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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TFDP1-TMCO3 (FusionGDB2 ID:90296)

Fusion Gene Summary for TFDP1-TMCO3

check button Fusion gene summary
Fusion gene informationFusion gene name: TFDP1-TMCO3
Fusion gene ID: 90296
HgeneTgene
Gene symbol

TFDP1

TMCO3

Gene ID

7027

55002

Gene nametranscription factor Dp-1transmembrane and coiled-coil domains 3
SynonymsDILC|DP1|DRTF1|Dp-1C13orf11
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cellstransmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000465174, ENST00000375370, 
ENST00000538138, ENST00000544902, 
ENST00000375391, ENST00000434316, 
ENST00000474393, 
Fusion gene scores* DoF score11 X 7 X 6=46215 X 14 X 11=2310
# samples 1524
** MAII scorelog2(15/462*10)=-1.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2310*10)=-3.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFDP1 [Title/Abstract] AND TMCO3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTFDP1(114277601)-TMCO3(114164553), # samples:2
TMCO3(114193822)-TFDP1(114265310), # samples:3
Anticipated loss of major functional domain due to fusion event.TFDP1-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TFDP1-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TMCO3-TFDP1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TMCO3-TFDP1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFDP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537

HgeneTFDP1

GO:0051091

positive regulation of DNA-binding transcription factor activity

17062573

HgeneTFDP1

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

17062573


check buttonFusion gene breakpoints across TFDP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMCO3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B9-01ATFDP1chr13

114277601

-TMCO3chr13

114164553

+
ChimerDB4BRCATCGA-BH-A0B9-01ATFDP1chr13

114277601

+TMCO3chr13

114164553

+
ChimerDB4BRCATCGA-BH-A0B9TFDP1chr13

114277601

+TMCO3chr13

114164552

+


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Fusion Gene ORF analysis for TFDP1-TMCO3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000465174ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164553

+
3UTR-3CDSENST00000465174ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164552

+
3UTR-3CDSENST00000465174ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164553

+
3UTR-3CDSENST00000465174ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164552

+
3UTR-3UTRENST00000465174ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164553

+
3UTR-3UTRENST00000465174ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164552

+
5CDS-3UTRENST00000375370ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164553

+
5CDS-3UTRENST00000375370ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164552

+
5CDS-3UTRENST00000538138ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164553

+
5CDS-3UTRENST00000538138ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164552

+
5CDS-3UTRENST00000544902ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164553

+
5CDS-3UTRENST00000544902ENST00000474393TFDP1chr13

114277601

+TMCO3chr13

114164552

+
Frame-shiftENST00000538138ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164553

+
Frame-shiftENST00000538138ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164552

+
Frame-shiftENST00000538138ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164553

+
Frame-shiftENST00000538138ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164552

+
Frame-shiftENST00000544902ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164553

+
Frame-shiftENST00000544902ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164552

+
Frame-shiftENST00000544902ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164553

+
Frame-shiftENST00000544902ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164552

+
In-frameENST00000375370ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164553

+
In-frameENST00000375370ENST00000375391TFDP1chr13

114277601

+TMCO3chr13

114164552

+
In-frameENST00000375370ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164553

+
In-frameENST00000375370ENST00000434316TFDP1chr13

114277601

+TMCO3chr13

114164552

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375370TFDP1chr13114277601+ENST00000434316TMCO3chr13114164552+20513982121393393
ENST00000375370TFDP1chr13114277601+ENST00000375391TMCO3chr13114164552+1179398212604130
ENST00000375370TFDP1chr13114277601+ENST00000434316TMCO3chr13114164553+20513982121393393
ENST00000375370TFDP1chr13114277601+ENST00000375391TMCO3chr13114164553+1179398212604130

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375370ENST00000434316TFDP1chr13114277601+TMCO3chr13114164552+0.0061400160.99386
ENST00000375370ENST00000375391TFDP1chr13114277601+TMCO3chr13114164552+0.0493702660.9506298
ENST00000375370ENST00000434316TFDP1chr13114277601+TMCO3chr13114164553+0.0061400160.99386
ENST00000375370ENST00000375391TFDP1chr13114277601+TMCO3chr13114164553+0.0493702660.9506298

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Fusion Genomic Features for TFDP1-TMCO3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TFDP1chr13114277601+TMCO3chr13114164552+3.96E-050.9999604
TFDP1chr13114277601+TMCO3chr13114164552+3.96E-050.9999604
TFDP1chr13114277601+TMCO3chr13114164552+3.96E-050.9999604
TFDP1chr13114277601+TMCO3chr13114164552+3.96E-050.9999604

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TFDP1-TMCO3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:114277601/chr13:114164553)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158350_370346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158416_436346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158456_476346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158498_518346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158554_574346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158578_598346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158608_628346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158640_660346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513350_370346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513416_436346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513456_476346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513498_518346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513554_574346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513578_598346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513608_628346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513640_660346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158350_370346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158416_436346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158456_476346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158498_518346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158554_574346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158578_598346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158608_628346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158640_660346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513350_370346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513416_436346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513456_476346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513498_518346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513554_574346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513578_598346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513608_628346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513640_660346678.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412250_25362411.0Compositional biasNote=Poly-Pro
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412394_41062411.0Compositional biasNote=Asp/Glu-rich (acidic%3B NCB domain)
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412250_25362411.0Compositional biasNote=Poly-Pro
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412394_41062411.0Compositional biasNote=Asp/Glu-rich (acidic%3B NCB domain)
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412113_19562411.0DNA bindingOntology_term=ECO:0000255
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412113_19562411.0DNA bindingOntology_term=ECO:0000255
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412161_19562411.0MotifNote=DEF box
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412161_19562411.0MotifNote=DEF box
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412204_27762411.0RegionDimerization
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412211_32762411.0RegionNote=Enhances binding of RB protein to E2F
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412214_24662411.0RegionNote=DCB1
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412259_31562411.0RegionNote=DCB2
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412204_27762411.0RegionDimerization
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412211_32762411.0RegionNote=Enhances binding of RB protein to E2F
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412214_24662411.0RegionNote=DCB1
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412259_31562411.0RegionNote=DCB2
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158124_204346415.0Coiled coilOntology_term=ECO:0000255
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513124_204346678.0Coiled coilOntology_term=ECO:0000255
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158124_204346415.0Coiled coilOntology_term=ECO:0000255
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513124_204346678.0Coiled coilOntology_term=ECO:0000255
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158221_224346415.0Compositional biasNote=Poly-Glu
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513221_224346678.0Compositional biasNote=Poly-Glu
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158221_224346415.0Compositional biasNote=Poly-Glu
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513221_224346678.0Compositional biasNote=Poly-Glu
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158286_306346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST0000037539158317_337346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513286_306346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164552ENST00000434316513317_337346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158286_306346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST0000037539158317_337346415.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513286_306346678.0TransmembraneHelical
TgeneTMCO3chr13:114277601chr13:114164553ENST00000434316513317_337346678.0TransmembraneHelical


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Fusion Gene Sequence for TFDP1-TMCO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90296_90296_1_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164552_ENST00000375391_length(transcript)=1179nt_BP=398nt
CGTCCCGGCGCCACTCGGCCCAGGGCAGGGACCCCGCCACGGCCGGGACCGCCCGGCCCGGCCCCAGCCCGCGCCTCTCCGCGCCGCCCC
GCGCTCCGCACCGCGCCCTCTCCGCGTCCCCGCCCGCGCGGCCGGACCGGGCAGCCAGAAAAATCATTTTTCTTCTCTGGGAAGGTGAAC
ATTTGTAGCATTGATTTCCCGGATCTGGTAACATGGCAAAAGATGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACC
AGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAA
CCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTGTGGAAGATTTCCTTACAAGGGCCGTGTTACATGACACTGTTAATGATTG
CATTTGGCTTGCTGTGGGGGCATCTCTTGCGGATCAAACCCACGCAGAGCGTCTTCATTTCCACGTGTCTGTCCTTGTCAAGCACACCCC
TCGTGTCCAGGTTCCTCATGGGCAGTGCTCGGGGTGACAAAGAAGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTGTTAT
CCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCCGGGA
CACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGTGAGT
TCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCAAATA
TTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTTTCTA
AAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCACTTA
AAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAATAAAGATAATTTATGATCATGGTATAATTAATTGAAATTTATTAAAATCT

>90296_90296_1_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164552_ENST00000375391_length(amino acids)=130AA_BP=62
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVWKISLQGPCYMTLLMIAFGLLWGHLLR

--------------------------------------------------------------
>90296_90296_2_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164552_ENST00000434316_length(transcript)=2051nt_BP=398nt
CGTCCCGGCGCCACTCGGCCCAGGGCAGGGACCCCGCCACGGCCGGGACCGCCCGGCCCGGCCCCAGCCCGCGCCTCTCCGCGCCGCCCC
GCGCTCCGCACCGCGCCCTCTCCGCGTCCCCGCCCGCGCGGCCGGACCGGGCAGCCAGAAAAATCATTTTTCTTCTCTGGGAAGGTGAAC
ATTTGTAGCATTGATTTCCCGGATCTGGTAACATGGCAAAAGATGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACC
AGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAA
CCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTGTGGAAGATTTCCTTACAAGGGCCGTGTTACATGACACTGTTAATGATTG
CATTTGGCTTGCTGTGGGGGCATCTCTTGCGGATCAAACCCACGCAGAGCGTCTTCATTTCCACGTGTCTGTCCTTGTCAAGCACACCCC
TCGTGTCCAGGTTCCTCATGGGCAGTGCTCGGGGTGACAAAGAAGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACGC
AGGACGTGCAGCTCGGGCTCTTCATGGCCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTTC
TCCGAATCCTGGTTTTGATTGGTCAGATTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGAC
CCTATTATCGGAAGCTGCACATGGAAAGCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACGG
TCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGA
TCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCGT
ACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCGA
GGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGAG
CGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCAA
TCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAGT
GAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTG
TTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCC
GGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGT
GAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCA
AATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTT
TCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCA

>90296_90296_2_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164552_ENST00000434316_length(amino acids)=393AA_BP=62
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVWKISLQGPCYMTLLMIAFGLLWGHLLR
IKPTQSVFISTCLSLSSTPLVSRFLMGSARGDKEGDIDYSTVLLGMLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEVLRILVLIGQIL
FSLAAVFLLCLVIKKYLIGPYYRKLHMESKGNKEILILGISAFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDF
LAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLL

--------------------------------------------------------------
>90296_90296_3_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164553_ENST00000375391_length(transcript)=1179nt_BP=398nt
CGTCCCGGCGCCACTCGGCCCAGGGCAGGGACCCCGCCACGGCCGGGACCGCCCGGCCCGGCCCCAGCCCGCGCCTCTCCGCGCCGCCCC
GCGCTCCGCACCGCGCCCTCTCCGCGTCCCCGCCCGCGCGGCCGGACCGGGCAGCCAGAAAAATCATTTTTCTTCTCTGGGAAGGTGAAC
ATTTGTAGCATTGATTTCCCGGATCTGGTAACATGGCAAAAGATGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACC
AGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAA
CCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTGTGGAAGATTTCCTTACAAGGGCCGTGTTACATGACACTGTTAATGATTG
CATTTGGCTTGCTGTGGGGGCATCTCTTGCGGATCAAACCCACGCAGAGCGTCTTCATTTCCACGTGTCTGTCCTTGTCAAGCACACCCC
TCGTGTCCAGGTTCCTCATGGGCAGTGCTCGGGGTGACAAAGAAGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTGTTAT
CCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCCGGGA
CACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGTGAGT
TCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCAAATA
TTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTTTCTA
AAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCACTTA
AAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAATAAAGATAATTTATGATCATGGTATAATTAATTGAAATTTATTAAAATCT

>90296_90296_3_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164553_ENST00000375391_length(amino acids)=130AA_BP=62
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVWKISLQGPCYMTLLMIAFGLLWGHLLR

--------------------------------------------------------------
>90296_90296_4_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164553_ENST00000434316_length(transcript)=2051nt_BP=398nt
CGTCCCGGCGCCACTCGGCCCAGGGCAGGGACCCCGCCACGGCCGGGACCGCCCGGCCCGGCCCCAGCCCGCGCCTCTCCGCGCCGCCCC
GCGCTCCGCACCGCGCCCTCTCCGCGTCCCCGCCCGCGCGGCCGGACCGGGCAGCCAGAAAAATCATTTTTCTTCTCTGGGAAGGTGAAC
ATTTGTAGCATTGATTTCCCGGATCTGGTAACATGGCAAAAGATGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACC
AGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAA
CCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTGTGGAAGATTTCCTTACAAGGGCCGTGTTACATGACACTGTTAATGATTG
CATTTGGCTTGCTGTGGGGGCATCTCTTGCGGATCAAACCCACGCAGAGCGTCTTCATTTCCACGTGTCTGTCCTTGTCAAGCACACCCC
TCGTGTCCAGGTTCCTCATGGGCAGTGCTCGGGGTGACAAAGAAGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACGC
AGGACGTGCAGCTCGGGCTCTTCATGGCCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTTC
TCCGAATCCTGGTTTTGATTGGTCAGATTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGAC
CCTATTATCGGAAGCTGCACATGGAAAGCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACGG
TCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGA
TCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCGT
ACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCGA
GGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGAG
CGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCAA
TCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAGT
GAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTG
TTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCC
GGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGT
GAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCA
AATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTT
TCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCA

>90296_90296_4_TFDP1-TMCO3_TFDP1_chr13_114277601_ENST00000375370_TMCO3_chr13_114164553_ENST00000434316_length(amino acids)=393AA_BP=62
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVWKISLQGPCYMTLLMIAFGLLWGHLLR
IKPTQSVFISTCLSLSSTPLVSRFLMGSARGDKEGDIDYSTVLLGMLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEVLRILVLIGQIL
FSLAAVFLLCLVIKKYLIGPYYRKLHMESKGNKEILILGISAFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDF
LAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TFDP1-TMCO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTFDP1chr13:114277601chr13:114164552ENST00000375370+412105_12762.0411.0CEBPA
HgeneTFDP1chr13:114277601chr13:114164553ENST00000375370+412105_12762.0411.0CEBPA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TFDP1-TMCO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TFDP1-TMCO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource