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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TEX101-NEDD4L (FusionGDB2 ID:90196)

Fusion Gene Summary for TEX101-NEDD4L

check button Fusion gene summary
Fusion gene informationFusion gene name: TEX101-NEDD4L
Fusion gene ID: 90196
HgeneTgene
Gene symbol

TEX101

NEDD4L

Gene ID

83639

23327

Gene nametestis expressed 101NEDD4 like E3 ubiquitin protein ligase
SynonymsCT131|GTPR867|NYD-SP8|PRO1884|SGRG|SPATA44|TES101RPNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
Cytomap

19q13.31

18q21.31

Type of geneprotein-codingprotein-coding
Descriptiontestis-expressed protein 101TES101-reactive proteincancer/testis antigen 131cell surface receptor NYD-SP8scleroderma-associated autoantigenspermatogenesis associated 44spermatogenesis-related gene proteintestis expressed sequence 101testis-expressE3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5
Modification date2020032020200329
UniProtAcc.

Q96PU5

Ensembl transtripts involved in fusion geneENST00000253435, ENST00000598265, 
ENST00000601707, ENST00000602198, 
ENST00000256830, ENST00000256832, 
ENST00000356462, ENST00000357895, 
ENST00000382850, ENST00000400345, 
ENST00000431212, ENST00000435432, 
ENST00000456173, ENST00000456986, 
ENST00000586263, ENST00000588516, 
ENST00000589054, 
Fusion gene scores* DoF score1 X 1 X 1=127 X 28 X 6=4536
# samples 132
** MAII scorelog2(1/1*10)=3.32192809488736log2(32/4536*10)=-3.82527683005487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEX101 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTEX101(43894593)-NEDD4L(55828684), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

TgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0010038

response to metal ion

11244092

TgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

TgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

TgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

TgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

TgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

TgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

TgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

TgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

TgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

TgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check buttonFusion gene breakpoints across TEX101 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NEDD4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF344201TEX101chr19

43894593

-NEDD4Lchr18

55828684

-


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Fusion Gene ORF analysis for TEX101-NEDD4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000253435ENST00000256830TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000256832TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000356462TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000357895TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000382850TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000400345TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000431212TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000435432TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000456173TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000456986TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000586263TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000588516TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000253435ENST00000589054TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000256830TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000256832TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000356462TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000357895TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000382850TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000400345TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000431212TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000435432TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000456173TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000456986TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000586263TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000588516TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000598265ENST00000589054TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000256830TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000256832TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000356462TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000357895TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000382850TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000400345TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000431212TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000435432TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000456173TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000456986TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000586263TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000588516TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000601707ENST00000589054TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000256830TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000256832TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000356462TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000357895TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000382850TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000400345TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000431212TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000435432TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000456173TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000456986TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000586263TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000588516TEX101chr19

43894593

-NEDD4Lchr18

55828684

-
intron-intronENST00000602198ENST00000589054TEX101chr19

43894593

-NEDD4Lchr18

55828684

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TEX101-NEDD4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TEX101-NEDD4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43894593/:55828684)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NEDD4L

Q96PU5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TEX101-NEDD4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TEX101-NEDD4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TEX101-NEDD4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TEX101-NEDD4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource