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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TCF4-CSF2RA (FusionGDB2 ID:89785)

Fusion Gene Summary for TCF4-CSF2RA

Fusion gene summary

Fusion gene information	Fusion gene name: TCF4-CSF2RA
	Fusion gene ID: 89785
		Hgene	Tgene
	Gene symbol	TCF4	CSF2RA
	Gene ID	6934	1438
	Gene name	transcription factor 7 like 2	colony stimulating factor 2 receptor subunit alpha
	Synonyms	TCF-4\|TCF4	CD116\|CDw116\|CSF2R\|CSF2RAX\|CSF2RAY\|CSF2RX\|CSF2RY\|GM-CSF-R-alpha\|GMCSFR\|GMCSFR-alpha\|GMR\|GMR-alpha\|SMDP4\|alphaGMR
	Cytomap	10q25.2-q25.3	Xp22.33 and Yp11.2
	Type of gene	protein-coding	protein-coding
	Description	transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)	granulocyte-macrophage colony-stimulating factor receptor subunit alphaCD116 antigenGM-CSF receptor alpha subunitalpha-GM-CSF receptorcolony stimulating factor 2 receptor alpha subunitcolony stimulating factor 2 receptor, alpha, low-affinity (granulo
	Modification date	20200315	20200326
	UniProtAcc	.	P15509
	Ensembl transtripts involved in fusion gene	ENST00000354452, ENST00000356073, ENST00000398339, ENST00000457482, ENST00000537578, ENST00000537856, ENST00000540999, ENST00000543082, ENST00000544241, ENST00000561831, ENST00000561992, ENST00000563760, ENST00000564228, ENST00000564403, ENST00000564999, ENST00000565018, ENST00000566279, ENST00000566286, ENST00000567880, ENST00000568673, ENST00000568740, ENST00000570177, ENST00000570287,	ENST00000355432, ENST00000355805, ENST00000361536, ENST00000381500, ENST00000381509, ENST00000381524, ENST00000381529, ENST00000417535, ENST00000432318, ENST00000494969, ENST00000498153, ENST00000501036,
Fusion gene scores	* DoF score	13 X 13 X 4=676	8 X 9 X 3=216
	# samples	13	8
	** MAII score	log2(13/676*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TCF4 [Title/Abstract] AND CSF2RA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CSF2RA(1435211)-TCF4(53037568), # samples:1 TCF4(53037568)-CSF2RA(1385211), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TCF4	GO:0000122	negative regulation of transcription by RNA polymerase II	12799378
Hgene	TCF4	GO:0006357	regulation of transcription by RNA polymerase II	9727977
Hgene	TCF4	GO:0032092	positive regulation of protein binding	12799378
Hgene	TCF4	GO:0032350	regulation of hormone metabolic process	15525634
Hgene	TCF4	GO:0042593	glucose homeostasis	15525634
Hgene	TCF4	GO:0043433	negative regulation of DNA-binding transcription factor activity	12799378
Hgene	TCF4	GO:0045444	fat cell differentiation	10937998
Hgene	TCF4	GO:0045892	negative regulation of transcription, DNA-templated	12799378\|15525634
Hgene	TCF4	GO:0045944	positive regulation of transcription by RNA polymerase II	9065401\|19168596
Hgene	TCF4	GO:0048625	myoblast fate commitment	10937998

Fusion gene breakpoints across TCF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CSF2RA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB051440	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-

Top

Fusion Gene ORF analysis for TCF4-CSF2RA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000354452	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000354452	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000356073	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000398339	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000457482	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537578	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000537856	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000540999	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000543082	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000544241	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561831	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000561992	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000563760	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564228	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564403	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000564999	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000565018	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566279	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000566286	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000567880	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568673	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000568740	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570177	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000355432	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000355805	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000361536	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000381500	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000381509	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000381524	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000381529	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000417535	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000432318	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000494969	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000498153	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-
intron-intron	ENST00000570287	ENST00000501036	TCF4	chr18	53037568	-	CSF2RA	chrY	1385211	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for TCF4-CSF2RA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TCF4-CSF2RA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1435211/:53037568)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CSF2RA P15509
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TCF4-CSF2RA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TCF4-CSF2RA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TCF4-CSF2RA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TCF4-CSF2RA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source