Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TCFL5-KDM3B (FusionGDB2 ID:89831)

Fusion Gene Summary for TCFL5-KDM3B

Fusion gene summary

Fusion gene information	Fusion gene name: TCFL5-KDM3B
	Fusion gene ID: 89831
		Hgene	Tgene
	Gene symbol	TCFL5	KDM3B
	Gene ID	10732	51780
	Gene name	transcription factor like 5	lysine demethylase 3B
	Synonyms	CHA\|E2BP-1\|Figlb\|SOSF1\|bHLHe82	5qNCA\|C5orf7\|JMJD1B\|NET22
	Cytomap	20q13.33	5q31.2
	Type of gene	protein-coding	protein-coding
	Description	transcription factor-like 5 proteinHPV-16 E2-binding protein 1cha transcription factorspermatogenesis- and oogenesis-specific bHLH-containing protein 1transcription factor-like 5 (basic helix-loop-helix)	lysine-specific demethylase 3BjmjC domain-containing histone demethylation protein 2Bjumonji domain containing 1Bjumonji domain-containing protein 1Blysine (K)-specific demethylase 3Bnuclear protein 5qNCA
	Modification date	20200313	20200313
	UniProtAcc	.	Q7LBC6
	Ensembl transtripts involved in fusion gene	ENST00000217162, ENST00000335351,	ENST00000394866, ENST00000508386, ENST00000542866, ENST00000314358,
Fusion gene scores	* DoF score	3 X 3 X 2=18	11 X 11 X 5=605
	# samples	3	13
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/605*10)=-2.2184235191335 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TCFL5 [Title/Abstract] AND KDM3B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TCFL5(61485368)-KDM3B(137717205), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TCFL5	GO:0000122	negative regulation of transcription by RNA polymerase II	12923186
Hgene	TCFL5	GO:0006355	regulation of transcription, DNA-templated	9763657

Fusion gene breakpoints across TCFL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KDM3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-19-0957-02A	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+

Top

Fusion Gene ORF analysis for TCFL5-KDM3B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000217162	ENST00000394866	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
5CDS-intron	ENST00000217162	ENST00000508386	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
5CDS-intron	ENST00000217162	ENST00000542866	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
5CDS-intron	ENST00000335351	ENST00000394866	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
5CDS-intron	ENST00000335351	ENST00000508386	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
5CDS-intron	ENST00000335351	ENST00000542866	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
In-frame	ENST00000217162	ENST00000314358	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+
In-frame	ENST00000335351	ENST00000314358	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000335351

TCFL5

chr20

61485368

ENST00000314358

KDM3B

chr5

137717205

7381

1473

6053

1986

ENST00000217162

TCFL5

chr20

61485368

ENST00000314358

KDM3B

chr5

137717205

7381

1473

6053

1986

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000335351	ENST00000314358	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+	0.000843538	0.9991565
ENST00000217162	ENST00000314358	TCFL5	chr20	61485368	-	KDM3B	chr5	137717205	+	0.000843538	0.9991565

Top

Fusion Genomic Features for TCFL5-KDM3B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TCFL5	chr20	61485367	-	KDM3B	chr5	137717204	+	1.09E-06	0.9999989
TCFL5	chr20	61485367	-	KDM3B	chr5	137717204	+	1.09E-06	0.9999989

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TCFL5-KDM3B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:61485368/chr5:137717205)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KDM3B Q7LBC6
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269\|PubMed:16603237}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCFL5

chr20:61485368

chr5:137717205

ENST00000335351

67_182

460

501.0

Compositional bias

Note=Ala-rich

Hgene

TCFL5

chr20:61485368

chr5:137717205

ENST00000335351

400_450

460

501.0

Domain

bHLH

Hgene

TCFL5

chr20:61485368

chr5:137717205

ENST00000335351

347_356

460

501.0

Region

Note=R3 epitope (recognized by Chagas's antibodies)

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000314358

647_744

235

1762.0

Compositional bias

Note=Ser-rich

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000394866

647_744

1418.0

Compositional bias

Note=Ser-rich

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000314358

1498_1721

235

1762.0

Domain

JmjC

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000394866

1498_1721

1418.0

Domain

JmjC

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000314358

1293_1297

235

1762.0

Motif

Note=LXXLL motif

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000394866

1293_1297

1418.0

Motif

Note=LXXLL motif

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000314358

1031_1056

235

1762.0

Zinc finger

C6-type

Tgene

KDM3B

chr20:61485368

chr5:137717205

ENST00000394866

1031_1056

1418.0

Zinc finger

C6-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCFL5

chr20:61485368

chr5:137717205

ENST00000335351

481_500

460

501.0

Region

Note=R1 epitope (recognized by Chagas's antibodies)

Top

Fusion Gene Sequence for TCFL5-KDM3B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89831_89831_1_TCFL5-KDM3B_TCFL5_chr20_61485368_ENST00000217162_KDM3B_chr5_137717205_ENST00000314358_length(transcript)=7381nt_BP=1473nt
CGGGCCGGGGGTCGCCTCCCGCCTCCCGCCTCCCGCCTCCCGCCGCCCGCCGCCCGCGTCGCCCTCGCCGCCGTTGGGCCGCGCCGCGCC
GCCATGTCGGGCCCCGGACCGCGGGAGCCGCCGCCGGAGGCAGGCGCGGCAGGCGGCGAGGCGGCCGTCGAGGGCGCGGGCGGCGGGGAC
GCGGCGCTGGGCGAGCCGGGGCTGAGCTTCACGACCACCGACCTGAGCCTGGTGGAGATGACGGAGGTGGAGTACACGCAGCTGCAGCAC
ATCCTCTGCTCGCACATGGAGGCGGCGGCTGACGGCGAGCTCGAGACGCGCCTCAACTCGGCGCTGCTGGCGGCGGCGGGCCCGGGCGCA
GGCGCGGGCGGCTTCGCGGCGGGCGGTCAGGGGGGCGCGGCGCCCGTGTACCCCGTGCTGTGCCCGTCCGCGCTGGCGGCCGACGCGCCC
TGCCTGGGCCACATCGACTTCCAGGAGCTGCGCATGATGCTGCTAAGCGAGGCGGGCGCGGCGGAGAAGACGTCGGGCGGCGGGGACGGA
GCGAGGGCCCGGGCCGACGGCGCCGCCAAGGAGGGCGCGGGCGCGGCTGCGGCTGCGGCTGGACCCGACGGCGCGCCCGAGGCCCGGGCC
AAGCCGGCCGTGCGCGTCCGCCTGGAGGACCGCTTCAACAGCATCCCCGCCGAGCCGCCGCCCGCGCCGCGCGGCCCCGAGCCCCCCGAG
CCGGGCGGGGCGCTCAACAATTTGGTAACTCTCATTCGACATCCATCTGAACTAATGAATGTTCCTCTTCAGCAACAAAACAAATGTACA
GCATTAGTGAAAAATAAAACTGCGGCTACAACTACTGCTTTGCAATTTACATACCCACTGTTTACTACAAATGCTTGCTCTACTAGTGGA
AATTCTAATCTTTCACAGACACAGAGTTCTAGTAACTCATGTTCTGTACTTGAAGCTGCCAAGCACCAGGATATTGGATTGCCTAGAGCA
TTTTCTTTCTGTTATCAGCAAGAAATTGAATCCACTAAACAGACGTTAGGTAGTAGAAACAAAGTTTTGCCTGAGCAAGTTTGGATTAAA
GTGGGAGAAGCAGCGCTATGCAAACAAGCACTGAAGAGGAATCGGAGTAGAATGCGTCAGTTGGACACAAATGTAGAGCGAAGAGCCCTT
GGAGAGATTCAGAATGTGGGCGAAGGTGCCACCGCCACACAAGGCGCTTGGCAGTCCTCGGAGTCCTCACAGGCAAACCTGGGGGAGCAG
GCCCAGAGTGGGCCCCAGGGAGGAAGGTCTCAACGTAGGGAGAGGCATAACCGAATGGAAAGAGATAGAAGGCGCAGAATCCGCATTTGC
TGTGATGAGTTGAATCTCTTAGTGCCGTTCTGCAATGCCGAGACTGACAAGGCCACAACTCTGCAGTGGACCACAGCATTCCTGAAATAC
ATCCAGGAAAGACATGGAGATTCTCTTAAAAAGAGTGGTGAGATCAAGTCGGTAGATCCCAGACTAATCCATGTGATGCTGATGGATAAT
TCAGCGCCTCAAAGCGAGGGGGGTACGTTAAAAGCAGTAAAATCTTCCAAAGGAAAGAAGAAGAGAGAAAGCATAGAGGGGAAAGATGGC
CGGAGGAGGAAAAGTGCTTCGGACTCTGGGTGTGACCCTGCATCAAAGAAATTAAAAGGAGACAGGGGTGAAGTAGACAGTAATGGGAGC
GATGGAGGTGAGGCAAGCCGAGGGCCCTGGAAAGGAGGGAATGCCAGTGGAGAGCCAGGGCTGGATCAGAGAGCCAAGCAGCCACCGTCT
ACATTTGTCCCCCAGATAAACCGCAACATTCGCTTTGCCACTTACACCAAAGAAAACGGCAGGACTCTGGTGGTGCAGGATGAGCCTGTA
GGTGGGGACACACCTGCATCTTTCACTCCATATTCTACAGCCACAGGTCAGACACCTTTGGCCCCAGAGGTGGGTGGAGCCGAAAACAAA
GAGGCAGGAAAAACACTGGAACAAGTTGGCCAGGGCATAGTGGCTTCCGCAGCTGTGGTCACTACCGCCAGCTCCACCCCAAACACAGTG
AGGATCTCAGACACTGGCCTTGCAGCAGGGACTGTGCCAGAAAAACAGAAAGGCAGCCGGTCGCAGGCCTCGGGAGAGAATTCAAGAAAT
TCTATTCTGGCCTCTTCTGGATTTGGAGCACCTCTCCCTAGTTCATCGCAACCTTTGACTTTTGGAAGTGGAAGGAGCCAGTCCAATGGT
GTTCTAGCCACAGAGAACAAACCTTTGGGCTTCTCTTTTGGCTGTAGCTCTGCACAAGAGGCACAGAAAGACACTGATCTCTCCAAAAAC
TTGTTTTTTCAATGCATGTCCCAAACTTTACCTACCAGTAACTACTTCACTACTGTTTCAGAGAGTTTGGCTGATGATTCTTCTAGTCGG
GACTCATTCAAACAAAGCCTTGAGAGCCTGAGCTCAGGCCTGTGTAAAGGCAGATCCGTTCTTGGAACAGACACTAAGCCAGGCTCTAAG
GCTGGCAGCTCTGTGGACCGGAAAGTGCCTGCAGAGTCCATGCCCACCCTCACTCCAGCCTTCCCACGGAGCCTCCTAAATGCCCGTACC
CCAGAGAATCATGAAAATCTATTTTTACAGCCCCCCAAATTGTCCCGAGAAGAGCCTTCTAATCCTTTCCTGGCATTTGTGGAGAAAGTT
GAACACAGCCCTTTCAGTAGTTTTGCATCTCAGGCATCAGGTAGCTCCTCTTCTGCTACCACTGTCACCTCCAAGGTGGCACCCAGCTGG
CCCGAGTCTCACTCCTCTGCAGATTCGGCATCTTTAGCAAAGAAGAAACCCCTCTTCATTACAACTGACTCCTCCAAGCTAGTATCTGGT
GTTCTGGGCTCAGCTCTTACCAGTGGGGGCCCAAGCCTCTCTGCCATGGGGAATGGCCGCTCCAGCTCGCCCACCAGCAGCCTCACTCAG
CCCATTGAGATGCCAACTCTCTCCTCTAGCCCCACAGAGGAGAGGCCAACTGTGGGGCCTGGGCAGCAGGACAATCCCCTCCTCAAAACC
TTTAGTAACGTCTTTGGCAGGCACTCAGGCGGCTTTCTGTCCTCCCCGGCAGATTTTTCACAGGAGAACAAAGCTCCTTTTGAAGCTGTG
AAAAGGTTCTCACTGGATGAACGAAGCTTGGCTTGCAGACAAGACTCGGACTCCAGCACCAACAGTGACCTGTCAGATTTGAGTGACTCT
GAGGAGCAGCTGCAGGCTAAGACAGGCCTGAAGGGAATTCCAGAGCACCTGATGGGGAAGCTGGGCCCCAATGGGGAGCGCAGTGCTGAG
CTGTTGCTGGGCAAAAGCAAAGGGAAGCAGGCCCCCAAGGGCCGGCCTCGGACTGCCCCCCTGAAAGTTGGCCAGTCAGTGCTGAAAGAT
GTAAGCAAAGTGAAGAAGCTGAAGCAATCTGGAGAGCCCTTCCTGCAGGATGGGTCATGCATCAATGTGGCACCTCATCTGCACAAGTGT
CGTGAATGCCGCCTGGAGCGGTACCGGAAGTTTAAGGAACAGGAGCAAGATGATTCTACTGTAGCCTGCCGTTTCTTTCACTTCCGGAGG
TTGATCTTCACTCGAAAAGGGGTACTCCGTGTGGAGGGGTTTTTAAGCCCCCAGCAAAGTGACCCTGATGCCATGAACCTGTGGATTCCC
TCTTCCTCCCTAGCAGAAGGGATAGATCTAGAGACCTCAAAATACATCCTGGCCAATGTTGGGGACCAGTTCTGCCAGCTCGTAATGTCT
GAGAAGGAGGCCATGATGATGGTGGAGCCACACCAGAAAGTGGCATGGAAGCGAGCTGTGCGTGGTGTACGGGAGATGTGTGATGTGTGT
GAAACAACTCTCTTCAACATCCACTGGGTTTGTCGCAAATGTGGATTTGGGGTCTGCCTTGACTGTTACCGGCTCAGGAAAAGCCGGCCA
CGCAGTGAGACAGAAGAGATGGGTGATGAAGAAGTTTTCTCCTGGTTGAAGTGTGCAAAGGGACAGTCCCACGAACCAGAGAATCTCATG
CCCACACAAATTATTCCTGGCACAGCTCTTTACAATATTGGAGACATGGTACATGCTGCCCGGGGCAAGTGGGGAATTAAAGCAAACTGC
CCTTGTATCAGTCGACAGAACAAATCTGTATTGAGACCTGCCGTCACCAATGGGATGTCACAGCTTCCTAGCATAAACCCTAGTGCCTCT
TCTGGAAACGAAACTACCTTCTCTGGTGGAGGAGGACCGGCACCAGTAACAACTCCAGAGCCGGACCATGTTCCCAAAGCCGACAGCACT
GACATCAGATCTGAAGAGCCTCTGAAAACAGACAGTTCGGCATCAAATAGCAATAGTGAACTGAAAGCCATCAGGCCTCCTTGCCCTGAC
ACGGCCCCACCCTCCTCCGCCCTGCACTGGTTGGCAGATTTAGCAACTCAGAAGGCTAAAGAAGAAACAAAAGAAGCAGGGTCCCTGAGG
TCGGTGCTCAATAAAGAGTCTCATTCACCCTTTGGGCTGGACTCGTTCAACTCCACTGCAAAGGTCTCTCCGCTGACTCCAAAGCTTTTT
AACAGTCTGTTGCTGGGTCCCACTGCCTCCAACAACAAAACCGAAGGGTCTAGCCTTCGAGACCTCCTTCACTCCGGGCCGGGAAAACTT
CCTCAAACCCCCTTGGACACAGGCATACCCTTTCCCCCGGTCTTCTCTACATCCTCAGCAGGAGTGAAGAGCAAGGCCAGCCTACCCAAC
TTTCTTGACCACATCATTGCCTCAGTGGTAGAAAATAAGAAAACCTCAGATGCTTCAAAGCGGGCCTGCAACTTGACTGATACCCAGAAG
GAAGTGAAGGAGATGGTGATGGGGTTAAATGTGCTAGATCCCCATACTTCTCACTCCTGGCTTTGTGATGGGAGGCTTCTGTGTCTCCAT
GACCCCAGCAACAAAAACAATTGGAAGATCTTCCGGGAGTGTTGGAAGCAAGGTCAGCCAGTGCTGGTTTCGGGGGTACATAAAAAGCTC
AAGTCTGAGCTCTGGAAGCCAGAAGCCTTTAGCCAGGAATTTGGAGACCAGGATGTAGACTTGGTGAACTGCAGGAACTGTGCTATAATT
TCCGATGTGAAAGTTCGGGATTTCTGGGATGGTTTCGAGATCATATGCAAACGACTACGGTCAGAAGATGGGCAGCCAATGGTGCTCAAA
CTCAAGGACTGGCCTCCTGGGGAAGATTTTCGAGACATGATGCCAACCAGGTTTGAAGATCTGATGGAGAACCTTCCTCTGCCAGAATAT
ACCAAACGAGATGGCAGGCTCAATCTGGCCTCTAGGCTACCTAGCTACTTTGTAAGGCCTGATCTGGGCCCCAAGATGTACAACGCCTAT
GGGTTGATAACAGCAGAAGATAGAAGAGTTGGTACAACAAATCTTCACTTAGATGTGTCTGATGCTGTTAATGTGATGGTGTATGTTGGG
ATTCCCATCGGGGAGGGTGCTCATGATGAAGAGGTACTCAAGACAATTGACGAGGGAGATGCCGATGAGGTGACGAAGCAGAGGATTCAT
GATGGAAAAGAGAAGCCAGGTGCTTTATGGCACATCTATGCAGCCAAGGATGCAGAGAAGATCCGGGAGCTGCTCCGAAAGGTTGGAGAA
GAACAAGGCCAAGAGAACCCCCCTGATCATGACCCAATTCATGACCAAAGTTGGTACCTGGACCAGACCCTCCGTAAGCGACTCTATGAG
GAGTATGGCGTGCAAGGCTGGGCTATTGTGCAGTTCCTAGGTGATGCTGTTTTCATACCTGCTGGAGCCCCACACCAGGTTCACAATCTA
TACAGTTGCATAAAAGTAGCAGAAGACTTTGTATCTCCAGAACATGTAAAGCACTGTTTCCGCCTGACTCAGGAATTCAGGCATCTCTCT
AACACTCATACAAATCATGAGGATAAACTGCAGGTGAAGAACATCATTTACCATGCAGTGAAAGATGCGGTTGGCACCCTCAAGGCTCAT
GAATCCAAACTGGCAAGGTCCTAGGCATGGAGAAACTCCAAGCTCCTCTGTGAAGCAGGTCTTTCACTCACAACACTTAACAGGGAACGG
CAGGGCTCTTTGCTGGAGCAGAGGCCCTTCACCCAGAGCCAGTGTGGTCAGTATTCCAAACTCTCCAGCCACTCTCTTCTACGCTGCCTC
AACACTGAAGGTTGACACAGGAAAGTCGTACTGTTCACACACACAGTTTGAGACTCCAAGCCAAGAGTGCCACATCCCTATCCTGTGGCC
TTTTGGAAATCCAAATTGCCTGAACATGGCGGGGCTTTCCTGCACATTCTCCTGATTTGAGATTCACGGGCACACCTTTCTTTTCTTTTC
CTCTTGTGCCTAGTTAAGTGGAAATGTGTTTGGAGATAGGGGAAATCACATAACTGGTACAAGTATGGGGTAATTGCTTAAACATGCCTG
GTGGAAGTCTGATAGCGTCTCTGCACGTGACCTCTGACAAAGCCCATCCCAGGAGACGGGGTGAAGCTATTCCCCACACTCTCCTGTGAA
CACTGGAGTCTTGCAAGACCCAGGGAGAACCCACTGCTTTTCCCAGGAGGCTCCAGGATTAGGAAATGTGTGTATTTAGTGAAAAATAGG
TTTGTAGTGAAATAGTTACTATTTCATGAAAGTAGATATTTTTAGAATTTTTGAAATACCACAGTTGTTTTCCTGGATTATAAGGAAAGG
CACATTACATTTAGTCTTCCTTTCGATATAAAACTCTTTGAAGAAATATGATTTTTAGAAATCAGCTACCCATTATAGCACAAAATCAGC
CAAAGCAGAATTTTTAAAAATTGGCTTTTTTAGGATTCTTTTTCTCCCCCTCCCATCTTAGTCTTACCTTGAGGGAACAGTCATATGAGA
AGGAACTTTGTCACATCTAAGCTGTGGTGTGTTCCCCATGTGTGTGTACAACACTGGTGACTCCAGGAACCATTTTCACCTATTACCAGT
GTTCCCTGGGGACTCCTCTTAATGTTTCCAAATGGGAAGGACAGTTGATTTCCAACATGAGGTTTTTTGTTTTTTATCCAGAAATATTTT
CAGCAAAACTTTCCAACTGAGTGGAGTCTGATTAAGGATTTATTTGAAAATGGTGGGATTCATTGGCCCATAGGTACATTGGAAAATGTA
TATCTCTCCAGCTGTACTGTAGTGCCCTGCAGGCTGTTTATATGTTCACAGTTACTTTTTTTTTTTTTTTTAAATAAAAGTCATTTAATG
TAGAATACTTTTAATTTCACTTTCTGTATTTTAATTTTGTTGAAGGGCTGATTGGGATTTCCATGTTCTTATTAAAAATCTAACAAATCT

>89831_89831_1_TCFL5-KDM3B_TCFL5_chr20_61485368_ENST00000217162_KDM3B_chr5_137717205_ENST00000314358_length(amino acids)=1986AA_BP=460
MSGPGPREPPPEAGAAGGEAAVEGAGGGDAALGEPGLSFTTTDLSLVEMTEVEYTQLQHILCSHMEAAADGELETRLNSALLAAAGPGAG
AGGFAAGGQGGAAPVYPVLCPSALAADAPCLGHIDFQELRMMLLSEAGAAEKTSGGGDGARARADGAAKEGAGAAAAAAGPDGAPEARAK
PAVRVRLEDRFNSIPAEPPPAPRGPEPPEPGGALNNLVTLIRHPSELMNVPLQQQNKCTALVKNKTAATTTALQFTYPLFTTNACSTSGN
SNLSQTQSSSNSCSVLEAAKHQDIGLPRAFSFCYQQEIESTKQTLGSRNKVLPEQVWIKVGEAALCKQALKRNRSRMRQLDTNVERRALG
EIQNVGEGATATQGAWQSSESSQANLGEQAQSGPQGGRSQRRERHNRMERDRRRRIRICCDELNLLVPFCNAETDKATTLQWTTAFLKYI
QERHGDSLKKSGEIKSVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKRESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSNGSD
GGEASRGPWKGGNASGEPGLDQRAKQPPSTFVPQINRNIRFATYTKENGRTLVVQDEPVGGDTPASFTPYSTATGQTPLAPEVGGAENKE
AGKTLEQVGQGIVASAAVVTTASSTPNTVRISDTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGV
LATENKPLGFSFGCSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYFTTVSESLADDSSSRDSFKQSLESLSSGLCKGRSVLGTDTKPGSKA
GSSVDRKVPAESMPTLTPAFPRSLLNARTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKVAPSWP
ESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTF
SNVFGRHSGGFLSSPADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEHLMGKLGPNGERSAEL
LLGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRL
IFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCE
TTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCP
CISRQNKSVLRPAVTNGMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSELKAIRPPCPDT
APPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLP
QTPLDTGIPFPPVFSTSSAGVKSKASLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHD
PSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKL
KDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGI
PIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEE
YGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHE

--------------------------------------------------------------
>89831_89831_2_TCFL5-KDM3B_TCFL5_chr20_61485368_ENST00000335351_KDM3B_chr5_137717205_ENST00000314358_length(transcript)=7381nt_BP=1473nt
CGGGCCGGGGGTCGCCTCCCGCCTCCCGCCTCCCGCCTCCCGCCGCCCGCCGCCCGCGTCGCCCTCGCCGCCGTTGGGCCGCGCCGCGCC
GCCATGTCGGGCCCCGGACCGCGGGAGCCGCCGCCGGAGGCAGGCGCGGCAGGCGGCGAGGCGGCCGTCGAGGGCGCGGGCGGCGGGGAC
GCGGCGCTGGGCGAGCCGGGGCTGAGCTTCACGACCACCGACCTGAGCCTGGTGGAGATGACGGAGGTGGAGTACACGCAGCTGCAGCAC
ATCCTCTGCTCGCACATGGAGGCGGCGGCTGACGGCGAGCTCGAGACGCGCCTCAACTCGGCGCTGCTGGCGGCGGCGGGCCCGGGCGCA
GGCGCGGGCGGCTTCGCGGCGGGCGGTCAGGGGGGCGCGGCGCCCGTGTACCCCGTGCTGTGCCCGTCCGCGCTGGCGGCCGACGCGCCC
TGCCTGGGCCACATCGACTTCCAGGAGCTGCGCATGATGCTGCTAAGCGAGGCGGGCGCGGCGGAGAAGACGTCGGGCGGCGGGGACGGA
GCGAGGGCCCGGGCCGACGGCGCCGCCAAGGAGGGCGCGGGCGCGGCTGCGGCTGCGGCTGGACCCGACGGCGCGCCCGAGGCCCGGGCC
AAGCCGGCCGTGCGCGTCCGCCTGGAGGACCGCTTCAACAGCATCCCCGCCGAGCCGCCGCCCGCGCCGCGCGGCCCCGAGCCCCCCGAG
CCGGGCGGGGCGCTCAACAATTTGGTAACTCTCATTCGACATCCATCTGAACTAATGAATGTTCCTCTTCAGCAACAAAACAAATGTACA
GCATTAGTGAAAAATAAAACTGCGGCTACAACTACTGCTTTGCAATTTACATACCCACTGTTTACTACAAATGCTTGCTCTACTAGTGGA
AATTCTAATCTTTCACAGACACAGAGTTCTAGTAACTCATGTTCTGTACTTGAAGCTGCCAAGCACCAGGATATTGGATTGCCTAGAGCA
TTTTCTTTCTGTTATCAGCAAGAAATTGAATCCACTAAACAGACGTTAGGTAGTAGAAACAAAGTTTTGCCTGAGCAAGTTTGGATTAAA
GTGGGAGAAGCAGCGCTATGCAAACAAGCACTGAAGAGGAATCGGAGTAGAATGCGTCAGTTGGACACAAATGTAGAGCGAAGAGCCCTT
GGAGAGATTCAGAATGTGGGCGAAGGTGCCACCGCCACACAAGGCGCTTGGCAGTCCTCGGAGTCCTCACAGGCAAACCTGGGGGAGCAG
GCCCAGAGTGGGCCCCAGGGAGGAAGGTCTCAACGTAGGGAGAGGCATAACCGAATGGAAAGAGATAGAAGGCGCAGAATCCGCATTTGC
TGTGATGAGTTGAATCTCTTAGTGCCGTTCTGCAATGCCGAGACTGACAAGGCCACAACTCTGCAGTGGACCACAGCATTCCTGAAATAC
ATCCAGGAAAGACATGGAGATTCTCTTAAAAAGAGTGGTGAGATCAAGTCGGTAGATCCCAGACTAATCCATGTGATGCTGATGGATAAT
TCAGCGCCTCAAAGCGAGGGGGGTACGTTAAAAGCAGTAAAATCTTCCAAAGGAAAGAAGAAGAGAGAAAGCATAGAGGGGAAAGATGGC
CGGAGGAGGAAAAGTGCTTCGGACTCTGGGTGTGACCCTGCATCAAAGAAATTAAAAGGAGACAGGGGTGAAGTAGACAGTAATGGGAGC
GATGGAGGTGAGGCAAGCCGAGGGCCCTGGAAAGGAGGGAATGCCAGTGGAGAGCCAGGGCTGGATCAGAGAGCCAAGCAGCCACCGTCT
ACATTTGTCCCCCAGATAAACCGCAACATTCGCTTTGCCACTTACACCAAAGAAAACGGCAGGACTCTGGTGGTGCAGGATGAGCCTGTA
GGTGGGGACACACCTGCATCTTTCACTCCATATTCTACAGCCACAGGTCAGACACCTTTGGCCCCAGAGGTGGGTGGAGCCGAAAACAAA
GAGGCAGGAAAAACACTGGAACAAGTTGGCCAGGGCATAGTGGCTTCCGCAGCTGTGGTCACTACCGCCAGCTCCACCCCAAACACAGTG
AGGATCTCAGACACTGGCCTTGCAGCAGGGACTGTGCCAGAAAAACAGAAAGGCAGCCGGTCGCAGGCCTCGGGAGAGAATTCAAGAAAT
TCTATTCTGGCCTCTTCTGGATTTGGAGCACCTCTCCCTAGTTCATCGCAACCTTTGACTTTTGGAAGTGGAAGGAGCCAGTCCAATGGT
GTTCTAGCCACAGAGAACAAACCTTTGGGCTTCTCTTTTGGCTGTAGCTCTGCACAAGAGGCACAGAAAGACACTGATCTCTCCAAAAAC
TTGTTTTTTCAATGCATGTCCCAAACTTTACCTACCAGTAACTACTTCACTACTGTTTCAGAGAGTTTGGCTGATGATTCTTCTAGTCGG
GACTCATTCAAACAAAGCCTTGAGAGCCTGAGCTCAGGCCTGTGTAAAGGCAGATCCGTTCTTGGAACAGACACTAAGCCAGGCTCTAAG
GCTGGCAGCTCTGTGGACCGGAAAGTGCCTGCAGAGTCCATGCCCACCCTCACTCCAGCCTTCCCACGGAGCCTCCTAAATGCCCGTACC
CCAGAGAATCATGAAAATCTATTTTTACAGCCCCCCAAATTGTCCCGAGAAGAGCCTTCTAATCCTTTCCTGGCATTTGTGGAGAAAGTT
GAACACAGCCCTTTCAGTAGTTTTGCATCTCAGGCATCAGGTAGCTCCTCTTCTGCTACCACTGTCACCTCCAAGGTGGCACCCAGCTGG
CCCGAGTCTCACTCCTCTGCAGATTCGGCATCTTTAGCAAAGAAGAAACCCCTCTTCATTACAACTGACTCCTCCAAGCTAGTATCTGGT
GTTCTGGGCTCAGCTCTTACCAGTGGGGGCCCAAGCCTCTCTGCCATGGGGAATGGCCGCTCCAGCTCGCCCACCAGCAGCCTCACTCAG
CCCATTGAGATGCCAACTCTCTCCTCTAGCCCCACAGAGGAGAGGCCAACTGTGGGGCCTGGGCAGCAGGACAATCCCCTCCTCAAAACC
TTTAGTAACGTCTTTGGCAGGCACTCAGGCGGCTTTCTGTCCTCCCCGGCAGATTTTTCACAGGAGAACAAAGCTCCTTTTGAAGCTGTG
AAAAGGTTCTCACTGGATGAACGAAGCTTGGCTTGCAGACAAGACTCGGACTCCAGCACCAACAGTGACCTGTCAGATTTGAGTGACTCT
GAGGAGCAGCTGCAGGCTAAGACAGGCCTGAAGGGAATTCCAGAGCACCTGATGGGGAAGCTGGGCCCCAATGGGGAGCGCAGTGCTGAG
CTGTTGCTGGGCAAAAGCAAAGGGAAGCAGGCCCCCAAGGGCCGGCCTCGGACTGCCCCCCTGAAAGTTGGCCAGTCAGTGCTGAAAGAT
GTAAGCAAAGTGAAGAAGCTGAAGCAATCTGGAGAGCCCTTCCTGCAGGATGGGTCATGCATCAATGTGGCACCTCATCTGCACAAGTGT
CGTGAATGCCGCCTGGAGCGGTACCGGAAGTTTAAGGAACAGGAGCAAGATGATTCTACTGTAGCCTGCCGTTTCTTTCACTTCCGGAGG
TTGATCTTCACTCGAAAAGGGGTACTCCGTGTGGAGGGGTTTTTAAGCCCCCAGCAAAGTGACCCTGATGCCATGAACCTGTGGATTCCC
TCTTCCTCCCTAGCAGAAGGGATAGATCTAGAGACCTCAAAATACATCCTGGCCAATGTTGGGGACCAGTTCTGCCAGCTCGTAATGTCT
GAGAAGGAGGCCATGATGATGGTGGAGCCACACCAGAAAGTGGCATGGAAGCGAGCTGTGCGTGGTGTACGGGAGATGTGTGATGTGTGT
GAAACAACTCTCTTCAACATCCACTGGGTTTGTCGCAAATGTGGATTTGGGGTCTGCCTTGACTGTTACCGGCTCAGGAAAAGCCGGCCA
CGCAGTGAGACAGAAGAGATGGGTGATGAAGAAGTTTTCTCCTGGTTGAAGTGTGCAAAGGGACAGTCCCACGAACCAGAGAATCTCATG
CCCACACAAATTATTCCTGGCACAGCTCTTTACAATATTGGAGACATGGTACATGCTGCCCGGGGCAAGTGGGGAATTAAAGCAAACTGC
CCTTGTATCAGTCGACAGAACAAATCTGTATTGAGACCTGCCGTCACCAATGGGATGTCACAGCTTCCTAGCATAAACCCTAGTGCCTCT
TCTGGAAACGAAACTACCTTCTCTGGTGGAGGAGGACCGGCACCAGTAACAACTCCAGAGCCGGACCATGTTCCCAAAGCCGACAGCACT
GACATCAGATCTGAAGAGCCTCTGAAAACAGACAGTTCGGCATCAAATAGCAATAGTGAACTGAAAGCCATCAGGCCTCCTTGCCCTGAC
ACGGCCCCACCCTCCTCCGCCCTGCACTGGTTGGCAGATTTAGCAACTCAGAAGGCTAAAGAAGAAACAAAAGAAGCAGGGTCCCTGAGG
TCGGTGCTCAATAAAGAGTCTCATTCACCCTTTGGGCTGGACTCGTTCAACTCCACTGCAAAGGTCTCTCCGCTGACTCCAAAGCTTTTT
AACAGTCTGTTGCTGGGTCCCACTGCCTCCAACAACAAAACCGAAGGGTCTAGCCTTCGAGACCTCCTTCACTCCGGGCCGGGAAAACTT
CCTCAAACCCCCTTGGACACAGGCATACCCTTTCCCCCGGTCTTCTCTACATCCTCAGCAGGAGTGAAGAGCAAGGCCAGCCTACCCAAC
TTTCTTGACCACATCATTGCCTCAGTGGTAGAAAATAAGAAAACCTCAGATGCTTCAAAGCGGGCCTGCAACTTGACTGATACCCAGAAG
GAAGTGAAGGAGATGGTGATGGGGTTAAATGTGCTAGATCCCCATACTTCTCACTCCTGGCTTTGTGATGGGAGGCTTCTGTGTCTCCAT
GACCCCAGCAACAAAAACAATTGGAAGATCTTCCGGGAGTGTTGGAAGCAAGGTCAGCCAGTGCTGGTTTCGGGGGTACATAAAAAGCTC
AAGTCTGAGCTCTGGAAGCCAGAAGCCTTTAGCCAGGAATTTGGAGACCAGGATGTAGACTTGGTGAACTGCAGGAACTGTGCTATAATT
TCCGATGTGAAAGTTCGGGATTTCTGGGATGGTTTCGAGATCATATGCAAACGACTACGGTCAGAAGATGGGCAGCCAATGGTGCTCAAA
CTCAAGGACTGGCCTCCTGGGGAAGATTTTCGAGACATGATGCCAACCAGGTTTGAAGATCTGATGGAGAACCTTCCTCTGCCAGAATAT
ACCAAACGAGATGGCAGGCTCAATCTGGCCTCTAGGCTACCTAGCTACTTTGTAAGGCCTGATCTGGGCCCCAAGATGTACAACGCCTAT
GGGTTGATAACAGCAGAAGATAGAAGAGTTGGTACAACAAATCTTCACTTAGATGTGTCTGATGCTGTTAATGTGATGGTGTATGTTGGG
ATTCCCATCGGGGAGGGTGCTCATGATGAAGAGGTACTCAAGACAATTGACGAGGGAGATGCCGATGAGGTGACGAAGCAGAGGATTCAT
GATGGAAAAGAGAAGCCAGGTGCTTTATGGCACATCTATGCAGCCAAGGATGCAGAGAAGATCCGGGAGCTGCTCCGAAAGGTTGGAGAA
GAACAAGGCCAAGAGAACCCCCCTGATCATGACCCAATTCATGACCAAAGTTGGTACCTGGACCAGACCCTCCGTAAGCGACTCTATGAG
GAGTATGGCGTGCAAGGCTGGGCTATTGTGCAGTTCCTAGGTGATGCTGTTTTCATACCTGCTGGAGCCCCACACCAGGTTCACAATCTA
TACAGTTGCATAAAAGTAGCAGAAGACTTTGTATCTCCAGAACATGTAAAGCACTGTTTCCGCCTGACTCAGGAATTCAGGCATCTCTCT
AACACTCATACAAATCATGAGGATAAACTGCAGGTGAAGAACATCATTTACCATGCAGTGAAAGATGCGGTTGGCACCCTCAAGGCTCAT
GAATCCAAACTGGCAAGGTCCTAGGCATGGAGAAACTCCAAGCTCCTCTGTGAAGCAGGTCTTTCACTCACAACACTTAACAGGGAACGG
CAGGGCTCTTTGCTGGAGCAGAGGCCCTTCACCCAGAGCCAGTGTGGTCAGTATTCCAAACTCTCCAGCCACTCTCTTCTACGCTGCCTC
AACACTGAAGGTTGACACAGGAAAGTCGTACTGTTCACACACACAGTTTGAGACTCCAAGCCAAGAGTGCCACATCCCTATCCTGTGGCC
TTTTGGAAATCCAAATTGCCTGAACATGGCGGGGCTTTCCTGCACATTCTCCTGATTTGAGATTCACGGGCACACCTTTCTTTTCTTTTC
CTCTTGTGCCTAGTTAAGTGGAAATGTGTTTGGAGATAGGGGAAATCACATAACTGGTACAAGTATGGGGTAATTGCTTAAACATGCCTG
GTGGAAGTCTGATAGCGTCTCTGCACGTGACCTCTGACAAAGCCCATCCCAGGAGACGGGGTGAAGCTATTCCCCACACTCTCCTGTGAA
CACTGGAGTCTTGCAAGACCCAGGGAGAACCCACTGCTTTTCCCAGGAGGCTCCAGGATTAGGAAATGTGTGTATTTAGTGAAAAATAGG
TTTGTAGTGAAATAGTTACTATTTCATGAAAGTAGATATTTTTAGAATTTTTGAAATACCACAGTTGTTTTCCTGGATTATAAGGAAAGG
CACATTACATTTAGTCTTCCTTTCGATATAAAACTCTTTGAAGAAATATGATTTTTAGAAATCAGCTACCCATTATAGCACAAAATCAGC
CAAAGCAGAATTTTTAAAAATTGGCTTTTTTAGGATTCTTTTTCTCCCCCTCCCATCTTAGTCTTACCTTGAGGGAACAGTCATATGAGA
AGGAACTTTGTCACATCTAAGCTGTGGTGTGTTCCCCATGTGTGTGTACAACACTGGTGACTCCAGGAACCATTTTCACCTATTACCAGT
GTTCCCTGGGGACTCCTCTTAATGTTTCCAAATGGGAAGGACAGTTGATTTCCAACATGAGGTTTTTTGTTTTTTATCCAGAAATATTTT
CAGCAAAACTTTCCAACTGAGTGGAGTCTGATTAAGGATTTATTTGAAAATGGTGGGATTCATTGGCCCATAGGTACATTGGAAAATGTA
TATCTCTCCAGCTGTACTGTAGTGCCCTGCAGGCTGTTTATATGTTCACAGTTACTTTTTTTTTTTTTTTTAAATAAAAGTCATTTAATG
TAGAATACTTTTAATTTCACTTTCTGTATTTTAATTTTGTTGAAGGGCTGATTGGGATTTCCATGTTCTTATTAAAAATCTAACAAATCT

>89831_89831_2_TCFL5-KDM3B_TCFL5_chr20_61485368_ENST00000335351_KDM3B_chr5_137717205_ENST00000314358_length(amino acids)=1986AA_BP=460
MSGPGPREPPPEAGAAGGEAAVEGAGGGDAALGEPGLSFTTTDLSLVEMTEVEYTQLQHILCSHMEAAADGELETRLNSALLAAAGPGAG
AGGFAAGGQGGAAPVYPVLCPSALAADAPCLGHIDFQELRMMLLSEAGAAEKTSGGGDGARARADGAAKEGAGAAAAAAGPDGAPEARAK
PAVRVRLEDRFNSIPAEPPPAPRGPEPPEPGGALNNLVTLIRHPSELMNVPLQQQNKCTALVKNKTAATTTALQFTYPLFTTNACSTSGN
SNLSQTQSSSNSCSVLEAAKHQDIGLPRAFSFCYQQEIESTKQTLGSRNKVLPEQVWIKVGEAALCKQALKRNRSRMRQLDTNVERRALG
EIQNVGEGATATQGAWQSSESSQANLGEQAQSGPQGGRSQRRERHNRMERDRRRRIRICCDELNLLVPFCNAETDKATTLQWTTAFLKYI
QERHGDSLKKSGEIKSVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKRESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSNGSD
GGEASRGPWKGGNASGEPGLDQRAKQPPSTFVPQINRNIRFATYTKENGRTLVVQDEPVGGDTPASFTPYSTATGQTPLAPEVGGAENKE
AGKTLEQVGQGIVASAAVVTTASSTPNTVRISDTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGV
LATENKPLGFSFGCSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYFTTVSESLADDSSSRDSFKQSLESLSSGLCKGRSVLGTDTKPGSKA
GSSVDRKVPAESMPTLTPAFPRSLLNARTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKVAPSWP
ESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTF
SNVFGRHSGGFLSSPADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEHLMGKLGPNGERSAEL
LLGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRL
IFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCE
TTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCP
CISRQNKSVLRPAVTNGMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSELKAIRPPCPDT
APPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLP
QTPLDTGIPFPPVFSTSSAGVKSKASLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHD
PSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKL
KDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGI
PIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEE
YGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TCFL5-KDM3B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TCFL5-KDM3B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TCFL5-KDM3B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source