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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TFE3-MED15 (FusionGDB2 ID:90318)

Fusion Gene Summary for TFE3-MED15

check button Fusion gene summary
Fusion gene informationFusion gene name: TFE3-MED15
Fusion gene ID: 90318
HgeneTgene
Gene symbol

TFE3

MED15

Gene ID

7030

51586

Gene nametranscription factor binding to IGHM enhancer 3mediator complex subunit 15
SynonymsRCCP2|RCCX1|TFEA|bHLHe33ARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
Cytomap

Xp11.23

22q11.21

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3mediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
Modification date2020032720200313
UniProtAcc.

Q96RN5

Ensembl transtripts involved in fusion geneENST00000315869, ENST00000487451, 
ENST00000263205, ENST00000382974, 
ENST00000406969, ENST00000478831, 
ENST00000541476, ENST00000542773, 
ENST00000292733, ENST00000425759, 
Fusion gene scores* DoF score9 X 12 X 6=64822 X 18 X 9=3564
# samples 1224
** MAII scorelog2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3564*10)=-3.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFE3 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED15(20929519)-TFE3(48891766), # samples:3
TFE3(48895535)-MED15(20936898), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TFE3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MED15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-6D-AA2E-01ATFE3chrX

48895535

-MED15chr22

20936898

+


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Fusion Gene ORF analysis for TFE3-MED15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000315869ENST00000263205TFE3chrX

48895535

-MED15chr22

20936898

+
5CDS-intronENST00000315869ENST00000382974TFE3chrX

48895535

-MED15chr22

20936898

+
5CDS-intronENST00000315869ENST00000406969TFE3chrX

48895535

-MED15chr22

20936898

+
5CDS-intronENST00000315869ENST00000478831TFE3chrX

48895535

-MED15chr22

20936898

+
5CDS-intronENST00000315869ENST00000541476TFE3chrX

48895535

-MED15chr22

20936898

+
5CDS-intronENST00000315869ENST00000542773TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-3CDSENST00000487451ENST00000292733TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-3CDSENST00000487451ENST00000425759TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-intronENST00000487451ENST00000263205TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-intronENST00000487451ENST00000382974TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-intronENST00000487451ENST00000406969TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-intronENST00000487451ENST00000478831TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-intronENST00000487451ENST00000541476TFE3chrX

48895535

-MED15chr22

20936898

+
5UTR-intronENST00000487451ENST00000542773TFE3chrX

48895535

-MED15chr22

20936898

+
In-frameENST00000315869ENST00000292733TFE3chrX

48895535

-MED15chr22

20936898

+
In-frameENST00000315869ENST00000425759TFE3chrX

48895535

-MED15chr22

20936898

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315869TFE3chrX48895535-ENST00000425759MED15chr2220936898+316711452602239659
ENST00000315869TFE3chrX48895535-ENST00000292733MED15chr2220936898+316811452602239659

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315869ENST00000425759TFE3chrX48895535-MED15chr2220936898+0.029630640.97036934
ENST00000315869ENST00000292733TFE3chrX48895535-MED15chr2220936898+0.0298151020.9701849

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Fusion Genomic Features for TFE3-MED15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TFE3chrX48895534-MED15chr2220936897+3.10E-060.9999969
TFE3chrX48895534-MED15chr2220936897+3.10E-060.9999969

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TFE3-MED15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:20929519/chr22:48891766)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MED15

Q96RN5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFE3chrX:48895535chr22:20936898ENST00000315869-510260_271295576.0RegionStrong transcription activation domain
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818449_456424789.0Compositional biasNote=Poly-Pro
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818602_611424789.0Compositional biasNote=Poly-Pro
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717449_456384749.0Compositional biasNote=Poly-Pro
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717602_611384749.0Compositional biasNote=Poly-Pro
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616360_367313678.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616449_456313678.0Compositional biasNote=Poly-Pro
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616602_611313678.0Compositional biasNote=Poly-Pro
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818547_564424789.0MotifNuclear localization signal
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717547_564384749.0MotifNuclear localization signal
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616547_564313678.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFE3chrX:48895535chr22:20936898ENST00000315869-510346_399295576.0DomainbHLH
HgeneTFE3chrX:48895535chr22:20936898ENST00000315869-510409_430295576.0RegionNote=Leucine-zipper
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818161_174424789.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818178_193424789.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818205_218424789.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818226_239424789.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818243_262424789.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818266_515424789.0Compositional biasNote=Pro-rich
TgeneMED15chrX:48895535chr22:20936898ENST00000263205818360_367424789.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717161_174384749.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717178_193384749.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717205_218384749.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717226_239384749.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717243_262384749.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717266_515384749.0Compositional biasNote=Pro-rich
TgeneMED15chrX:48895535chr22:20936898ENST00000292733717360_367384749.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616161_174313678.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616178_193313678.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616205_218313678.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616226_239313678.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616243_262313678.0Compositional biasNote=Poly-Gln
TgeneMED15chrX:48895535chr22:20936898ENST00000382974616266_515313678.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for TFE3-MED15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90318_90318_1_TFE3-MED15_TFE3_chrX_48895535_ENST00000315869_MED15_chr22_20936898_ENST00000292733_length(transcript)=3168nt_BP=1145nt
GGGAGGAGGGGGAAGAAGACGAGGGGGAGGAGGGCGGTCGTCCGGGGTTAGGTTGAGGGGGGGCGTCGGTCCGTTCTGGGCGGGGGATGA
CTCACAGCCCATCCCATCTCCCAGACGCCGCCCGCCCGCGCAGTGCTAGCTCCATGGCTTAGCGGAGGAGGCGGCAGTGGCGAGCTGGGG
GGAGGGGGGACTCTTATTTTGTTAGGGGGACCGGGCCGAGGCCCGACCGGCCTGGCAGGGCTCGCCCGGGGCCGGGCGTCATGTCTCATG
CGGCCGAACCAGCTCGGGATGGCGTAGAGGCCAGCGCGGAGGGCCCTCGAGCCGTGTTCGTGCTGTTGGAGGAGCGCAGGCCGGCCGACT
CGGCTCAGCTGCTCAGCCTGAACTCTTTGCTTCCGGAATCCGGGATTGTTGCTGACATAGAATTAGAAAACGTCCTTGATCCTGACAGCT
TCTACGAGCTCAAAAGCCAACCCTTACCCCTTCGCTCAAGCCTCCCAATATCACTGCAGGCCACACCAGCCACCCCAGCTACACTCTCTG
CATCGTCTTCTGCAGGGGGCTCCAGGACCCCTGCCATGTCGTCATCTTCTTCATCGAGGGTCTTGCTGCGGCAGCAGCTAATGCGGGCCC
AGGCGCAGGAGCAGGAGAGGCGTGAGCGTCGGGAACAGGCCGCCGCGGCTCCCTTCCCCAGTCCTGCACCTGCCTCTCCTGCCATCTCTG
TGGTTGGCGTCTCTGCTGGGGGCCACACATTGAGCCGTCCACCCCCTGCTCAGGTGCCCAGGGAGGTGCTCAAGGTGCAGACCCATCTGG
AGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCC
AGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGC
CCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCA
GTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGGTCAGCCAGAGCAGCCTCCCCATGC
TGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCT
CACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAG
TGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTG
GCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGA
TCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGA
AGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCA
AACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCG
TTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGA
GCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCA
CTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAA
GCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGC
TCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGC
AGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTA
GGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCG
GGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTC
ACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCAC
CCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATG
CTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCT
GCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATC
CTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAG
AGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGG
GCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATTTATTATTCCT

>90318_90318_1_TFE3-MED15_TFE3_chrX_48895535_ENST00000315869_MED15_chr22_20936898_ENST00000292733_length(amino acids)=659AA_BP=66
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIIS
LESSYNDEMLSYLPGGTTGLQLPSTVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPS
QSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKR
CPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDD
ERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSR

--------------------------------------------------------------
>90318_90318_2_TFE3-MED15_TFE3_chrX_48895535_ENST00000315869_MED15_chr22_20936898_ENST00000425759_length(transcript)=3167nt_BP=1145nt
GGGAGGAGGGGGAAGAAGACGAGGGGGAGGAGGGCGGTCGTCCGGGGTTAGGTTGAGGGGGGGCGTCGGTCCGTTCTGGGCGGGGGATGA
CTCACAGCCCATCCCATCTCCCAGACGCCGCCCGCCCGCGCAGTGCTAGCTCCATGGCTTAGCGGAGGAGGCGGCAGTGGCGAGCTGGGG
GGAGGGGGGACTCTTATTTTGTTAGGGGGACCGGGCCGAGGCCCGACCGGCCTGGCAGGGCTCGCCCGGGGCCGGGCGTCATGTCTCATG
CGGCCGAACCAGCTCGGGATGGCGTAGAGGCCAGCGCGGAGGGCCCTCGAGCCGTGTTCGTGCTGTTGGAGGAGCGCAGGCCGGCCGACT
CGGCTCAGCTGCTCAGCCTGAACTCTTTGCTTCCGGAATCCGGGATTGTTGCTGACATAGAATTAGAAAACGTCCTTGATCCTGACAGCT
TCTACGAGCTCAAAAGCCAACCCTTACCCCTTCGCTCAAGCCTCCCAATATCACTGCAGGCCACACCAGCCACCCCAGCTACACTCTCTG
CATCGTCTTCTGCAGGGGGCTCCAGGACCCCTGCCATGTCGTCATCTTCTTCATCGAGGGTCTTGCTGCGGCAGCAGCTAATGCGGGCCC
AGGCGCAGGAGCAGGAGAGGCGTGAGCGTCGGGAACAGGCCGCCGCGGCTCCCTTCCCCAGTCCTGCACCTGCCTCTCCTGCCATCTCTG
TGGTTGGCGTCTCTGCTGGGGGCCACACATTGAGCCGTCCACCCCCTGCTCAGGTGCCCAGGGAGGTGCTCAAGGTGCAGACCCATCTGG
AGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCC
AGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGC
CCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCA
GTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGGTCAGCCAGAGCAGCCTCCCCATGC
TGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCT
CACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAG
TGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTG
GCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGA
TCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGA
AGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCA
AACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCG
TTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGA
GCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCA
CTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAA
GCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGC
TCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGC
AGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTA
GGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCG
GGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTC
ACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCAC
CCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATG
CTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCT
GCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATC
CTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAG
AGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGG
GCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATTTATTATTCCT

>90318_90318_2_TFE3-MED15_TFE3_chrX_48895535_ENST00000315869_MED15_chr22_20936898_ENST00000425759_length(amino acids)=659AA_BP=66
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIIS
LESSYNDEMLSYLPGGTTGLQLPSTVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPS
QSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKR
CPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDD
ERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSR

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Fusion Gene PPI Analysis for TFE3-MED15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMED15chrX:48895535chr22:20936898ENST000002632058189_73424.0789.0SREBF1
TgeneMED15chrX:48895535chr22:20936898ENST000002927337179_73384.0749.0SREBF1
TgeneMED15chrX:48895535chr22:20936898ENST000003829746169_73313.0678.0SREBF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TFE3-MED15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TFE3-MED15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource