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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TES-CAV1 (FusionGDB2 ID:90116)

Fusion Gene Summary for TES-CAV1

check button Fusion gene summary
Fusion gene informationFusion gene name: TES-CAV1
Fusion gene ID: 90116
HgeneTgene
Gene symbol

TES

CAV1

Gene ID

26136

857

Gene nametestin LIM domain proteincaveolin 1
SynonymsTESS|TESS-2BSCL3|CGL3|LCCNS|MSTP085|PPH3|VIP21
Cytomap

7q31.2

7q31.2

Type of geneprotein-codingprotein-coding
Descriptiontestintestis derived transcript (3 LIM domains)caveolin-1caveolin 1, caveolae protein, 22kDacell growth-inhibiting protein 32
Modification date2020031320200329
UniProtAcc.

Q03135

Ensembl transtripts involved in fusion geneENST00000358204, ENST00000537767, 
ENST00000393481, ENST00000485009, 
ENST00000393467, ENST00000393468, 
ENST00000405348, ENST00000393470, 
ENST00000341049, 
Fusion gene scores* DoF score10 X 7 X 4=28011 X 9 X 7=693
# samples 914
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/693*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TES [Title/Abstract] AND CAV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTES(115850788)-CAV1(116166579), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAV1

GO:0009617

response to bacterium

24625804

TgeneCAV1

GO:0010875

positive regulation of cholesterol efflux

24576892

TgeneCAV1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

25893292

TgeneCAV1

GO:0031295

T cell costimulation

17287217

TgeneCAV1

GO:0031623

receptor internalization

25893292

TgeneCAV1

GO:0032091

negative regulation of protein binding

16890161

TgeneCAV1

GO:0032570

response to progesterone

12388746

TgeneCAV1

GO:0033137

negative regulation of peptidyl-serine phosphorylation

18081315

TgeneCAV1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18081315

TgeneCAV1

GO:0043627

response to estrogen

12388746

TgeneCAV1

GO:0051480

regulation of cytosolic calcium ion concentration

19052258

TgeneCAV1

GO:0072584

caveolin-mediated endocytosis

19931615

TgeneCAV1

GO:1900027

regulation of ruffle assembly

24625804

TgeneCAV1

GO:2000535

regulation of entry of bacterium into host cell

24625804


check buttonFusion gene breakpoints across TES (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8576-01ATESchr7

115850788

+CAV1chr7

116166579

+


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Fusion Gene ORF analysis for TES-CAV1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358204ENST00000393467TESchr7

115850788

+CAV1chr7

116166579

+
5CDS-5UTRENST00000358204ENST00000393468TESchr7

115850788

+CAV1chr7

116166579

+
5CDS-5UTRENST00000358204ENST00000405348TESchr7

115850788

+CAV1chr7

116166579

+
5CDS-intronENST00000358204ENST00000393470TESchr7

115850788

+CAV1chr7

116166579

+
5UTR-3CDSENST00000537767ENST00000341049TESchr7

115850788

+CAV1chr7

116166579

+
5UTR-5UTRENST00000537767ENST00000393467TESchr7

115850788

+CAV1chr7

116166579

+
5UTR-5UTRENST00000537767ENST00000393468TESchr7

115850788

+CAV1chr7

116166579

+
5UTR-5UTRENST00000537767ENST00000405348TESchr7

115850788

+CAV1chr7

116166579

+
5UTR-intronENST00000537767ENST00000393470TESchr7

115850788

+CAV1chr7

116166579

+
In-frameENST00000358204ENST00000341049TESchr7

115850788

+CAV1chr7

116166579

+
intron-3CDSENST00000393481ENST00000341049TESchr7

115850788

+CAV1chr7

116166579

+
intron-3CDSENST00000485009ENST00000341049TESchr7

115850788

+CAV1chr7

116166579

+
intron-5UTRENST00000393481ENST00000393467TESchr7

115850788

+CAV1chr7

116166579

+
intron-5UTRENST00000393481ENST00000393468TESchr7

115850788

+CAV1chr7

116166579

+
intron-5UTRENST00000393481ENST00000405348TESchr7

115850788

+CAV1chr7

116166579

+
intron-5UTRENST00000485009ENST00000393467TESchr7

115850788

+CAV1chr7

116166579

+
intron-5UTRENST00000485009ENST00000393468TESchr7

115850788

+CAV1chr7

116166579

+
intron-5UTRENST00000485009ENST00000405348TESchr7

115850788

+CAV1chr7

116166579

+
intron-intronENST00000393481ENST00000393470TESchr7

115850788

+CAV1chr7

116166579

+
intron-intronENST00000485009ENST00000393470TESchr7

115850788

+CAV1chr7

116166579

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358204TESchr7115850788+ENST00000341049CAV1chr7116166579+26382425748247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358204ENST00000341049TESchr7115850788+CAV1chr7116166579+0.0010447340.99895525

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Fusion Genomic Features for TES-CAV1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TESchr7115850788+CAV1chr7116166578+4.76E-050.99995244
TESchr7115850788+CAV1chr7116166578+4.76E-050.99995244

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TES-CAV1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:115850788/chr7:116166579)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAV1

Q03135

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCAV1chr7:115850788chr7:116166579ENST0000034104903105_12510179.0IntramembraneHelical
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346702105_1250148.0IntramembraneHelical
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346803105_1250148.0IntramembraneHelical
TgeneCAV1chr7:115850788chr7:116166579ENST0000040534803105_1250148.0IntramembraneHelical
TgeneCAV1chr7:115850788chr7:116166579ENST0000034104903131_14210179.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000034104903149_16010179.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000034104903167_17810179.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346702131_1420148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346702149_1600148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346702167_1780148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST00000393467022_940148.0RegionRequired for homooligomerization
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346803131_1420148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346803149_1600148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346803167_1780148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST00000393468032_940148.0RegionRequired for homooligomerization
TgeneCAV1chr7:115850788chr7:116166579ENST0000040534803131_1420148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000040534803149_1600148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST0000040534803167_1780148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:115850788chr7:116166579ENST00000405348032_940148.0RegionRequired for homooligomerization
TgeneCAV1chr7:115850788chr7:116166579ENST0000034104903126_17810179.0Topological domainCytoplasmic
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346702126_1780148.0Topological domainCytoplasmic
TgeneCAV1chr7:115850788chr7:116166579ENST00000393467022_1040148.0Topological domainCytoplasmic
TgeneCAV1chr7:115850788chr7:116166579ENST0000039346803126_1780148.0Topological domainCytoplasmic
TgeneCAV1chr7:115850788chr7:116166579ENST00000393468032_1040148.0Topological domainCytoplasmic
TgeneCAV1chr7:115850788chr7:116166579ENST0000040534803126_1780148.0Topological domainCytoplasmic
TgeneCAV1chr7:115850788chr7:116166579ENST00000405348032_1040148.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTESchr7:115850788chr7:116166579ENST00000358204+1722_469422.0Compositional biasNote=Cys-rich
HgeneTESchr7:115850788chr7:116166579ENST00000393481+1722_460413.0Compositional biasNote=Cys-rich
HgeneTESchr7:115850788chr7:116166579ENST00000358204+17234_2979422.0DomainLIM zinc-binding 1
HgeneTESchr7:115850788chr7:116166579ENST00000358204+17299_3599422.0DomainLIM zinc-binding 2
HgeneTESchr7:115850788chr7:116166579ENST00000358204+17362_4219422.0DomainLIM zinc-binding 3
HgeneTESchr7:115850788chr7:116166579ENST00000358204+1792_1999422.0DomainPET
HgeneTESchr7:115850788chr7:116166579ENST00000393481+17234_2970413.0DomainLIM zinc-binding 1
HgeneTESchr7:115850788chr7:116166579ENST00000393481+17299_3590413.0DomainLIM zinc-binding 2
HgeneTESchr7:115850788chr7:116166579ENST00000393481+17362_4210413.0DomainLIM zinc-binding 3
HgeneTESchr7:115850788chr7:116166579ENST00000393481+1792_1990413.0DomainPET
TgeneCAV1chr7:115850788chr7:116166579ENST00000341049032_9410179.0RegionRequired for homooligomerization
TgeneCAV1chr7:115850788chr7:116166579ENST00000341049032_10410179.0Topological domainCytoplasmic


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Fusion Gene Sequence for TES-CAV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90116_90116_1_TES-CAV1_TES_chr7_115850788_ENST00000358204_CAV1_chr7_116166579_ENST00000341049_length(transcript)=2638nt_BP=242nt
ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG
TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG
ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGGGACATCTCTACACCGTTCCCATCCGGG
AACAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGACGAGCTGAGCGAGAAGCAAGTGTACGACGCGCACACCAAGGAGATCG
ACCTGGTCAACCGCGACCCTAAACACCTCAACGATGACGTGGTCAAGATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACACACA
GTTTTGACGGCATTTGGAAGGCCAGCTTCACCACCTTCACTGTGACGAAATACTGGTTTTACCGCTTGCTGTCTGCCCTCTTTGGCATCC
CGATGGCACTCATCTGGGGCATTTACTTCGCCATTCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATTAAGAGCTTCCTGATTG
AGATTCAGTGCATCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCACTCTTTGAAGCTGTTGGGAAAATATTCAGCAATG
TCCGCATCAACTTGCAGAAAGAAATATAAATGACATTTCAAGGATAGAAGTATACCTGATTTTTTTTCCTTTTAATTTTCCTGGTGCCAA
TTTCAAGTTCCAAGTTGCTAATACAGCAACAATTTATGAATTGAATTATCTTGGTTGAAAATAAAAAGATCACTTTCTCAGTTTTCATAA
GTATTATGTCTCTTCTGAGCTATTTCATCTATTTTTGGCAGTCTGAATTTTTAAAACCCATTTAAATTTTTTTCCTTACCTTTTTATTTG
CATGTGGATCAACCATCGCTTTATTGGCTGAGATATGAACATATTGTTGAAAGGTAATTTGAGAGAAATATGAAGAACTGAGGAGGAAAA
AAAAAAAAAAGAAAAGAACCAACAACCTCAACTGCCTACTCCAAAATGTTGGTCATTTTATGTTAAGGGAAGAATTCCAGGGTATGGCCA
TGGAGTGTACAAGTATGTGGGCAGATTTTCAGCAAACTCTTTTCCCACTGTTTAAGGAGTTAGTGGATTACTGCCATTCACTTCATAATC
CAGTAGGATCCAGTGATCCTTACAAGTTAGAAAACATAATCTTCTGCCTTCTCATGATCCAACTAATGCCTTACTCTTCTTGAAATTTTA
ACCTATGATATTTTCTGTGCCTGAATATTTGTTATGTAGATAACAAGACCTCAGTGCCTTCCTGTTTTTCACATTTTCCTTTTCAAATAG
GGTCTAACTCAGCAACTCGCTTTAGGTCAGCAGCCTCCCTGAAGACCAAAATTAGAATATCCATGACCTAGTTTTCCATGCGTGTTTCTG
ACTCTGAGCTACAGAGTCTGGTGAAGCTCACTTCTGGGCTTCATCTGGCAACATCTTTATCCGTAGTGGGTATGGTTGACACTAGCCCAA
TGAAATGAATTAAAGTGGACCAATAGGGCTGAGCTCTCTGTGGGCTGGCAGTCCTGGAAGCCAGCTTTCCCTGCCTCTCATCAACTGAAT
GAGGTCAGCATGTCTATTCAGCTTCGTTTATTTTCAAGAATAATCACGCTTTCCTGAATCCAAACTAATCCATCACCGGGGTGGTTTAGT
GGCTCAACATTGTGTTCCCATTTCAGCTGATCAGTGGGCCTCCAAGGAGGGGCTGTAAAATGGAGGCCATTGTGTGAGCCTATCAGAGTT
GCTGCAAACCTGACCCCTGCTCAGTAAAGCACTTGCAACCGTCTGTTATGCTGTGACACATGGCCCCTCCCCCTGCCAGGAGCTTTGGAC
CTAATCCAAGCATCCCTTTGCCCAGAAAGAAGATGGGGGAGGAGGCAGTAATAAAAAGATTGAAGTATTTTGCTGGAATAAGTTCAAATT
CTTCTGAACTCAAACTGAGGAATTTCACCTGTAAACCTGAGTCGTACAGAAAGCTGCCTGGTATATCCAAAAGCTTTTTATTCCTCCTGC
TCATATTGTGATTCTGCCTTTGGGGACTTTTCTTAAACCTTCAGTTATGATTTTTTTTTCATACACTTATTGGAACTCTGCTTGATTTTT
GCCTCTTCCAGTCTTCCTGACACTTTAATTACCAACCTGTTACCTACTTTGACTTTTTGCATTTAAAACAGACACTGGCATGGATATAGT
TTTACTTTTAAACTGTGTACATAACTGAAAATGTGCTATACTGCATACTTTTTAAATGTAAAGATATTTTTATCTTTATATGAAGAAAAT
CACTTAGGAAATGGCTTTGTGATTCAATCTGTAAACTGTGTATTCCAAGACATGTCTGTTCTACATAGATGCTTAGTCCCTCATGCAAAT
CAATTACTGGTCCAAAAGATTGCTGAAATTTTATATGCTTACTGATATATTTTACAATTTTTTATCATGCATGTCCTGTAAAGGTTACAA

>90116_90116_1_TES-CAV1_TES_chr7_115850788_ENST00000358204_CAV1_chr7_116166579_ENST00000341049_length(amino acids)=247AA_BP=1
MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKGHLYTVPIREQ
GNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TES-CAV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCAV1chr7:115850788chr7:116166579ENST000003410490382_9410.0179.0CAVIN3
TgeneCAV1chr7:115850788chr7:116166579ENST000003934670282_940148.0CAVIN3
TgeneCAV1chr7:115850788chr7:116166579ENST000003934680382_940148.0CAVIN3
TgeneCAV1chr7:115850788chr7:116166579ENST000004053480382_940148.0CAVIN3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TES-CAV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TES-CAV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource