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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TEAD2-NOSIP (FusionGDB2 ID:89968)

Fusion Gene Summary for TEAD2-NOSIP

check button Fusion gene summary
Fusion gene informationFusion gene name: TEAD2-NOSIP
Fusion gene ID: 89968
HgeneTgene
Gene symbol

TEAD2

NOSIP

Gene ID

8463

51070

Gene nameTEA domain transcription factor 2nitric oxide synthase interacting protein
SynonymsETF|TEAD-2|TEF-4|TEF4CGI-25
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional enhancer factor TEF-4TEA domain family member 2nitric oxide synthase-interacting proteinE3 ubiquitin-protein ligase NOSIPRING-type E3 ubiquitin transferase NOSIPeNOS-interacting protein
Modification date2020031320200313
UniProtAcc.

Q9Y314

Ensembl transtripts involved in fusion geneENST00000598397, ENST00000377214, 
ENST00000539846, ENST00000593945, 
ENST00000598810, ENST00000601519, 
ENST00000311227, 		ENST00000339093, 
ENST00000391853, ENST00000596358, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 2 X 5=80
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/80*10)=0
Context

PubMed: TEAD2 [Title/Abstract] AND NOSIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTEAD2(49858405)-NOSIP(50060506), # samples:2
Anticipated loss of major functional domain due to fusion event.TEAD2-NOSIP seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TEAD2-NOSIP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TEAD2-NOSIP seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TEAD2-NOSIP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTEAD2

GO:0035329

hippo signaling

18579750|19324877

TgeneNOSIP

GO:0043086

negative regulation of catalytic activity

11149895

TgeneNOSIP

GO:0051001

negative regulation of nitric-oxide synthase activity

11149895


check buttonFusion gene breakpoints across TEAD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOSIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8060-01ATEAD2chr19

49858405

-NOSIPchr19

50060506

-


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Fusion Gene ORF analysis for TEAD2-NOSIP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000598397ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
5UTR-3CDSENST00000598397ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
5UTR-3CDSENST00000598397ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000377214ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000377214ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000377214ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000539846ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000539846ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000539846ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000593945ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000593945ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000593945ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000598810ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000598810ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000598810ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000601519ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000601519ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
Frame-shiftENST00000601519ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-
In-frameENST00000311227ENST00000339093TEAD2chr19

49858405

-NOSIPchr19

50060506

-
In-frameENST00000311227ENST00000391853TEAD2chr19

49858405

-NOSIPchr19

50060506

-
In-frameENST00000311227ENST00000596358TEAD2chr19

49858405

-NOSIPchr19

50060506

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311227TEAD2chr1949858405-ENST00000339093NOSIPchr1950060506-13156185791274231
ENST00000311227TEAD2chr1949858405-ENST00000596358NOSIPchr1950060506-13066185791265228
ENST00000311227TEAD2chr1949858405-ENST00000391853NOSIPchr1950060506-13046185791265228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311227ENST00000339093TEAD2chr1949858405-NOSIPchr1950060506-0.55734980.44265026
ENST00000311227ENST00000596358TEAD2chr1949858405-NOSIPchr1950060506-0.567753730.43224624
ENST00000311227ENST00000391853TEAD2chr1949858405-NOSIPchr1950060506-0.555139540.44486043

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Fusion Genomic Features for TEAD2-NOSIP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TEAD2-NOSIP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49858405/chr19:50060506)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NOSIP

Q9Y314

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTEAD2chr19:49858405chr19:50060506ENST00000311227-61238_114175448.0DNA bindingTEA
HgeneTEAD2chr19:49858405chr19:50060506ENST00000377214-51138_114178451.0DNA bindingTEA
HgeneTEAD2chr19:49858405chr19:50060506ENST00000601519-61238_114178451.0DNA bindingTEA

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTEAD2chr19:49858405chr19:50060506ENST00000311227-612152_216175448.0Compositional biasNote=Pro-rich
HgeneTEAD2chr19:49858405chr19:50060506ENST00000377214-511152_216178451.0Compositional biasNote=Pro-rich
HgeneTEAD2chr19:49858405chr19:50060506ENST00000539846-612152_21647320.0Compositional biasNote=Pro-rich
HgeneTEAD2chr19:49858405chr19:50060506ENST00000601519-612152_216178451.0Compositional biasNote=Pro-rich
HgeneTEAD2chr19:49858405chr19:50060506ENST00000539846-61238_11447320.0DNA bindingTEA
HgeneTEAD2chr19:49858405chr19:50060506ENST00000311227-612172_447175448.0RegionTranscriptional activation
HgeneTEAD2chr19:49858405chr19:50060506ENST00000377214-511172_447178451.0RegionTranscriptional activation
HgeneTEAD2chr19:49858405chr19:50060506ENST00000539846-612172_44747320.0RegionTranscriptional activation
HgeneTEAD2chr19:49858405chr19:50060506ENST00000601519-612172_447178451.0RegionTranscriptional activation
TgeneNOSIPchr19:49858405chr19:50060506ENST0000039185341078_10186302.0MotifNote=Nuclear localization signal
TgeneNOSIPchr19:49858405chr19:50060506ENST000005963583978_10186302.0MotifNote=Nuclear localization signal
TgeneNOSIPchr19:49858405chr19:50060506ENST0000039185341055_7586302.0RegionNote=U-box-like
TgeneNOSIPchr19:49858405chr19:50060506ENST000005963583955_7586302.0RegionNote=U-box-like


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Fusion Gene Sequence for TEAD2-NOSIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89968_89968_1_TEAD2-NOSIP_TEAD2_chr19_49858405_ENST00000311227_NOSIP_chr19_50060506_ENST00000339093_length(transcript)=1315nt_BP=618nt
CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCGCGGCTCCCCAGCCCCAGGCCGGGAGGCCCA
GATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG
TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTA
TCCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG
AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAA
GGACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT
GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAG
CAGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCT
ATCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGGTGACTCAGATGATGTCCAACCTGGGCCCAGT
GTGGGTCCTCCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAG
AAGCCGTCCCGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGC
TCCGTGGACCGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCT
GTGCTGCGGCCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAA
CTCACAGACCGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCG

>89968_89968_1_TEAD2-NOSIP_TEAD2_chr19_49858405_ENST00000311227_NOSIP_chr19_50060506_ENST00000339093_length(amino acids)=231AA_BP=13
MVWRIWAPLECSRAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPGDSDDVQPGPSVGPPSKDKDKVLP
SFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLEC

--------------------------------------------------------------
>89968_89968_2_TEAD2-NOSIP_TEAD2_chr19_49858405_ENST00000311227_NOSIP_chr19_50060506_ENST00000391853_length(transcript)=1304nt_BP=618nt
CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCGCGGCTCCCCAGCCCCAGGCCGGGAGGCCCA
GATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG
TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTA
TCCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG
AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAA
GGACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT
GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAG
CAGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCT
ATCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGATGATGTCCAACCTGGGCCCAGTGTGGGTCCT
CCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGAAGCCGTCC
CGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCTCCGTGGAC
CGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTGTGCTGCGG
CCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAACTCACAGAC
CGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGGTGATGCAG

>89968_89968_2_TEAD2-NOSIP_TEAD2_chr19_49858405_ENST00000311227_NOSIP_chr19_50060506_ENST00000391853_length(amino acids)=228AA_BP=13
MVWRIWAPLECSRAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFW
IPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEK

--------------------------------------------------------------
>89968_89968_3_TEAD2-NOSIP_TEAD2_chr19_49858405_ENST00000311227_NOSIP_chr19_50060506_ENST00000596358_length(transcript)=1306nt_BP=618nt
CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCGCGGCTCCCCAGCCCCAGGCCGGGAGGCCCA
GATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG
TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTA
TCCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG
AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAA
GGACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT
GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAG
CAGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCT
ATCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGATGATGTCCAACCTGGGCCCAGTGTGGGTCCT
CCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGAAGCCGTCC
CGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCTCCGTGGAC
CGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTGTGCTGCGG
CCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAACTCACAGAC
CGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGGTGATGCAG

>89968_89968_3_TEAD2-NOSIP_TEAD2_chr19_49858405_ENST00000311227_NOSIP_chr19_50060506_ENST00000596358_length(amino acids)=228AA_BP=13
MVWRIWAPLECSRAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFW
IPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TEAD2-NOSIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TEAD2-NOSIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TEAD2-NOSIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource