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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCN2-THOC5 (FusionGDB2 ID:89848)

Fusion Gene Summary for TCN2-THOC5

check button Fusion gene summary
Fusion gene informationFusion gene name: TCN2-THOC5
Fusion gene ID: 89848
HgeneTgene
Gene symbol

TCN2

THOC5

Gene ID

6948

8563

Gene nametranscobalamin 2THO complex 5
SynonymsD22S676|D22S750|II|TC|TC II|TC-2|TC2|TCIIC22orf19|Fmip|PK1.3|fSAP79
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptiontranscobalamin-2macrocytic anemiatranscobalamin IItranscobalamin II; macrocytic anemiavitamin B12-binding protein 2THO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000215838, ENST00000405742, 
ENST00000407817, 		ENST00000397871, 
ENST00000397872, ENST00000397873, 
ENST00000490103, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 4=144
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCN2 [Title/Abstract] AND THOC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCN2(31010488)-THOC5(29908125), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCN2

GO:0015889

cobalamin transport

8443384

TgeneTHOC5

GO:0006406

mRNA export from nucleus

17190602

TgeneTHOC5

GO:0030224

monocyte differentiation

19015024

TgeneTHOC5

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across TCN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THOC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AD-6965-01ATCN2chr22

31010488

-THOC5chr22

29908125

-
ChimerDB4COADTCGA-AD-6965-01ATCN2chr22

31010488

+THOC5chr22

29908125

-


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Fusion Gene ORF analysis for TCN2-THOC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000215838ENST00000397871TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000215838ENST00000397872TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000215838ENST00000397873TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000215838ENST00000490103TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000405742ENST00000397871TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000405742ENST00000397872TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000405742ENST00000397873TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000405742ENST00000490103TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000407817ENST00000397871TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000407817ENST00000397872TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000407817ENST00000397873TCN2chr22

31010488

+THOC5chr22

29908125

-
In-frameENST00000407817ENST00000490103TCN2chr22

31010488

+THOC5chr22

29908125

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000215838TCN2chr2231010488+ENST00000490103THOC5chr2229908125-402310744641444326
ENST00000215838TCN2chr2231010488+ENST00000397871THOC5chr2229908125-173410744641444326
ENST00000215838TCN2chr2231010488+ENST00000397872THOC5chr2229908125-173410744641444326
ENST00000215838TCN2chr2231010488+ENST00000397873THOC5chr2229908125-154410744641444326
ENST00000405742TCN2chr2231010488+ENST00000490103THOC5chr2229908125-36977481501118322
ENST00000405742TCN2chr2231010488+ENST00000397871THOC5chr2229908125-14087481501118322
ENST00000405742TCN2chr2231010488+ENST00000397872THOC5chr2229908125-14087481501118322
ENST00000405742TCN2chr2231010488+ENST00000397873THOC5chr2229908125-12187481501118322
ENST00000407817TCN2chr2231010488+ENST00000490103THOC5chr2229908125-357662798997299
ENST00000407817TCN2chr2231010488+ENST00000397871THOC5chr2229908125-128762798997299
ENST00000407817TCN2chr2231010488+ENST00000397872THOC5chr2229908125-128762798997299
ENST00000407817TCN2chr2231010488+ENST00000397873THOC5chr2229908125-109762798997299

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000215838ENST00000490103TCN2chr2231010488+THOC5chr2229908125-0.001462590.9985374
ENST00000215838ENST00000397871TCN2chr2231010488+THOC5chr2229908125-0.0056560910.9943439
ENST00000215838ENST00000397872TCN2chr2231010488+THOC5chr2229908125-0.0056560910.9943439
ENST00000215838ENST00000397873TCN2chr2231010488+THOC5chr2229908125-0.0063393120.99366075
ENST00000405742ENST00000490103TCN2chr2231010488+THOC5chr2229908125-0.0009843570.99901557
ENST00000405742ENST00000397871TCN2chr2231010488+THOC5chr2229908125-0.0049280570.99507195
ENST00000405742ENST00000397872TCN2chr2231010488+THOC5chr2229908125-0.0049280570.99507195
ENST00000405742ENST00000397873TCN2chr2231010488+THOC5chr2229908125-0.0057010780.99429893
ENST00000407817ENST00000490103TCN2chr2231010488+THOC5chr2229908125-0.0022356950.99776435
ENST00000407817ENST00000397871TCN2chr2231010488+THOC5chr2229908125-0.010139060.9898609
ENST00000407817ENST00000397872TCN2chr2231010488+THOC5chr2229908125-0.010139060.9898609
ENST00000407817ENST00000397873TCN2chr2231010488+THOC5chr2229908125-0.0110223160.98897773

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Fusion Genomic Features for TCN2-THOC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCN2-THOC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:31010488/chr22:29908125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCN2chr22:31010488chr22:29908125ENST00000215838+49152_156193428.0RegionCob(II)alamin binding
HgeneTCN2chr22:31010488chr22:29908125ENST00000215838+49190_194193428.0RegionCob(II)alamin binding
HgeneTCN2chr22:31010488chr22:29908125ENST00000407817+49152_156166401.0RegionCob(II)alamin binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCN2chr22:31010488chr22:29908125ENST00000215838+49395_397193428.0RegionCob(II)alamin binding
HgeneTCN2chr22:31010488chr22:29908125ENST00000407817+49190_194166401.0RegionCob(II)alamin binding
HgeneTCN2chr22:31010488chr22:29908125ENST00000407817+49395_397166401.0RegionCob(II)alamin binding
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787116207_10560684.0MotifNuclear localization signal
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787217217_10560684.0MotifNuclear localization signal
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787317217_10560684.0MotifNuclear localization signal
TgeneTHOC5chr22:31010488chr22:29908125ENST0000049010316207_10560684.0MotifNuclear localization signal


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Fusion Gene Sequence for TCN2-THOC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89848_89848_1_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000397871_length(transcript)=1734nt_BP=1074nt
ACTCCTTGTCCTGGGCTAGGTGGGCACTACCAGGGGCTCCTTTGGTAAGGAGTACCGGGTAGGCACCCGGTCCTGCCAATCCACCACTGG
AACAGCTGGGGGGACAGCAGACAGGCACGGTCGGACAGACTTGACAGATCAGGCATCAGGCCCTCTGCGCTGGTCCCGGGCTCTTTAAGC
AGGAACGTGAATGGCCTCAAGATGTCTCACATGGTCCCACTAGCCCTCCTCCTCCCTTTGTTCCCTACCTCCAGGAGGGCTGCTCTGCCC
TTCCTTCCTCTGTTCTTTGGCCTTATGTTCCCCGCCACCACAGACCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGG
CATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGA
GTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGG
CCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTT
CCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCC
TCAAGCTTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGG
CCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGG
AGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGTGTC
TCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCAAAC
TGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACA
GCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGA
CCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTC
CCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATC
GCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTT
GATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTG
GAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGA

>89848_89848_1_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000397871_length(amino acids)=326AA_BP=203
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKR
VHDSVVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQ

--------------------------------------------------------------
>89848_89848_2_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000397872_length(transcript)=1734nt_BP=1074nt
ACTCCTTGTCCTGGGCTAGGTGGGCACTACCAGGGGCTCCTTTGGTAAGGAGTACCGGGTAGGCACCCGGTCCTGCCAATCCACCACTGG
AACAGCTGGGGGGACAGCAGACAGGCACGGTCGGACAGACTTGACAGATCAGGCATCAGGCCCTCTGCGCTGGTCCCGGGCTCTTTAAGC
AGGAACGTGAATGGCCTCAAGATGTCTCACATGGTCCCACTAGCCCTCCTCCTCCCTTTGTTCCCTACCTCCAGGAGGGCTGCTCTGCCC
TTCCTTCCTCTGTTCTTTGGCCTTATGTTCCCCGCCACCACAGACCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGG
CATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGA
GTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGG
CCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTT
CCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCC
TCAAGCTTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGG
CCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGG
AGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGTGTC
TCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCAAAC
TGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACA
GCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGA
CCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTC
CCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATC
GCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTT
GATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTG
GAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGA

>89848_89848_2_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000397872_length(amino acids)=326AA_BP=203
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKR
VHDSVVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQ

--------------------------------------------------------------
>89848_89848_3_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000397873_length(transcript)=1544nt_BP=1074nt
ACTCCTTGTCCTGGGCTAGGTGGGCACTACCAGGGGCTCCTTTGGTAAGGAGTACCGGGTAGGCACCCGGTCCTGCCAATCCACCACTGG
AACAGCTGGGGGGACAGCAGACAGGCACGGTCGGACAGACTTGACAGATCAGGCATCAGGCCCTCTGCGCTGGTCCCGGGCTCTTTAAGC
AGGAACGTGAATGGCCTCAAGATGTCTCACATGGTCCCACTAGCCCTCCTCCTCCCTTTGTTCCCTACCTCCAGGAGGGCTGCTCTGCCC
TTCCTTCCTCTGTTCTTTGGCCTTATGTTCCCCGCCACCACAGACCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGG
CATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGA
GTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGG
CCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTT
CCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCC
TCAAGCTTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGG
CCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGG
AGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGTGTC
TCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCAAAC
TGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACA
GCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGA
CCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTC
CCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATC
GCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTT

>89848_89848_3_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000397873_length(amino acids)=326AA_BP=203
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKR
VHDSVVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQ

--------------------------------------------------------------
>89848_89848_4_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000490103_length(transcript)=4023nt_BP=1074nt
ACTCCTTGTCCTGGGCTAGGTGGGCACTACCAGGGGCTCCTTTGGTAAGGAGTACCGGGTAGGCACCCGGTCCTGCCAATCCACCACTGG
AACAGCTGGGGGGACAGCAGACAGGCACGGTCGGACAGACTTGACAGATCAGGCATCAGGCCCTCTGCGCTGGTCCCGGGCTCTTTAAGC
AGGAACGTGAATGGCCTCAAGATGTCTCACATGGTCCCACTAGCCCTCCTCCTCCCTTTGTTCCCTACCTCCAGGAGGGCTGCTCTGCCC
TTCCTTCCTCTGTTCTTTGGCCTTATGTTCCCCGCCACCACAGACCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGG
CATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGA
GTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGG
CCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTT
CCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCC
TCAAGCTTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGG
CCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGG
AGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGTGTC
TCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCAAAC
TGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACA
GCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGA
CCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTC
CCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATC
GCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTT
GATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTG
GAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGA
TTCCAATTCTGCAGAGAGATGCTCACCTCTTGTCTACGCACACCCTATTTGTGCTTTGCGGGGTGAGGTCCTCATGATCTTGTATTTATT
ATCCCAAGTTCCTGCTGTTAAGAGGTGGTAGGAGAAGCCAAAGGCAGCAGAGCACAAAAAGCAAAACTCTTCCCTCCCCACCCGCTCTTC
CCATTAGTCCTGTCAGGGTTGCCGATGGACAAATTGTCTCTGATCGTTGGATGTTATAAATGTCTGACAGTGCAGTGCAAACAGAAGACA
AACTCAGTTGATCCTTGAACAACTCAGGGGTTAGGGGCACCAACACCCCCTGCCCTGCACAGTTGAAAAATCCGTGTATAACTTTTGACT
CCCTAAAAACTTAACTAATAGCCTGCTGTTGACCAGTAGTATGCTATTAGTAGTTACTTACTGCTAACATAGTCAGTACATATTTTCAGT
ATATATTTTGTATCTTATACACTGTATTCTTACAATACAGTAAACTAGAGAAAAGAAAATGTTATAAGGAAAGTCACAAGGGGGCCTGAG
TGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCGA
CATGGTGAAACCCTGTCTCTACTAAAAACATGGAAATTAGCCAAGCGTGGTGGCGCATGCCTGTAGTCCCAGTTACTCAGGAGGCTGAGG
CAGAATTACTTGAACCCATGAGGCAGAGGTTGCAGTAAGCCAAGATCACGCTCCTGCGCTCCGGCTTGGGCGAGAGTGAGACTCCGTCTC
AAAAATAAATAAATAAGAAAGCCATAAGGAAGAAAATATATATCTACTATTAAGTAGAAGTGGATCACCATAAAGGTCTTCACATACTGT
CTCAGGGTTGAATAGTCTAAGGAAGAGGAGGGGTTGGTCTTGGTGTCTCAGGGATGGCAGAGGCAGAAAAAGTGGGGGAGGTGGAGGGGG
AGGCAGGCACCACTGTTATTTTTATTGAACAAAATCTGTGCAGGGACTCATGACTGTAATCCTAGTACTTTGGAAAGCTAAGGCGGGAGG
ATCCCTTGAGGCCAGGAGTTCAGGTCCAGCCTGGGCAACGTAGTGAGAGACCCTGTATCTACAAAAAATTTAAAAATCAGCCAGGTGTGG
TGGTATGCACCAATAGTCCCAGTTACTCAGAAGGCTGAGGTGGGCGGATGACTGGAGTCCAGGAGTTCAAGGTAGCAGTGAGCTATTCAT
CGTGCCTGTACTGTACTCCAGCCTGGGAAACAATGCGAGTCCCTATCTCTAAAAAATTTTAAAAAAAGAAATCTGCATATAATAGACCCA
CAGAGTCCAAACTATTGTTCAGAGATCAACTGTACTTCACAGAGAGTAATTCTAAGTCTTACAGGATTTCATGGAGATGGCGAGAGTGGT
GTTGGAGAATCAATCACATACAGAGATACAGGACAGTGAGACCAGGTAACATTTGAGGAGAATATTTTTTTTTTATTGAGACAGGGTCTT
GCTCTGTTGTCCAGGCTGGAGTGCAGTGGCACGAACACAGCTCACTGCCGCCTCAACCTCTCCTGGGTTCAAGTGATCCTCCTGCCTCAG
CCTCCCAAGTAGCTGGGACCACAGGTGTGTGCCACCATTTCTGGCTAATTTTTAAATTTTTTGTAGAGGCGGGATCCCACTATTTTTCCC
AGGCTGGTCTCAAACTCCTGGGCTCAAATGATCCTCCCACCTCGGCCTCCCAAAGTGCTAGGATTATAGGCATGAGCCACCACACCCGGC
CTGAGTAGAGTCTTTAAGGTAATGACAAAAGTGCCTCAAAATATAATTATTTGATTAAGAGAAGTCTTGGGAAGATAGGTAACAACCTTT
AAAATGTTCATAAAATTACATCCTTTGTAATACTCCTGCAAGTCAAAGTAAAGGATGGCATAGACTATTCTTGGACAGTTTTGTCAAAAA
GTGTATCTTGACCCCACCATCAGTACTCCATTCTTCATTTTAAAAAATAAGATGGGCTGGGCACAGTGGCTTACGCCTTTAATATCAGTA
CTTTGGGAGGCTGGTGGGCGGATCACCTGAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGCATGGTGGTGCGCGCCTGTAATCCCAGCCACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCCCGAGGCGGAG

>89848_89848_4_TCN2-THOC5_TCN2_chr22_31010488_ENST00000215838_THOC5_chr22_29908125_ENST00000490103_length(amino acids)=326AA_BP=203
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKR
VHDSVVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQ

--------------------------------------------------------------
>89848_89848_5_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000397871_length(transcript)=1408nt_BP=748nt
CCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGGCATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCG
GTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCC
ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTG
GTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC
TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTACCAGCAGTGCCTCCTAGGCGAGGATGACGGT
GACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGG
GACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTAC
TACCAGTATGGCCTGGGCATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAA
CCTTTCCACCAGGGCCACCATTCTGTGGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAG
CTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAG
CTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGC
CATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTT
AAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGC
TTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTG
TCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTT

>89848_89848_5_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000397871_length(amino acids)=322AA_BP=199
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDS
VVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCV

--------------------------------------------------------------
>89848_89848_6_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000397872_length(transcript)=1408nt_BP=748nt
CCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGGCATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCG
GTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCC
ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTG
GTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC
TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTACCAGCAGTGCCTCCTAGGCGAGGATGACGGT
GACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGG
GACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTAC
TACCAGTATGGCCTGGGCATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAA
CCTTTCCACCAGGGCCACCATTCTGTGGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAG
CTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAG
CTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGC
CATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTT
AAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGC
TTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTG
TCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTT

>89848_89848_6_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000397872_length(amino acids)=322AA_BP=199
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDS
VVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCV

--------------------------------------------------------------
>89848_89848_7_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000397873_length(transcript)=1218nt_BP=748nt
CCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGGCATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCG
GTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCC
ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTG
GTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC
TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTACCAGCAGTGCCTCCTAGGCGAGGATGACGGT
GACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGG
GACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTAC
TACCAGTATGGCCTGGGCATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAA
CCTTTCCACCAGGGCCACCATTCTGTGGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAG
CTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAG
CTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGC
CATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTT
AAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGC

>89848_89848_7_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000397873_length(amino acids)=322AA_BP=199
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDS
VVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCV

--------------------------------------------------------------
>89848_89848_8_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000490103_length(transcript)=3697nt_BP=748nt
CCTTCCCCCGCCCCACCCCTCTGCAGACTTAGCCGTGCATTGCAGGCATGGAGGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCG
GTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTTCCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCC
ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTG
GTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC
TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTACCAGCAGTGCCTCCTAGGCGAGGATGACGGT
GACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGGGGCCACAAGGGG
GACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGAGCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTAC
TACCAGTATGGCCTGGGCATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAA
CCTTTCCACCAGGGCCACCATTCTGTGGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAG
CTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAG
CTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGC
CATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTT
AAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGC
TTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTG
TCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTT
TCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAGAGATGCTCACCTCTTGTCTACGCACACCCTATTTGTGCTT
TGCGGGGTGAGGTCCTCATGATCTTGTATTTATTATCCCAAGTTCCTGCTGTTAAGAGGTGGTAGGAGAAGCCAAAGGCAGCAGAGCACA
AAAAGCAAAACTCTTCCCTCCCCACCCGCTCTTCCCATTAGTCCTGTCAGGGTTGCCGATGGACAAATTGTCTCTGATCGTTGGATGTTA
TAAATGTCTGACAGTGCAGTGCAAACAGAAGACAAACTCAGTTGATCCTTGAACAACTCAGGGGTTAGGGGCACCAACACCCCCTGCCCT
GCACAGTTGAAAAATCCGTGTATAACTTTTGACTCCCTAAAAACTTAACTAATAGCCTGCTGTTGACCAGTAGTATGCTATTAGTAGTTA
CTTACTGCTAACATAGTCAGTACATATTTTCAGTATATATTTTGTATCTTATACACTGTATTCTTACAATACAGTAAACTAGAGAAAAGA
AAATGTTATAAGGAAAGTCACAAGGGGGCCTGAGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCA
CTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTCTACTAAAAACATGGAAATTAGCCAAGCGTGGTGGCGC
ATGCCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGAATTACTTGAACCCATGAGGCAGAGGTTGCAGTAAGCCAAGATCACGCTCCTG
CGCTCCGGCTTGGGCGAGAGTGAGACTCCGTCTCAAAAATAAATAAATAAGAAAGCCATAAGGAAGAAAATATATATCTACTATTAAGTA
GAAGTGGATCACCATAAAGGTCTTCACATACTGTCTCAGGGTTGAATAGTCTAAGGAAGAGGAGGGGTTGGTCTTGGTGTCTCAGGGATG
GCAGAGGCAGAAAAAGTGGGGGAGGTGGAGGGGGAGGCAGGCACCACTGTTATTTTTATTGAACAAAATCTGTGCAGGGACTCATGACTG
TAATCCTAGTACTTTGGAAAGCTAAGGCGGGAGGATCCCTTGAGGCCAGGAGTTCAGGTCCAGCCTGGGCAACGTAGTGAGAGACCCTGT
ATCTACAAAAAATTTAAAAATCAGCCAGGTGTGGTGGTATGCACCAATAGTCCCAGTTACTCAGAAGGCTGAGGTGGGCGGATGACTGGA
GTCCAGGAGTTCAAGGTAGCAGTGAGCTATTCATCGTGCCTGTACTGTACTCCAGCCTGGGAAACAATGCGAGTCCCTATCTCTAAAAAA
TTTTAAAAAAAGAAATCTGCATATAATAGACCCACAGAGTCCAAACTATTGTTCAGAGATCAACTGTACTTCACAGAGAGTAATTCTAAG
TCTTACAGGATTTCATGGAGATGGCGAGAGTGGTGTTGGAGAATCAATCACATACAGAGATACAGGACAGTGAGACCAGGTAACATTTGA
GGAGAATATTTTTTTTTTATTGAGACAGGGTCTTGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCACGAACACAGCTCACTGCCGCCTCAA
CCTCTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACCACAGGTGTGTGCCACCATTTCTGGCTAATTTTTAAA
TTTTTTGTAGAGGCGGGATCCCACTATTTTTCCCAGGCTGGTCTCAAACTCCTGGGCTCAAATGATCCTCCCACCTCGGCCTCCCAAAGT
GCTAGGATTATAGGCATGAGCCACCACACCCGGCCTGAGTAGAGTCTTTAAGGTAATGACAAAAGTGCCTCAAAATATAATTATTTGATT
AAGAGAAGTCTTGGGAAGATAGGTAACAACCTTTAAAATGTTCATAAAATTACATCCTTTGTAATACTCCTGCAAGTCAAAGTAAAGGAT
GGCATAGACTATTCTTGGACAGTTTTGTCAAAAAGTGTATCTTGACCCCACCATCAGTACTCCATTCTTCATTTTAAAAAATAAGATGGG
CTGGGCACAGTGGCTTACGCCTTTAATATCAGTACTTTGGGAGGCTGGTGGGCGGATCACCTGAGATCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGTGCGCGCCTGTAATCCCAGCCACTCGGGAGGCTG
AGGCAGGAGAATTGCTTGAATCCCCGAGGCGGAGGTTGCACTGAGCCGAGATGGTGCCACTGCACCATCTGGACAACAGAGCAAGACTCC

>89848_89848_8_TCN2-THOC5_TCN2_chr22_31010488_ENST00000405742_THOC5_chr22_29908125_ENST00000490103_length(amino acids)=322AA_BP=199
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDS
VVDKLLYAVEPFHQGHHSVAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCV

--------------------------------------------------------------
>89848_89848_9_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000397871_length(transcript)=1287nt_BP=627nt
GGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTT
CCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCA
CTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGG
AGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGC
TTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCT
ACCTGCTCGCTCTCAGAGCCAACTGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGT
GTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCA
AACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCA
ACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGT
TGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAAT
TTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCC
ATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACT
CTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGT
CTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAA

>89848_89848_9_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000397871_length(amino acids)=299AA_BP=176
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANWHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVAKLQ
AAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQ

--------------------------------------------------------------
>89848_89848_10_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000397872_length(transcript)=1287nt_BP=627nt
GGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTT
CCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCA
CTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGG
AGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGC
TTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCT
ACCTGCTCGCTCTCAGAGCCAACTGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGT
GTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCA
AACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCA
ACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGT
TGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAAT
TTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCC
ATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACT
CTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGT
CTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAA

>89848_89848_10_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000397872_length(amino acids)=299AA_BP=176
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANWHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVAKLQ
AAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQ

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>89848_89848_11_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000397873_length(transcript)=1097nt_BP=627nt
GGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTT
CCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCA
CTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGG
AGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGC
TTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCT
ACCTGCTCGCTCTCAGAGCCAACTGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGT
GTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCA
AACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCA
ACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGT
TGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAAT
TTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCC
ATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACT

>89848_89848_11_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000397873_length(amino acids)=299AA_BP=176
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANWHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVAKLQ
AAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQ

--------------------------------------------------------------
>89848_89848_12_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000490103_length(transcript)=3576nt_BP=627nt
GGATTAATCAGTGACAGGAAGCTGCGTCTCTCGGAGCGGTGACCAGCTGTGGTCAGGAGAGCCTCAGCAGGGCCAGCCCCAGGAGTCTTT
CCCGATTCTTGCTCACTGCTCACCCACCTGCTGCTGCCATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCA
CTGAGATGTGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCTTGGATGGACCGGCTTTCCCTGG
AGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTCTCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGC
TTGGTTACCAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCTTCCATGGGCCAGCTGGCCCTCT
ACCTGCTCGCTCTCAGAGCCAACTGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGCATTCTGGCCCTGT
GTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTGTATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGCCA
AACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCA
ACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGT
TGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAAT
TTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCC
ATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACT
CTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGT
CTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAA
AGATTCCAATTCTGCAGAGAGATGCTCACCTCTTGTCTACGCACACCCTATTTGTGCTTTGCGGGGTGAGGTCCTCATGATCTTGTATTT
ATTATCCCAAGTTCCTGCTGTTAAGAGGTGGTAGGAGAAGCCAAAGGCAGCAGAGCACAAAAAGCAAAACTCTTCCCTCCCCACCCGCTC
TTCCCATTAGTCCTGTCAGGGTTGCCGATGGACAAATTGTCTCTGATCGTTGGATGTTATAAATGTCTGACAGTGCAGTGCAAACAGAAG
ACAAACTCAGTTGATCCTTGAACAACTCAGGGGTTAGGGGCACCAACACCCCCTGCCCTGCACAGTTGAAAAATCCGTGTATAACTTTTG
ACTCCCTAAAAACTTAACTAATAGCCTGCTGTTGACCAGTAGTATGCTATTAGTAGTTACTTACTGCTAACATAGTCAGTACATATTTTC
AGTATATATTTTGTATCTTATACACTGTATTCTTACAATACAGTAAACTAGAGAAAAGAAAATGTTATAAGGAAAGTCACAAGGGGGCCT
GAGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGC
CGACATGGTGAAACCCTGTCTCTACTAAAAACATGGAAATTAGCCAAGCGTGGTGGCGCATGCCTGTAGTCCCAGTTACTCAGGAGGCTG
AGGCAGAATTACTTGAACCCATGAGGCAGAGGTTGCAGTAAGCCAAGATCACGCTCCTGCGCTCCGGCTTGGGCGAGAGTGAGACTCCGT
CTCAAAAATAAATAAATAAGAAAGCCATAAGGAAGAAAATATATATCTACTATTAAGTAGAAGTGGATCACCATAAAGGTCTTCACATAC
TGTCTCAGGGTTGAATAGTCTAAGGAAGAGGAGGGGTTGGTCTTGGTGTCTCAGGGATGGCAGAGGCAGAAAAAGTGGGGGAGGTGGAGG
GGGAGGCAGGCACCACTGTTATTTTTATTGAACAAAATCTGTGCAGGGACTCATGACTGTAATCCTAGTACTTTGGAAAGCTAAGGCGGG
AGGATCCCTTGAGGCCAGGAGTTCAGGTCCAGCCTGGGCAACGTAGTGAGAGACCCTGTATCTACAAAAAATTTAAAAATCAGCCAGGTG
TGGTGGTATGCACCAATAGTCCCAGTTACTCAGAAGGCTGAGGTGGGCGGATGACTGGAGTCCAGGAGTTCAAGGTAGCAGTGAGCTATT
CATCGTGCCTGTACTGTACTCCAGCCTGGGAAACAATGCGAGTCCCTATCTCTAAAAAATTTTAAAAAAAGAAATCTGCATATAATAGAC
CCACAGAGTCCAAACTATTGTTCAGAGATCAACTGTACTTCACAGAGAGTAATTCTAAGTCTTACAGGATTTCATGGAGATGGCGAGAGT
GGTGTTGGAGAATCAATCACATACAGAGATACAGGACAGTGAGACCAGGTAACATTTGAGGAGAATATTTTTTTTTTATTGAGACAGGGT
CTTGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCACGAACACAGCTCACTGCCGCCTCAACCTCTCCTGGGTTCAAGTGATCCTCCTGCCT
CAGCCTCCCAAGTAGCTGGGACCACAGGTGTGTGCCACCATTTCTGGCTAATTTTTAAATTTTTTGTAGAGGCGGGATCCCACTATTTTT
CCCAGGCTGGTCTCAAACTCCTGGGCTCAAATGATCCTCCCACCTCGGCCTCCCAAAGTGCTAGGATTATAGGCATGAGCCACCACACCC
GGCCTGAGTAGAGTCTTTAAGGTAATGACAAAAGTGCCTCAAAATATAATTATTTGATTAAGAGAAGTCTTGGGAAGATAGGTAACAACC
TTTAAAATGTTCATAAAATTACATCCTTTGTAATACTCCTGCAAGTCAAAGTAAAGGATGGCATAGACTATTCTTGGACAGTTTTGTCAA
AAAGTGTATCTTGACCCCACCATCAGTACTCCATTCTTCATTTTAAAAAATAAGATGGGCTGGGCACAGTGGCTTACGCCTTTAATATCA
GTACTTTGGGAGGCTGGTGGGCGGATCACCTGAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAA
TACAAAAATTAGCTGGGCATGGTGGTGCGCGCCTGTAATCCCAGCCACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCCCGAGGCG

>89848_89848_12_TCN2-THOC5_TCN2_chr22_31010488_ENST00000407817_THOC5_chr22_29908125_ENST00000490103_length(amino acids)=299AA_BP=176
MLTAHPPAAAMRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGY
QQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANWHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVAKLQ
AAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TCN2-THOC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787116202_144560.3333333333334684.0CSF1R
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787217212_144560.3333333333334684.0CSF1R
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787317212_144560.3333333333334684.0CSF1R
TgeneTHOC5chr22:31010488chr22:29908125ENST0000049010316202_144560.3333333333334684.0CSF1R
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787116202_199560.3333333333334684.0THOC7
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787217212_199560.3333333333334684.0THOC7
TgeneTHOC5chr22:31010488chr22:29908125ENST0000039787317212_199560.3333333333334684.0THOC7
TgeneTHOC5chr22:31010488chr22:29908125ENST0000049010316202_199560.3333333333334684.0THOC7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCN2-THOC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCN2-THOC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource