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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCTN1-GORASP2 (FusionGDB2 ID:89898)

Fusion Gene Summary for TCTN1-GORASP2

check button Fusion gene summary
Fusion gene informationFusion gene name: TCTN1-GORASP2
Fusion gene ID: 89898
HgeneTgene
Gene symbol

TCTN1

GORASP2

Gene ID

79600

26003

Gene nametectonic family member 1golgi reassembly stacking protein 2
SynonymsJBTS13|TECT1GOLPH6|GRASP55|GRS2|p59
Cytomap

12q24.11

2q31.1

Type of geneprotein-codingprotein-coding
Descriptiontectonic-1Golgi reassembly-stacking protein 2golgi phosphoprotein 6golgi reassembly stacking protein 2, 55kDa
Modification date2020031320200327
UniProtAcc.

Q9H8Y8

Ensembl transtripts involved in fusion geneENST00000551555, ENST00000377654, 
ENST00000397655, ENST00000397659, 
ENST00000550703, ENST00000551590, 
ENST00000471804, 		ENST00000234160, 
ENST00000452526, ENST00000493692, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 6 X 3=162
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/162*10)=-1.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCTN1 [Title/Abstract] AND GORASP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCTN1(111066723)-GORASP2(171806048), # samples:1
Anticipated loss of major functional domain due to fusion event.TCTN1-GORASP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGORASP2

GO:0034976

response to endoplasmic reticulum stress

21884936|27062250|28067262

TgeneGORASP2

GO:0061951

establishment of protein localization to plasma membrane

28067262


check buttonFusion gene breakpoints across TCTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GORASP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A4A4TCTN1chr12

111066723

+GORASP2chr2

171806048

+


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Fusion Gene ORF analysis for TCTN1-GORASP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000551555ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
3UTR-3UTRENST00000551555ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
3UTR-3UTRENST00000551555ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000377654ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000377654ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000397655ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000397655ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000397659ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000397659ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000550703ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000550703ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000551590ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
5CDS-3UTRENST00000551590ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+
Frame-shiftENST00000550703ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
In-frameENST00000377654ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
In-frameENST00000397655ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
In-frameENST00000397659ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
In-frameENST00000551590ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
intron-3CDSENST00000471804ENST00000234160TCTN1chr12

111066723

+GORASP2chr2

171806048

+
intron-3UTRENST00000471804ENST00000452526TCTN1chr12

111066723

+GORASP2chr2

171806048

+
intron-3UTRENST00000471804ENST00000493692TCTN1chr12

111066723

+GORASP2chr2

171806048

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000551590TCTN1chr12111066723+ENST00000234160GORASP2chr2171806048+299478091994661
ENST00000397655TCTN1chr12111066723+ENST00000234160GORASP2chr2171806048+290869441908634
ENST00000377654TCTN1chr12111066723+ENST00000234160GORASP2chr2171806048+2884670461884612
ENST00000397659TCTN1chr12111066723+ENST00000234160GORASP2chr2171806048+2857643191857612

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000551590ENST00000234160TCTN1chr12111066723+GORASP2chr2171806048+0.0011325140.9988675
ENST00000397655ENST00000234160TCTN1chr12111066723+GORASP2chr2171806048+0.0009373570.9990626
ENST00000377654ENST00000234160TCTN1chr12111066723+GORASP2chr2171806048+0.0009303460.99906963
ENST00000397659ENST00000234160TCTN1chr12111066723+GORASP2chr2171806048+0.0009624180.9990376

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Fusion Genomic Features for TCTN1-GORASP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TCTN1chr12111066723+GORASP2chr2171806048+1.20E-060.9999988
TCTN1chr12111066723+GORASP2chr2171806048+1.20E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TCTN1-GORASP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:111066723/chr2:171806048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GORASP2

Q9H8Y8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCTN1chr12:111066723chr2:171806048ENST00000397655+41578_97208506.0Compositional biasNote=Cys-rich
HgeneTCTN1chr12:111066723chr2:171806048ENST00000397659+41578_97208542.0Compositional biasNote=Cys-rich
HgeneTCTN1chr12:111066723chr2:171806048ENST00000551590+41578_97208592.0Compositional biasNote=Cys-rich
TgeneGORASP2chr12:111066723chr2:171806048ENST00000234160110277_37248453.0Compositional biasNote=Pro-rich
TgeneGORASP2chr12:111066723chr2:171806048ENST00000234160110111_19948453.0DomainPDZ GRASP-type 2
TgeneGORASP2chr12:111066723chr2:171806048ENST00000234160110194_19948453.0RegionNote=Important for membrane binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCTN1chr12:111066723chr2:171806048ENST00000377654+41378_9730208.0Compositional biasNote=Cys-rich
TgeneGORASP2chr12:111066723chr2:171806048ENST0000023416011015_10548453.0DomainPDZ GRASP-type 1
TgeneGORASP2chr12:111066723chr2:171806048ENST0000023416011015_21548453.0RegionGRASP


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Fusion Gene Sequence for TCTN1-GORASP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89898_89898_1_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000377654_GORASP2_chr2_171806048_ENST00000234160_length(transcript)=2884nt_BP=670nt
GCAACGCGCTGTCCATGTCGCGGGCCTCGCTGGGACTCCCTGGGAGATGAGGCCGCGAGGTCTCCCGCCGCTCCTGGTGGTGCTCCTGGG
CTGCTGGGCCTCCGTGAGCGCCCAGACCGATGCCACCCCGGCGGTGACGACAGAGGGCCTCAACTCCACCGAGGCAGCCCTGGCCACCTT
CGGAACTTTCCCGTCGACCAGGCCCCCCGGGACTCCCAGGGCTCCAGGGCCCTCCTCCGGCCCCAGGCCTACCCCAGTCACGGACGTTGC
TGTTCTCTGTGTCTGTGACTTATCCCCAGCACAGTGTGACATCAACTGCTGCTGTGATCCCGACTGCAGCTCCGTGGATTTCAGTGTCTT
TTCTGCCTGCTCAGTTCCAGTTGTCACGGGCGACAGCCAGTTTTGTAGTCAAAAAGCAGTCATCTATTCATTGAATTTTACAGCAAACCC
ACCTCAAAGAGTATTTGAACTTGTTGACCAGATTAATCCATCTATTTTCTGCATTCATATTACAAACTATAAACCTGCATTATCCTTTAT
TAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAATGCTGAATCATATGTTTCCTT
CACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGAATAAAGACAATGACACTCTTAAGGATCTGCTGAAAGCAAACGTTGAAAA
GCCTGTAAAGATGCTTATCTATAGCAGCAAAACATTGGAACTGCGAGAGACCTCAGTCACACCAAGTAACCTGTGGGGCGGCCAGGGCTT
ATTGGGAGTGAGCATTCGTTTCTGCAGCTTTGATGGGGCAAATGAAAATGTTTGGCATGTGCTGGAGGTGGAATCAAATTCTCCTGCAGC
ACTGGCAGGTCTTAGACCACACAGTGATTATATAATTGGAGCAGATACAGTCATGAATGAGTCTGAAGATCTATTCAGCCTTATCGAAAC
ACATGAAGCAAAACCATTGAAACTGTATGTGTACAACACAGACACTGATAACTGTCGAGAAGTGATTATTACACCAAATTCTGCATGGGG
TGGAGAAGGCAGCCTAGGATGTGGCATTGGATATGGTTATTTGCATCGAATACCTACACGCCCATTTGAGGAAGGAAAGAAAATTTCTCT
TCCAGGACAAATGGCTGGTACACCTATTACACCTCTTAAAGATGGGTTTACAGAGGTCCAGCTGTCCTCAGTTAATCCCCCGTCTTTGTC
ACCACCAGGAACTACAGGAATTGAACAGAGTCTGACTGGACTTTCTATTAGCTCAACTCCACCAGCTGTCAGTAGTGTTCTCAGTACAGG
TGTACCAACAGTACCGTTATTGCCACCACAAGTAAACCAGTCCCTCACTTCTGTGCCACCAATGAATCCAGCTACTACATTACCAGGTCT
GATGCCTTTACCAGCAGGACTGCCCAACCTCCCCAACCTCAACCTCAACCTCCCAGCACCACACATCATGCCAGGGGTTGGCTTACCAGA
ACTTGTAAACCCAGGTCTGCCACCTCTTCCTTCCATGCCTCCCCGAAACTTACCTGGCATTGCACCTCTCCCCCTGCCATCCGAGTTCCT
CCCGTCATTCCCCTTGGTTCCAGAGAGCTCTTCTGCAGCAAGCTCAGGAGAGCTGCTGTCTTCCCTCCCGCCCACCAGCAACGCACCCTC
CGACCCTGCCACAACTACTGCAAAGGCAGACGCTGCCTCCTCACTCACTGTGGATGTGACGCCCCCCACTGCCAAGGCCCCCACCACCGT
TGAGGACAGAGTCGGCGACTCCACCCCAGTCAGCGAGAAGCCTGTTTCTGCGGCTGTGGATGCCAATGCTTCTGAGTCACCTTAACTTTG
AACCATTCTTTGGAATTGGCGTGGTATATTTAACCACGGGAGCGTGTCTGGAAACGCAAACTATCATTAATTTCATACTAGTTTGTACCG
TATCTGTAGGCATCCTGTAAATAATTCCAAGGGGAAAACTAAACGAGGACGTGGGTTGTATCCTGCCAGGTTGAGTGGGGCTCACACGCT
AGGGTGAGATGTCAGAAAGCGCTTGTATTTTAAACAACCAAAAAGAATTGTAAGGGTGGCTTGCTGCCAGGCTTGCACTGCCGTTCCTGG
GGGTGTGCATCTTCGGGAAAGGTGGTGGCGGGGCGTCCACTAGGTTTCCTGTCCCCTGCTGCTCCTTCCGTAAGAAAATGAAATATTCTA
TGCCTAATACTCACACGCAACATTTCTTGTACTTTGTAAGTCGTTTGCGAGAATGCAGACCACCTCACTAAACTGTAAACGGTAAAGAGA
TTTTTACTTTTGGTCTCCGTGAGTCGCATCTCTACTAAGGTTTACACAGGAATTCCACCTGAAGACTTGTGTTAAAGTTCTACAGCGCGC
ACTGTTAACTGAACGTCTTTTTCTTCAGCCTATACGCGGATCCTTGTTTTGAGCTCTCAGAATCACTCAGACAACATTTTGTAACTGCTG
CTGTTGCTTTCTACATACACCTTATAAAGTGACATTTCAAAAGAAATAAGGTGCCACAGTTTTAAACCAGAAGGTGGCACTCTGTGGCTC
CTTGTAGTATTATAGCTATACTGGGAAAGCATAGATACAGCAATAAAGTACAGTAATTTTACTTTTTTTCTTGTGTTACATCTAAATTAC
AACCCTTAATTGCCACGTGTGCACTTACTACTCTCCAGTATGTCTTATTACTCTCCAGTATGTCACGCATCTTTAACTTTTCACGTCCTA
TGTTTGCTTTCTCCCATTTTTAAGAGATGGTAAGTTAACTGGAATTGATTTACTGAATGAAATTAAATGCAGATATCCCTGTTTTTGAAA

>89898_89898_1_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000377654_GORASP2_chr2_171806048_ENST00000234160_length(amino acids)=612AA_BP=208
MRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEAALATFGTFPSTRPPGTPRAPGPSSGPRPTPVTDVAVLCVCDLSPAQCDIN
CCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFTANPPQRVFELVDQINPSIFCIHITNYKPALSFINPEVPDENNFDTLMK
TSDGFTLNAESYVSFTTKLDIPTAAKYENKDNDTLKDLLKANVEKPVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANE
NVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLH
RIPTRPFEEGKKISLPGQMAGTPITPLKDGFTEVQLSSVNPPSLSPPGTTGIEQSLTGLSISSTPPAVSSVLSTGVPTVPLLPPQVNQSL
TSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGVGLPELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLPSFPLVPESSSAASS

--------------------------------------------------------------
>89898_89898_2_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000397655_GORASP2_chr2_171806048_ENST00000234160_length(transcript)=2908nt_BP=694nt
GCGCCTGGCTGTCGCGGTTGCCGGGCAACGCGCTGTCCATGTCGCGGGCCTCGCTGGGACTCCCTGGGAGATGAGGCCGCGAGGTCTCCC
GCCGCTCCTGGTGGTGCTCCTGGGCTGCTGGGCCTCCGTGAGCGCCCAGACCGATGCCACCCCGGCGGTGACGACAGAGGGCCTCAACTC
CACCGAGGCAGCCCTGGCCACCTTCGGAACTTTCCCGTCGACCAGGCCCCCCGGGACTCCCAGGGCTCCAGGGCCCTCCTCCGGCCCCAG
GCCTACCCCAGTCACGGACGTTGCTGTTCTCTGTGTCTGTGACTTATCCCCAGCACAGTGTGACATCAACTGCTGCTGTGATCCCGACTG
CAGCTCCGTGGATTTCAGTGTCTTTTCTGCCTGCTCAGTTCCAGTTGTCACGGGCGACAGCCAGTTTTGTAGTCAAAAAGCAGTCATCTA
TTCATTGAATTTTACAGCAAACCCACCTCAAAGAGTATTTGAACTTGTTGACCAGATTAATCCATCTATTTTCTGCATTCATATTACAAA
CTATAAACCTGCATTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATT
GAATGCTGAATCATATGTTTCCTTCACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGAATAAAGACAATGACACTCTTAAGGA
TCTGCTGAAAGCAAACGTTGAAAAGCCTGTAAAGATGCTTATCTATAGCAGCAAAACATTGGAACTGCGAGAGACCTCAGTCACACCAAG
TAACCTGTGGGGCGGCCAGGGCTTATTGGGAGTGAGCATTCGTTTCTGCAGCTTTGATGGGGCAAATGAAAATGTTTGGCATGTGCTGGA
GGTGGAATCAAATTCTCCTGCAGCACTGGCAGGTCTTAGACCACACAGTGATTATATAATTGGAGCAGATACAGTCATGAATGAGTCTGA
AGATCTATTCAGCCTTATCGAAACACATGAAGCAAAACCATTGAAACTGTATGTGTACAACACAGACACTGATAACTGTCGAGAAGTGAT
TATTACACCAAATTCTGCATGGGGTGGAGAAGGCAGCCTAGGATGTGGCATTGGATATGGTTATTTGCATCGAATACCTACACGCCCATT
TGAGGAAGGAAAGAAAATTTCTCTTCCAGGACAAATGGCTGGTACACCTATTACACCTCTTAAAGATGGGTTTACAGAGGTCCAGCTGTC
CTCAGTTAATCCCCCGTCTTTGTCACCACCAGGAACTACAGGAATTGAACAGAGTCTGACTGGACTTTCTATTAGCTCAACTCCACCAGC
TGTCAGTAGTGTTCTCAGTACAGGTGTACCAACAGTACCGTTATTGCCACCACAAGTAAACCAGTCCCTCACTTCTGTGCCACCAATGAA
TCCAGCTACTACATTACCAGGTCTGATGCCTTTACCAGCAGGACTGCCCAACCTCCCCAACCTCAACCTCAACCTCCCAGCACCACACAT
CATGCCAGGGGTTGGCTTACCAGAACTTGTAAACCCAGGTCTGCCACCTCTTCCTTCCATGCCTCCCCGAAACTTACCTGGCATTGCACC
TCTCCCCCTGCCATCCGAGTTCCTCCCGTCATTCCCCTTGGTTCCAGAGAGCTCTTCTGCAGCAAGCTCAGGAGAGCTGCTGTCTTCCCT
CCCGCCCACCAGCAACGCACCCTCCGACCCTGCCACAACTACTGCAAAGGCAGACGCTGCCTCCTCACTCACTGTGGATGTGACGCCCCC
CACTGCCAAGGCCCCCACCACCGTTGAGGACAGAGTCGGCGACTCCACCCCAGTCAGCGAGAAGCCTGTTTCTGCGGCTGTGGATGCCAA
TGCTTCTGAGTCACCTTAACTTTGAACCATTCTTTGGAATTGGCGTGGTATATTTAACCACGGGAGCGTGTCTGGAAACGCAAACTATCA
TTAATTTCATACTAGTTTGTACCGTATCTGTAGGCATCCTGTAAATAATTCCAAGGGGAAAACTAAACGAGGACGTGGGTTGTATCCTGC
CAGGTTGAGTGGGGCTCACACGCTAGGGTGAGATGTCAGAAAGCGCTTGTATTTTAAACAACCAAAAAGAATTGTAAGGGTGGCTTGCTG
CCAGGCTTGCACTGCCGTTCCTGGGGGTGTGCATCTTCGGGAAAGGTGGTGGCGGGGCGTCCACTAGGTTTCCTGTCCCCTGCTGCTCCT
TCCGTAAGAAAATGAAATATTCTATGCCTAATACTCACACGCAACATTTCTTGTACTTTGTAAGTCGTTTGCGAGAATGCAGACCACCTC
ACTAAACTGTAAACGGTAAAGAGATTTTTACTTTTGGTCTCCGTGAGTCGCATCTCTACTAAGGTTTACACAGGAATTCCACCTGAAGAC
TTGTGTTAAAGTTCTACAGCGCGCACTGTTAACTGAACGTCTTTTTCTTCAGCCTATACGCGGATCCTTGTTTTGAGCTCTCAGAATCAC
TCAGACAACATTTTGTAACTGCTGCTGTTGCTTTCTACATACACCTTATAAAGTGACATTTCAAAAGAAATAAGGTGCCACAGTTTTAAA
CCAGAAGGTGGCACTCTGTGGCTCCTTGTAGTATTATAGCTATACTGGGAAAGCATAGATACAGCAATAAAGTACAGTAATTTTACTTTT
TTTCTTGTGTTACATCTAAATTACAACCCTTAATTGCCACGTGTGCACTTACTACTCTCCAGTATGTCTTATTACTCTCCAGTATGTCAC
GCATCTTTAACTTTTCACGTCCTATGTTTGCTTTCTCCCATTTTTAAGAGATGGTAAGTTAACTGGAATTGATTTACTGAATGAAATTAA

>89898_89898_2_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000397655_GORASP2_chr2_171806048_ENST00000234160_length(amino acids)=634AA_BP=230
MAVAVAGQRAVHVAGLAGTPWEMRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEAALATFGTFPSTRPPGTPRAPGPSSGPRP
TPVTDVAVLCVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFTANPPQRVFELVDQINPSIFCIHITNY
KPALSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFTTKLDIPTAAKYENKDNDTLKDLLKANVEKPVKMLIYSSKTLELRETSVTPSN
LWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVII
TPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQMAGTPITPLKDGFTEVQLSSVNPPSLSPPGTTGIEQSLTGLSISSTPPAV
SSVLSTGVPTVPLLPPQVNQSLTSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGVGLPELVNPGLPPLPSMPPRNLPGIAPL
PLPSEFLPSFPLVPESSSAASSGELLSSLPPTSNAPSDPATTTAKADAASSLTVDVTPPTAKAPTTVEDRVGDSTPVSEKPVSAAVDANA

--------------------------------------------------------------
>89898_89898_3_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000397659_GORASP2_chr2_171806048_ENST00000234160_length(transcript)=2857nt_BP=643nt
CGCTGGGACTCCCTGGGAGATGAGGCCGCGAGGTCTCCCGCCGCTCCTGGTGGTGCTCCTGGGCTGCTGGGCCTCCGTGAGCGCCCAGAC
CGATGCCACCCCGGCGGTGACGACAGAGGGCCTCAACTCCACCGAGGCAGCCCTGGCCACCTTCGGAACTTTCCCGTCGACCAGGCCCCC
CGGGACTCCCAGGGCTCCAGGGCCCTCCTCCGGCCCCAGGCCTACCCCAGTCACGGACGTTGCTGTTCTCTGTGTCTGTGACTTATCCCC
AGCACAGTGTGACATCAACTGCTGCTGTGATCCCGACTGCAGCTCCGTGGATTTCAGTGTCTTTTCTGCCTGCTCAGTTCCAGTTGTCAC
GGGCGACAGCCAGTTTTGTAGTCAAAAAGCAGTCATCTATTCATTGAATTTTACAGCAAACCCACCTCAAAGAGTATTTGAACTTGTTGA
CCAGATTAATCCATCTATTTTCTGCATTCATATTACAAACTATAAACCTGCATTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAA
TTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAATGCTGAATCATATGTTTCCTTCACAACCAAACTGGATATTCCTACTGC
TGCTAAATATGAGAATAAAGACAATGACACTCTTAAGGATCTGCTGAAAGCAAACGTTGAAAAGCCTGTAAAGATGCTTATCTATAGCAG
CAAAACATTGGAACTGCGAGAGACCTCAGTCACACCAAGTAACCTGTGGGGCGGCCAGGGCTTATTGGGAGTGAGCATTCGTTTCTGCAG
CTTTGATGGGGCAAATGAAAATGTTTGGCATGTGCTGGAGGTGGAATCAAATTCTCCTGCAGCACTGGCAGGTCTTAGACCACACAGTGA
TTATATAATTGGAGCAGATACAGTCATGAATGAGTCTGAAGATCTATTCAGCCTTATCGAAACACATGAAGCAAAACCATTGAAACTGTA
TGTGTACAACACAGACACTGATAACTGTCGAGAAGTGATTATTACACCAAATTCTGCATGGGGTGGAGAAGGCAGCCTAGGATGTGGCAT
TGGATATGGTTATTTGCATCGAATACCTACACGCCCATTTGAGGAAGGAAAGAAAATTTCTCTTCCAGGACAAATGGCTGGTACACCTAT
TACACCTCTTAAAGATGGGTTTACAGAGGTCCAGCTGTCCTCAGTTAATCCCCCGTCTTTGTCACCACCAGGAACTACAGGAATTGAACA
GAGTCTGACTGGACTTTCTATTAGCTCAACTCCACCAGCTGTCAGTAGTGTTCTCAGTACAGGTGTACCAACAGTACCGTTATTGCCACC
ACAAGTAAACCAGTCCCTCACTTCTGTGCCACCAATGAATCCAGCTACTACATTACCAGGTCTGATGCCTTTACCAGCAGGACTGCCCAA
CCTCCCCAACCTCAACCTCAACCTCCCAGCACCACACATCATGCCAGGGGTTGGCTTACCAGAACTTGTAAACCCAGGTCTGCCACCTCT
TCCTTCCATGCCTCCCCGAAACTTACCTGGCATTGCACCTCTCCCCCTGCCATCCGAGTTCCTCCCGTCATTCCCCTTGGTTCCAGAGAG
CTCTTCTGCAGCAAGCTCAGGAGAGCTGCTGTCTTCCCTCCCGCCCACCAGCAACGCACCCTCCGACCCTGCCACAACTACTGCAAAGGC
AGACGCTGCCTCCTCACTCACTGTGGATGTGACGCCCCCCACTGCCAAGGCCCCCACCACCGTTGAGGACAGAGTCGGCGACTCCACCCC
AGTCAGCGAGAAGCCTGTTTCTGCGGCTGTGGATGCCAATGCTTCTGAGTCACCTTAACTTTGAACCATTCTTTGGAATTGGCGTGGTAT
ATTTAACCACGGGAGCGTGTCTGGAAACGCAAACTATCATTAATTTCATACTAGTTTGTACCGTATCTGTAGGCATCCTGTAAATAATTC
CAAGGGGAAAACTAAACGAGGACGTGGGTTGTATCCTGCCAGGTTGAGTGGGGCTCACACGCTAGGGTGAGATGTCAGAAAGCGCTTGTA
TTTTAAACAACCAAAAAGAATTGTAAGGGTGGCTTGCTGCCAGGCTTGCACTGCCGTTCCTGGGGGTGTGCATCTTCGGGAAAGGTGGTG
GCGGGGCGTCCACTAGGTTTCCTGTCCCCTGCTGCTCCTTCCGTAAGAAAATGAAATATTCTATGCCTAATACTCACACGCAACATTTCT
TGTACTTTGTAAGTCGTTTGCGAGAATGCAGACCACCTCACTAAACTGTAAACGGTAAAGAGATTTTTACTTTTGGTCTCCGTGAGTCGC
ATCTCTACTAAGGTTTACACAGGAATTCCACCTGAAGACTTGTGTTAAAGTTCTACAGCGCGCACTGTTAACTGAACGTCTTTTTCTTCA
GCCTATACGCGGATCCTTGTTTTGAGCTCTCAGAATCACTCAGACAACATTTTGTAACTGCTGCTGTTGCTTTCTACATACACCTTATAA
AGTGACATTTCAAAAGAAATAAGGTGCCACAGTTTTAAACCAGAAGGTGGCACTCTGTGGCTCCTTGTAGTATTATAGCTATACTGGGAA
AGCATAGATACAGCAATAAAGTACAGTAATTTTACTTTTTTTCTTGTGTTACATCTAAATTACAACCCTTAATTGCCACGTGTGCACTTA
CTACTCTCCAGTATGTCTTATTACTCTCCAGTATGTCACGCATCTTTAACTTTTCACGTCCTATGTTTGCTTTCTCCCATTTTTAAGAGA

>89898_89898_3_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000397659_GORASP2_chr2_171806048_ENST00000234160_length(amino acids)=612AA_BP=208
MRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEAALATFGTFPSTRPPGTPRAPGPSSGPRPTPVTDVAVLCVCDLSPAQCDIN
CCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFTANPPQRVFELVDQINPSIFCIHITNYKPALSFINPEVPDENNFDTLMK
TSDGFTLNAESYVSFTTKLDIPTAAKYENKDNDTLKDLLKANVEKPVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANE
NVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLH
RIPTRPFEEGKKISLPGQMAGTPITPLKDGFTEVQLSSVNPPSLSPPGTTGIEQSLTGLSISSTPPAVSSVLSTGVPTVPLLPPQVNQSL
TSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGVGLPELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLPSFPLVPESSSAASS

--------------------------------------------------------------
>89898_89898_4_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000551590_GORASP2_chr2_171806048_ENST00000234160_length(transcript)=2994nt_BP=780nt
ATCCGCCCCCTGCCTCATCCAGGCTTCGCCCCAGTCAGTCTCCGGCAGCTTCTCGCGGCTTCGCAAGCCCCTTCCCGTGATGCCCCGCGC
CTGGCTGTCGCGGTTGCCGGGCAACGCGCTGTCCATGTCGCGGGCCTCGCTGGGACTCCCTGGGAGATGAGGCCGCGAGGTCTCCCGCCG
CTCCTGGTGGTGCTCCTGGGCTGCTGGGCCTCCGTGAGCGCCCAGACCGATGCCACCCCGGCGGTGACGACAGAGGGCCTCAACTCCACC
GAGGCAGCCCTGGCCACCTTCGGAACTTTCCCGTCGACCAGGCCCCCCGGGACTCCCAGGGCTCCAGGGCCCTCCTCCGGCCCCAGGCCT
ACCCCAGTCACGGACGTTGCTGTTCTCTGTGTCTGTGACTTATCCCCAGCACAGTGTGACATCAACTGCTGCTGTGATCCCGACTGCAGC
TCCGTGGATTTCAGTGTCTTTTCTGCCTGCTCAGTTCCAGTTGTCACGGGCGACAGCCAGTTTTGTAGTCAAAAAGCAGTCATCTATTCA
TTGAATTTTACAGCAAACCCACCTCAAAGAGTATTTGAACTTGTTGACCAGATTAATCCATCTATTTTCTGCATTCATATTACAAACTAT
AAACCTGCATTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAAT
GCTGAATCATATGTTTCCTTCACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGAATAAAGACAATGACACTCTTAAGGATCTG
CTGAAAGCAAACGTTGAAAAGCCTGTAAAGATGCTTATCTATAGCAGCAAAACATTGGAACTGCGAGAGACCTCAGTCACACCAAGTAAC
CTGTGGGGCGGCCAGGGCTTATTGGGAGTGAGCATTCGTTTCTGCAGCTTTGATGGGGCAAATGAAAATGTTTGGCATGTGCTGGAGGTG
GAATCAAATTCTCCTGCAGCACTGGCAGGTCTTAGACCACACAGTGATTATATAATTGGAGCAGATACAGTCATGAATGAGTCTGAAGAT
CTATTCAGCCTTATCGAAACACATGAAGCAAAACCATTGAAACTGTATGTGTACAACACAGACACTGATAACTGTCGAGAAGTGATTATT
ACACCAAATTCTGCATGGGGTGGAGAAGGCAGCCTAGGATGTGGCATTGGATATGGTTATTTGCATCGAATACCTACACGCCCATTTGAG
GAAGGAAAGAAAATTTCTCTTCCAGGACAAATGGCTGGTACACCTATTACACCTCTTAAAGATGGGTTTACAGAGGTCCAGCTGTCCTCA
GTTAATCCCCCGTCTTTGTCACCACCAGGAACTACAGGAATTGAACAGAGTCTGACTGGACTTTCTATTAGCTCAACTCCACCAGCTGTC
AGTAGTGTTCTCAGTACAGGTGTACCAACAGTACCGTTATTGCCACCACAAGTAAACCAGTCCCTCACTTCTGTGCCACCAATGAATCCA
GCTACTACATTACCAGGTCTGATGCCTTTACCAGCAGGACTGCCCAACCTCCCCAACCTCAACCTCAACCTCCCAGCACCACACATCATG
CCAGGGGTTGGCTTACCAGAACTTGTAAACCCAGGTCTGCCACCTCTTCCTTCCATGCCTCCCCGAAACTTACCTGGCATTGCACCTCTC
CCCCTGCCATCCGAGTTCCTCCCGTCATTCCCCTTGGTTCCAGAGAGCTCTTCTGCAGCAAGCTCAGGAGAGCTGCTGTCTTCCCTCCCG
CCCACCAGCAACGCACCCTCCGACCCTGCCACAACTACTGCAAAGGCAGACGCTGCCTCCTCACTCACTGTGGATGTGACGCCCCCCACT
GCCAAGGCCCCCACCACCGTTGAGGACAGAGTCGGCGACTCCACCCCAGTCAGCGAGAAGCCTGTTTCTGCGGCTGTGGATGCCAATGCT
TCTGAGTCACCTTAACTTTGAACCATTCTTTGGAATTGGCGTGGTATATTTAACCACGGGAGCGTGTCTGGAAACGCAAACTATCATTAA
TTTCATACTAGTTTGTACCGTATCTGTAGGCATCCTGTAAATAATTCCAAGGGGAAAACTAAACGAGGACGTGGGTTGTATCCTGCCAGG
TTGAGTGGGGCTCACACGCTAGGGTGAGATGTCAGAAAGCGCTTGTATTTTAAACAACCAAAAAGAATTGTAAGGGTGGCTTGCTGCCAG
GCTTGCACTGCCGTTCCTGGGGGTGTGCATCTTCGGGAAAGGTGGTGGCGGGGCGTCCACTAGGTTTCCTGTCCCCTGCTGCTCCTTCCG
TAAGAAAATGAAATATTCTATGCCTAATACTCACACGCAACATTTCTTGTACTTTGTAAGTCGTTTGCGAGAATGCAGACCACCTCACTA
AACTGTAAACGGTAAAGAGATTTTTACTTTTGGTCTCCGTGAGTCGCATCTCTACTAAGGTTTACACAGGAATTCCACCTGAAGACTTGT
GTTAAAGTTCTACAGCGCGCACTGTTAACTGAACGTCTTTTTCTTCAGCCTATACGCGGATCCTTGTTTTGAGCTCTCAGAATCACTCAG
ACAACATTTTGTAACTGCTGCTGTTGCTTTCTACATACACCTTATAAAGTGACATTTCAAAAGAAATAAGGTGCCACAGTTTTAAACCAG
AAGGTGGCACTCTGTGGCTCCTTGTAGTATTATAGCTATACTGGGAAAGCATAGATACAGCAATAAAGTACAGTAATTTTACTTTTTTTC
TTGTGTTACATCTAAATTACAACCCTTAATTGCCACGTGTGCACTTACTACTCTCCAGTATGTCTTATTACTCTCCAGTATGTCACGCAT
CTTTAACTTTTCACGTCCTATGTTTGCTTTCTCCCATTTTTAAGAGATGGTAAGTTAACTGGAATTGATTTACTGAATGAAATTAAATGC

>89898_89898_4_TCTN1-GORASP2_TCTN1_chr12_111066723_ENST00000551590_GORASP2_chr2_171806048_ENST00000234160_length(amino acids)=661AA_BP=257
MPHPGFAPVSLRQLLAASQAPSRDAPRLAVAVAGQRAVHVAGLAGTPWEMRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEAA
LATFGTFPSTRPPGTPRAPGPSSGPRPTPVTDVAVLCVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNF
TANPPQRVFELVDQINPSIFCIHITNYKPALSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFTTKLDIPTAAKYENKDNDTLKDLLKA
NVEKPVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFS
LIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQMAGTPITPLKDGFTEVQLSSVNP
PSLSPPGTTGIEQSLTGLSISSTPPAVSSVLSTGVPTVPLLPPQVNQSLTSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGV
GLPELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLPSFPLVPESSSAASSGELLSSLPPTSNAPSDPATTTAKADAASSLTVDVTPPTAKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TCTN1-GORASP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCTN1-GORASP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCTN1-GORASP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource