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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BAX-ISLR (FusionGDB2 ID:9002)

Fusion Gene Summary for BAX-ISLR

Fusion gene summary

Fusion gene information	Fusion gene name: BAX-ISLR
	Fusion gene ID: 9002
		Hgene	Tgene
	Gene symbol	BAX	ISLR
	Gene ID	581	3671
	Gene name	BCL2 associated X, apoptosis regulator	immunoglobulin superfamily containing leucine rich repeat
	Synonyms	BCL2L4	HsT17563\|Meflin
	Cytomap	19q13.33	15q24.1
	Type of gene	protein-coding	protein-coding
	Description	apoptosis regulator BAXBCL2 associated X proteinBCL2-associated X protein omegaBaxdelta2G9Baxdelta2G9omegaBaxdelta2omegabcl-2-like protein 4bcl2-L-4	immunoglobulin superfamily containing leucine-rich repeat proteinmesenchymal stromal cell- and fibroblast-expressing Linx paralogue
	Modification date	20200322	20200313
	UniProtAcc	TMBIM6	Q6UXK2
	Ensembl transtripts involved in fusion gene	ENST00000391871, ENST00000293288, ENST00000345358, ENST00000415969, ENST00000539787, ENST00000354470,	ENST00000249842, ENST00000395118,
Fusion gene scores	* DoF score	6 X 5 X 5=150	6 X 7 X 3=126
	# samples	7	7
	** MAII score	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BAX [Title/Abstract] AND ISLR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BAX(49459090)-ISLR(74468295), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BAX	GO:0001783	B cell apoptotic process	15214043\|16424160
Hgene	BAX	GO:0001836	release of cytochrome c from mitochondria	9843949\|16199525\|17052454
Hgene	BAX	GO:0006915	apoptotic process	9660918
Hgene	BAX	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	11912183
Hgene	BAX	GO:0008053	mitochondrial fusion	14769861
Hgene	BAX	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	15214043
Hgene	BAX	GO:0008637	apoptotic mitochondrial changes	9843949
Hgene	BAX	GO:0009636	response to toxic substance	16307838
Hgene	BAX	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	9843949
Hgene	BAX	GO:0010917	negative regulation of mitochondrial membrane potential	16751333
Hgene	BAX	GO:0031334	positive regulation of protein complex assembly	9111042\|19805544
Hgene	BAX	GO:0032091	negative regulation of protein binding	9388232
Hgene	BAX	GO:0032976	release of matrix enzymes from mitochondria	9843949
Hgene	BAX	GO:0043065	positive regulation of apoptotic process	16751333\|17464193
Hgene	BAX	GO:0043525	positive regulation of neuron apoptotic process	15637643
Hgene	BAX	GO:0043653	mitochondrial fragmentation involved in apoptotic process	12499352
Hgene	BAX	GO:0051881	regulation of mitochondrial membrane potential	9843949
Hgene	BAX	GO:0090200	positive regulation of release of cytochrome c from mitochondria	14963330
Hgene	BAX	GO:0097190	apoptotic signaling pathway	16424160
Hgene	BAX	GO:0097191	extrinsic apoptotic signaling pathway	15214043
Hgene	BAX	GO:0097193	intrinsic apoptotic signaling pathway	9219694\|16462759
Hgene	BAX	GO:1990117	B cell receptor apoptotic signaling pathway	15214043

Fusion gene breakpoints across BAX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ISLR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8284-01A	BAX	chr19	49459090	+	ISLR	chr15	74468295	+

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Fusion Gene ORF analysis for BAX-ISLR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000391871	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
3UTR-3CDS	ENST00000391871	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000293288	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000293288	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000345358	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000345358	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000415969	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000415969	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000539787	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
In-frame	ENST00000539787	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
intron-3CDS	ENST00000354470	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+
intron-3CDS	ENST00000354470	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000539787	BAX	chr19	49459090	+	ENST00000249842	ISLR	chr15	74468295	+	1220	302	18	323	101
ENST00000539787	BAX	chr19	49459090	+	ENST00000395118	ISLR	chr15	74468295	+	1220	302	18	323	101
ENST00000345358	BAX	chr19	49459090	+	ENST00000249842	ISLR	chr15	74468295	+	1203	285	1	306	101
ENST00000345358	BAX	chr19	49459090	+	ENST00000395118	ISLR	chr15	74468295	+	1203	285	1	306	101
ENST00000415969	BAX	chr19	49459090	+	ENST00000249842	ISLR	chr15	74468295	+	1151	233	251	553	100
ENST00000415969	BAX	chr19	49459090	+	ENST00000395118	ISLR	chr15	74468295	+	1151	233	251	553	100
ENST00000293288	BAX	chr19	49459090	+	ENST00000249842	ISLR	chr15	74468295	+	1151	233	251	553	100
ENST00000293288	BAX	chr19	49459090	+	ENST00000395118	ISLR	chr15	74468295	+	1151	233	251	553	100

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000539787	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.09231792	0.90768206
ENST00000539787	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.09231792	0.90768206
ENST00000345358	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.21430248	0.7856975
ENST00000345358	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.21430248	0.7856975
ENST00000415969	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.17045605	0.82954395
ENST00000415969	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.17045605	0.82954395
ENST00000293288	ENST00000249842	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.17045605	0.82954395
ENST00000293288	ENST00000395118	BAX	chr19	49459090	+	ISLR	chr15	74468295	+	0.17045605	0.82954395

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Fusion Genomic Features for BAX-ISLR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAX-ISLR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49459090/chr15:74468295)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BAX TMBIM6	ISLR Q6UXK2
237	FUNCTION: Required for axon extension during neural development. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000293288

59_73

219.0

Motif

Note=BH3

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000345358

59_73

193.0

Motif

Note=BH3

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000415969

59_73

180.0

Motif

Note=BH3

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000539787

59_73

205.66666666666666

Motif

Note=BH3

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

180_231

429.0

Domain

Note=LRRCT

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

19_50

429.0

Domain

Note=LRRNT

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

232_343

429.0

Domain

Note=Ig-like

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

180_231

429.0

Domain

Note=LRRCT

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

19_50

429.0

Domain

Note=LRRNT

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

232_343

429.0

Domain

Note=Ig-like

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

123_144

429.0

Repeat

Note=LRR 4

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

147_168

429.0

Repeat

Note=LRR 5

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

51_72

429.0

Repeat

Note=LRR 1

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

75_96

429.0

Repeat

Note=LRR 2

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000249842

99_122

429.0

Repeat

Note=LRR 3

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

123_144

429.0

Repeat

Note=LRR 4

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

147_168

429.0

Repeat

Note=LRR 5

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

51_72

429.0

Repeat

Note=LRR 1

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

75_96

429.0

Repeat

Note=LRR 2

Tgene

ISLR

chr19:49459090

chr15:74468295

ENST00000395118

99_122

429.0

Repeat

Note=LRR 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000293288

150_165

219.0

Motif

Note=BH2

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000293288

98_118

219.0

Motif

Note=BH1

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000345358

150_165

193.0

Motif

Note=BH2

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000345358

98_118

193.0

Motif

Note=BH1

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000354470

150_165

144.0

Motif

Note=BH2

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000354470

59_73

144.0

Motif

Note=BH3

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000354470

98_118

144.0

Motif

Note=BH1

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000391871

150_165

88.33333333333333

Motif

Note=BH2

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000391871

59_73

88.33333333333333

Motif

Note=BH3

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000391871

98_118

88.33333333333333

Motif

Note=BH1

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000415969

150_165

180.0

Motif

Note=BH2

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000415969

98_118

180.0

Motif

Note=BH1

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000539787

150_165

205.66666666666666

Motif

Note=BH2

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000539787

98_118

205.66666666666666

Motif

Note=BH1

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000293288

172_192

219.0

Transmembrane

Helical

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000345358

172_192

193.0

Transmembrane

Helical

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000354470

172_192

144.0

Transmembrane

Helical

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000391871

172_192

88.33333333333333

Transmembrane

Helical

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000415969

172_192

180.0

Transmembrane

Helical

Hgene

BAX

chr19:49459090

chr15:74468295

ENST00000539787

172_192

205.66666666666666

Transmembrane

Helical

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Fusion Gene Sequence for BAX-ISLR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9002_9002_1_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_1_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_2_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_2_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_3_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1203nt_BP=285nt
GCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCC
CACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACC
CGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAA
CATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCA
GCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCC
TCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGG
GGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCC
CCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCAT
TGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACT
GTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAG
GAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGAT
TTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAG
CCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAAGGCCAGCCAGCTTGGGA

>9002_9002_3_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=101AA_BP=
LRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------
>9002_9002_4_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1203nt_BP=285nt
GCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCC
CACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACC
CGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAA
CATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCA
GCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCC
TCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGG
GGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCC
CCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCAT
TGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACT
GTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAG
GAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGAT
TTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAG
CCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAAGGCCAGCCAGCTTGGGA

>9002_9002_4_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=101AA_BP=
LRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------
>9002_9002_5_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_5_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_6_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_6_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_7_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1220nt_BP=302nt
TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAG
CCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGA
ATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGG
GACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGT
GGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCT
GGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCC
CCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTC
TAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTC
ATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTG
GTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCA
GACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCT
TGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCT
TACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAA

>9002_9002_7_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=101AA_BP=
MRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------
>9002_9002_8_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1220nt_BP=302nt
TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAG
CCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGA
ATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGG
GACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGT
GGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCT
GGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCC
CCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTC
TAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTC
ATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTG
GTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCA
GACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCT
TGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCT
TACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAA

>9002_9002_8_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=101AA_BP=
MRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BAX-ISLR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BAX-ISLR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BAX-ISLR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source