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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TDP2-DCDC2 (FusionGDB2 ID:89923)

Fusion Gene Summary for TDP2-DCDC2

Fusion gene summary

Fusion gene information	Fusion gene name: TDP2-DCDC2
	Fusion gene ID: 89923
		Hgene	Tgene
	Gene symbol	TDP2	DCDC2
	Gene ID	51567	51473
	Gene name	tyrosyl-DNA phosphodiesterase 2	doublecortin domain containing 2
	Synonyms	AD022\|EAP2\|EAPII\|TTRAP\|dJ30M3.3\|hTDP2	DCDC2A\|DFNB66\|NPHP19\|NSC\|RU2\|RU2S
	Cytomap	6p22.3	6p22.3
	Type of gene	protein-coding	protein-coding
	Description	tyrosyl-DNA phosphodiesterase 25'-Tyr-DNA phosphodiesterase5'-tyrosyl-DNA phosphodiesteraseETS1-associated protein 2ETS1-associated protein IITRAF and TNF receptor-associated proteinVPg unlinkaseepididymis secretory sperm binding proteintyr-DNA ph	doublecortin domain-containing protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q9UHG0
	Ensembl transtripts involved in fusion gene	ENST00000341060, ENST00000378198, ENST00000545995, ENST00000478285,	ENST00000378450, ENST00000378454,
Fusion gene scores	* DoF score	2 X 2 X 2=8	14 X 8 X 11=1232
	# samples	2	16
	** MAII score	log2(2/8*10)=1.32192809488736	log2(16/1232*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TDP2 [Title/Abstract] AND DCDC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TDP2(24653211)-DCDC2(24302272), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TDP2	GO:0006302	double-strand break repair	19794497

Fusion gene breakpoints across TDP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCDC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PAAD	TCGA-HZ-A77P-01A	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
ChimerDB4	PAAD	TCGA-HZ-A77P	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-

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Fusion Gene ORF analysis for TDP2-DCDC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000341060	ENST00000378450	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
5CDS-intron	ENST00000378198	ENST00000378450	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
5CDS-intron	ENST00000545995	ENST00000378450	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
In-frame	ENST00000341060	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
In-frame	ENST00000378198	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
In-frame	ENST00000545995	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
intron-3CDS	ENST00000478285	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-
intron-intron	ENST00000478285	ENST00000378450	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378198	TDP2	chr6	24653211	-	ENST00000378454	DCDC2	chr6	24302272	-	5035	978	24	2060	678
ENST00000545995	TDP2	chr6	24653211	-	ENST00000378454	DCDC2	chr6	24302272	-	4954	897	0	1979	659
ENST00000341060	TDP2	chr6	24653211	-	ENST00000378454	DCDC2	chr6	24302272	-	5086	1029	396	2111	571

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378198	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-	0.000410517	0.9995895
ENST00000545995	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-	0.000393414	0.99960667
ENST00000341060	ENST00000378454	TDP2	chr6	24653211	-	DCDC2	chr6	24302272	-	0.000253533	0.9997465

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Fusion Genomic Features for TDP2-DCDC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TDP2-DCDC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:24653211/chr6:24302272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DCDC2 Q9UHG0
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250\|UniProtKB:D3ZR10, ECO:0000269\|PubMed:25557784, ECO:0000269\|PubMed:25601850, ECO:0000269\|PubMed:27319779}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DCDC2

chr6:24653211

chr6:24302272

ENST00000378450

139_221

230.0

Domain

Doublecortin 2

Tgene

DCDC2

chr6:24653211

chr6:24302272

ENST00000378450

17_100

230.0

Domain

Doublecortin 1

Tgene

DCDC2

chr6:24653211

chr6:24302272

ENST00000378454

139_221

116

477.0

Domain

Doublecortin 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DCDC2

chr6:24653211

chr6:24302272

ENST00000378454

17_100

116

477.0

Domain

Doublecortin 1

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Fusion Gene Sequence for TDP2-DCDC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>89923_89923_1_TDP2-DCDC2_TDP2_chr6_24653211_ENST00000341060_DCDC2_chr6_24302272_ENST00000378454_length(transcript)=5086nt_BP=1029nt
CGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTAGTAAGTGATGAGGGGAGCGGGAGC
CAGTCCGCACGGAGGCAGTTTGATACCAGGTAGCCCTGCGCGTCCTGGGACCTGCCGTGGAGCTGGGCGGACGATGCTGAGGCAGATCTC
CAAGCTGCGTAGCCAGAGGAGCAGGGCTTGCGTTGCTGCTGCTGCGCGGAGTTGCGCCCCAGCAGCGGATCTAACACTGCACCAGACTGT
CGCTTCGAACGTGATTTGGGGTCCAGGGAGGAAAAGATGGAAATGTAATGTTTAACTCAAATGAAAGGAAATAAGTAAGCGAGAGGTTTG
AAACAAATGAACGAAGGCTAAACCTTCTATCGAAAAATGGCAACTTGGAAGTCTCCTTGCTTCCTGTATTGTTTATTTATTCTAGGCCCT
AGGCTGACCGGCCAGAATAACAGTGTTGACCTAACCAATGAAGAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACT
CAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAATATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTG
TGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTACAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGT
AATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACAGCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATT
ATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGTGTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCAT
TTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAGTTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACA
GTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTAAAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAA
CCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGAGACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTG
AATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATCACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAA
CTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTATGTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTA
CTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAAGCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGT
GGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGACAACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTG
AATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTAAAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAA
GCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTCCAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCA
GCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAACAAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTT
GAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAAGTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGT
GTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAGCAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCT
CAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCTCAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAAT
GAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAGAACATTTTTAAAAAGAGAGTATATGGATCGCAAGAAAAATGAAGGGTT
ATCATACTTGAAAGATAAGCACATAGTTATTGCTGAATATAATGTGACACTATGGTCGAATACTACCTACGAATTATAACATTAGAAGCC
TAGTGGAAAGACCAGATAACTTTAAATGGCTACTAAAGGATAATTACTTACTTTTATTGCATGTGTTTTAAAAGTCATATAGAAATATTA
AATAAGACGGACAGAGGAGAATTTGCACTGGAAGACAATTGCCACTTGTAAAGGATGAAAAATAGGATCACTCTTATTGTACGCTTTATT
ATAAGTTTAGAAGGCAGTTTATTCTAAATAATTTTTCTCTAGGAAGGCGTAGAATTTTAAAGAACTGGTAATAGGAAAGCATGTACTATT
TTCTTAAAGCAATAAACTCTTGAATGAACAGATTGCGATTTACTTTCAGACATAATTTGGAGATGGCAGTAGATCAAAATGTGTCCATGA
CTTGTTAACATGCCTTTCTTTCTTCCTCCTTAGCCAAAATCCACCTTTGAACTACAAAGACAGAGCAAGGCGTTCATTTTGGTGGGAGGA
AGCATTGGTTCAGAGTGTTAGTGACTAGTATCGCCATGCCGTCACTTAAATGCTTTCAGGCTTGCATGCTTGTGGCTCCAATGGCGCACA
CTCAGGAAGGAATTGTAAAGGAGCACCCAGTTATATTATAAAGCCTGGATGTATGGTTTGCAGATAATGGAAATCCTGTGGATTTTCACT
GATCCAGTCTATCTTTACCAATAGTATCTCTCTCTTCTCCCTTATGTTATTAGAGAACCTGATATTGGCTATTCCAAAGATTAAATTATT
TTCAAATAGTTTTCAACAAAAATAAAAGTGTATTAGGAAGAAAAAAGTAGACTATATGAAGAGTTTGTGACTGCTCAATTTAACTTGTTT
TTTGCCTTATTTCTATTAAGACTGTTTTACTATGTTTTTGCCCTAGGGATATCAGCAAATATTTATTTTTCCTAGCATGATATAGTTAGA
ATTTCAAGCAGATTTCTTTGTAATTAGAAGGCATCTGATAGAAATTGTAAAACTTTAGAAGTTATTATAATGAAACCAATTCCTGAATCA
CAACTTCATGGACTGACTAAATTGATTTATAGTTGCCTTGTGAGGTATGTATGGGGAAAACATAAAAACATAATTAAAACATAATTTCGT
CCTTTTTATGAATTCTTAAGAGATGTTCTTCCATAAATATAGAAATAATATATTTTTCTTAAAGGATATATTTTTAATTATGTGGAAGTT
GTAAGCTTGAAATTTTAACTTCTAGTGCTTTTCTAAAATTCACAATTACAAGTTTAAAACATTTTTTCTCTTCCAGGTTTCATTTGGAAT
AAAGAGTTGGCAGTTATATAAAGCACTTAATAATACTATAGAAAATAGATGTGTTTTTTCTTAATATGATTTTGGTATTTTCCACAGATC
AGAAGTGTAAACAGAGAGATAATGTAACAGTATTTGGAAGAGATAATGACACAAGGATATAGTGATCTGGGAGCATGAATTAGAAACAGG
GTACTATGTTTCTGGTGTAAAATCTAAATTGTGCTTTCTACTAGCGTTACTTTTTCAAATGGGATGATATAAAGCACTGTGGGCTATAAG
CAACAATCTTGGGTTGGTAGGCAAATAGACCAATTGATCTTTATTATTATTATTATTATTATTATTATTATTTTTTGAGATGAAGTCTTG
CTCTTGTCGCCCAGGCTGGGTGCAGTGGCATGATCTTGGCTTACTGCAACCTCTGCCTCCTGGGTTCAAGCACCTGAGCCTCCCGAGTAG
CTGGGATTACAGGCATCTGCCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGACAGATGTTTCACCATGTTGGCCAGGCTGGTCTC
AAACTCCTGACCTCAGGTGATCCGCCCGCCTTTGCATCCCAAAATGCTGGGATTACAGGTGTGAGCCACAGCACCCGGTCCCAGTTGGTC
TTTTAATATTAAATTTGTGCACTATTACTGGGTCTGGAGTTAATGATTTCAAATAGTTTCTAAAAATAACTGATTAAATGTAAGAAATTA
TAACTAATTATCAAGGTGATTCTCTTTTGTTTCTTCAATGGAGAGTTTCTCTTTCTCTTTTCCTCCTCTAATAAAAATATTTCTTTTTTT
CCTGTCCTTTTATTCATTATATTATGAAACTTAGGTTTTAGGAAACACCTTAAGCGTCATTTTAATGAAGCACAACATTGATATTTTACA
TGAATAATAACGTTTGGTATTTTAAATATACTTCAAGGGGGTAATAAGCCACAATAACTGTACCAAAAAAACTTAAAAATGGGGACATAT
TCATCCCTTGTGTGTGCATATTTTACCACTTGTTGACAAGATACAATTGTGACCTACTTTGAGGGGATGAATAACGACTTATCACTTTAA
GACACTTTGCAAACATGTTACTAAAAAAAGGTGCCTAGCCAAGGAAAAAACCATTCACTTGGAATTAAAATTGTGGATGTCACTTCAGAG
ATGACTTTAACATAAATGCTGAAAGTTCATTCACCTCACAAATGTGGCAGTTTTCTCTGTGGAGAATGGTGGTCTCCGTGGCAGACTGGC
TCTCCAAATTAAATGAAACTCATTGACAGACCTGGGACCTTTTATGTGAGTGGACAGACAAGATCTTGGTTTGGCTTCATGTACTGTTTT
CTAGAGAGAGTGCTACGAAAAACTTATGATGCTTTTATGTGATAACCAATATAATGCTTTAATATGTTAATTCTTTGTGATGCTATATAC
ATAGTTTTTATAGTTTTATGAAACCACTTTGTTAAACTTATCTGGATTTTAAGACACTTGTAAACAAATGGTTTGTTAGTAAAATTGGGG

>89923_89923_1_TDP2-DCDC2_TDP2_chr6_24653211_ENST00000341060_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=571AA_BP=0
MATWKSPCFLYCLFILGPRLTGQNNSVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVI
FLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERM
NQLKMVLKKMQEAPESATVIFAGDTNLRDREVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTE
KITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGS
SDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK
ANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADV

--------------------------------------------------------------
>89923_89923_2_TDP2-DCDC2_TDP2_chr6_24653211_ENST00000378198_DCDC2_chr6_24302272_ENST00000378454_length(transcript)=5035nt_BP=978nt
GCACCCACCGCCCCGGCGGCTCCCTTGCGGCGCAGCTGCACCAGTTTTCCGAGAGCAGCGCATTTCCCCGCCGGGCGGTTGATGCGGGAG
CGCCATGACACAGGCGCCTGCGCAGAGCCGCGCGTTGGCCTCCTGTTCCGCTTAAAGGGGCGGTGCAGAGGCGGCAGGAAGATGGAGTTG
GGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCTGAGGTGAAAAAGCGGCGACTTCTGTGTGTGGAGTTTGCC
TCGGTCGCAAGCTGCGATGCCGCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAAAGGGCTCTGAACTCCTACTTCGAG
CCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTATGTTGACCTAACCAATGAAGAAACAACT
GATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAATATTGATGGA
TTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTACAGGAAGTT
ATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACAGCTATAATG
TTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGTGTGCATGTG
AACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAGTTAAAAATG
GTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTAAAACCAGTA
ATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGAGACCTCATA
AACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATCACTCTGAGG
AGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTATGTGGCTGTT
GGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAAGCTTCTTCA
CTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGACAACTCATCT
CCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTAAAGAATTCA
CAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTCCAAGAAGAT
GAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAACAAGGATGCA
GAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAAGTCGAGGAG
ATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAGCAGGTTAAT
AATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCTCAAAGACCA
CCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAGAACATTTTT
AAAAAGAGAGTATATGGATCGCAAGAAAAATGAAGGGTTATCATACTTGAAAGATAAGCACATAGTTATTGCTGAATATAATGTGACACT
ATGGTCGAATACTACCTACGAATTATAACATTAGAAGCCTAGTGGAAAGACCAGATAACTTTAAATGGCTACTAAAGGATAATTACTTAC
TTTTATTGCATGTGTTTTAAAAGTCATATAGAAATATTAAATAAGACGGACAGAGGAGAATTTGCACTGGAAGACAATTGCCACTTGTAA
AGGATGAAAAATAGGATCACTCTTATTGTACGCTTTATTATAAGTTTAGAAGGCAGTTTATTCTAAATAATTTTTCTCTAGGAAGGCGTA
GAATTTTAAAGAACTGGTAATAGGAAAGCATGTACTATTTTCTTAAAGCAATAAACTCTTGAATGAACAGATTGCGATTTACTTTCAGAC
ATAATTTGGAGATGGCAGTAGATCAAAATGTGTCCATGACTTGTTAACATGCCTTTCTTTCTTCCTCCTTAGCCAAAATCCACCTTTGAA
CTACAAAGACAGAGCAAGGCGTTCATTTTGGTGGGAGGAAGCATTGGTTCAGAGTGTTAGTGACTAGTATCGCCATGCCGTCACTTAAAT
GCTTTCAGGCTTGCATGCTTGTGGCTCCAATGGCGCACACTCAGGAAGGAATTGTAAAGGAGCACCCAGTTATATTATAAAGCCTGGATG
TATGGTTTGCAGATAATGGAAATCCTGTGGATTTTCACTGATCCAGTCTATCTTTACCAATAGTATCTCTCTCTTCTCCCTTATGTTATT
AGAGAACCTGATATTGGCTATTCCAAAGATTAAATTATTTTCAAATAGTTTTCAACAAAAATAAAAGTGTATTAGGAAGAAAAAAGTAGA
CTATATGAAGAGTTTGTGACTGCTCAATTTAACTTGTTTTTTGCCTTATTTCTATTAAGACTGTTTTACTATGTTTTTGCCCTAGGGATA
TCAGCAAATATTTATTTTTCCTAGCATGATATAGTTAGAATTTCAAGCAGATTTCTTTGTAATTAGAAGGCATCTGATAGAAATTGTAAA
ACTTTAGAAGTTATTATAATGAAACCAATTCCTGAATCACAACTTCATGGACTGACTAAATTGATTTATAGTTGCCTTGTGAGGTATGTA
TGGGGAAAACATAAAAACATAATTAAAACATAATTTCGTCCTTTTTATGAATTCTTAAGAGATGTTCTTCCATAAATATAGAAATAATAT
ATTTTTCTTAAAGGATATATTTTTAATTATGTGGAAGTTGTAAGCTTGAAATTTTAACTTCTAGTGCTTTTCTAAAATTCACAATTACAA
GTTTAAAACATTTTTTCTCTTCCAGGTTTCATTTGGAATAAAGAGTTGGCAGTTATATAAAGCACTTAATAATACTATAGAAAATAGATG
TGTTTTTTCTTAATATGATTTTGGTATTTTCCACAGATCAGAAGTGTAAACAGAGAGATAATGTAACAGTATTTGGAAGAGATAATGACA
CAAGGATATAGTGATCTGGGAGCATGAATTAGAAACAGGGTACTATGTTTCTGGTGTAAAATCTAAATTGTGCTTTCTACTAGCGTTACT
TTTTCAAATGGGATGATATAAAGCACTGTGGGCTATAAGCAACAATCTTGGGTTGGTAGGCAAATAGACCAATTGATCTTTATTATTATT
ATTATTATTATTATTATTATTTTTTGAGATGAAGTCTTGCTCTTGTCGCCCAGGCTGGGTGCAGTGGCATGATCTTGGCTTACTGCAACC
TCTGCCTCCTGGGTTCAAGCACCTGAGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCCACCACACCTGGCTAATTTTTGTATTTTTTG
TAGAGACAGATGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTTTGCATCCCAAAATGCTGGG
ATTACAGGTGTGAGCCACAGCACCCGGTCCCAGTTGGTCTTTTAATATTAAATTTGTGCACTATTACTGGGTCTGGAGTTAATGATTTCA
AATAGTTTCTAAAAATAACTGATTAAATGTAAGAAATTATAACTAATTATCAAGGTGATTCTCTTTTGTTTCTTCAATGGAGAGTTTCTC
TTTCTCTTTTCCTCCTCTAATAAAAATATTTCTTTTTTTCCTGTCCTTTTATTCATTATATTATGAAACTTAGGTTTTAGGAAACACCTT
AAGCGTCATTTTAATGAAGCACAACATTGATATTTTACATGAATAATAACGTTTGGTATTTTAAATATACTTCAAGGGGGTAATAAGCCA
CAATAACTGTACCAAAAAAACTTAAAAATGGGGACATATTCATCCCTTGTGTGTGCATATTTTACCACTTGTTGACAAGATACAATTGTG
ACCTACTTTGAGGGGATGAATAACGACTTATCACTTTAAGACACTTTGCAAACATGTTACTAAAAAAAGGTGCCTAGCCAAGGAAAAAAC
CATTCACTTGGAATTAAAATTGTGGATGTCACTTCAGAGATGACTTTAACATAAATGCTGAAAGTTCATTCACCTCACAAATGTGGCAGT
TTTCTCTGTGGAGAATGGTGGTCTCCGTGGCAGACTGGCTCTCCAAATTAAATGAAACTCATTGACAGACCTGGGACCTTTTATGTGAGT
GGACAGACAAGATCTTGGTTTGGCTTCATGTACTGTTTTCTAGAGAGAGTGCTACGAAAAACTTATGATGCTTTTATGTGATAACCAATA
TAATGCTTTAATATGTTAATTCTTTGTGATGCTATATACATAGTTTTTATAGTTTTATGAAACCACTTTGTTAAACTTATCTGGATTTTA

>89923_89923_2_TDP2-DCDC2_TDP2_chr6_24653211_ENST00000378198_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=678AA_BP=1
MRRSCTSFPRAAHFPAGRLMRERHDTGACAEPRVGLLFRLKGRCRGGRKMELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAA
VAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSE
RARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELC
LMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLI
PRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSR
KSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVP
VDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLD

--------------------------------------------------------------
>89923_89923_3_TDP2-DCDC2_TDP2_chr6_24653211_ENST00000545995_DCDC2_chr6_24302272_ENST00000378454_length(transcript)=4954nt_BP=897nt
ATGCGGGAGCGCCATGACACAGGCGCCTGCGCAGAGCCGCGCGTTGGCCTCCTGTTCCGCTTAAAGGGGCGGTGCAGAGGCGGCAGGAAG
ATGGAGTTGGGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCTGAGGTGAAAAAGCGGCGACTTCTGTGTGTG
GAGTTTGCCTCGGTCGCAAGCTGCGATGCCGCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAAAGGGCTCTGAACTCC
TACTTCGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTATGTTGACCTAACCAATGAA
GAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAAT
ATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTA
CAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACA
GCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGT
GTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAG
TTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTA
AAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGA
GACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATC
ACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTAT
GTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAA
GCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGAC
AACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTA
AAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTC
CAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAAC
AAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAA
GTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAG
CAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCT
CAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAG
AACATTTTTAAAAAGAGAGTATATGGATCGCAAGAAAAATGAAGGGTTATCATACTTGAAAGATAAGCACATAGTTATTGCTGAATATAA
TGTGACACTATGGTCGAATACTACCTACGAATTATAACATTAGAAGCCTAGTGGAAAGACCAGATAACTTTAAATGGCTACTAAAGGATA
ATTACTTACTTTTATTGCATGTGTTTTAAAAGTCATATAGAAATATTAAATAAGACGGACAGAGGAGAATTTGCACTGGAAGACAATTGC
CACTTGTAAAGGATGAAAAATAGGATCACTCTTATTGTACGCTTTATTATAAGTTTAGAAGGCAGTTTATTCTAAATAATTTTTCTCTAG
GAAGGCGTAGAATTTTAAAGAACTGGTAATAGGAAAGCATGTACTATTTTCTTAAAGCAATAAACTCTTGAATGAACAGATTGCGATTTA
CTTTCAGACATAATTTGGAGATGGCAGTAGATCAAAATGTGTCCATGACTTGTTAACATGCCTTTCTTTCTTCCTCCTTAGCCAAAATCC
ACCTTTGAACTACAAAGACAGAGCAAGGCGTTCATTTTGGTGGGAGGAAGCATTGGTTCAGAGTGTTAGTGACTAGTATCGCCATGCCGT
CACTTAAATGCTTTCAGGCTTGCATGCTTGTGGCTCCAATGGCGCACACTCAGGAAGGAATTGTAAAGGAGCACCCAGTTATATTATAAA
GCCTGGATGTATGGTTTGCAGATAATGGAAATCCTGTGGATTTTCACTGATCCAGTCTATCTTTACCAATAGTATCTCTCTCTTCTCCCT
TATGTTATTAGAGAACCTGATATTGGCTATTCCAAAGATTAAATTATTTTCAAATAGTTTTCAACAAAAATAAAAGTGTATTAGGAAGAA
AAAAGTAGACTATATGAAGAGTTTGTGACTGCTCAATTTAACTTGTTTTTTGCCTTATTTCTATTAAGACTGTTTTACTATGTTTTTGCC
CTAGGGATATCAGCAAATATTTATTTTTCCTAGCATGATATAGTTAGAATTTCAAGCAGATTTCTTTGTAATTAGAAGGCATCTGATAGA
AATTGTAAAACTTTAGAAGTTATTATAATGAAACCAATTCCTGAATCACAACTTCATGGACTGACTAAATTGATTTATAGTTGCCTTGTG
AGGTATGTATGGGGAAAACATAAAAACATAATTAAAACATAATTTCGTCCTTTTTATGAATTCTTAAGAGATGTTCTTCCATAAATATAG
AAATAATATATTTTTCTTAAAGGATATATTTTTAATTATGTGGAAGTTGTAAGCTTGAAATTTTAACTTCTAGTGCTTTTCTAAAATTCA
CAATTACAAGTTTAAAACATTTTTTCTCTTCCAGGTTTCATTTGGAATAAAGAGTTGGCAGTTATATAAAGCACTTAATAATACTATAGA
AAATAGATGTGTTTTTTCTTAATATGATTTTGGTATTTTCCACAGATCAGAAGTGTAAACAGAGAGATAATGTAACAGTATTTGGAAGAG
ATAATGACACAAGGATATAGTGATCTGGGAGCATGAATTAGAAACAGGGTACTATGTTTCTGGTGTAAAATCTAAATTGTGCTTTCTACT
AGCGTTACTTTTTCAAATGGGATGATATAAAGCACTGTGGGCTATAAGCAACAATCTTGGGTTGGTAGGCAAATAGACCAATTGATCTTT
ATTATTATTATTATTATTATTATTATTATTTTTTGAGATGAAGTCTTGCTCTTGTCGCCCAGGCTGGGTGCAGTGGCATGATCTTGGCTT
ACTGCAACCTCTGCCTCCTGGGTTCAAGCACCTGAGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCCACCACACCTGGCTAATTTTTG
TATTTTTTGTAGAGACAGATGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTTTGCATCCCAA
AATGCTGGGATTACAGGTGTGAGCCACAGCACCCGGTCCCAGTTGGTCTTTTAATATTAAATTTGTGCACTATTACTGGGTCTGGAGTTA
ATGATTTCAAATAGTTTCTAAAAATAACTGATTAAATGTAAGAAATTATAACTAATTATCAAGGTGATTCTCTTTTGTTTCTTCAATGGA
GAGTTTCTCTTTCTCTTTTCCTCCTCTAATAAAAATATTTCTTTTTTTCCTGTCCTTTTATTCATTATATTATGAAACTTAGGTTTTAGG
AAACACCTTAAGCGTCATTTTAATGAAGCACAACATTGATATTTTACATGAATAATAACGTTTGGTATTTTAAATATACTTCAAGGGGGT
AATAAGCCACAATAACTGTACCAAAAAAACTTAAAAATGGGGACATATTCATCCCTTGTGTGTGCATATTTTACCACTTGTTGACAAGAT
ACAATTGTGACCTACTTTGAGGGGATGAATAACGACTTATCACTTTAAGACACTTTGCAAACATGTTACTAAAAAAAGGTGCCTAGCCAA
GGAAAAAACCATTCACTTGGAATTAAAATTGTGGATGTCACTTCAGAGATGACTTTAACATAAATGCTGAAAGTTCATTCACCTCACAAA
TGTGGCAGTTTTCTCTGTGGAGAATGGTGGTCTCCGTGGCAGACTGGCTCTCCAAATTAAATGAAACTCATTGACAGACCTGGGACCTTT
TATGTGAGTGGACAGACAAGATCTTGGTTTGGCTTCATGTACTGTTTTCTAGAGAGAGTGCTACGAAAAACTTATGATGCTTTTATGTGA
TAACCAATATAATGCTTTAATATGTTAATTCTTTGTGATGCTATATACATAGTTTTTATAGTTTTATGAAACCACTTTGTTAAACTTATC
TGGATTTTAAGACACTTGTAAACAAATGGTTTGTTAGTAAAATTGGGGCATTAAGAGTTTTACAGAGCAAATAAAGAAGATTTTGACAAA

>89923_89923_3_TDP2-DCDC2_TDP2_chr6_24653211_ENST00000545995_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=659AA_BP=0
MRERHDTGACAEPRVGLLFRLKGRCRGGRKMELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFL
QEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKI
TLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSD
NSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKAN
KDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TDP2-DCDC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	TDP2	chr6:24653211	chr6:24302272	ENST00000378198	-	6	7	120_124	269.0	363.0	5' end of substrate DNA
Hgene	TDP2	chr6:24653211	chr6:24302272	ENST00000378198	-	6	7	226_231	269.0	363.0	5' end of substrate DNA
Hgene	TDP2	chr6:24653211	chr6:24302272	ENST00000378198	-	6	7	264_266	269.0	363.0	5' end of substrate DNA
Hgene	TDP2	chr6:24653211	chr6:24302272	ENST00000545995	-	6	7	120_124	299.0	393.0	5' end of substrate DNA
Hgene	TDP2	chr6:24653211	chr6:24302272	ENST00000545995	-	6	7	226_231	299.0	393.0	5' end of substrate DNA
Hgene	TDP2	chr6:24653211	chr6:24302272	ENST00000545995	-	6	7	264_266	299.0	393.0	5' end of substrate DNA

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TDP2-DCDC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TDP2-DCDC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source