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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TES-MET (FusionGDB2 ID:90140)

Fusion Gene Summary for TES-MET

check button Fusion gene summary
Fusion gene informationFusion gene name: TES-MET
Fusion gene ID: 90140
HgeneTgene
Gene symbol

TES

MET

Gene ID

26136

8731

Gene nametestin LIM domain proteinRNA guanine-7 methyltransferase
SynonymsTESS|TESS-2CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

7q31.2

18p11.21

Type of geneprotein-codingprotein-coding
Descriptiontestintestis derived transcript (3 LIM domains)mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2020031320200329
UniProtAcc.

Q9H1A3

Ensembl transtripts involved in fusion geneENST00000358204, ENST00000537767, 
ENST00000393481, ENST00000485009, 
ENST00000495962, ENST00000318493, 
ENST00000397752, ENST00000436117, 
ENST00000539704, 
Fusion gene scores* DoF score10 X 7 X 4=28014 X 18 X 10=2520
# samples 927
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TES [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMET(116340338)-TES(115874588), # samples:1
TES(115850788)-MET(116339125), # samples:1
TES(115850788)-MET(116371722), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonFusion gene breakpoints across TES (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8576-01ATESchr7

115850788

+METchr7

116339125

+
ChimerDB4STADTCGA-D7-8576-01ATESchr7

115850788

+METchr7

116371722

+


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Fusion Gene ORF analysis for TES-MET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000358204ENST00000495962TESchr7

115850788

+METchr7

116371722

+
5CDS-5UTRENST00000358204ENST00000318493TESchr7

115850788

+METchr7

116339125

+
5CDS-5UTRENST00000358204ENST00000397752TESchr7

115850788

+METchr7

116339125

+
5CDS-intronENST00000358204ENST00000436117TESchr7

115850788

+METchr7

116339125

+
5CDS-intronENST00000358204ENST00000495962TESchr7

115850788

+METchr7

116339125

+
5CDS-intronENST00000358204ENST00000539704TESchr7

115850788

+METchr7

116339125

+
5CDS-intronENST00000358204ENST00000539704TESchr7

115850788

+METchr7

116371722

+
5UTR-3CDSENST00000537767ENST00000318493TESchr7

115850788

+METchr7

116371722

+
5UTR-3CDSENST00000537767ENST00000397752TESchr7

115850788

+METchr7

116371722

+
5UTR-3CDSENST00000537767ENST00000436117TESchr7

115850788

+METchr7

116371722

+
5UTR-3UTRENST00000537767ENST00000495962TESchr7

115850788

+METchr7

116371722

+
5UTR-5UTRENST00000537767ENST00000318493TESchr7

115850788

+METchr7

116339125

+
5UTR-5UTRENST00000537767ENST00000397752TESchr7

115850788

+METchr7

116339125

+
5UTR-intronENST00000537767ENST00000436117TESchr7

115850788

+METchr7

116339125

+
5UTR-intronENST00000537767ENST00000495962TESchr7

115850788

+METchr7

116339125

+
5UTR-intronENST00000537767ENST00000539704TESchr7

115850788

+METchr7

116339125

+
5UTR-intronENST00000537767ENST00000539704TESchr7

115850788

+METchr7

116371722

+
In-frameENST00000358204ENST00000318493TESchr7

115850788

+METchr7

116371722

+
In-frameENST00000358204ENST00000397752TESchr7

115850788

+METchr7

116371722

+
In-frameENST00000358204ENST00000436117TESchr7

115850788

+METchr7

116371722

+
intron-3CDSENST00000393481ENST00000318493TESchr7

115850788

+METchr7

116371722

+
intron-3CDSENST00000393481ENST00000397752TESchr7

115850788

+METchr7

116371722

+
intron-3CDSENST00000393481ENST00000436117TESchr7

115850788

+METchr7

116371722

+
intron-3CDSENST00000485009ENST00000318493TESchr7

115850788

+METchr7

116371722

+
intron-3CDSENST00000485009ENST00000397752TESchr7

115850788

+METchr7

116371722

+
intron-3CDSENST00000485009ENST00000436117TESchr7

115850788

+METchr7

116371722

+
intron-3UTRENST00000393481ENST00000495962TESchr7

115850788

+METchr7

116371722

+
intron-3UTRENST00000485009ENST00000495962TESchr7

115850788

+METchr7

116371722

+
intron-5UTRENST00000393481ENST00000318493TESchr7

115850788

+METchr7

116339125

+
intron-5UTRENST00000393481ENST00000397752TESchr7

115850788

+METchr7

116339125

+
intron-5UTRENST00000485009ENST00000318493TESchr7

115850788

+METchr7

116339125

+
intron-5UTRENST00000485009ENST00000397752TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000393481ENST00000436117TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000393481ENST00000495962TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000393481ENST00000539704TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000393481ENST00000539704TESchr7

115850788

+METchr7

116371722

+
intron-intronENST00000485009ENST00000436117TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000485009ENST00000495962TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000485009ENST00000539704TESchr7

115850788

+METchr7

116339125

+
intron-intronENST00000485009ENST00000539704TESchr7

115850788

+METchr7

116371722

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358204TESchr7115850788+ENST00000397752METchr7116371722+5477242532141069
ENST00000358204TESchr7115850788+ENST00000318493METchr7116371722+3487242532681087
ENST00000358204TESchr7115850788+ENST00000436117METchr7116371722+133724251336444

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358204ENST00000397752TESchr7115850788+METchr7116371722+0.0001158630.9998841
ENST00000358204ENST00000318493TESchr7115850788+METchr7116371722+0.0001714180.9998286
ENST00000358204ENST00000436117TESchr7115850788+METchr7116371722+0.0023798130.99762017

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Fusion Genomic Features for TES-MET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TESchr7115850788+METchr7116371721+0.0423194320.95768064
TESchr7115850788+METchr7116339124+0.0003805860.99961936
TESchr7115850788+METchr7116371721+0.0423194320.95768064
TESchr7115850788+METchr7116339124+0.0003805860.99961936

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TES-MET


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116340338/chr7:115874588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MET

Q9H1A3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:115850788chr7:116371722ENST000003184931211078_13454001409.0DomainProtein kinase
TgeneMETchr7:115850788chr7:116371722ENST00000318493121563_6554001409.0DomainNote=IPT/TIG 1
TgeneMETchr7:115850788chr7:116371722ENST00000318493121657_7394001409.0DomainNote=IPT/TIG 2
TgeneMETchr7:115850788chr7:116371722ENST00000318493121742_8364001409.0DomainNote=IPT/TIG 3
TgeneMETchr7:115850788chr7:116371722ENST000003977521211078_13454001391.0DomainProtein kinase
TgeneMETchr7:115850788chr7:116371722ENST00000397752121563_6554001391.0DomainNote=IPT/TIG 1
TgeneMETchr7:115850788chr7:116371722ENST00000397752121657_7394001391.0DomainNote=IPT/TIG 2
TgeneMETchr7:115850788chr7:116371722ENST00000397752121742_8364001391.0DomainNote=IPT/TIG 3
TgeneMETchr7:115850788chr7:116371722ENST00000436117091078_1345400765.0DomainProtein kinase
TgeneMETchr7:115850788chr7:116371722ENST0000043611709563_655400765.0DomainNote=IPT/TIG 1
TgeneMETchr7:115850788chr7:116371722ENST0000043611709657_739400765.0DomainNote=IPT/TIG 2
TgeneMETchr7:115850788chr7:116371722ENST0000043611709742_836400765.0DomainNote=IPT/TIG 3
TgeneMETchr7:115850788chr7:116371722ENST000003184931211084_10924001409.0Nucleotide bindingATP
TgeneMETchr7:115850788chr7:116371722ENST000003977521211084_10924001391.0Nucleotide bindingATP
TgeneMETchr7:115850788chr7:116371722ENST00000436117091084_1092400765.0Nucleotide bindingATP
TgeneMETchr7:115850788chr7:116371722ENST00000318493121956_13904001409.0Topological domainCytoplasmic
TgeneMETchr7:115850788chr7:116371722ENST00000397752121956_13904001391.0Topological domainCytoplasmic
TgeneMETchr7:115850788chr7:116371722ENST0000043611709956_1390400765.0Topological domainCytoplasmic
TgeneMETchr7:115850788chr7:116371722ENST00000318493121933_9554001409.0TransmembraneHelical
TgeneMETchr7:115850788chr7:116371722ENST00000397752121933_9554001391.0TransmembraneHelical
TgeneMETchr7:115850788chr7:116371722ENST0000043611709933_955400765.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTESchr7:115850788chr7:116371722ENST00000358204+1722_469422.0Compositional biasNote=Cys-rich
HgeneTESchr7:115850788chr7:116371722ENST00000393481+1722_460413.0Compositional biasNote=Cys-rich
HgeneTESchr7:115850788chr7:116371722ENST00000358204+17234_2979422.0DomainLIM zinc-binding 1
HgeneTESchr7:115850788chr7:116371722ENST00000358204+17299_3599422.0DomainLIM zinc-binding 2
HgeneTESchr7:115850788chr7:116371722ENST00000358204+17362_4219422.0DomainLIM zinc-binding 3
HgeneTESchr7:115850788chr7:116371722ENST00000358204+1792_1999422.0DomainPET
HgeneTESchr7:115850788chr7:116371722ENST00000393481+17234_2970413.0DomainLIM zinc-binding 1
HgeneTESchr7:115850788chr7:116371722ENST00000393481+17299_3590413.0DomainLIM zinc-binding 2
HgeneTESchr7:115850788chr7:116371722ENST00000393481+17362_4210413.0DomainLIM zinc-binding 3
HgeneTESchr7:115850788chr7:116371722ENST00000393481+1792_1990413.0DomainPET
TgeneMETchr7:115850788chr7:116371722ENST0000031849312127_5154001409.0DomainSema
TgeneMETchr7:115850788chr7:116371722ENST0000039775212127_5154001391.0DomainSema
TgeneMETchr7:115850788chr7:116371722ENST000004361170927_515400765.0DomainSema
TgeneMETchr7:115850788chr7:116371722ENST0000031849312125_9324001409.0Topological domainExtracellular
TgeneMETchr7:115850788chr7:116371722ENST0000039775212125_9324001391.0Topological domainExtracellular
TgeneMETchr7:115850788chr7:116371722ENST000004361170925_932400765.0Topological domainExtracellular


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Fusion Gene Sequence for TES-MET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90140_90140_1_TES-MET_TES_chr7_115850788_ENST00000358204_MET_chr7_116371722_ENST00000318493_length(transcript)=3487nt_BP=242nt
ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG
TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG
ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGACACTTCTGAGAAATTCATCAGGCTGTG
AAGCGCGCCGTGATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAA
CATCTATATCCACCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGAT
CAGGACCATCAACCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATG
GCTACACACTGGTTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCC
TCTCTGCCCCACCCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGA
TCTGTCTGCCTGCAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGAT
TTCGGAGGAATAATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGA
ATACATTGAAATGCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACA
GTACATTCTCCTATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAA
ATTACCTAAACAGTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTT
ATACCCCAGCCCAAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTG
AAGATCCCATTGTCTATGAAATTCATCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTT
GCTTTGCCAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAG
CAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGC
AACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTA
AGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAG
GTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGA
AATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCA
CAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTA
AAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAA
CTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCC
GACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCC
ACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATG
AAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCT
TGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGC
TCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATG
AGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCC
ACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATA
AAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCA
CCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATA
TAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACC
CTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATG
TGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACAC
GACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGAC
CTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAA

>90140_90140_1_TES-MET_TES_chr7_115850788_ENST00000358204_MET_chr7_116371722_ENST00000318493_length(amino acids)=1087AA_BP=1
MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKTLLRNSSGCEA
RRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY
TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFR
RNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY
LNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCF
ASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKP
FEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTG
LIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQ
VQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN
RITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR
DLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDIT
VYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRP

--------------------------------------------------------------
>90140_90140_2_TES-MET_TES_chr7_115850788_ENST00000358204_MET_chr7_116371722_ENST00000397752_length(transcript)=5477nt_BP=242nt
ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG
TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG
ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGACACTTCTGAGAAATTCATCAGGCTGTG
AAGCGCGCCGTGATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAA
CATCTATATCCACCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGAT
CAGGACCATCAACCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATG
GCTACACACTGGTTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCC
TCTCTGCCCCACCCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGA
TCTGTCTGCCTGCAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGAT
TTCGGAGGAATAATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGA
ATACATTGAAATGCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACA
GTACATTCTCCTATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAA
ATTACCTAAACAGTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTT
ATACCCCAGCCCAAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTG
AAGATCCCATTGTCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAG
TTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCT
GTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAAT
ACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAA
TTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTG
AAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCC
TTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTG
GGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATT
TGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAG
ATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACT
CTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAG
TGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACA
ATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCA
TCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACA
TGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCA
AAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGG
TTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGA
TGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAG
GAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAG
ACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGA
TCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGT
CATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAG
TCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGA
CTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGAC
CAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTT
GATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCG
GCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGAT
GGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTG
CAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCC
GGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCT
CAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAAT
ATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTA
AGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTA
ATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAG
ATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTG
GATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGC
ATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAAT
AGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACT
GGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAA
AACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAA
ATGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTC
ACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAG
ACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAA
ATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACT
CGGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAAC
TTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTG

>90140_90140_2_TES-MET_TES_chr7_115850788_ENST00000358204_MET_chr7_116371722_ENST00000397752_length(amino acids)=1069AA_BP=1
MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKTLLRNSSGCEA
RRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY
TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFR
RNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY
LNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVS
VPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIK
GNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGF
FLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSD
ISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIM
KDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVA
DFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDP

--------------------------------------------------------------
>90140_90140_3_TES-MET_TES_chr7_115850788_ENST00000358204_MET_chr7_116371722_ENST00000436117_length(transcript)=1337nt_BP=242nt
ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG
TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG
ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGACACTTCTGAGAAATTCATCAGGCTGTG
AAGCGCGCCGTGATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAA
CATCTATATCCACCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGAT
CAGGACCATCAACCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATG
GCTACACACTGGTTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCC
TCTCTGCCCCACCCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGA
TCTGTCTGCCTGCAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGAT
TTCGGAGGAATAATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGA
ATACATTGAAATGCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACA
GTACATTCTCCTATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAA
ATTACCTAAACAGTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTT
ATACCCCAGCCCAAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTG

>90140_90140_3_TES-MET_TES_chr7_115850788_ENST00000358204_MET_chr7_116371722_ENST00000436117_length(amino acids)=444AA_BP=1
MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKTLLRNSSGCEA
RRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY
TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFR
RNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY

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Fusion Gene PPI Analysis for TES-MET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMETchr7:115850788chr7:116371722ENST000003184931211320_1359400.01409.0MUC20
TgeneMETchr7:115850788chr7:116371722ENST000003977521211320_1359400.01391.0MUC20
TgeneMETchr7:115850788chr7:116371722ENST00000436117091320_1359400.0765.0MUC20
TgeneMETchr7:115850788chr7:116371722ENST000003184931211212_1390400.01409.0RANBP9
TgeneMETchr7:115850788chr7:116371722ENST000003977521211212_1390400.01391.0RANBP9
TgeneMETchr7:115850788chr7:116371722ENST00000436117091212_1390400.0765.0RANBP9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TES-MET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TES-MET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource