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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:TECPR2-WDR20 (FusionGDB2 ID:89995)

Fusion Gene Summary for TECPR2-WDR20

check button Fusion gene summary
Fusion gene informationFusion gene name: TECPR2-WDR20
Fusion gene ID: 89995
HgeneTgene
Gene symbol

TECPR2

WDR20

Gene ID

9895

91833

Gene nametectonin beta-propeller repeat containing 2WD repeat domain 20
SynonymsKIAA0329|SPG49DMR
Cytomap

14q32.31

14q32.31

Type of geneprotein-codingprotein-coding
Descriptiontectonin beta-propeller repeat-containing protein 2WD repeat-containing protein 20
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359520, ENST00000558678, 
ENST00000561228, 		ENST00000299135, 
ENST00000454394, ENST00000556511, 
ENST00000342702, ENST00000499851, 
ENST00000556807, ENST00000322340, 
ENST00000545563, ENST00000557186, 
ENST00000558567, ENST00000424963, 
ENST00000335263, 
Fusion gene scores* DoF score6 X 6 X 3=1085 X 5 X 6=150
# samples 67
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TECPR2 [Title/Abstract] AND WDR20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTECPR2(102931626)-WDR20(102675199), # samples:1
WDR20(102606509)-TECPR2(102963316), # samples:1
Anticipated loss of major functional domain due to fusion event.TECPR2-WDR20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TECPR2-WDR20 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
WDR20-TECPR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WDR20-TECPR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TECPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDR20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-FV-A496-01ATECPR2chr14

102931626

-WDR20chr14

102675199

+


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Fusion Gene ORF analysis for TECPR2-WDR20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000359520ENST00000299135TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-3UTRENST00000359520ENST00000454394TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-3UTRENST00000359520ENST00000556511TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-3UTRENST00000558678ENST00000299135TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-3UTRENST00000558678ENST00000454394TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-3UTRENST00000558678ENST00000556511TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-5UTRENST00000359520ENST00000342702TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-5UTRENST00000359520ENST00000499851TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-5UTRENST00000359520ENST00000556807TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-5UTRENST00000558678ENST00000342702TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-5UTRENST00000558678ENST00000499851TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-5UTRENST00000558678ENST00000556807TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000359520ENST00000322340TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000359520ENST00000545563TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000359520ENST00000557186TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000359520ENST00000558567TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000558678ENST00000322340TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000558678ENST00000545563TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000558678ENST00000557186TECPR2chr14

102931626

-WDR20chr14

102675199

+
5CDS-intronENST00000558678ENST00000558567TECPR2chr14

102931626

-WDR20chr14

102675199

+
Frame-shiftENST00000359520ENST00000424963TECPR2chr14

102931626

-WDR20chr14

102675199

+
Frame-shiftENST00000558678ENST00000335263TECPR2chr14

102931626

-WDR20chr14

102675199

+
Frame-shiftENST00000558678ENST00000424963TECPR2chr14

102931626

-WDR20chr14

102675199

+
In-frameENST00000359520ENST00000335263TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-3CDSENST00000561228ENST00000335263TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-3CDSENST00000561228ENST00000424963TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-3UTRENST00000561228ENST00000299135TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-3UTRENST00000561228ENST00000454394TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-3UTRENST00000561228ENST00000556511TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-5UTRENST00000561228ENST00000342702TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-5UTRENST00000561228ENST00000499851TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-5UTRENST00000561228ENST00000556807TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-intronENST00000561228ENST00000322340TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-intronENST00000561228ENST00000545563TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-intronENST00000561228ENST00000557186TECPR2chr14

102931626

-WDR20chr14

102675199

+
intron-intronENST00000561228ENST00000558567TECPR2chr14

102931626

-WDR20chr14

102675199

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359520TECPR2chr14102931626-ENST00000335263WDR20chr14102675199+5859401522040711283

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359520ENST00000335263TECPR2chr14102931626-WDR20chr14102675199+0.0009349010.9990651

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Fusion Genomic Features for TECPR2-WDR20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TECPR2-WDR20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102931626/chr14:102675199)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720462_47112631412.0Compositional biasNote=Poly-Lys
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720115_16112631412.0RepeatNote=WD 3
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-17201179_120912631412.0RepeatNote=TECPR 3
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-17201226_125912631412.0RepeatNote=TECPR 4
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720162_20312631412.0RepeatNote=WD 4
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720204_26512631412.0RepeatNote=WD 5
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-172023_6612631412.0RepeatNote=WD 1
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720266_30912631412.0RepeatNote=WD 6
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720310_34312631412.0RepeatNote=WD 7
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-172067_11412631412.0RepeatNote=WD 2
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720945_97612631412.0RepeatNote=TECPR 1
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-1720994_102712631412.0RepeatNote=TECPR 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000029913503139_2100640.6666666666666RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000029913503211_2520640.6666666666666RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000029913503253_3310640.6666666666666RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000029913503332_4260640.6666666666666RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000029913503427_5230640.6666666666666RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000029913503524_5590640.6666666666666RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000002991350394_1380640.6666666666666RepeatNote=WD 1
TgeneWDR20chr14:102931626chr14:102675199ENST0000032234004139_2100196.0RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000032234004211_2520196.0RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000032234004253_3310196.0RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000032234004332_4260196.0RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000032234004427_5230196.0RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000032234004524_5590196.0RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000003223400494_1380196.0RepeatNote=WD 1
TgeneWDR20chr14:102931626chr14:102675199ENST0000033526304139_2100582.0RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000033526304211_2520582.0RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000033526304253_3310582.0RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000033526304332_4260582.0RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000033526304427_5230582.0RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000033526304524_5590582.0RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000003352630494_1380582.0RepeatNote=WD 1
TgeneWDR20chr14:102931626chr14:102675199ENST0000034270203139_2100570.0RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000034270203211_2520570.0RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000034270203253_3310570.0RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000034270203332_4260570.0RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000034270203427_5230570.0RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000034270203524_5590570.0RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000003427020394_1380570.0RepeatNote=WD 1
TgeneWDR20chr14:102931626chr14:102675199ENST0000045439404139_2100601.0RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000045439404211_2520601.0RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000045439404253_3310601.0RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000045439404332_4260601.0RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000045439404427_5230601.0RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000045439404524_5590601.0RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000004543940494_1380601.0RepeatNote=WD 1
TgeneWDR20chr14:102931626chr14:102675199ENST0000055651102139_2100509.0RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000055651102211_2520509.0RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000055651102253_3310509.0RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000055651102332_4260509.0RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000055651102427_5230509.0RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000055651102524_5590509.0RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000005565110294_1380509.0RepeatNote=WD 1
TgeneWDR20chr14:102931626chr14:102675199ENST0000055680703139_2100521.0RepeatNote=WD 2
TgeneWDR20chr14:102931626chr14:102675199ENST0000055680703211_2520521.0RepeatNote=WD 3
TgeneWDR20chr14:102931626chr14:102675199ENST0000055680703253_3310521.0RepeatNote=WD 4
TgeneWDR20chr14:102931626chr14:102675199ENST0000055680703332_4260521.0RepeatNote=WD 5
TgeneWDR20chr14:102931626chr14:102675199ENST0000055680703427_5230521.0RepeatNote=WD 6
TgeneWDR20chr14:102931626chr14:102675199ENST0000055680703524_5590521.0RepeatNote=WD 7
TgeneWDR20chr14:102931626chr14:102675199ENST000005568070394_1380521.0RepeatNote=WD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117462_47101268.0Compositional biasNote=Poly-Lys
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-17201279_131012631412.0RepeatNote=TECPR 5
HgeneTECPR2chr14:102931626chr14:102675199ENST00000359520-17201322_135312631412.0RepeatNote=TECPR 6
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117115_16101268.0RepeatNote=WD 3
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-1171179_120901268.0RepeatNote=TECPR 3
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-1171226_125901268.0RepeatNote=TECPR 4
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-1171279_131001268.0RepeatNote=TECPR 5
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-1171322_135301268.0RepeatNote=TECPR 6
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117162_20301268.0RepeatNote=WD 4
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117204_26501268.0RepeatNote=WD 5
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-11723_6601268.0RepeatNote=WD 1
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117266_30901268.0RepeatNote=WD 6
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117310_34301268.0RepeatNote=WD 7
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-11767_11401268.0RepeatNote=WD 2
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117945_97601268.0RepeatNote=TECPR 1
HgeneTECPR2chr14:102931626chr14:102675199ENST00000558678-117994_102701268.0RepeatNote=TECPR 2


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Fusion Gene Sequence for TECPR2-WDR20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89995_89995_1_TECPR2-WDR20_TECPR2_chr14_102931626_ENST00000359520_WDR20_chr14_102675199_ENST00000335263_length(transcript)=5859nt_BP=4015nt
CCCCCGGCGGAGCCAGCTGCTGCTCTTCGGTGCTGGCCCCGGTGCCGGCCCCGTTGCCCAGGGAACAGGCTCCCGGCAGCCCCCGCGGCC
CGGAGTCCATCCCGCCTCCTCCGGCCCGGCGGGGCCGACGAGTCCGGAGGGGCTGCCGCGGGAGCCCCCAGGTTTCCCTAGATGACAAAT
AAACATTCCTTTTCCTGCGTGAAGATAGTCTGTGGAAACCTTGGCCATGGCATCGATATCAGAGCCTGTTACATTCAGAGAGTTCTGCCC
GTTGTACTATCTCCTCAATGCCATTCCGACAAAGATCCAGAAGGGTTTCCGCTCTATCGTGGTCTATCTCACGGCCCTCGACACCAACGG
GGACTACATCGCGGTGGGCAGCAGCATCGGCATGCTCTATCTGTACTGCCGGCACCTCAACCAGATGAGGAAGTACAACTTTGAGGGGAA
GACGGAATCTATCACTGTGGTGAAGCTGCTGAGCTGCTTTGATGACCTGGTGGCAGCAGGCACAGCCTCTGGCAGGGTTGCAGTTTTTCA
ACTTGTATCTTCATTGCCAGGGAGAAATAAACAGCTTCGGAGATTTGATGTCACTGGTATTCACAAAAATAGCATTACAGCTCTGGCTTG
GAGCCCCAATGGAATGAAATTGTTCTCTGGAGATGACAAAGGCAAAATTGTTTATTCTTCTCTGGATCTAGACCAGGGGCTCTGTAACTC
CCAGCTGGTGTTGGAGGAGCCATCTTCCATTGTGCAGCTGGATTATAGCCAGAAAGTGCTGCTGGTCTCTACTCTGCAAAGAAGTCTGCT
CTTTTACACTGAAGAAAAGTCTGTAAGGCAAATTGGAACACAACCAAGGAAAAGTACTGGGAAATTTGGTGCTTGTTTTATACCAGGACT
CTGTAAGCAAAGTGATCTAACCTTGTATGCGTCACGGCCCGGGCTCCGGCTATGGAAGGCTGATGTCCACGGGACTGTTCAAGCCACGTT
TATCTTAAAAGATGCTTTTGCCGGGGGAGTCAAGCCTTTTGAACTGCACCCGCGTCTGGAATCCCCCAACAGTGGAAGTTGCAGCTTACC
TGAGAGGCACCTGGGGCTTGTTTCATGTTTCTTTCAAGAAGGCTGGGTGCTGAGTTGGAATGAATATAGTATCTATCTCCTAGACACAGT
CAACCAGGCCACAGTTGCTGGTTTGGAAGGATCCGGTGATATTGTGTCTGTTTCGTGCACAGAAAATGAAATATTTTTCTTGAAAGGAGA
TAGGAACATTATAAGAATTTCAAGCAGGCCTGAAGGATTAACATCAACAGTGAGAGATGGTCTGGAGATGTCTGGATGCTCAGAGCGTGT
CCACGTGCAGCAAGCGGAGAAGCTGCCAGGGGCCACAGTTTCTGAGACGAGGCTCAGAGGCTCTTCCATGGCCAGCTCCGTGGCCAGCGA
GCCAAGGAGCAGGAGCAGCTCGCTCAACTCCACCGACAGCGGCTCCGGGCTCCTGCCCCCTGGGCTCCAGGCCACCCCTGAGCTGGGCAA
GGGCAGCCAGCCCCTGTCACAGAGATTCAACGCCATCAGCTCAGAGGACTTTGACCAGGAGCTTGTCGTGAAGCCTATCAAAGTGAAAAG
GAAGAAGAAGAAGAAGAAGACAGAAGGTGGAAGCAGGAGCACCTGTCACAGCTCCCTGGAATCGACACCCTGCTCCGAATTTCCTGGGGA
CAGTCCCCAGTCCTTGAACACAGACTTGCTGTCGATGACCTCAAGTGTCCTGGGCAGTAGCGTGGATCAGTTAAGTGCAGAGTCTCCAGA
CCAGGAAAGCAGCTTCAATGGTGAAGTGAACGGTGTCCCACAGGAAAATACTGACCCCGAAACGTTTAATGTCCTGGAGGTGTCAGGATC
AATGCCTGATTCTCTGGCTGAGGAAGATGACATTAGAACTGAAATGCCACACTGTCACCATGCACATGGGCGGGAGCTGCTCAATGGAGC
GAGGGAAGATGTGGGAGGCAGTGATGTCACGGGACTCGGAGATGAGCCGTGTCCTGCAGATGATGGACCAAATAGCACACAGTTACCCTT
CCAAGAACAGGACAGCTCTCCTGGGGCGCATGATGGGGAAGACATCCAACCCATTGGCCCCCAAAGCACTTTTTGTGAAGTCCCCCTCCT
GAACTCACTCACTGTGCCTTCCAGCCTCAGCTGGGCCCCAAGTGCTGAACAGTGGCTGCCTGGGACCAGAGCTGATGAAGGCAGCCCCGT
GGAGCCCAGCCAAGAGCAGGACATCCTAACCAGCATGGAGGCCTCTGGCCACCTCAGCACAAATCTCTGGCATGCTGTCACTGATGATGA
CACAGGTCAGAAAGAAATACCCATTTCTGAACGTGTCTTGGGGAGTGTGGGAGGACAGCTGACTCCGGTCTCTGCCTTGGCAGCCAGCAC
TCACAAGCCCTGGCTTGAGCAGCCTCCACGGGATCAGACATTGACGTCCAGCGATGAGGAGGACATCTATGCCCACGGGCTTCCTTCTTC
ATCCTCAGAGACGAGTGTGACAGAGCTCGGACCTAGTTGCTCCCAGCAGGACCTGAGCCGGCTGGGTGCAGAGGACGCCGGGCTGCTCAA
GCCAGATCAGTTTGCAGAAAGCTGGATGGGCTACTCGGGTCCCGGCTATGGCATCCTCAGCTTGGTGGTCTCCGAGAAGTATATCTGGTG
CCTGGACTACAAAGGCGGCCTGTTCTGCAGCGCGTTGCCGGGCGCCGGGCTGCGCTGGCAGAAGTTTGAAGATGCTGTCCAGCAGGTGGC
AGTCTCGCCCTCAGGAGCCCTTCTCTGGAAGATTGAACAGAAATCTAACCGGGCTTTTGCTTGTGGGAAAGTCACCATCAAGGGGAAGCG
GCACTGGTACGAAGCCCTGCCCCAGGCAGTGTTTGTGGCCCTGAGCGATGACACGGCCTGGATCATCAGGACCAGTGGGGACCTATACTT
GCAGACAGGTCTGAGCGTGGATCGCCCTTGTGCCAGAGCCGTAAAGGTGGACTGTCCCTACCCGCTGTCCCAGATCACAGCCCGGAACAA
TGTGGTGTGGGCGCTGACAGAGCAGAGGGCCCTCCTGTACCGGGAGGGCGTGAGCAGCTTCTGTCCGGAAGGCGAGCAGTGGAAGTGTGA
CATTGTCAGCGAAAGGCAAGCTTTAGAACCCGTCTGCATAACGCTCGGGGATCAGCAGACTCTCTGGGCCCTGGACATCCATGGGAACCT
GTGGTTCAGAACTGGCATTATTTCCAAGAAGCCCCAAGGAGATGACGACCATTGGTGGCAAGTGAGCATCACGGACTATGTGGTGTTTGA
CCAGTGCAGCTTATTTCAGACGATAATCCATGCCACTCACTCGGTGGCCACAGCAGCCCAAGCCCCCGTAGAAAAGGTGGCAGATAAGCT
GCGCATGGCGTTTTGGTCCCAGCAGCTTCAGTGCCAGCCAAGCCTTCTCGGGGTCAATAACAGCGGTGTCTGGATCTCCTCGGGCAAGAA
TGAATTCCACGTCGCTAAGGGAAGTCTCATAGGCACCTACTGGAATCATGTGGTTCCCCGTGGGACAGCTTCTGCTACAAAATGGGCCTT
TGTGTTGGCTTCTGCAGCTCCCACGAAGGAAGGAAGCTTCCTGTGGCTGTGCCAGAGCAGCAAGGACCTGTGCAGCGTCAGCGCCCAGAG
CGCACAGTCGCGGCCCTCCACGGTGCAGCTGCCTCCCGAAGCCGAGATGCGCGCCTATGCCGCCTGCCAGGATGCGCTGTGGGCGCTGGA
CAGCCTCGGCCAGGTGTTCATCAGGACGCTCTCCAAGAGCTGCCCCACGGGCATGCACTGGACCAGGCTGGACCTCTCCCAGCTAGGAGC
TGTAAAATTGACAAGCTTGGCATGTGGAAATCAGCACATCTGGGCCTGTGATTCCAGGGGTGGAGTTTACTTCCGTGTAGGGACTCAGCC
TCTCAATCCCAGTCTCATGCTTCCAGCCTGGATAATGATTGAGCCACCTGTCCAGTGGCAAGTTCTTAGCGTGCGTGAGCCAGGACGGGT
TTCTGCGGGTGTTCAACTTTGACTCAGTGGAGCTGCACGGTACGATGAAAAGCTACTTTGGGGGCTTGCTGTGTGTGTGCTGGAGCCCGG
ATGGCAAGTACATCGTGACAGGTGGGGAGGACGACTTGGTGACAGTCTGGTCCTTTGTAGACTGCCGAGTAATAGCCAGAGGCCACGGGC
ACAAGTCCTGGGTCAGTGTTGTAGCGTTTGACCCTTATACCACTAGTGTAGAAGAAGGTGACCCTATGGAGTTTAGTGGCAGCGATGAGG
ACTTCCAAGACCTTCTTCATTTTGGCAGAGATCGAGCAAATAGTACACAGTCCAGGCTCTCCAAACGGAACTCTACAGACAGCCGCCCCG
TAAGTGTCACGTATCGGTTTGGTTCCGTGGGCCAGGACACACAGCTCTGTTTATGGGACCTTACAGAAGATATCCTTTTCCCTCACCAAC
CCCTCTCAAGAGCAAGGACACACACAAATGTCATGAATGCCACGAGTCCTCCTGCTGGAAGCAATGGGAACAGTGTTACAACACCCGGGA
ACTCTGTGCCGCCTCCTCTGCCACGGTCCAACAGCCTTCCACATTCAGCAGTCTCAAATGCTGGCAGCAAAAGCAGTGTCATGGACGGGG
CCATTGCTTCTGGGGTCAGCAAATTTGCAACACTTTCACTACATGACCGGAAGGAGAGGCACCACGAGAAAGATCACAAGCGAAATCATA
GCATGGGACACATTTCTAGCAAGAGCAGTGACAAACTGAATCTAGTTACCAAAACCAAAACGGACCCTGCTAAAACTCTGGGAACGCCCC
TGTGTCCTCGAATGGAAGATGTTCCCTTGTTAGAGCCGCTGATATGTAAAAAGATAGCACATGAGAGACTGACTGTACTAATATTTCTTG
AAGACTGTATAGTCACTGCTTGTCAGGAGGGATTTATTTGCACATGGGGAAGGCCTGGTAAAGTGGGCTCATTGTCATCCCCAAGCCAGG
CCAGTTCTCCAGGTGGAACTGTAGTGTAGCGACCTCACTGCTGCGCGCACAGTCTCCCGGGACTTGGACTCGAGGGAGTGACGAGGAGGA
GCTCCGAGCTGCGCCTGAGCCGTGCCAGCCGGCGGACCTCAGGCGGTGGACGTCGGCGATAGCCGTGTGGACGGTGACCGGCTCACTCTG
CGGCGCCGTGCTCCCGCTGCTCACCCAAAGAAGTTGTTTCCATTTTAAACCGGTCTTTTGGGGCTGCAGTAAAAAATAAGAAATGGAGTT
TTCTTGCTTTTTACTCTAAAATTCAATGTAATTAAATTTCATATATATATAATATATACATATATACATAGTGTAAAATAAAATGTTTCT
TGGACAAGAAATCCCCTGAAATTCAGCTGTTATAGTGCTTCACTGTTTTTGCACTGATTTTTCTATACCTTAGGTGGTCAGAAGACAACC
TTGAATGCACTCATAGAGAAAACTGTTACTTTCTGACGTAATGTAATTCAGGAAGACAGACGCTGCAATCACAGATTTTAAAAAATTGTT
TGCACTTAAAAATAGTTGAATGCTGGTGGAAAGTTACTTTGCAGATGGGTGTAAGGACTCATGGCCCTCTGAGGTGCGGCGTGAAGATGC
CCTTTTTACCCGTTGACGTTTATTTTACGTAAAATAAACTGTTGTTTCCAATGCAATCAACTCTGTATTATATGTATAAATATTGTAATT
CTGCAATTGGGGAAAATAGTTACTTCACTAGTAATTTTCATCATTTAAGAGTGATATTTCTAATTCACAAAAGTTAATATTAAAACTATC

>89995_89995_1_TECPR2-WDR20_TECPR2_chr14_102931626_ENST00000359520_WDR20_chr14_102675199_ENST00000335263_length(amino acids)=1283AA_BP=1265
MAMASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCF
DDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQL
DYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPF
ELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGL
TSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAIS
SEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVP
QENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGE
DIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVL
GSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSG
PGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVA
LSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCI
TLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQP
SLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPE
AEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMI

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Fusion Gene PPI Analysis for TECPR2-WDR20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TECPR2-WDR20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TECPR2-WDR20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource