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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAX-VAV2 (FusionGDB2 ID:9003)

Fusion Gene Summary for BAX-VAV2

check button Fusion gene summary
Fusion gene informationFusion gene name: BAX-VAV2
Fusion gene ID: 9003
HgeneTgene
Gene symbol

BAX

VAV2

Gene ID

581

7410

Gene nameBCL2 associated X, apoptosis regulatorvav guanine nucleotide exchange factor 2
SynonymsBCL2L4VAV-2
Cytomap

19q13.33

9q34.2

Type of geneprotein-codingprotein-coding
Descriptionapoptosis regulator BAXBCL2 associated X proteinBCL2-associated X protein omegaBaxdelta2G9Baxdelta2G9omegaBaxdelta2omegabcl-2-like protein 4bcl2-L-4guanine nucleotide exchange factor VAV2vav 2 oncogene
Modification date2020032220200313
UniProtAcc

TMBIM6

.
Ensembl transtripts involved in fusion geneENST00000391871, ENST00000539787, 
ENST00000293288, ENST00000345358, 
ENST00000354470, ENST00000415969, 
ENST00000371850, ENST00000371851, 
ENST00000406606, ENST00000486113, 
Fusion gene scores* DoF score6 X 5 X 5=15011 X 10 X 5=550
# samples 712
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/550*10)=-2.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAX [Title/Abstract] AND VAV2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAX(49464171)-VAV2(136629231), # samples:3
Anticipated loss of major functional domain due to fusion event.BAX-VAV2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BAX-VAV2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAX

GO:0001783

B cell apoptotic process

15214043|16424160

HgeneBAX

GO:0001836

release of cytochrome c from mitochondria

9843949|16199525|17052454

HgeneBAX

GO:0006915

apoptotic process

9660918

HgeneBAX

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

11912183

HgeneBAX

GO:0008053

mitochondrial fusion

14769861

HgeneBAX

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

15214043

HgeneBAX

GO:0008637

apoptotic mitochondrial changes

9843949

HgeneBAX

GO:0009636

response to toxic substance

16307838

HgeneBAX

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

9843949

HgeneBAX

GO:0010917

negative regulation of mitochondrial membrane potential

16751333

HgeneBAX

GO:0031334

positive regulation of protein complex assembly

9111042|19805544

HgeneBAX

GO:0032091

negative regulation of protein binding

9388232

HgeneBAX

GO:0032976

release of matrix enzymes from mitochondria

9843949

HgeneBAX

GO:0043065

positive regulation of apoptotic process

16751333|17464193

HgeneBAX

GO:0043525

positive regulation of neuron apoptotic process

15637643

HgeneBAX

GO:0043653

mitochondrial fragmentation involved in apoptotic process

12499352

HgeneBAX

GO:0051881

regulation of mitochondrial membrane potential

9843949

HgeneBAX

GO:0090200

positive regulation of release of cytochrome c from mitochondria

14963330

HgeneBAX

GO:0097190

apoptotic signaling pathway

16424160

HgeneBAX

GO:0097191

extrinsic apoptotic signaling pathway

15214043

HgeneBAX

GO:0097193

intrinsic apoptotic signaling pathway

9219694|16462759

HgeneBAX

GO:1990117

B cell receptor apoptotic signaling pathway

15214043


check buttonFusion gene breakpoints across BAX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VAV2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A73A-01ABAXchr19

49464171

-VAV2chr9

136629231

-
ChimerDB4LIHCTCGA-DD-A73A-01ABAXchr19

49464171

+VAV2chr9

136629231

-


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Fusion Gene ORF analysis for BAX-VAV2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000391871ENST00000371850BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-3CDSENST00000391871ENST00000371851BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-3CDSENST00000391871ENST00000406606BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-3CDSENST00000539787ENST00000371850BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-3CDSENST00000539787ENST00000371851BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-3CDSENST00000539787ENST00000406606BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-intronENST00000391871ENST00000486113BAXchr19

49464171

+VAV2chr9

136629231

-
3UTR-intronENST00000539787ENST00000486113BAXchr19

49464171

+VAV2chr9

136629231

-
5CDS-intronENST00000293288ENST00000486113BAXchr19

49464171

+VAV2chr9

136629231

-
5CDS-intronENST00000345358ENST00000486113BAXchr19

49464171

+VAV2chr9

136629231

-
5CDS-intronENST00000354470ENST00000486113BAXchr19

49464171

+VAV2chr9

136629231

-
5CDS-intronENST00000415969ENST00000486113BAXchr19

49464171

+VAV2chr9

136629231

-
Frame-shiftENST00000293288ENST00000371850BAXchr19

49464171

+VAV2chr9

136629231

-
Frame-shiftENST00000293288ENST00000371851BAXchr19

49464171

+VAV2chr9

136629231

-
Frame-shiftENST00000345358ENST00000406606BAXchr19

49464171

+VAV2chr9

136629231

-
Frame-shiftENST00000354470ENST00000406606BAXchr19

49464171

+VAV2chr9

136629231

-
Frame-shiftENST00000415969ENST00000406606BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000293288ENST00000406606BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000345358ENST00000371850BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000345358ENST00000371851BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000354470ENST00000371850BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000354470ENST00000371851BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000415969ENST00000371850BAXchr19

49464171

+VAV2chr9

136629231

-
In-frameENST00000415969ENST00000371851BAXchr19

49464171

+VAV2chr9

136629231

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345358BAXchr1949464171+ENST00000371850VAV2chr9136629231-27425261573190
ENST00000345358BAXchr1949464171+ENST00000371851VAV2chr9136629231-27425261573190
ENST00000415969BAXchr1949464171+ENST00000371850VAV2chr9136629231-26904740521173
ENST00000415969BAXchr1949464171+ENST00000371851VAV2chr9136629231-26904740521173
ENST00000354470BAXchr1949464171+ENST00000371850VAV2chr9136629231-254332719781496160
ENST00000354470BAXchr1949464171+ENST00000371851VAV2chr9136629231-254332719781496160
ENST00000293288BAXchr1949464171+ENST00000406606VAV2chr9136629231-346912530551183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345358ENST00000371850BAXchr1949464171+VAV2chr9136629231-0.0166004860.98339945
ENST00000345358ENST00000371851BAXchr1949464171+VAV2chr9136629231-0.0166004860.98339945
ENST00000415969ENST00000371850BAXchr1949464171+VAV2chr9136629231-0.0204195040.97958046
ENST00000415969ENST00000371851BAXchr1949464171+VAV2chr9136629231-0.0204195040.97958046
ENST00000354470ENST00000371850BAXchr1949464171+VAV2chr9136629231-0.281305340.7186946
ENST00000354470ENST00000371851BAXchr1949464171+VAV2chr9136629231-0.281305340.7186946
ENST00000293288ENST00000406606BAXchr1949464171+VAV2chr9136629231-0.34604370.6539563

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Fusion Genomic Features for BAX-VAV2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAX-VAV2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49464171/chr9:136629231)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAX

TMBIM6

.
237FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAXchr19:49464171chr9:136629231ENST00000345358+5659_73158193.0MotifNote=BH3
HgeneBAXchr19:49464171chr9:136629231ENST00000345358+5698_118158193.0MotifNote=BH1
HgeneBAXchr19:49464171chr9:136629231ENST00000354470+4559_73109144.0MotifNote=BH3
HgeneBAXchr19:49464171chr9:136629231ENST00000391871+45150_16514088.33333333333333MotifNote=BH2
HgeneBAXchr19:49464171chr9:136629231ENST00000391871+4559_7314088.33333333333333MotifNote=BH3
HgeneBAXchr19:49464171chr9:136629231ENST00000391871+4598_11814088.33333333333333MotifNote=BH1
HgeneBAXchr19:49464171chr9:136629231ENST00000415969+5659_73158180.0MotifNote=BH3
HgeneBAXchr19:49464171chr9:136629231ENST00000415969+5698_118158180.0MotifNote=BH1
HgeneBAXchr19:49464171chr9:136629231ENST00000539787+67150_165190205.66666666666666MotifNote=BH2
HgeneBAXchr19:49464171chr9:136629231ENST00000539787+6759_73190205.66666666666666MotifNote=BH3
HgeneBAXchr19:49464171chr9:136629231ENST00000539787+6798_118190205.66666666666666MotifNote=BH1
HgeneBAXchr19:49464171chr9:136629231ENST00000391871+45172_19214088.33333333333333TransmembraneHelical
HgeneBAXchr19:49464171chr9:136629231ENST00000539787+67172_192190205.66666666666666TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAXchr19:49464171chr9:136629231ENST00000293288+15150_1650219.0MotifNote=BH2
HgeneBAXchr19:49464171chr9:136629231ENST00000293288+1559_730219.0MotifNote=BH3
HgeneBAXchr19:49464171chr9:136629231ENST00000293288+1598_1180219.0MotifNote=BH1
HgeneBAXchr19:49464171chr9:136629231ENST00000345358+56150_165158193.0MotifNote=BH2
HgeneBAXchr19:49464171chr9:136629231ENST00000354470+45150_165109144.0MotifNote=BH2
HgeneBAXchr19:49464171chr9:136629231ENST00000354470+4598_118109144.0MotifNote=BH1
HgeneBAXchr19:49464171chr9:136629231ENST00000415969+56150_165158180.0MotifNote=BH2
HgeneBAXchr19:49464171chr9:136629231ENST00000293288+15172_1920219.0TransmembraneHelical
HgeneBAXchr19:49464171chr9:136629231ENST00000345358+56172_192158193.0TransmembraneHelical
HgeneBAXchr19:49464171chr9:136629231ENST00000354470+45172_192109144.0TransmembraneHelical
HgeneBAXchr19:49464171chr9:136629231ENST00000415969+56172_192158180.0TransmembraneHelical
TgeneVAV2chr19:49464171chr9:136629231ENST000003718502830198_376863879.0DomainDH
TgeneVAV2chr19:49464171chr9:136629231ENST0000037185028301_120863879.0DomainCalponin-homology (CH)
TgeneVAV2chr19:49464171chr9:136629231ENST000003718502830405_512863879.0DomainPH
TgeneVAV2chr19:49464171chr9:136629231ENST000003718502830586_652863879.0DomainSH3 1
TgeneVAV2chr19:49464171chr9:136629231ENST000003718502830673_767863879.0DomainSH2
TgeneVAV2chr19:49464171chr9:136629231ENST000003718502830816_877863879.0DomainSH3 2
TgeneVAV2chr19:49464171chr9:136629231ENST000003718512628198_376853869.0DomainDH
TgeneVAV2chr19:49464171chr9:136629231ENST0000037185126281_120853869.0DomainCalponin-homology (CH)
TgeneVAV2chr19:49464171chr9:136629231ENST000003718512628405_512853869.0DomainPH
TgeneVAV2chr19:49464171chr9:136629231ENST000003718512628586_652853869.0DomainSH3 1
TgeneVAV2chr19:49464171chr9:136629231ENST000003718512628673_767853869.0DomainSH2
TgeneVAV2chr19:49464171chr9:136629231ENST000003718512628816_877853869.0DomainSH3 2
TgeneVAV2chr19:49464171chr9:136629231ENST000004066062527198_376824840.0DomainDH
TgeneVAV2chr19:49464171chr9:136629231ENST0000040660625271_120824840.0DomainCalponin-homology (CH)
TgeneVAV2chr19:49464171chr9:136629231ENST000004066062527405_512824840.0DomainPH
TgeneVAV2chr19:49464171chr9:136629231ENST000004066062527586_652824840.0DomainSH3 1
TgeneVAV2chr19:49464171chr9:136629231ENST000004066062527673_767824840.0DomainSH2
TgeneVAV2chr19:49464171chr9:136629231ENST000004066062527816_877824840.0DomainSH3 2
TgeneVAV2chr19:49464171chr9:136629231ENST000003718502830523_572863879.0Zinc fingerPhorbol-ester/DAG-type
TgeneVAV2chr19:49464171chr9:136629231ENST000003718512628523_572853869.0Zinc fingerPhorbol-ester/DAG-type
TgeneVAV2chr19:49464171chr9:136629231ENST000004066062527523_572824840.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for BAX-VAV2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9003_9003_1_BAX-VAV2_BAX_chr19_49464171_ENST00000293288_VAV2_chr9_136629231_ENST00000406606_length(transcript)=3469nt_BP=1253nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGACACAGACTCCCCCCGAGAG
GTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTG
GTGCTCAAGGTGAGACTCCTCAAGCCTCCTCACCCCCACCACCGCGCCCTCACCACCGCCCCTGCCCCACCGTCCCTGCCCCCCGCCACT
CCTCTGGGACCCTGGGCCTTCTGGAGCAGGTCACAGTGGTGCCCTCTCCCCATCTTCAGATCATCAGATGTGGTCTATAATGCGTTTTCC
TTACGTGTCTGATCAATCCCCGATTCATCTACCCTGCTGACCTCCCAGTGACCCCTGACCTCACTGTGACCTTGACTTGATTAGTGCCTT
CTGCCCTCCCTGGAGCCTCCACTGCCTCTGGAATTGCTCAAGTTCATTGATGACCCTCTGACCCTAGCTCTTTCCTTTTTTTTTTTTTCC
CCACTGAGAAGGGGTCTCGCTATGTTGCCCAGGTTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCGCCTCAGCCTCTCAAAGTGCTG
GGATTACAGGTGTGAGCCACCATGCCTGGCCTGAGTCCAGCTCTTTAATGCCCGTTCATCTCAGTCCCCTGCCCGCAATCCTGCCTTCTG
GCCTCCTCCGTCCCTGATCCCGCCTCTGCCTGCCCAGGGGCTGCCCCTGGCCGAGTCACTGAAGCGACTGATGTCCCTGTCTCCAGGACG
GCCTCCTCTCCTACTTTGGGACGCCCACGTGGCAGACCGTGACCATCTTTGTGGCGGGAGTGCTCACCGCCTCACTCACCATCTGGAAGA
AGATGGGCTGAGGCCCCCAGCTGCCTTGGACTGTGTTTTTCCTCCATAAATTATGGCATTTTTCTGGGAGGGGTGGGGATTGGGGGACGT
GGGCATTTTTCTTACTTTTGTAATTATTGGGGGGTGTGGGGAAGAGTGGTCTTGAGGGGGTAATAAACCTCCTTCGGGACACAATTGGCT
GGTTTCCTTCAACGTACGTAGAAGAGGAGGGCATCCAGTGACGGCAGGAACGTGGACAAGACTCGCAGATTTTCTTGGGAGAGTCACTCC
AGCCCTGAAGTCTGTCTCTAGCTCCTCTGTGACTCAGAGGGGAAATACCAACCTCCCAGTCTTCCACTGCCCACAGGGATAGGGAGGGTG
TTGAGAATCCTAAACTCGAACCGTTTCACTGTCAGCCTGCCCTCGGCGACCCATCACTGGGTATGCTATTGTACATAGAGGAAACCTGGG
CTAGCCCCACCCAGAGCGCAGAGGAGGGGGCACCGACAGCGCTGCGAGCCAGGCTCTGGGTAGTGGCTGAGGCCAGAGGCCCATCGCCTG
CCCCTGTCCAACTGAGATGGCCTTCAGGAGCCTAGGTTTGAACAGCAGATGCTGTCCCAGGAAGGGCTAGGGACATCGGAGGGGACCTGC
CCCCACACCCTCTGCTCAGCCCCTGGACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCCAGGGGGAGGTGTCAGACCTCGGGAGGCAGAC
GGGACCAGAGCCAGGCTGTTCACTGTGGGCCCACTTGCCCCACTGTGCTAGGGCGCGGGAGGAGAGAGCACTGTGGTCGCCCTCTGCAGC
CACTCTGGCTCCCAAGACTTCCCTGACTCCCCCACTCCCCTCCTTGCCAGGGGCACACCCGGACCCCACACGGCAGGCCCCTCTCTTGGG
AGGGGCCTTTGGAATGATGAAATTCCAACCCTGCTGCCCGGTCAGCGGTACCGTTTCCTGCCCTCTCTCTGAGAGGCCCTTTCTGGAGTC
CTGGGAAGGTGTCTGCCTGGCCGCGCTGCCAGATCAGTACATCTTTTGTAAAAACCCTGAAATGGGCAGGGAAGAAAACAGGGATTTCCC
CTCTCTAGATCCCTGCCAGGTCCCTCTCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGGTCCCTGAGGGTCTGCCCAGCCTTGGCACGAG
AGGTTGGTTCCAGCCCCTGGCAGGGCTTCCTTCCAAGGGCCCCTGCAGCCTACAAACTGGGCCTCGGGCGACTCAAAATAAGTGCTCTTG
GGGGTGGCTCTACCCCATTACCTCCCCCAGCCACAACTCCTGGCCTTCGACTTCTGGCTGGGTTAGCCAGACCCTGGTTTCTCTACCCTG
ATGTTGCATGAGACCTGGTAACAGTGTCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTTGAGACCTGGGCTTCTTGTAGCCCCTTCTCCC
TCTGGCCAGCTGCACAGCCTGTGGGAGGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCTGGTCCCTGCTGTGGGTGGCGCTGGGGACCTA
GGGGCTCCTTCTGAGGTTGGCCTTGTGGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGGAAGAGGCGGGAGGAGTCATGGGGATGGGGAG
CGGCAGGGGGAGAGAGGGGCCCTCGACAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCAGGGCAGGGGAAGCGAAGAGTCAGCCTTGGAG
AGAGCACCCTGGGGCCTCCGTGTCGGGGTACACCCAGCACTTTGCGACCTGCGGCCCAGCAGGCGCGGAGGATGGCGGGGAGGAAGCCAG
CAGCCCCTGTGTTTACTGTCGTCAGAAAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTTTTGTTTGTGTTTTGTTTGGCTTGTTTGTTTT
TTAAGGGGAAAAAAGTTTGTAATTATTTCATCCAAATCTCCCGTTATATATCTGTGAATAATAAGAGATTTTATAATAGCAAGAAAATGA
TGTATATTTTAGTTTGTTGACAAATAAGTCATCATGATCACGAAGGACACTGAGAAAAAATAATTTAGAACCCTGGTTTTTGTGAATTTT
TTTGTTTTGTGTTTCTTTGTTTTGAGATTTGTGTTTGGTTTGGTTTTTGCACTGCACTAAGGCAGGAGGGTTGGAGGGCTGGGTGCAGCC
TGGGAGTCCGATGGTTTTCAGCAGGAGACGGGGTGTCCCCTGCAGGGGGCTAAACTGCAGGGGCCTGAGATTAGCTGTGAACATGTGGGA
GCCCGATGCATGTGGGTCAGGGATCTGGGGGCCCCCCCAGCTGGCGGGAACCCCAAATGGACACAAACTGTACATTTGCCAATGGGTTTT

>9003_9003_1_BAX-VAV2_BAX_chr19_49464171_ENST00000293288_VAV2_chr9_136629231_ENST00000406606_length(amino acids)=183AA_BP=
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPRE
VFFRVAADMFSDGNFNWGRVVALFYFASKLVLKVRLLKPPHPHHRALTTAPAPPSLPPATPLGPWAFWSRSQWCPLPIFRSSDVVYNAFS

--------------------------------------------------------------
>9003_9003_2_BAX-VAV2_BAX_chr19_49464171_ENST00000345358_VAV2_chr9_136629231_ENST00000371850_length(transcript)=2742nt_BP=526nt
GCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCC
CACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACC
CGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAA
CATGGAGCTGCAGAGGATGATTGCCGCCGTGGACACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGG
CAACTTCAACTGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGAT
CAGAACCATCATGGGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGATTGGCTGGTTTCC
TTCAACGTACGTAGAAGAGGAGGGCATCCAGTGACGGCAGGAACGTGGACAAGACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTG
AAGTCTGTCTCTAGCTCCTCTGTGACTCAGAGGGGAAATACCAACCTCCCAGTCTTCCACTGCCCACAGGGATAGGGAGGGTGTTGAGAA
TCCTAAACTCGAACCGTTTCACTGTCAGCCTGCCCTCGGCGACCCATCACTGGGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCC
CACCCAGAGCGCAGAGGAGGGGGCACCGACAGCGCTGCGAGCCAGGCTCTGGGTAGTGGCTGAGGCCAGAGGCCCATCGCCTGCCCCTGT
CCAACTGAGATGGCCTTCAGGAGCCTAGGTTTGAACAGCAGATGCTGTCCCAGGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACA
CCCTCTGCTCAGCCCCTGGACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCCAGGGGGAGGTGTCAGACCTCGGGAGGCAGACGGGACCA
GAGCCAGGCTGTTCACTGTGGGCCCACTTGCCCCACTGTGCTAGGGCGCGGGAGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTG
GCTCCCAAGACTTCCCTGACTCCCCCACTCCCCTCCTTGCCAGGGGCACACCCGGACCCCACACGGCAGGCCCCTCTCTTGGGAGGGGCC
TTTGGAATGATGAAATTCCAACCCTGCTGCCCGGTCAGCGGTACCGTTTCCTGCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAA
GGTGTCTGCCTGGCCGCGCTGCCAGATCAGTACATCTTTTGTAAAAACCCTGAAATGGGCAGGGAAGAAAACAGGGATTTCCCCTCTCTA
GATCCCTGCCAGGTCCCTCTCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGGTCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGG
TTCCAGCCCCTGGCAGGGCTTCCTTCCAAGGGCCCCTGCAGCCTACAAACTGGGCCTCGGGCGACTCAAAATAAGTGCTCTTGGGGGTGG
CTCTACCCCATTACCTCCCCCAGCCACAACTCCTGGCCTTCGACTTCTGGCTGGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGC
ATGAGACCTGGTAACAGTGTCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTTGAGACCTGGGCTTCTTGTAGCCCCTTCTCCCTCTGGCC
AGCTGCACAGCCTGTGGGAGGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCTGGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTC
CTTCTGAGGTTGGCCTTGTGGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGGAAGAGGCGGGAGGAGTCATGGGGATGGGGAGCGGCAGG
GGGAGAGAGGGGCCCTCGACAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCAGGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCAC
CCTGGGGCCTCCGTGTCGGGGTACACCCAGCACTTTGCGACCTGCGGCCCAGCAGGCGCGGAGGATGGCGGGGAGGAAGCCAGCAGCCCC
TGTGTTTACTGTCGTCAGAAAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTTTTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGG
GAAAAAAGTTTGTAATTATTTCATCCAAATCTCCCGTTATATATCTGTGAATAATAAGAGATTTTATAATAGCAAGAAAATGATGTATAT
TTTAGTTTGTTGACAAATAAGTCATCATGATCACGAAGGACACTGAGAAAAAATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTT
TGTGTTTCTTTGTTTTGAGATTTGTGTTTGGTTTGGTTTTTGCACTGCACTAAGGCAGGAGGGTTGGAGGGCTGGGTGCAGCCTGGGAGT
CCGATGGTTTTCAGCAGGAGACGGGGTGTCCCCTGCAGGGGGCTAAACTGCAGGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGAT
GCATGTGGGTCAGGGATCTGGGGGCCCCCCCAGCTGGCGGGAACCCCAAATGGACACAAACTGTACATTTGCCAATGGGTTTTTTTCAGA

>9003_9003_2_BAX-VAV2_BAX_chr19_49464171_ENST00000345358_VAV2_chr9_136629231_ENST00000371850_length(amino acids)=190AA_BP=175
LRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN
MELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWIGWFP

--------------------------------------------------------------
>9003_9003_3_BAX-VAV2_BAX_chr19_49464171_ENST00000345358_VAV2_chr9_136629231_ENST00000371851_length(transcript)=2742nt_BP=526nt
GCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCC
CACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACC
CGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAA
CATGGAGCTGCAGAGGATGATTGCCGCCGTGGACACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGG
CAACTTCAACTGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGAT
CAGAACCATCATGGGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGATTGGCTGGTTTCC
TTCAACGTACGTAGAAGAGGAGGGCATCCAGTGACGGCAGGAACGTGGACAAGACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTG
AAGTCTGTCTCTAGCTCCTCTGTGACTCAGAGGGGAAATACCAACCTCCCAGTCTTCCACTGCCCACAGGGATAGGGAGGGTGTTGAGAA
TCCTAAACTCGAACCGTTTCACTGTCAGCCTGCCCTCGGCGACCCATCACTGGGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCC
CACCCAGAGCGCAGAGGAGGGGGCACCGACAGCGCTGCGAGCCAGGCTCTGGGTAGTGGCTGAGGCCAGAGGCCCATCGCCTGCCCCTGT
CCAACTGAGATGGCCTTCAGGAGCCTAGGTTTGAACAGCAGATGCTGTCCCAGGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACA
CCCTCTGCTCAGCCCCTGGACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCCAGGGGGAGGTGTCAGACCTCGGGAGGCAGACGGGACCA
GAGCCAGGCTGTTCACTGTGGGCCCACTTGCCCCACTGTGCTAGGGCGCGGGAGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTG
GCTCCCAAGACTTCCCTGACTCCCCCACTCCCCTCCTTGCCAGGGGCACACCCGGACCCCACACGGCAGGCCCCTCTCTTGGGAGGGGCC
TTTGGAATGATGAAATTCCAACCCTGCTGCCCGGTCAGCGGTACCGTTTCCTGCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAA
GGTGTCTGCCTGGCCGCGCTGCCAGATCAGTACATCTTTTGTAAAAACCCTGAAATGGGCAGGGAAGAAAACAGGGATTTCCCCTCTCTA
GATCCCTGCCAGGTCCCTCTCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGGTCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGG
TTCCAGCCCCTGGCAGGGCTTCCTTCCAAGGGCCCCTGCAGCCTACAAACTGGGCCTCGGGCGACTCAAAATAAGTGCTCTTGGGGGTGG
CTCTACCCCATTACCTCCCCCAGCCACAACTCCTGGCCTTCGACTTCTGGCTGGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGC
ATGAGACCTGGTAACAGTGTCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTTGAGACCTGGGCTTCTTGTAGCCCCTTCTCCCTCTGGCC
AGCTGCACAGCCTGTGGGAGGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCTGGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTC
CTTCTGAGGTTGGCCTTGTGGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGGAAGAGGCGGGAGGAGTCATGGGGATGGGGAGCGGCAGG
GGGAGAGAGGGGCCCTCGACAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCAGGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCAC
CCTGGGGCCTCCGTGTCGGGGTACACCCAGCACTTTGCGACCTGCGGCCCAGCAGGCGCGGAGGATGGCGGGGAGGAAGCCAGCAGCCCC
TGTGTTTACTGTCGTCAGAAAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTTTTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGG
GAAAAAAGTTTGTAATTATTTCATCCAAATCTCCCGTTATATATCTGTGAATAATAAGAGATTTTATAATAGCAAGAAAATGATGTATAT
TTTAGTTTGTTGACAAATAAGTCATCATGATCACGAAGGACACTGAGAAAAAATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTT
TGTGTTTCTTTGTTTTGAGATTTGTGTTTGGTTTGGTTTTTGCACTGCACTAAGGCAGGAGGGTTGGAGGGCTGGGTGCAGCCTGGGAGT
CCGATGGTTTTCAGCAGGAGACGGGGTGTCCCCTGCAGGGGGCTAAACTGCAGGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGAT
GCATGTGGGTCAGGGATCTGGGGGCCCCCCCAGCTGGCGGGAACCCCAAATGGACACAAACTGTACATTTGCCAATGGGTTTTTTTCAGA

>9003_9003_3_BAX-VAV2_BAX_chr19_49464171_ENST00000345358_VAV2_chr9_136629231_ENST00000371851_length(amino acids)=190AA_BP=175
LRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN
MELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWIGWFP

--------------------------------------------------------------
>9003_9003_4_BAX-VAV2_BAX_chr19_49464171_ENST00000354470_VAV2_chr9_136629231_ENST00000371850_length(transcript)=2543nt_BP=327nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGGATG
ATTGCCGCCGTGGACACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGG
GTTGTCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATGGGCTGG
ACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGATTGGCTGGTTTCCTTCAACGTACGTAGAAGAG
GAGGGCATCCAGTGACGGCAGGAACGTGGACAAGACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTGAAGTCTGTCTCTAGCTCCT
CTGTGACTCAGAGGGGAAATACCAACCTCCCAGTCTTCCACTGCCCACAGGGATAGGGAGGGTGTTGAGAATCCTAAACTCGAACCGTTT
CACTGTCAGCCTGCCCTCGGCGACCCATCACTGGGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCCCACCCAGAGCGCAGAGGAG
GGGGCACCGACAGCGCTGCGAGCCAGGCTCTGGGTAGTGGCTGAGGCCAGAGGCCCATCGCCTGCCCCTGTCCAACTGAGATGGCCTTCA
GGAGCCTAGGTTTGAACAGCAGATGCTGTCCCAGGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACACCCTCTGCTCAGCCCCTGG
ACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCCAGGGGGAGGTGTCAGACCTCGGGAGGCAGACGGGACCAGAGCCAGGCTGTTCACTGT
GGGCCCACTTGCCCCACTGTGCTAGGGCGCGGGAGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTGGCTCCCAAGACTTCCCTGA
CTCCCCCACTCCCCTCCTTGCCAGGGGCACACCCGGACCCCACACGGCAGGCCCCTCTCTTGGGAGGGGCCTTTGGAATGATGAAATTCC
AACCCTGCTGCCCGGTCAGCGGTACCGTTTCCTGCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAAGGTGTCTGCCTGGCCGCGC
TGCCAGATCAGTACATCTTTTGTAAAAACCCTGAAATGGGCAGGGAAGAAAACAGGGATTTCCCCTCTCTAGATCCCTGCCAGGTCCCTC
TCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGGTCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGGTTCCAGCCCCTGGCAGGGC
TTCCTTCCAAGGGCCCCTGCAGCCTACAAACTGGGCCTCGGGCGACTCAAAATAAGTGCTCTTGGGGGTGGCTCTACCCCATTACCTCCC
CCAGCCACAACTCCTGGCCTTCGACTTCTGGCTGGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGCATGAGACCTGGTAACAGTG
TCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTTGAGACCTGGGCTTCTTGTAGCCCCTTCTCCCTCTGGCCAGCTGCACAGCCTGTGGGA
GGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCTGGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTCCTTCTGAGGTTGGCCTTGT
GGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGGAAGAGGCGGGAGGAGTCATGGGGATGGGGAGCGGCAGGGGGAGAGAGGGGCCCTCGA
CAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCAGGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCACCCTGGGGCCTCCGTGTCGG
GGTACACCCAGCACTTTGCGACCTGCGGCCCAGCAGGCGCGGAGGATGGCGGGGAGGAAGCCAGCAGCCCCTGTGTTTACTGTCGTCAGA
AAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTTTTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGGGAAAAAAGTTTGTAATTAT
TTCATCCAAATCTCCCGTTATATATCTGTGAATAATAAGAGATTTTATAATAGCAAGAAAATGATGTATATTTTAGTTTGTTGACAAATA
AGTCATCATGATCACGAAGGACACTGAGAAAAAATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTTTGTGTTTCTTTGTTTTGAG
ATTTGTGTTTGGTTTGGTTTTTGCACTGCACTAAGGCAGGAGGGTTGGAGGGCTGGGTGCAGCCTGGGAGTCCGATGGTTTTCAGCAGGA
GACGGGGTGTCCCCTGCAGGGGGCTAAACTGCAGGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGATGCATGTGGGTCAGGGATCT
GGGGGCCCCCCCAGCTGGCGGGAACCCCAAATGGACACAAACTGTACATTTGCCAATGGGTTTTTTTCAGACCATGGTTTTTACTTGCAA

>9003_9003_4_BAX-VAV2_BAX_chr19_49464171_ENST00000354470_VAV2_chr9_136629231_ENST00000371850_length(amino acids)=160AA_BP=
MTTVNTGAAGFLPAILRACWAAGRKVLGVPRHGGPRVLSPRLTLRFPCPASTSPHFPSLCRGPLSPPAAPHPHDSSRLFPTPQRHTAQRP

--------------------------------------------------------------
>9003_9003_5_BAX-VAV2_BAX_chr19_49464171_ENST00000354470_VAV2_chr9_136629231_ENST00000371851_length(transcript)=2543nt_BP=327nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGGATG
ATTGCCGCCGTGGACACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGG
GTTGTCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATGGGCTGG
ACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGATTGGCTGGTTTCCTTCAACGTACGTAGAAGAG
GAGGGCATCCAGTGACGGCAGGAACGTGGACAAGACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTGAAGTCTGTCTCTAGCTCCT
CTGTGACTCAGAGGGGAAATACCAACCTCCCAGTCTTCCACTGCCCACAGGGATAGGGAGGGTGTTGAGAATCCTAAACTCGAACCGTTT
CACTGTCAGCCTGCCCTCGGCGACCCATCACTGGGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCCCACCCAGAGCGCAGAGGAG
GGGGCACCGACAGCGCTGCGAGCCAGGCTCTGGGTAGTGGCTGAGGCCAGAGGCCCATCGCCTGCCCCTGTCCAACTGAGATGGCCTTCA
GGAGCCTAGGTTTGAACAGCAGATGCTGTCCCAGGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACACCCTCTGCTCAGCCCCTGG
ACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCCAGGGGGAGGTGTCAGACCTCGGGAGGCAGACGGGACCAGAGCCAGGCTGTTCACTGT
GGGCCCACTTGCCCCACTGTGCTAGGGCGCGGGAGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTGGCTCCCAAGACTTCCCTGA
CTCCCCCACTCCCCTCCTTGCCAGGGGCACACCCGGACCCCACACGGCAGGCCCCTCTCTTGGGAGGGGCCTTTGGAATGATGAAATTCC
AACCCTGCTGCCCGGTCAGCGGTACCGTTTCCTGCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAAGGTGTCTGCCTGGCCGCGC
TGCCAGATCAGTACATCTTTTGTAAAAACCCTGAAATGGGCAGGGAAGAAAACAGGGATTTCCCCTCTCTAGATCCCTGCCAGGTCCCTC
TCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGGTCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGGTTCCAGCCCCTGGCAGGGC
TTCCTTCCAAGGGCCCCTGCAGCCTACAAACTGGGCCTCGGGCGACTCAAAATAAGTGCTCTTGGGGGTGGCTCTACCCCATTACCTCCC
CCAGCCACAACTCCTGGCCTTCGACTTCTGGCTGGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGCATGAGACCTGGTAACAGTG
TCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTTGAGACCTGGGCTTCTTGTAGCCCCTTCTCCCTCTGGCCAGCTGCACAGCCTGTGGGA
GGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCTGGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTCCTTCTGAGGTTGGCCTTGT
GGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGGAAGAGGCGGGAGGAGTCATGGGGATGGGGAGCGGCAGGGGGAGAGAGGGGCCCTCGA
CAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCAGGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCACCCTGGGGCCTCCGTGTCGG
GGTACACCCAGCACTTTGCGACCTGCGGCCCAGCAGGCGCGGAGGATGGCGGGGAGGAAGCCAGCAGCCCCTGTGTTTACTGTCGTCAGA
AAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTTTTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGGGAAAAAAGTTTGTAATTAT
TTCATCCAAATCTCCCGTTATATATCTGTGAATAATAAGAGATTTTATAATAGCAAGAAAATGATGTATATTTTAGTTTGTTGACAAATA
AGTCATCATGATCACGAAGGACACTGAGAAAAAATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTTTGTGTTTCTTTGTTTTGAG
ATTTGTGTTTGGTTTGGTTTTTGCACTGCACTAAGGCAGGAGGGTTGGAGGGCTGGGTGCAGCCTGGGAGTCCGATGGTTTTCAGCAGGA
GACGGGGTGTCCCCTGCAGGGGGCTAAACTGCAGGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGATGCATGTGGGTCAGGGATCT
GGGGGCCCCCCCAGCTGGCGGGAACCCCAAATGGACACAAACTGTACATTTGCCAATGGGTTTTTTTCAGACCATGGTTTTTACTTGCAA

>9003_9003_5_BAX-VAV2_BAX_chr19_49464171_ENST00000354470_VAV2_chr9_136629231_ENST00000371851_length(amino acids)=160AA_BP=
MTTVNTGAAGFLPAILRACWAAGRKVLGVPRHGGPRVLSPRLTLRFPCPASTSPHFPSLCRGPLSPPAAPHPHDSSRLFPTPQRHTAQRP

--------------------------------------------------------------
>9003_9003_6_BAX-VAV2_BAX_chr19_49464171_ENST00000415969_VAV2_chr9_136629231_ENST00000371850_length(transcript)=2690nt_BP=474nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGACACAGACTCCCCCCGAGAG
GTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTG
GTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATGGGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGC
TGGATCCAAGACCAGGGTGGTTGGATTGGCTGGTTTCCTTCAACGTACGTAGAAGAGGAGGGCATCCAGTGACGGCAGGAACGTGGACAA
GACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTGAAGTCTGTCTCTAGCTCCTCTGTGACTCAGAGGGGAAATACCAACCTCCCAG
TCTTCCACTGCCCACAGGGATAGGGAGGGTGTTGAGAATCCTAAACTCGAACCGTTTCACTGTCAGCCTGCCCTCGGCGACCCATCACTG
GGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCCCACCCAGAGCGCAGAGGAGGGGGCACCGACAGCGCTGCGAGCCAGGCTCTGG
GTAGTGGCTGAGGCCAGAGGCCCATCGCCTGCCCCTGTCCAACTGAGATGGCCTTCAGGAGCCTAGGTTTGAACAGCAGATGCTGTCCCA
GGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACACCCTCTGCTCAGCCCCTGGACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCC
AGGGGGAGGTGTCAGACCTCGGGAGGCAGACGGGACCAGAGCCAGGCTGTTCACTGTGGGCCCACTTGCCCCACTGTGCTAGGGCGCGGG
AGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTGGCTCCCAAGACTTCCCTGACTCCCCCACTCCCCTCCTTGCCAGGGGCACACC
CGGACCCCACACGGCAGGCCCCTCTCTTGGGAGGGGCCTTTGGAATGATGAAATTCCAACCCTGCTGCCCGGTCAGCGGTACCGTTTCCT
GCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAAGGTGTCTGCCTGGCCGCGCTGCCAGATCAGTACATCTTTTGTAAAAACCCTG
AAATGGGCAGGGAAGAAAACAGGGATTTCCCCTCTCTAGATCCCTGCCAGGTCCCTCTCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGG
TCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGGTTCCAGCCCCTGGCAGGGCTTCCTTCCAAGGGCCCCTGCAGCCTACAAACTG
GGCCTCGGGCGACTCAAAATAAGTGCTCTTGGGGGTGGCTCTACCCCATTACCTCCCCCAGCCACAACTCCTGGCCTTCGACTTCTGGCT
GGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGCATGAGACCTGGTAACAGTGTCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTT
GAGACCTGGGCTTCTTGTAGCCCCTTCTCCCTCTGGCCAGCTGCACAGCCTGTGGGAGGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCT
GGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTCCTTCTGAGGTTGGCCTTGTGGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGG
AAGAGGCGGGAGGAGTCATGGGGATGGGGAGCGGCAGGGGGAGAGAGGGGCCCTCGACAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCA
GGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCACCCTGGGGCCTCCGTGTCGGGGTACACCCAGCACTTTGCGACCTGCGGCCCAG
CAGGCGCGGAGGATGGCGGGGAGGAAGCCAGCAGCCCCTGTGTTTACTGTCGTCAGAAAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTT
TTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGGGAAAAAAGTTTGTAATTATTTCATCCAAATCTCCCGTTATATATCTGTGAAT
AATAAGAGATTTTATAATAGCAAGAAAATGATGTATATTTTAGTTTGTTGACAAATAAGTCATCATGATCACGAAGGACACTGAGAAAAA
ATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTTTGTGTTTCTTTGTTTTGAGATTTGTGTTTGGTTTGGTTTTTGCACTGCACTA
AGGCAGGAGGGTTGGAGGGCTGGGTGCAGCCTGGGAGTCCGATGGTTTTCAGCAGGAGACGGGGTGTCCCCTGCAGGGGGCTAAACTGCA
GGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGATGCATGTGGGTCAGGGATCTGGGGGCCCCCCCAGCTGGCGGGAACCCCAAATG

>9003_9003_6_BAX-VAV2_BAX_chr19_49464171_ENST00000415969_VAV2_chr9_136629231_ENST00000371850_length(amino acids)=173AA_BP=158
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPRE

--------------------------------------------------------------
>9003_9003_7_BAX-VAV2_BAX_chr19_49464171_ENST00000415969_VAV2_chr9_136629231_ENST00000371851_length(transcript)=2690nt_BP=474nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGACACAGACTCCCCCCGAGAG
GTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTG
GTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATGGGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGC
TGGATCCAAGACCAGGGTGGTTGGATTGGCTGGTTTCCTTCAACGTACGTAGAAGAGGAGGGCATCCAGTGACGGCAGGAACGTGGACAA
GACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTGAAGTCTGTCTCTAGCTCCTCTGTGACTCAGAGGGGAAATACCAACCTCCCAG
TCTTCCACTGCCCACAGGGATAGGGAGGGTGTTGAGAATCCTAAACTCGAACCGTTTCACTGTCAGCCTGCCCTCGGCGACCCATCACTG
GGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCCCACCCAGAGCGCAGAGGAGGGGGCACCGACAGCGCTGCGAGCCAGGCTCTGG
GTAGTGGCTGAGGCCAGAGGCCCATCGCCTGCCCCTGTCCAACTGAGATGGCCTTCAGGAGCCTAGGTTTGAACAGCAGATGCTGTCCCA
GGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACACCCTCTGCTCAGCCCCTGGACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCC
AGGGGGAGGTGTCAGACCTCGGGAGGCAGACGGGACCAGAGCCAGGCTGTTCACTGTGGGCCCACTTGCCCCACTGTGCTAGGGCGCGGG
AGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTGGCTCCCAAGACTTCCCTGACTCCCCCACTCCCCTCCTTGCCAGGGGCACACC
CGGACCCCACACGGCAGGCCCCTCTCTTGGGAGGGGCCTTTGGAATGATGAAATTCCAACCCTGCTGCCCGGTCAGCGGTACCGTTTCCT
GCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAAGGTGTCTGCCTGGCCGCGCTGCCAGATCAGTACATCTTTTGTAAAAACCCTG
AAATGGGCAGGGAAGAAAACAGGGATTTCCCCTCTCTAGATCCCTGCCAGGTCCCTCTCCAGGAGGCCCCTCTGCTCTCCTGAAGGGTGG
TCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGGTTCCAGCCCCTGGCAGGGCTTCCTTCCAAGGGCCCCTGCAGCCTACAAACTG
GGCCTCGGGCGACTCAAAATAAGTGCTCTTGGGGGTGGCTCTACCCCATTACCTCCCCCAGCCACAACTCCTGGCCTTCGACTTCTGGCT
GGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGCATGAGACCTGGTAACAGTGTCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTT
GAGACCTGGGCTTCTTGTAGCCCCTTCTCCCTCTGGCCAGCTGCACAGCCTGTGGGAGGTGCCCGGCCCAGGCTGGGTGTGGGGGAAGCT
GGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTCCTTCTGAGGTTGGCCTTGTGGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGG
AAGAGGCGGGAGGAGTCATGGGGATGGGGAGCGGCAGGGGGAGAGAGGGGCCCTCGACAAAGGCTTGGGAAATGAGGGGAGGTGGAGGCA
GGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCACCCTGGGGCCTCCGTGTCGGGGTACACCCAGCACTTTGCGACCTGCGGCCCAG
CAGGCGCGGAGGATGGCGGGGAGGAAGCCAGCAGCCCCTGTGTTTACTGTCGTCAGAAAGGTCTTGTGTTTTGGTTTTGGGGTTTTTGTT
TTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGGGAAAAAAGTTTGTAATTATTTCATCCAAATCTCCCGTTATATATCTGTGAAT
AATAAGAGATTTTATAATAGCAAGAAAATGATGTATATTTTAGTTTGTTGACAAATAAGTCATCATGATCACGAAGGACACTGAGAAAAA
ATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTTTGTGTTTCTTTGTTTTGAGATTTGTGTTTGGTTTGGTTTTTGCACTGCACTA
AGGCAGGAGGGTTGGAGGGCTGGGTGCAGCCTGGGAGTCCGATGGTTTTCAGCAGGAGACGGGGTGTCCCCTGCAGGGGGCTAAACTGCA
GGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGATGCATGTGGGTCAGGGATCTGGGGGCCCCCCCAGCTGGCGGGAACCCCAAATG

>9003_9003_7_BAX-VAV2_BAX_chr19_49464171_ENST00000415969_VAV2_chr9_136629231_ENST00000371851_length(amino acids)=173AA_BP=158
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPRE

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Fusion Gene PPI Analysis for BAX-VAV2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAX-VAV2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAX-VAV2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource