chr19:1619110chr19:1461823ENST00000262965-1619549_602483655.0DomainbHLH
HgeneTCF3chr19:1619110chr19:1461823ENST00000344749-1619549_602483652.0DomainbHLH
HgeneTCF3chr19:1619110chr19:1461823ENST00000588136-1519549_602483527.0DomainbHLH


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Fusion Gene Sequence for TCF3-C19orf25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89763_89763_1_TCF3-C19orf25_TCF3_chr19_1619110_ENST00000453954_C19orf25_chr19_1461823_ENST00000588427_length(transcript)=1924nt_BP=1242nt
GGAGGTGAGTGCCTGGCCTGGTGCGGTCCCTCTGCTGTGCACAGATGTGCAGACGTGGGCCTTGGCATGGTCAGTGCACGCACAGCGCCA
GGCAAAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGC
TGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGA
GAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAG
GTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCA
GCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCC
CGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATG
GAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGC
CTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCT
ACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGC
CTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGG
CCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCA
CCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGC
ACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGCTGGAGTGCAGTGGCGA
GATCTCGACTCACTGCAGGCTCCGACTCCCCAGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGACACCCGCCA
CCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCG
CCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAGAGCCACCGCGCCCGGCCCAGTGAGGTTGTTTTTTTGAGACGCAGTCTTGCT
CTGTGGCCCAGGCTGGAATGCAGTGGCGCAACCTCCGCCTCCTAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGACTAA
CAGGCGCCCGCTGCCACGCCTGGCTGTTTTTTTTAGTAGAGATGGGGTCTGACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAA
GTGAGCCACGGCGCCCAGCCCACATTTGCTTTCAAAGAGCAGTGACATGAGGAGTGAGCCCCAGCCGGTCTGAGGCTGGACCACCCGCTA
AGCAGTGAGCTGTTCAACTTGATTTCCTCCCAAGTCGGAGAGCTCGCCCGCTGCCGCCAGCAGTCTCCTTCCAGTGACTGAAGAAGCATC

>89763_89763_1_TCF3-C19orf25_TCF3_chr19_1619110_ENST00000453954_C19orf25_chr19_1461823_ENST00000588427_length(amino acids)=436AA_BP=1
MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGS
LDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGP
VGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHS
SNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSL

--------------------------------------------------------------
>89763_89763_2_TCF3-C19orf25_TCF3_chr19_1619110_ENST00000588136_C19orf25_chr19_1461823_ENST00000588427_length(transcript)=2629nt_BP=1947nt
GGGGAATCACCAAATTTCCCTCGGGGCGGGGTAGGATCGGGCTGTTCCTCCCTTTCCCGGGGGTAGGGGGCCTCAGAGGAAGCCCGGGGT
TGGTTGGAAATGAGAGAGTTGGAGAAAGGAGAGGTTCTGGCTGCCCTGCGTGCAGTTTAAACTTGGCAACTTGATGCCCTGGTGTTCCCT
GGGGGAGTTAGGGAGTTTATATTTGCACACCCTCCCCCCATTTTTCAGACTCCCTGTGGTCTCTGGGGAGGACTCTGCAGGGACCTAGAC
TCTGGAATTCCAGCTTCCCTGCGCCTGCTCCCAGGGCTCCCCGTGCCCCCAGGGCTCTGCTGGAACTCAGACCCCAGGGCGGTTGAGGGT
TTTTTAGGTGGCTTTTAGCACTCTGTGCTTTGACCACTCACAACTCTTCTCCCCTCCCTGTTTCTCCCTGTCCATCTGTCCCCACATCCA
CCAAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGG
AGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGT
TCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCT
TCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGC
GGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCC
CCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCA
GCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCA
GGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAG
CCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCC
CGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACG
GTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCG
ACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACT
CAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCC
CCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCC
GCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCAC
TGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCC
TCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGCTGGAGTGCAGTGGCGAGATCTCGACTCACTG
CAGGCTCCGACTCCCCAGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGACACCCGCCACCACGCCCGGCTAAT
TTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCC
CAAAGTGCTGGGATTACAGGCAAGAGCCACCGCGCCCGGCCCAGTGAGGTTGTTTTTTTGAGACGCAGTCTTGCTCTGTGGCCCAGGCTG
GAATGCAGTGGCGCAACCTCCGCCTCCTAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGACTAACAGGCGCCCGCTGCC
ACGCCTGGCTGTTTTTTTTAGTAGAGATGGGGTCTGACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGAGCCACGGCGCC
CAGCCCACATTTGCTTTCAAAGAGCAGTGACATGAGGAGTGAGCCCCAGCCGGTCTGAGGCTGGACCACCCGCTAAGCAGTGAGCTGTTC
AACTTGATTTCCTCCCAAGTCGGAGAGCTCGCCCGCTGCCGCCAGCAGTCTCCTTCCAGTGACTGAAGAAGCATCCCTGCCGCCCACCGG

>89763_89763_2_TCF3-C19orf25_TCF3_chr19_1619110_ENST00000588136_C19orf25_chr19_1461823_ENST00000588427_length(amino acids)=511AA_BP=0
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TCF3-C19orf25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCF3-C19orf25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCF3-C19orf25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource