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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCF3-OAZ1 (FusionGDB2 ID:89774)

Fusion Gene Summary for TCF3-OAZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3-OAZ1
Fusion gene ID: 89774
HgeneTgene
Gene symbol

TCF3

OAZ1

Gene ID

83439

4946

Gene nametranscription factor 7 like 1ornithine decarboxylase antizyme 1
SynonymsTCF-3|TCF3AZ1|AZI|OAZ
Cytomap

2p11.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)ornithine decarboxylase antizyme 1ODC-Azantizyme 1
Modification date2020031320200313
UniProtAcc

TFPT

.
Ensembl transtripts involved in fusion geneENST00000262965, ENST00000344749, 
ENST00000395423, ENST00000588136, 
ENST00000453954, 		ENST00000588673, 
ENST00000322297, ENST00000582888, 
ENST00000583542, ENST00000602676, 
Fusion gene scores* DoF score21 X 26 X 9=491414 X 9 X 8=1008
# samples 2715
** MAII scorelog2(27/4914*10)=-4.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF3 [Title/Abstract] AND OAZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCF3(1646354)-OAZ1(2271384), # samples:1
Anticipated loss of major functional domain due to fusion event.TCF3-OAZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TCF3-OAZ1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TCF3-OAZ1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TCF3-OAZ1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TCF3-OAZ1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOAZ1

GO:0045732

positive regulation of protein catabolic process

17900240


check buttonFusion gene breakpoints across TCF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OAZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GM-A2DF-01ATCF3chr19

1646354

-OAZ1chr19

2271384

+


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Fusion Gene ORF analysis for TCF3-OAZ1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262965ENST00000588673TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000344749ENST00000588673TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000395423ENST00000322297TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000395423ENST00000582888TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000395423ENST00000583542TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000395423ENST00000602676TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000588136ENST00000322297TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000588136ENST00000582888TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000588136ENST00000583542TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000588136ENST00000588673TCF3chr19

1646354

-OAZ1chr19

2271384

+
Frame-shiftENST00000588136ENST00000602676TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000262965ENST00000322297TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000262965ENST00000582888TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000262965ENST00000583542TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000262965ENST00000602676TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000344749ENST00000322297TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000344749ENST00000582888TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000344749ENST00000583542TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000344749ENST00000602676TCF3chr19

1646354

-OAZ1chr19

2271384

+
In-frameENST00000395423ENST00000588673TCF3chr19

1646354

-OAZ1chr19

2271384

+
intron-3CDSENST00000453954ENST00000322297TCF3chr19

1646354

-OAZ1chr19

2271384

+
intron-3CDSENST00000453954ENST00000582888TCF3chr19

1646354

-OAZ1chr19

2271384

+
intron-3CDSENST00000453954ENST00000583542TCF3chr19

1646354

-OAZ1chr19

2271384

+
intron-3CDSENST00000453954ENST00000588673TCF3chr19

1646354

-OAZ1chr19

2271384

+
intron-3CDSENST00000453954ENST00000602676TCF3chr19

1646354

-OAZ1chr19

2271384

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344749TCF3chr191646354-ENST00000582888OAZ1chr192271384+972212282746154
ENST00000344749TCF3chr191646354-ENST00000602676OAZ1chr192271384+1133212288752154
ENST00000344749TCF3chr191646354-ENST00000322297OAZ1chr192271384+1130212285749154
ENST00000344749TCF3chr191646354-ENST00000583542OAZ1chr192271384+1157212288776162
ENST00000262965TCF3chr191646354-ENST00000582888OAZ1chr192271384+12504905922197
ENST00000262965TCF3chr191646354-ENST00000602676OAZ1chr192271384+14114904760159
ENST00000262965TCF3chr191646354-ENST00000322297OAZ1chr192271384+14084904760159
ENST00000262965TCF3chr191646354-ENST00000583542OAZ1chr192271384+14354905661054162
ENST00000395423TCF3chr191646354-ENST00000588673OAZ1chr192271384+78117328714228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344749ENST00000582888TCF3chr191646354-OAZ1chr192271384+0.81176460.18823543
ENST00000344749ENST00000602676TCF3chr191646354-OAZ1chr192271384+0.791501940.20849814
ENST00000344749ENST00000322297TCF3chr191646354-OAZ1chr192271384+0.787502650.21249738
ENST00000344749ENST00000583542TCF3chr191646354-OAZ1chr192271384+0.75908070.24091925
ENST00000262965ENST00000582888TCF3chr191646354-OAZ1chr192271384+0.72895650.27104345
ENST00000262965ENST00000602676TCF3chr191646354-OAZ1chr192271384+0.76246060.23753941
ENST00000262965ENST00000322297TCF3chr191646354-OAZ1chr192271384+0.83038450.16961548
ENST00000262965ENST00000583542TCF3chr191646354-OAZ1chr192271384+0.677369530.3226305
ENST00000395423ENST00000588673TCF3chr191646354-OAZ1chr192271384+0.0202545970.97974545

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Fusion Genomic Features for TCF3-OAZ1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TCF3chr191646353-OAZ1chr192271383+0.0006989710.9993011
TCF3chr191646353-OAZ1chr192271383+0.0006989710.9993011

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TCF3-OAZ1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1646354/chr19:2271384)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

TFPT

.
253FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF3chr19:1646354chr19:2271384ENST00000262965-31919_2748655.0MotifNote=9aaTAD
HgeneTCF3chr19:1646354chr19:2271384ENST00000344749-31919_2748652.0MotifNote=9aaTAD
HgeneTCF3chr19:1646354chr19:2271384ENST00000588136-21919_2748527.0MotifNote=9aaTAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF3chr19:1646354chr19:2271384ENST00000262965-319549_60248655.0DomainbHLH
HgeneTCF3chr19:1646354chr19:2271384ENST00000344749-319549_60248652.0DomainbHLH
HgeneTCF3chr19:1646354chr19:2271384ENST00000588136-219549_60248527.0DomainbHLH
HgeneTCF3chr19:1646354chr19:2271384ENST00000262965-319170_17648655.0MotifNuclear localization signal
HgeneTCF3chr19:1646354chr19:2271384ENST00000344749-319170_17648652.0MotifNuclear localization signal
HgeneTCF3chr19:1646354chr19:2271384ENST00000588136-219170_17648527.0MotifNuclear localization signal
HgeneTCF3chr19:1646354chr19:2271384ENST00000262965-319389_42548655.0RegionNote=Leucine-zipper
HgeneTCF3chr19:1646354chr19:2271384ENST00000344749-319389_42548652.0RegionNote=Leucine-zipper
HgeneTCF3chr19:1646354chr19:2271384ENST00000588136-219389_42548527.0RegionNote=Leucine-zipper


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Fusion Gene Sequence for TCF3-OAZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89774_89774_1_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000322297_length(transcript)=1408nt_BP=490nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGT
GGTGCGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACT
CCGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAAC
GCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTG
CAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGC
TCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACA
CGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGG
GTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTG
TATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAATTTATATTTTACTTTTTTATTGCTGG
TTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGGAAA

>89774_89774_1_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000322297_length(amino acids)=159AA_BP=61
MRPGQGGGPALPVGDRQREHHAEVQEVTELLVCAHRRHPLRLVHSPGARAGTSGLETLLGAAGHAARGGGRRHEAGGPPPGQRCVAAGPP

--------------------------------------------------------------
>89774_89774_2_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000582888_length(transcript)=1250nt_BP=490nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCT
CCGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCG
ATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCA
TTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAG
TTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCC
GAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGT
TCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGGGTG
GGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTGTAT

>89774_89774_2_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000582888_length(amino acids)=197AA_BP=1
MTIPSPTWDLQGWVRGIGAPPRPRTRVTTAVEGDPEPPNCAPAREAGRPFPLVTGSGNIMLKSRRSLSSLSVPTGAILCGWFILLGPGRA
PQAWKPCWARPGTRRVGGGGGMKRGGPPPDKGASRPGPRGSRVGGGGGARGPGPSHPRVARPAGPVRAAGRGAPGAAACAVPAVPAAASA

--------------------------------------------------------------
>89774_89774_3_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000583542_length(transcript)=1435nt_BP=490nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGT
GGTGCTCCGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCT
ACTCCGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCA
AACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCC
GAGACGCTGACACTCGCTGCAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACA
AGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGA
GACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGG
CCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAA
ATAAACGCTCACTCCGAATTAGCGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAA
ATTTATATTTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGA

>89774_89774_3_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000583542_length(amino acids)=162AA_BP=
MKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSRDADTRCSF

--------------------------------------------------------------
>89774_89774_4_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000602676_length(transcript)=1411nt_BP=490nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGT
GGTGCTCCGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCT
ACTCCGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCA
AACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCT
TTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCT
TGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCT
ACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGC
CGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCG
GTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAATTTATATTTTACTTTTTTATTGC
TGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGG

>89774_89774_4_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000262965_OAZ1_chr19_2271384_ENST00000602676_length(amino acids)=159AA_BP=61
MRPGQGGGPALPVGDRQREHHAEVQEVTELLVCAHRRHPLRLVHSPGARAGTSGLETLLGAAGHAARGGGRRHEAGGPPPGQRCVAAGPP

--------------------------------------------------------------
>89774_89774_5_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000322297_length(transcript)=1130nt_BP=212nt
GCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGC
GCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGC
CTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCGAT
GCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGATGAT
CGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAAC
TGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTC
CTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACC
TTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAG
AGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAG
GAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTGTATTTCTT
GAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAATTTATATTTTACTTTTTTATTGCTGGTTTAAGAT
GATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGGAAAGATGAGGT

>89774_89774_5_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000322297_length(amino acids)=154AA_BP=
MKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAE

--------------------------------------------------------------
>89774_89774_6_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000582888_length(transcript)=972nt_BP=212nt
GCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGC
GCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGC
CTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCTCCGATGCC
CCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGATGATCGG
CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGG
CGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTG
GAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTC
AGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGA
GAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAA
CCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTGTATTTCTTGAA

>89774_89774_6_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000582888_length(amino acids)=154AA_BP=
MKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAE

--------------------------------------------------------------
>89774_89774_7_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000583542_length(transcript)=1157nt_BP=212nt
GCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGC
GCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGC
CTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCTCC
GATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGAT
GATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATT
AACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCCGAGACGCT
GACACTCGCTGCAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGC
GAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGAC
GCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGG
GCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGC
TCACTCCGAATTAGCGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAATTTATAT
TTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCT

>89774_89774_7_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000583542_length(amino acids)=162AA_BP=
MKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSRDADTRCSF

--------------------------------------------------------------
>89774_89774_8_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000602676_length(transcript)=1133nt_BP=212nt
GCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGC
GCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGC
CTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCTCC
GATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGAT
GATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATT
AACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTT
CTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGA
ACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTC
GAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGG
TAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTGTATTT
CTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAATTTATATTTTACTTTTTTATTGCTGGTTTAA
GATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGGAAAGATGA

>89774_89774_8_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000344749_OAZ1_chr19_2271384_ENST00000602676_length(amino acids)=154AA_BP=
MKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAE

--------------------------------------------------------------
>89774_89774_9_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000395423_OAZ1_chr19_2271384_ENST00000588673_length(transcript)=781nt_BP=173nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGTTCCAGG
GTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCTCCTGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCG
AGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGA
CAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACAT
CGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCA
TGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGG
GCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCG

>89774_89774_9_TCF3-OAZ1_TCF3_chr19_1646354_ENST00000395423_OAZ1_chr19_2271384_ENST00000588673_length(amino acids)=228AA_BP=47
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSVPGSPSTAVVTRVRGLGGAPDAPHPPLKIPGGRGNSQRDHNL
SANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNR

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Fusion Gene PPI Analysis for TCF3-OAZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCF3-OAZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCF3-OAZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource